With an increase in the incidence of human papillomavirus (HPV)-associated oropharyngeal squamous cell carcinoma (OPSCC) and more favourable survival outcomes, there is now a population of head and neck cancer...
Mon Jul 06, 2020 03:00
Anshika Jindal, Yogendra Singh Rathore, Shubhra Jain, VK Jain, Vinod JoshiIndian Journal of Allergy, Asthma and Immunology 2020 34(1):34-38INTRODUCTION: Allergic bronchopulmonary aspergillosis (ABPA) is an immunologically mediated lung disease, predominantly in patients with asthma and is caused by hypersensitivity to colonized dimorphic fungus Aspergillus, commonly Aspergillus fumigatus. Early diagnosis with recognition and treatment of chest radiographic infiltrates appears to prevent progression...
Mon Jul 06, 2020 00:00
Nikhil Sarangdhar, SN GaurIndian Journal of Allergy, Asthma and Immunology 2020 34(1):1-4
Mon Jul 06, 2020 00:00
Mahendra K Agarwal, Anand B Singh, Shailendra N Gaur, PC Kathuria, VK Jain, Mahesh Goyal, KV Nagendra PrasadIndian Journal of Allergy, Asthma and Immunology 2020 34(1):5-7We are living in an unprecedented difficult time due to the infectious COVID-19 pandemic, a global emergency. During the on-going pandemic, most allergy/immunology care could be postponed/delayed or handled through virtual care. Seven experts from different parts of India deliberated on this subject in 3 weekly webinars (May 10,...
Mon Jul 06, 2020 00:00
Arun AgarwalIndian Journal of Allergy, Asthma and Immunology 2020 34(1):43-48Immunoglobulin M (IgM) is the first antibody to be produced during an immune response, and most of the primary humoral immune response is mediated by IgM. Selective IgM deficiency (sIgMD) is a rare immune disorder that has been reported in the association with serious infections. Patients with sIgMD may be asymptomatic; however, approximately 80% of patients present with infections with bacteria, viruses, or protozoa or...
Mon Jul 06, 2020 00:00
Subodh K Katiyar, Sandeep KatiyarIndian Journal of Allergy, Asthma and Immunology 2020 34(1):8-14Inhaled therapy is the cornerstone in the management of obstructive airway diseases (OADs). Nebulization is often used for the delivery of bronchodilators and corticosteroids among the elderly and children. The present pandemic of coronavirus disease 2019 (COVID-19), caused by a newly identified, highly contagious, novel coronavirus, called severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2),...
Mon Jul 06, 2020 00:00
Sudhir Bhandari, Ajeet Singh, Subrata Banerjee, Raman Sharma, Govind Rankawat, Vishal Gupta, Prakash Keswani, Ashwin Mathur, Abhishek Agarwal, Shrikant Sharma, PD MeenaIndian Journal of Allergy, Asthma and Immunology 2020 34(1):28-33PURPOSE: The present study was undertaken to investigate the behavioral distribution pattern and progression of coronavirus disease 2019 (COVID-19) across age and gender in the state of Rajasthan, India, inherently distinctive and native to localized part of the globe...
Mon Jul 06, 2020 00:00
Nagaraju Kuravi, Karthik Nagaraju, Venkata Kasyapi VoorakaranamIndian Journal of Allergy, Asthma and Immunology 2020 34(1):15-22Coronavirus disease 2019 (COVID 19) is caused by the novel coronavirus, which has affected 184 countries and the WHO has declared it a pandemic on March 2020. Allergic diseases such as allergic rhinitis and asthma are exaggerated by viral infections. Symptoms of allergic diseases overlap with COVID 19. Current recommendations include following social distancing and frequent...
Mon Jul 06, 2020 00:00
Komal Chauhan, Shetanshu Srivastava, Rajendra PrasadIndian Journal of Allergy, Asthma and Immunology 2020 34(1):39-42BACKGROUND: Children with asthma have a high prevalence of environmental allergies. Sensitization to various allergens, especially to indoor allergens is crucial for effective measures for asthma management. Indian data on allergic sensitization in children is scarce, necessitating the need of the study. METHODS: A Cross-sectional study was conducted to determine the indoor allergen...
