The finding of hematological malignancies within bone marrow in heterotopic ossification has been reported only a handful of times previously in the literature. We described a case of true trilineage hematopoi...
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Adrenocortical carcinoma is a rare malignancy, with 43% being non-functional. These may arise from adrenal rest anywhere in the embryonic pathway of the adrenal glands. In the context of extra-adrenal and retr...
03:00
Malignant peripheral nerve sheath tumor is a rare and aggressive form of sarcoma that arises from a peripheral nerve, mostly in association with neurofibromatosis type 1. Half of the cases were reported in the...
Tue Jul 07, 2020 03:00
Neoadjuvant chemoradiotherapy is currently the gold standard treatment for esophageal cancer prior to surgery. This radiation therapy will sometimes lead to liver damage parallel to esophageal lesions, which m...
Tue Jul 07, 2020 03:00
Antineutrophil cytoplasmic antibodies comprise a family of autoantibodies that are often used as biomarkers for certain forms of small-vessel vasculitis; however, chronic infections tend to induce the producti...
Mon Jul 06, 2020 03:00
Thyroid, Ahead of Print.
Mon Jul 06, 2020 10:00
Thyroid, Ahead of Print.
Mon Jul 06, 2020 10:00
Abstract Purpose of Review Pediatric migraine is a common, chronic, and disabling neurological disorder in children and adolescents. Outpatient management is not always effective, and intravenous migraine management may be necessary for headache treatment in the pediatric emergency department. Most current treatment is based on retrospective evidence and there is a lack of well-designed randomized double-blinded controlled pediatric...
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Abstract Background Despite advances in endoscopic drainage procedures, percutaneous transhepatic biliary drainage (PTBD) remains an essential interventional radiology (IR) procedure. Several factors may adversely affect the success of PTBD. We report the experience of our IR unit with PTBD in patients considered at higher risk for adverse events. Material ...
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Abstract Purpose To evaluate the rapeutic effectiveness of Angio-CT or cone-beam CT (CBCT)-guided immediate radiofrequency ablation (RFA) after transcatheter arterial chemoembolization (TACE) for large hepatocellular carcinoma (HCC). Methods 117 large HCC patients (mean maximum diameter: 9.3 cm; range 5.3–17.7 cm) were retrospective studied...
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Abstract Purpose To evaluate the pancreatic duct cutoff sign in detecting pancreatic adenocarcinoma using CT and MRI. Methods A retrospective analysis of patients with a pancreatic duct (PD) cutoff sign on CT or MRI from 2000 to 2019 was performed. The primary outcome measured was the presence or absence of a malignant pancreatic tumor. Variables...
06:17
Abstract Purpose To determine preferences of clinicians and surgeons regarding radiology reporting of liver observations in patients at risk for hepatocellular carcinoma (HCC). Methods Members of the American College of Radiology Liver Imaging and Data Reporting System (LI-RADS) Outreach & Education Group (30 members) as well as Society...
06:17
Abstract Purpose To evaluate the biliary tree and hepatic parenchymal findings on magnetic resonance imaging (MRI) and magnetic resonance cholangiopancreatography (MRCP) in small-duct primary sclerosing cholangitis (SD-PSC). Methods Thirty-nine patients with biopsy-proven primary sclerosing cholangitis (PSC) without any bile duct abnormality...
06:17
Abstract The pattern of disease causing acute abdominal pain has changed over last few decades, some of this has been attributed to intraabdominal cancers. The most common acute abdominal complaints in cancer patients are related to the gastrointestinal system. Abdominal emergencies in cancer patients can result from the underlying malignancy itself, cancer therapy and/or result from the standard pathologies causing acute abdomen in otherwise healthy population. Therapy-related...
06:17
Abstract Purpose To identify gadoxetate disodium-enhanced MRI features distinguishing hepatic IPT from CLM. Methods From February 2008 to December 2019, 162 lesions (IPT, n = 31 and CLM, n = 131) from 94 patients (mean age 65.1 ± 12.2 years; 65 men and 29 women) were retrospectively assessed for the presence or absence of obscure boundary, rim...
06:17
Abstract Purpose To investigate the diagnostic efficacy of ZOOMit coronal diffusion-weighted imaging (Z-DWI) and MR texture analysis (MRTA) for differentiating benign from malignant distal bile duct strictures. Methods We retrospectively enrolled a total of 71 patients with distal bile duct stricture who underwent magnetic resonance cholangiopancreatography...
