Volatile Organic Compounds in Head and Neck Squamous Cell Carcinoma - An In Vitro Pilot Study.

Volatile Organic Compounds in Head and Neck Squamous Cell Carcinoma - An In Vitro Pilot Study.:

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Volatile Organic Compounds in Head and Neck Squamous Cell Carcinoma - An In Vitro Pilot Study.

Biomed Chromatogr. 2020 Feb 14;:e4811

Authors: Kulas P, Seidel M, Bozzato A, Schick B, Sessler DI, Kreuer S, Hüppe T

Abstract

OBJECTIVES: Due to lack of specific symptoms diagnosis of head and neck squamous cell carcinoma (HNSCC) may be delayed. We evaluated volatile organic compounds in tumor samples from patients suffering from HNSCC and tested the hypothesis that there is a characteristic altered composition in the headspace of HNSCC compared to control samples from the same patient with normal squamous epithelium. These results provide the basis for future non-invasive breath analysis in HNSCC.

METHODS: Headspace air of suspected tumor and contralateral control samples in 20 patients were analyzed using ion-mobility spectrometry.

RESULTS: Squamous cell carcinoma was diagnosed in 16 patients. In total, we observed 93 different signals in headspace measurements. Squamous cell carcinomas revealed significantly higher levels of volatile cyclohexanol (0.54 ppbv , 25th -75th 0.35-0.86) compared to healthy squamous epithelium (0.24 ppbv , 25th -75th 0.12-0.3; p<0.001).

CONCLUSION: In conclusion, head and neck squamous cell carcinoma emitted significantly higher levels of volatile cyclohexanol in headspace compared to normal squamous epithelium. These findings form the basis for future breath analysis for diagnosis, therapy control and the follow-up of HNSSC to improve successful therapy and aftercare.

PMID: 32059060 [PubMed - as supplied by publisher]