Trophoblastic differentiation (including choriocarcinoma) arising in urothelial carcinoma has been described in numerous case reports, but never in a single series. We present a series of these tumors, describing the morphologic spectrum, applying traditional and novel immunohistochemical stains, and characterizing clinical follow-up. We identified 16 cases, arising predominantly in the bladder (N=14), but also the ureter (N=1) and prostatic urethra (N=1). Six of our cases (38%) contained invasive...
Fri Jul 03, 2020 03:00
The eighth edition of the American Joint Committee on Cancer (AJCC) Staging Manual attempts to address ambiguity in the pT category assignment for colon cancer from prior editions. Despite modifications, the distinction between the pT3 and pT4a categories continues to be a source of diagnostic confusion. In this study, we assessed interobserver agreement among pathologists from different institutions in the application of AJCC eighth edition criteria for categorizing deeply invasive colonic adenocarcinomas....
Fri Jul 03, 2020 03:00
This study determined the frequency and the clinicopathologic and genetic features of colorectal carcinomas driven by oncogenic fusions of the anaplastic lymphoma kinase gene (ALK). Of the 8150 screened tumors, 12 (0.15%) were immunohistochemically ALK-positive with D5F3 antibody. These cancers harbored CAD-ALK (n=1), DIAPH2-ALK (n=2), EML4-ALK (n=2), LOC101929227-ALK (n=1), SLMAP-ALK (n=1), SPTBN1-ALK (n=4), and STRN-ALK (n=1) fusions, as detected by an RNA-based next-generation sequencing assay....
Fri Jul 03, 2020 03:00
Background: Conservative management with progestin is a treatment option for atypical hyperplasia (AH). However, pathologic diagnosis of residual/recurrent lesions is often problematic because of the profound morphologic changes induced by progestin and the lack of established diagnostic criteria for progestin-treated residual AH. Methods: We conducted a longitudinal study of 265 endometrial biopsies from 54 patients with a history of AH on progestin therapy. Patient outcomes were divided...
Fri Jul 03, 2020 03:00
The spectrum of benign superficial fibroblastic/myofibroblastic tumors continues to expand and includes entities such as plexiform fibrohistiocytic tumor, dermatomyofibroma and fibroblastic connective tissue nevus. Here, we describe a seemingly distinctive group of lesions which we have labeled “plexiform myofibroblastoma” (PM). PM is a rare superficial mesenchymal tumor of fibroblastic/myofibroblastic lineage that predominantly occurs in children and young adults. Thirty-six cases from the consultation...
Fri Jul 03, 2020 03:00
Steatohepatitic hepatocellular carcinoma (SH-HCC) is a variant of hepatocellular carcinoma (HCC) with established association with nonalcoholic steatohepatitis (NASH), while its association with alcoholic steatohepatitis (ASH) is unclear. We studied 2 cohorts of patients who underwent resection for HCC in the setting of steatohepatitis. In our Mount Sinai (New York) cohort, we found SH-HCC in 17/24 (71%) patients with NASH and in 14/19 (74%) patients with ASH, while SH-HCC was the predominant tumor...
Fri Jul 03, 2020 03:00
Objectives: We investigated the ability of single-sided deaf listeners implanted with a cochlear implant (SSD-CI) to (1) determine the front-back and left-right location of sound sources presented from loudspeakers surrounding the listener and (2) use small head rotations to further improve their localization performance. The resulting behavioral data were used for further analyses investigating the value of so-called “monaural” spectral shape cues for front-back sound source localization. ...
Tue Jun 30, 2020 03:00
Summary Purpose MDM2 is a negative regulator of the tumor suppressor p53. RO6839921 is an inactive pegylated prodrug of idasanutlin, an MDM2 antagonist, developed for intravenous administration. On cleavage by plasma esterases, the active principle (AP = idasanutlin) is released. This phase 1 study investigated the safety, pharmacokinetics, and pharmacodynamics of RO6839921 in patients with advanced solid tumors (NCT02098967). Methods Patients were evaluated on a 5-day dosing...
Tue Jul 07, 2020 10:05
Summary Chemotherapy has always been the first therapeutic option for patients with advanced non-small cell lung cancer (NSCLC) with untreatable oncogenic mutations. However, chemotherapy has demonstrated limited success and is associated with severe side effects. This research aimed to investigate the antitumor efficacy and cytotoxic safety of the conjugate ZHER2:V2-pemetrexed, a novel targeted chemotherapeutic drug. In this context, human epidermal growth factor receptor 2...
Tue Jul 07, 2020 10:05
Summary This study provides new information on the cellular effects of 1,3,5-triazine nitrogen mustards with different peptide groups in DLD and Ht-29 human colon cancer cell lines. A novel series of 2,4,6-trisubstituted 1,3,5-triazine derivatives bearing 2-chloroethyl and oligopeptide moieties was designed and synthesized. The most cytotoxic derivative was triazine with an Ala-Ala-OMe substituent on the ring (compound 7b). This compound induced time- and dose-dependent cytotoxicity...
Tue Jul 07, 2020 10:05
Summary Gliomas account for nearly 70% of the central nervous system tumors and present a median survival of approximately 12–17 months. Studies have shown that administration of novel natural antineoplastic agents is been highly effective for treating gliomas. This study was conducted to investigate the antitumor potential (in vitro and in vivo) of Miconia chamissois Naudin for treating glioblastomas. We investigated the cytotoxicity of the chloroform partition and its sub-fraction...