06:17
SARS-CoV-1 and SARS-CoV-2 are not phylogenetically closely related; however, both use the ACE2 receptor in humans for cell entry. This is not a universal sarbecovirus trait; for example, many known sarbecoviruses related to SARS-CoV-1 have two deletions in the receptor binding domain of the spike protein that render them incapable of using human ACE2. Further, we report three novel sarbecoviruses from Rwanda and Uganda which are phylogenetically intermediate to SARS-CoV-1 and SARS-CoV-2 and demonstrate...
Tue Jul 07, 2020 03:00
Dragonflies and damselflies, representing the insect order Odonata, are among the earliest flying insects with living (extant) representatives. However, unravelling details of their long evolutionary history, such as egg laying (oviposition) strategies, is impeded by unresolved phylogenetic relationships, an issue particularly prevalent in damselfly families and fossil lineages. Here we present the first transcriptome-based phylogenetic reconstruction of Odonata, analyzing 2,980 protein-coding genes...
Tue Jul 07, 2020 03:00
Balancing selection is an important process, which maintains genetic variability in many functionally important genes. To increase our understanding of its effects on patterns of genetic diversity, we analyse two models of long-term balancing selection at a biallelic locus, one with a constant population size and the other with recent population size changes, as well as a model of recent balancing selection. We use time-inhomogeneous phase-type theory to obtain the expected properties of the gene...
Tue Jul 07, 2020 03:00
Many animal species remain separate not because they fail to produce viable hybrids, but because their individuals choose not to mate. However, we still know very little of the genetic mechanisms underlying changes in these mate preference behaviours. Heliconius butterflies display bright warning patterns, which they also use to recognize conspecifics. Here, we couple QTL for divergence in visual preference behaviours with population genomic and gene expression analyses of neural tissue (central...
Tue Jul 07, 2020 03:00
Diplomonad parasites of the genus Giardia have adapted to colonizing different hosts, most notably the intestinal tract of mammals. The human-pathogenic Giardia species, Giardia intestinalis, has been extensively studied at the genome and gene expression level, but no such information is available for other Giardia species. Comparative data would be particularly valuable for Giardia muris, which colonizes mice and is commonly used as a prototypic in vivo model for investigating host responses to...
Mon Jul 06, 2020 03:00
Future Oncology, Ahead of Print.
Tue Jul 07, 2020 13:43
Chemical modifications are found on almost all RNAs and affect their coding and non-coding functions. The identification of m6A on mRNA and its important role in gene regulation stimulated the field to investigate whether additional modifications are present on mRNAs. Indeed, modifications including m1A, m5C, m7G, 2’-OMe and were detected. However, since their abundances are low and tools used for their corroboration are often not well characterized, their physiological relevance remains largely...
Tue Jul 07, 2020 20:23
Survival and growth of developing salmonids are negatively affected by low oxygen levels within gravel nests in natural streams, and hypoxic stress is often experienced by farmed Atlantic salmon (Salmo salar) within hatcheries. Exposure to hypoxia during early development may have long-lasting effects by altering epigenetic marks and gene expression in oxygen regulatory pathways. Here, we examine the transcriptomic response to low dissolved oxygen (DO) in post-hatch salmon reared continuously in...
00:17
Abstract Purpose This study aims to attain metric data of the velopharyngeal dimensions of healthy subjects as well as patients with velopharyngeal insufficiency using the example of cleft and lip palate (CLP) in order to determine possible differences in the volumes of both groups. Methods Volumes and distances of velopharyngeal areas were analyzed...
03:00
Background. This study is aimed at examining the prognostic role of pre-to-postoperative dynamics of De Ritis ratio (aspartate aminotransaminase (AST)/alanine aminotransaminase (ALT)) in patients with nonmetastatic renal cell carcinoma (RCC) following radical nephrectomy. Methods. We retrospectively reviewed the records of 670 patients who underwent radical nephrectomy for nonmetastatic RCC between 1996 and 2012 at our institution. The cutoff points for preoperative (=1.0) and postoperative AST/ALT...