Mon Jul 06, 2020 00:00
Shalini Gandhi, Sandeep Kumar Sharma, Purva Shoor, Jitender Sorout, Abhay Raina, Rohit Raina, Urvashi Miglani, Uma Kant Chaudhari, Shivi SrivastavaIndian Journal of Allergy, Asthma and Immunology 2020 34(1):23-27There is a new public health crises threatening globally with the emergence and spread of 2019 novel coronavirus or the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). It is the seventh member of the coronavirus (CoV) family, which infects humans and to which the Middle East...
Mon Jul 06, 2020 00:00
PC Kathuria, Manisha Rai, Neelam KathuriaIndian Journal of Allergy, Asthma and Immunology 2020 34(1):49-52Hereditary angioedema (HAE) is a potentially life-threatening disorder, due to a mutation in complement one-inhibitor (C1-INH) gene, which blocks the activity of various components of complement – fibrinolytic and bradykinin control system. Our seven cases of HAE give different clinical presentations of TYPE I/II/III HAE as facial, abdominal, laryngeal, and genital involvement along with comorbidities...
Mon Jul 06, 2020 00:00
Abstract Background Nonspecific vaginitis, also known as Bacterial vaginosis, unlike genital candidiasis and trichomoniasis, is caused by microbiome breakdown. Döderlein’s bacillus are gram‐positive bacillus that form a microbiome, reproduce in the female vagina after gaining sexual maturity, secrete lactic acid, and prevent the growth of other vaginitis‐causing bacteria. Clue cell are squamous epithelial cells with Gardnerella sp. attached to their cell surface. The presence of clue cell is...
Mon Jul 06, 2020 17:42
Abstract Solitary fibrous tumor (SFT) is a mesenchymal tumor initially described in the pleura. When the tumor is located in the pleura and the classic histologic findings are present, the diagnosis of SFT can be straightforward. However, the cytologic diagnosis of perigastric SFT can be challenging due its rarity with only one cytology case report. Another confounding factor is its potential mimicry with other perigastric/gastric mesenchymal tumors. Herein, we report a case of perigastric SFT diagnosed...
Mon Jul 06, 2020 17:16
Abstract Squamous cell carcinoma (SCC) of the prostate is a rare and clinically aggressive entity that may arise de novo or through transformation of prostatic adenocarcinoma, typically following hormonal or radiation therapy. Confirmation of prostatic origin, especially when evaluating a metastatic focus, often requires correlation with clinical and imaging findings, as the morphologic and immunohistochemical features of SCC are not organ‐specific. Comprehensive genomic profiling (CGP) may provide...
Mon Jul 06, 2020 17:14
New Findings What is the central question of this study? Whether or not individuals with a patent foramen ovale (PFO+) have a larger alveolar‐to‐arterial difference in PO2 (A‐aDO2) than those without (PFO‐) and/or an exaggerated increase in pulmonary artery systolic pressure (PASP) in response to hypoxia. What is the main finding and its importance? PFO+ had a greater A‐aDO2 while breathing air, 16% and 14%, but not 12% or 10% O2. PASP increased equally in hypoxia between PFO+...
Mon Jul 06, 2020 13:18
Mon Jul 06, 2020 16:35
Mon Jul 06, 2020 16:31
Abstract Objective Hematopoietic stem cell transplantation (HSCT) can compromise long‐term health and social functioning. We examined the impact of physical and social‐emotional factors on the social functioning of long‐term adolescent and young adult (AYA) HSCT survivors. Methods This cross‐sectional analysis included HSCT recipients from the INSPIRE trial [NCT00799461] who received their first transplant between ages 15‐39. Patient‐reported outcome measures included the Short Form‐36v2,...
