Surgical Infections, Ahead of Print.
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Water hyacinths pose serious challenges to humanity and the environment. Considering the enormity of the menace associated with the growth and spread of the plant and the difficulty in achieving a single, generally acceptable control method, it is becoming increasingly imperative to explore the potentials of the plant. New water hyacinth-related articles are regularly being published. Recently published articles about the plant were accessed, and the information in these articles is presented in...
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Aim. The purpose of this study is to systematically review patient characteristics and clinical determinants that may influence return to driving status and time frames following a primary TKA or THA and provide an update of the current literature. Methods. This review was completed per the Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) guidelines. Final electronic database searches were completed in October 2019 in Medline/PubMed, Medline/OVID, Cumulative Index to Nursing...
Purpose. The objective of the current study was to determine the prevalence and practice of unused and expired medicine among Saudi adults. Subjects and Methods. The study used cross-sectional web-based design to collect the data, over a period of 4 months among people who are living in Riyadh, Saudi Arabia. Results. A total of 337 questionnaires were obtained during the study period. The majority of respondents were university graduates (74.7%). The prevalence of unused medicine was (89.3%). The...
Toxoplasmosis is a zoonotic infection caused by the protozoan parasite, Toxoplasma gondii. It was discovered over 100 years ago and is credited as the most successful parasitic organism worldwide, able to infect and multiply in all warm blooded animals including an estimated 2.3 billion people. Toxoplasmosis is asymptomatic in immunocompetent individuals. Infection in the developing fetus and immunocompromised individuals can cause severe clinical disease. Toxoplasmosis is also a major cause of reproductive...
Spontaneous bacterial peritonitis (SBP) is a common cirrhotic ascites complication which exacerbates the patient’s condition. SBP is caused by gram-negative bacilli and, to a lesser extent, gram-positive cocci. Hospital-acquired infections show higher levels of drug-resistant bacteria. Geographical location influences pathogenic bacteria distribution; therefore, different hospitals in the same country record different bacteria strains. Intestinal changes and a weak immune system in patients with...
Male Sprague-Dawley rats () were randomly divided into three groups: a saline group (20 mL/kg by gavage), a ketamine (KET) group (100 mg/kg by gavage), and a KET (the same routes and doses) combined with levo-tetrahydropalmatine (L-THP; 40 mg/kg by gavage) group (). Blood samples were acquired at different time points after drug administration. A simple and sensitive ultraperformance liquid chromatography tandem mass spectrometry (UPLC-MS/MS) method was established to determine the concentrations...
Exosomes can reach distant tissues through blood circulation to communicate directly with target cells and rapidly regulate intracellular signals. Exosomes play an important role in cardiovascular pathophysiology. Different exosomes derived from different sources, and their cargos have different mechanisms of action. In addition to being biomarkers, exosomes also have a certain significance in the diagnosis, treatment, and even prevention of cardiovascular diseases. Here, we provide a review of the...
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Abstract Since prostate cancer incidence, prevalence and mortality are still highest among Black men in the United States, it is important to effectively address the factors that contribute to prostate cancer disparities in this at-risk population as well as their low participation in biomedical research/clinical trials. An effective communication strategy that can be used to disseminate information with high public health impact to Black men is one way to combat prostate cancer...
Abstract Immigrants and refugees have an increased risk for developing chronic health conditions, such as breast and colorectal cancer, the longer they reside in the USA. Moreover, refugees are less even likely to use preventive health services like mammography and colonoscopy screening when compared with US-born counterparts. Focused ethnography was employed to examine sociocultural factors that influenced cancer screening behaviors among aging Afghan refugee women. We conducted...
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ObjectivesThe objective of this historical cohort study was to determine the claimant and prescriber factors associated with receiving opioids at first postinjury dispense compared with non-steroidal anti-inflammatory drugs (NSAIDs) and skeletal muscle relaxants (SMRs) in a sample of workers’ compensation claimants with low back pain (LBP) claims between 1998 and 2009 in British Columbia, Canada.MethodsAdministrative workers’ compensation, prescription and healthcare data were linked. The association...
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Publication date: Available online 7 July 2020Source: Clinical TherapeuticsAuthor(s): Aixia Sui, Huiling Song, Huimin Yu, Hongtao Zhang, Qilu Hu, Yuying Lei, Lijuan Zhang, Juan Wang
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Nature Communications, Published online: 07 July 2020; doi:10.1038/s41467-020-16899-xRoads are widespread and can impact ecological communities. Cooke et al. use data for 75 bird species across Great Britain to show that common species are disproportionately abundant near roads, whereas rarer, smaller-bodied and migrant species are more likely to be negatively associated with roads.