Tue Jul 07, 2020 17:50
British Journal of Cancer, Published online: 08 July 2020; doi:10.1038/s41416-020-0972-xSystematic analysis reveals a functional role for STAMBPL1 in the epithelial–mesenchymal transition process across multiple carcinomas
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01:18
Purpose: Metastatic castration resistant prostate cancer (mCRPC) is a lethal, heterogeneous disease with few therapeutic strategies that significantly prolong survival. Innovative therapies for mCRPC are needed, however, the development of new therapies relies on accurate imaging to assess metastasis and monitor response. Standard imaging modalities for prostate cancer require improvement and there remains a need for selective and sensitive imaging probes that can be widely used in mCRPC patients....
Tue Jul 07, 2020 17:32
Purpose The phase 3 CELESTIAL study demonstrated improved overall survival (OS) and progression-free survival (PFS) with cabozantinib versus placebo in patients with previously treated, advanced hepatocellular carcinoma (HCC). We analyzed outcomes by baseline alpha-fetoprotein (AFP) and on-treatment AFP changes. Experimental design Serum AFP was measured every 8 weeks by blinded, centralized testing. Outcomes were analyzed by baseline AFP bifurcated at 400 ng/mL and by on-treatment AFP response (≥20%...
Tue Jul 07, 2020 17:32
Purpose: To assess the antitumor activity and safety of tipifarnib, a highly potent and selective farnesyltransferase inhibitor, we performed a phase II clinical trial in patients with advanced and refractory urothelial carcinoma (UC) harboring missense HRAS mutations. Experimental Design: A total of 245 adult patients with previously-treated, advanced UC entered the molecular screening program including HRAS. Those with missense HRAS mutations or STK11:rs2075606 received oral tipifarnib 900 mg bid...
Tue Jul 07, 2020 17:32
Abstract Intellectual humility has attracted attention in both philosophy and psychology. Philosophers have clarified the nature of intellectual humility as an epistemic virtue; and psychologists have developed scales for measuring people’s intellectual humility. Much less attention has been paid to the potential effects of intellectual humility on people’s negative attitudes and to its relationship with prejudice-based epistemic vices. Here we fill these gaps by focusing on the...
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Abstract Rationale Obsessive–compulsive disorder (OCD) is characterized by executive function impairment and by clinical responsivity to selective serotonin reuptake inhibitors (SSRIs). Executive planning deficits constitute a candidate endophenotype for OCD. It is not known whether this endophenotype is responsive to acute serotonin manipulation. Objective ...
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Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c05139
Tue Jul 07, 2020 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c06412
Tue Jul 07, 2020 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c07226
Tue Jul 07, 2020 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c04981
Tue Jul 07, 2020 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c04302
Tue Jul 07, 2020 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c00241
Tue Jul 07, 2020 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c02899
Tue Jul 07, 2020 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c03643
Tue Jul 07, 2020 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c05766
Tue Jul 07, 2020 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c05319
Tue Jul 07, 2020 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c05175
Tue Jul 07, 2020 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c04801
Tue Jul 07, 2020 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c05591
Tue Jul 07, 2020 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c02155
Mon Jul 06, 2020 07:00
Analytical ChemistryDOI: 10.1021/acs.analchem.0c01501
Tue Jul 07, 2020 07:00
Analytical ChemistryDOI: 10.1021/acs.analchem.0c01842
Tue Jul 07, 2020 07:00
Analytical ChemistryDOI: 10.1021/acs.analchem.0c01284
Tue Jul 07, 2020 07:00
Analytical ChemistryDOI: 10.1021/acs.analchem.0c01719
Tue Jul 07, 2020 07:00
Analytical ChemistryDOI: 10.1021/acs.analchem.0c02203
Tue Jul 07, 2020 07:00
Analytical ChemistryDOI: 10.1021/acs.analchem.0c00755
Tue Jul 07, 2020 07:00
Analytical ChemistryDOI: 10.1021/acs.analchem.0c01373
Tue Jul 07, 2020 07:00
Analytical ChemistryDOI: 10.1021/acs.analchem.0c01525
Tue Jul 07, 2020 07:00
Analytical ChemistryDOI: 10.1021/acs.analchem.0c02200
Tue Jul 07, 2020 07:00
Analytical ChemistryDOI: 10.1021/acs.analchem.0c00606
Tue Jul 07, 2020 07:00
Analytical ChemistryDOI: 10.1021/acs.analchem.0c01908
Tue Jul 07, 2020 07:00
Analytical ChemistryDOI: 10.1021/acs.analchem.0c02138
Tue Jul 07, 2020 07:00
Analytical ChemistryDOI: 10.1021/acs.analchem.0c01328
Tue Jul 07, 2020 07:00
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