Tue Jul 07, 2020 10:05
Summary Background Resistance to Epidermal Growth Factor inhibition (EGFRi) in patients with KRAS wild-type (wt) Colorectal Cancer (CRC) may occur as a result of PI3K/AKT/mTOR signaling. We conducted a study to establish the recommended phase II dose (RP2D) and response rate of panitumumab, an EGFRi, plus BKM120, a PI3K inhibitor, in advanced CRC. Methods Patients with chemotherapy refractory KRAS wt CRC, who were EGFRi naive were enrolled. A 3 + 3 dose escalation design was...
Tue Jul 07, 2020 10:05
Journal of Cutaneous Medicine and Surgery, Ahead of Print.
Mon Jul 06, 2020 07:02
Abstract Objective The aim of this study was to determine if the timing of administration of systemic enzyme therapy [SET] has any effect on its efficacy in controlling postoperative sequelae of third molar surgery. Study design A double blinded prospective randomized control trial was planned. The sample included patients requiring impacted mandibular...
Tue Jul 07, 2020 03:00
In the article "Decreasing Thickness and Remodeling of Ligamentum Flavum After Oblique Lumbar Interbody Fusion”, Figure 2 captions contained mistakes as descriptions for the Figure sections were not assigned correctly.
Tue Jul 07, 2020 03:00
Objectives Spiral magnetic resonance imaging acquisition may enable improved image quality and higher scan speeds than Cartesian trajectories. We tested the performance of four 3D T1-weighted (T1w) TFE sequences (magnetization-prepared gradient echo magnetic resonance sequence) with isotropic spatial resolution for brain imaging at 1.5 T in a clinical patient cohort based on qualitative and quantitative image quality metrics. Two prototypical spiral TFE sequences (spiral 1.0 and spiral 0.85)...
Tue Jun 30, 2020 03:00
Objective: To perform a systematic review and meta-analysis of surgical outcomes following repair of patulous Eustachian tube (PET). Data Sources: Analysis of cases collected from studies published between January 1990 and December 2018 and identified using PubMed, Google Scholar, and Cochrane databases. Study Selection: Articles addressing interventions to treat PET were selected. Data Extraction: The database was searched using the keywords “patulous Eustachian tube...
Fri Jul 03, 2020 03:00
Objective: Patients with chronic, subjective tinnitus are often administered a battery of audiometric tests to characterize their tinnitus percept. Even a comprehensive battery, if applied just once, cannot capture fluctuations in tinnitus strength or quality over time. Moreover, subjects experience a learning curve when reporting the detailed characteristics of their tinnitus percept, such that a single assessment will reflect a lack of familiarity with test requirements. We addressed these...
Fri Jul 03, 2020 03:00
Objective: Definitive treatment of sporadic vestibular schwannoma (VS) following documented growth is common practice at most centers in the United States. However, as a natural extension of this paradigm, very little evidence exists surrounding the natural history of growing tumors. The primary objective of the current work was to describe the natural history of sporadic VS following documentation of initial tumor growth. Study Design: Retrospective cohort study. Setting: Tertiary...
Fri Jul 03, 2020 03:00
Objective: To describe malformations associated with pediatric congenital cholesteatomas of the middle ear. Study Design: Retrospective study. Setting: Tertiary referral center. Patients: One hundred and seventy-three cases of middle ear congenital cholesteatoma (CC) in 171 children operated between 2007 and 2017. Interventions: Demographic, clinical, and surgical data were collected from operative reports. Main Outcome Measures: We first described...
Fri Jul 03, 2020 03:00
Objective: To review our experience with cochlear implant infections over the past 5 years, the management strategy and to identify predictive factors that led to explantation. Study Design: Retrospective record-base case series of cochlear implant infections. Setting: Tertiary otology and implant center. Patients: All patients who had cochlear implantation over a period of 5 years. Intervention(s): None. Main Outcome Measure(s): To identify risk...
Fri Jul 03, 2020 03:00
Objectives: The aim of this study was to determine whether the dexamethasone-eluting electrode (DEXEL) has a protective anti-inflammatory effect in a normal hearing implanted cochlea, as well as its performance and safety. Design: Ten healthy and normal hearing cynomolgus macaques (Mf) were divided into two cohorts: DEXEL group (DG) (CONCERTO CI device containing a DEXEL) and conventional CI group (CG) (unmodified CONCERTO CI device). The electrode was inserted into the scala tympani...
Fri Jul 03, 2020 03:00
Background: To coordinate and align the content for registration of cholesteatoma care. Methods: Systematic Delphi consensus procedure, consisting three rounds: two written sessions followed by a face-to-face meeting. Before this procedure, input on important patient outcomes was obtained. Consensus was defined as at least 80% agreement by participants. Hundred-thirty-six adult patients who had undergone cholesteatoma surgery and all ENT surgeons of the Dutch ENT Society were invited....
Fri Jul 03, 2020 03:00
Objective: To review occupational ergonomic risks for the Otologist and Neurotologist. Data Sources: MEDLINE, OVID, PubMed, and Google Scholar. Study Selection: A search was conducted to identify all studies in the English language that involve ergonomic-related risks for surgeons. Results: Occupational hazards, particularly musculoskeletal disorders (MSDs), are common in the surgical community in general and among Otolaryngologists in particular. Very few studies...
Fri Jul 03, 2020 03:00
Objectives: To evaluate blood–labyrinth barrier permeability using delayed gadolinium enhanced three-dimensional fluid-attenuated inversion recovery (3D-FLAIR) in patients with untreated sporadic vestibular schwannoma (VS) to interrogate the etiopathogenesis of progressive sensorineural hearing loss. Design: Prospective case series. Setting: Single institution tertiary care center. Participants: Patients with previously untreated small to medium-sized unilateral VS...
Fri Jul 03, 2020 03:00
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