Mon Jul 06, 2020 16:30
Mon Jul 06, 2020 16:29
Abstract Background We aimed to estimate minimally important difference (MID) for interpreting group‐level change over time for European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire core 30 (EORTC QLQ‐C30) scores in head and neck cancer. Methods Data were derived retrospectively from two published EORTC trials. Clinical anchors were selected using correlation strength and clinical plausibility of the given anchor/QLQ‐C30 scale pair. MIDs for within‐group...
Mon Jul 06, 2020 22:40
Abstract Background The use of infrared thermography to evaluate the perfusion of tissue flaps have been studied. This study aims to evaluate the utility of thermal imaging for flap monitoring with a low‐cost, readily available smartphone imaging device. Methods Adult subjects who underwent head and neck reconstruction using a microvascular free flap with a cutaneous paddle were recruited. Thermal images were taken of the free flap before, during and after anastomosis. Thermal images were...
Mon Jul 06, 2020 11:04
To create 3D reconstructions of the brachial plexus by diffusion tensor magnetic resonance imaging, the geometry of the brachial plexus must be defined at high resolution and throughout its course. Our study traces the brachial plexus in ten cadavers to resolve the step/turning angles at a resolution of 2.5 mm2. We show that the tortuosity of the roots increases in the caudal direction and show that a step/turning angle of 70° is optimal. Abstract Diffusion tensor magnetic resonance imaging...
Mon Jul 06, 2020 20:20
The outbreak of COVID‐19, resulting from widespread transmission of the SARS‐CoV‐2 virus, represents one of the foremost current challenges to societies across the globe, with few areas of life remaining untouched. Here, we detail the immediate impact that COVID‐19 has had on the teaching and practice of anatomy, providing specific examples of the varied responses from several UK, Irish and German universities and medical schools. Alongside significant issues for, and suspension of, body donation...
Mon Jul 06, 2020 20:18
Cochlear implantation in patients with intracochlear schwannomas has been reported anecdotally in case reports or small case series (1–5). The applied techniques have varied considerably ranging from extended cochleostomy (2–4), “push-through” and ”pull-through” techniques (3,4), partial and subtotal cochleoectomy (4) to cochlear implant insertion through the tumor (5). We here illustrate (see Video, Supplemental Digital Content 1, http://links.lww.com/MAO/A999) our improved surgical technique of...
Fri Jul 03, 2020 03:00
Objective: This study aimed to describe our experience with the retrolabyrinthine or infralabyrinthine approach in acoustic neuroma surgery, and to discuss its advantages, limitations, complications, and the outcomes of hearing and facial function preservation. Study Design: This study was a retrospective analysis of all acoustic neuroma cases, operated with a retrolabyrinthine approach in our hospital. Setting: This study was conducted at a tertiary university hospital. Patients:...
Fri Jul 03, 2020 03:00
Objectives: This study aimed to demonstrate the application of our automated facial recognition system to measure facial nerve function and compare its effectiveness with other conventional systems and provide a preliminary evaluation of deep learning-facial grading systems. Study Design: Retrospective, observational. Setting: Tertiary referral center, hospital. Patients: Facial photos taken from 128 patients with facial paralysis and two persons with no history of facial palsy...
Fri Jul 03, 2020 03:00
Objectives: The aim was to model residual Vestibular Schwannoma (VS) over time to identify prognostic factors of postsurgical growth. Study Design: Multicenter retrospective study. Setting: Tertiary referral centers. Patients: A group of 135 patients who underwent incomplete resection for VS between January 2010 and December 2018. On magnetic resonance imaging (MRI) examinations at baseline (1 year after surgery), patients included were divided into two groups: near-total resection...
Fri Jul 03, 2020 03:00
Objective: The aim of the study was to evaluate the predictive value regarding postoperative hearing benefit of electrically evoked auditory brainstem response audiometry in sporadic vestibular schwannoma patients undergoing simultaneous tumor resection and cochlear implantation. Design: Patients were included in a prospective study conducted between October 2016 and January 2019. Setting: The study was conducted at a tertiary care center. Participants: Subjects with unilateral...