Nature Communications, Published online: 07 July 2020; doi:10.1038/s41467-020-17095-7Immunoglobulin (Ig) rearrangement and translocation information are usually obtained by targeted sequencing of the respective loci. Here, the authors present the IgCaller algorithm, which extracts Ig heavy and light chain genetic properties from short-read whole-genome sequencing results to provide a feasible alternative to direct sequencing.
Nature Communications, Published online: 07 July 2020; doi:10.1038/s41467-020-17088-6Meiotic cell division in oocytes is asymmetric and requires microtubule spindle migration after anaphase-onset. Here, the authors show that Nampt, an enzyme of the Nicotinamide adenine dinucleotide (NAD) biosynthetic pathway, contributes to post-anaphase spindle migration and oocyte division asymmetry by controlling spindle length.
Nature Communications, Published online: 07 July 2020; doi:10.1038/s41467-020-17156-xSTING is considered central to antiviral immunity via induction of type 1 interferons, but can also activate autophagy. Here the authors made two mice with different STING mutations that differentially affect these antiviral responses, and surprisingly show that inhibiting STING-dependent type 1 interferon production does not affect susceptibility to HSV-1 infection.
Nature Communications, Published online: 07 July 2020; doi:10.1038/s41467-020-17071-1Author Correction: Response outcomes gate the impact of expectations on perceptual decisions
Nature Communications, Published online: 07 July 2020; doi:10.1038/s41467-020-17215-3Designing energy efficient and scalable artificial networks for neuromorphic computing remains a challenge. Here, the authors demonstrate online learning in a monolithically integrated 4 × 4 fully memristive neural network consisting of volatile NbOx memristor neurons and nonvolatile TaOx memristor synapses.
Nature Communications, Published online: 07 July 2020; doi:10.1038/s41467-020-17210-8Publisher Correction: MBNL1 regulates essential alternative RNA splicing patterns in MLL-rearranged leukemia
Pathogenic <i>ARH3</i> mutations result in ADP-ribose chromatin scars during DNA strand break repair
Nature Communications, Published online: 07 July 2020; doi:10.1038/s41467-020-17069-9Defects in DNA single-strand break repair are associated with neurodegenerative disease. Here the authors reveal that mutations in ARH3 interfere with the catabolism of mono-(ADP-ribose) and lead to its accumulation on core histones following repair of endogenous or exogenous DNA single-strand breaks.
Nature Communications, Published online: 07 July 2020; doi:10.1038/s41467-020-17213-5Height-related changes in forest composition explain increasing tree mortality with height during an extreme drought
Pathogenic <i>ARH3</i> mutations result in ADP-ribose chromatin scars during DNA strand break repair
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Abstract Background Pancreatic cancer is a devastating disease with a 5-year survival rate of 20–25%. As approximately only 20% of patients diagnosed with pancreatic cancer are initially staged as resectable, it is necessary to evaluate new therapeutic approaches. Hence, neoadjuvant (radio)chemotherapy is a promising therapeutic option, especially in patients with a borderline resectable tumor. The aim of this non-randomized, monocentric,...
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Abstract Dystonia is a movement disorder characterised by involuntary muscle contractions resulting in abnormal movements, postures and tremor. The pathophysiology of dystonia is not fully understood but loss of neuronal inhibition, excessive sensorimotor plasticity and defective sensory processing are thought to contribute to network dysfunction underlying the disorder. Neurophysiology studies have been important in furthering our understanding of dystonia and have provided insights...
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Cancer Biotherapy and Radiopharmaceuticals, Ahead of Print.
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Publication date: Available online 6 July 2020Source: Journal of Neuroscience MethodsAuthor(s): Zhihua Huang, Wenming Zheng, Yingjie Wu, Yiwen Wang
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Publication date: September 2020Source: World Neurosurgery, Volume 141Author(s): Ying Yu, Zeping Dong, Dawei Chen, Fan Chen
Publication date: September 2020Source: World Neurosurgery, Volume 141Author(s): Harsh Deora, Nishant S. Yagnick, Manjul Tripathi
Publication date: August 2020Source: World Neurosurgery, Volume 140Author(s): Monish M. Maharaj, Rakesh Biju, Manar Khashram, Zakier Hussain
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Abstract Identifying the genes causing male infertility is important to increase our biological understanding as well as the diagnostic yield and clinical relevance of genetic testing in this disorder. While significant progress has been made in some areas, mainly in our knowledge of the genes underlying rare qualitative sperm defects, the same cannot be said for the genetics of quantitative sperm defects. Technological advances and approaches in genomics are critical for the...
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