Fri Jul 03, 2020 03:00
Objective: To perform a systematic review and meta-analysis of surgical outcomes following repair of patulous Eustachian tube (PET). Data Sources: Analysis of cases collected from studies published between January 1990 and December 2018 and identified using PubMed, Google Scholar, and Cochrane databases. Study Selection: Articles addressing interventions to treat PET were selected. Data Extraction: The database was searched using the keywords “patulous Eustachian tube treatment”...
Fri Jul 03, 2020 03:00
Objective: Patients with chronic, subjective tinnitus are often administered a battery of audiometric tests to characterize their tinnitus percept. Even a comprehensive battery, if applied just once, cannot capture fluctuations in tinnitus strength or quality over time. Moreover, subjects experience a learning curve when reporting the detailed characteristics of their tinnitus percept, such that a single assessment will reflect a lack of familiarity with test requirements. We addressed these challenges...
Fri Jul 03, 2020 03:00
Objective: Definitive treatment of sporadic vestibular schwannoma (VS) following documented growth is common practice at most centers in the United States. However, as a natural extension of this paradigm, very little evidence exists surrounding the natural history of growing tumors. The primary objective of the current work was to describe the natural history of sporadic VS following documentation of initial tumor growth. Study Design: Retrospective cohort study. Setting: Tertiary referral...
Fri Jul 03, 2020 03:00
Objective: To describe malformations associated with pediatric congenital cholesteatomas of the middle ear. Study Design: Retrospective study. Setting: Tertiary referral center. Patients: One hundred and seventy-three cases of middle ear congenital cholesteatoma (CC) in 171 children operated between 2007 and 2017. Interventions: Demographic, clinical, and surgical data were collected from operative reports. Main Outcome Measures: We first described the type and rate of...
Fri Jul 03, 2020 03:00
Objective: To review our experience with cochlear implant infections over the past 5 years, the management strategy and to identify predictive factors that led to explantation. Study Design: Retrospective record-base case series of cochlear implant infections. Setting: Tertiary otology and implant center. Patients: All patients who had cochlear implantation over a period of 5 years. Intervention(s): None. Main Outcome Measure(s): To identify risk factors, rates and outcomes...
Fri Jul 03, 2020 03:00
Objectives: The aim of this study was to determine whether the dexamethasone-eluting electrode (DEXEL) has a protective anti-inflammatory effect in a normal hearing implanted cochlea, as well as its performance and safety. Design: Ten healthy and normal hearing cynomolgus macaques (Mf) were divided into two cohorts: DEXEL group (DG) (CONCERTO CI device containing a DEXEL) and conventional CI group (CG) (unmodified CONCERTO CI device). The electrode was inserted into the scala tympani via...
Fri Jul 03, 2020 03:00
Background: To coordinate and align the content for registration of cholesteatoma care. Methods: Systematic Delphi consensus procedure, consisting three rounds: two written sessions followed by a face-to-face meeting. Before this procedure, input on important patient outcomes was obtained. Consensus was defined as at least 80% agreement by participants. Hundred-thirty-six adult patients who had undergone cholesteatoma surgery and all ENT surgeons of the Dutch ENT Society were invited. The...
Fri Jul 03, 2020 03:00
Objective: To review occupational ergonomic risks for the Otologist and Neurotologist. Data Sources: MEDLINE, OVID, PubMed, and Google Scholar. Study Selection: A search was conducted to identify all studies in the English language that involve ergonomic-related risks for surgeons. Results: Occupational hazards, particularly musculoskeletal disorders (MSDs), are common in the surgical community in general and among Otolaryngologists in particular. Very few studies have been conducted...
Fri Jul 03, 2020 03:00
Objectives: To evaluate blood–labyrinth barrier permeability using delayed gadolinium enhanced three-dimensional fluid-attenuated inversion recovery (3D-FLAIR) in patients with untreated sporadic vestibular schwannoma (VS) to interrogate the etiopathogenesis of progressive sensorineural hearing loss. Design: Prospective case series. Setting: Single institution tertiary care center. Participants: Patients with previously untreated small to medium-sized unilateral VS undergoing 3D-FLAIR...
Fri Jul 03, 2020 03:00
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