Antibiotics, Vol. 9, Pages 374: Identification of Genetic Alterations Associated with Acquired Colistin Resistance in Klebsiella pneumoniae Isogenic Strains by Whole-Genome Sequencing Antibiotics doi: 10.3390/antibiotics9070374 Authors: Myeongjin Choi Kwan Soo Ko The present study was undertaken to find novel genes associated with colistin resistance in Klebsiella pneumoniae. Five colistin-resistant mutants were derived from four colistin-susceptible parental K. pneumoniae strains...
Thu Jul 02, 2020 03:00
Antibiotics, Vol. 9, Pages 373: Squalamine and Aminosterol Mimics Inhibit the Peptidoglycan Glycosyltransferase Activity of PBP1b Antibiotics doi: 10.3390/antibiotics9070373 Authors: Adrien Boes Jean Michel Brunel Adeline Derouaux Frédéric Kerff Ahmed Bouhss Thierry Touze Eefjan Breukink Mohammed Terrak Peptidoglycan (PG) is an essential polymer of the bacterial cell wall and a major antibacterial target. Its synthesis requires glycosyltransferase (GTase) and transpeptidase...
Thu Jul 02, 2020 03:00
Antibodies, Vol. 9, Pages 29: Rapid Isolation of Rare Isotype-Switched Hybridoma Variants: Application to the Generation of IgG2a and IgG2b MAb to CD63, a Late Endosome and Exosome Marker Antibodies doi: 10.3390/antib9030029 Authors: Stéphanie Charrin Roberta Palmulli Martine Billard Denis Clay Claude Boucheix Guillaume Van Niel Eric Rubinstein CD63, a member of the tetraspanin superfamily, is used as a marker of late endosomes and lysosome-related organelles, as well...
Thu Jul 02, 2020 03:00
Antioxidants, Vol. 9, Pages 576: Enrichment in Antioxidant Flavonoids of Stamen Extracts from Nymphaea lotus L. Using Ultrasonic-Assisted Extraction and Macroporous Resin Adsorption Antioxidants doi: 10.3390/antiox9070576 Authors: Tungmunnithum Drouet Kabra Hano Nymphaea lotus L. is the medicinal plant that has long been used for food, cosmetics and traditional medicines in Africa and Asia since ancient times. Its flavonoids and other interesting phytochemical compounds...
Thu Jul 02, 2020 03:00
Antioxidants, Vol. 9, Pages 578: Serum Malondialdehyde is Associated with Non-Alcoholic Fatty Liver and Related Liver Damage Differentially in Men and Women Antioxidants doi: 10.3390/antiox9070578 Authors: Shira Zelber-Sagi Dana Ivancovsky-Wajcman Naomi Fliss-Isakov Michal Hahn Muriel Webb Oren Shibolet Revital Kariv Oren Tirosh Background: Non-alcoholic fatty liver disease (NAFLD) and steatohepatitis (NASH) are associated with increased oxidative stress and lipid...
Thu Jul 02, 2020 03:00
Antioxidants, Vol. 9, Pages 577: Reactive Species in Huntington Disease: Are They Really the Radicals You Want to Catch? Antioxidants doi: 10.3390/antiox9070577 Authors: José Bono-Yagüe Ana Pilar Gómez-Escribano José María Millán Rafael Pascual Vázquez-Manrique Huntington disease (HD) is a neurodegenerative condition and one of the so-called rare or minority diseases, due to its low prevalence (affecting 1–10 of every 100,000 people in western countries). The causative...
Thu Jul 02, 2020 03:00
Antioxidants, Vol. 9, Pages 579: Insights into Arbutin Effects on Bone Cells: Towards the Development of Antioxidant Titanium Implants Antioxidants doi: 10.3390/antiox9070579 Authors: Bonifacio Cerqueni Cometa Licini Sabbatini Mattioli-Belmonte De Giglio Arbutin is a plant-derived glycosylated hydroquinone with antioxidant features, exploited to combat cell damage induced by oxidative stress. The latter hinders the osseointegration of bone prostheses, leading...
Thu Jul 02, 2020 03:00
Antioxidants, Vol. 9, Pages 575: A Potent Lignan from Prunes Alleviates Inflammation and Oxidative Stress in Lithium/Pilocarpine-Induced Epileptic Seizures in Rats Antioxidants doi: 10.3390/antiox9070575 Authors: Fadia S. Youssef Esther T. Menze Mohamed L. Ashour Prunus domestica L. is an edible plant that is included in the family Rosaceae and proven to possess potent anti-inflammatory and anxiolytic activity. Pinoresinol-4-O-β-d-glucopyranoside (PGu) was isolated from...
Thu Jul 02, 2020 03:00
Antioxidants, Vol. 9, Pages 574: Perivascular Adipose Tissue as a Target for Antioxidant Therapy for Cardiovascular Complications Antioxidants doi: 10.3390/antiox9070574 Authors: Andy W. C. Man Yawen Zhou Ning Xia Huige Li Perivascular adipose tissue (PVAT) is the connective tissue surrounding most of the systemic blood vessels. PVAT is now recognized as an important endocrine tissue that maintains vascular homeostasis. Healthy PVAT has anticontractile, anti-inflammatory, and...
Thu Jul 02, 2020 03:00
Antioxidants, Vol. 9, Pages 573: Medicinal Plant Polyphenols Attenuate Oxidative Stress and Improve Inflammatory and Vasoactive Markers in Cerebral Endothelial Cells during Hyperglycemic Condition Antioxidants doi: 10.3390/antiox9070573 Authors: Janice Taïlé Angélique Arcambal Patricia Clerc Anne Gauvin-Bialecki Marie-Paule Gonthier Blood-brain barrier endothelial cells are the main targets of diabetes-related hyperglycemia that alters endothelial functions and brain homeostasis....
Thu Jul 02, 2020 03:00
Atmosphere, Vol. 11, Pages 709: Preface: Ozone Evolution in the Past and Future Atmosphere doi: 10.3390/atmos11070709 Authors: Eugene Rozanov The stratospheric ozone plays an important role in the protection of the biosphere from the dangerous ultraviolet radiation of the sun [...]
03:00
Atmosphere, Vol. 11, Pages 708: Air Quality Degradation by Mineral Dust over Beijing, Chengdu and Shanghai Chinese Megacities Atmosphere doi: 10.3390/atmos11070708 Authors: Mathieu Lachatre Gilles Foret Benoit Laurent Guillaume Siour Juan Cuesta Gaëlle Dufour Fan Meng Wei Tang Qijie Zhang Matthias Beekmann Air pollution in Chinese megacities has reached extremely hazardous levels, and human activities are responsible for the emission or production of large...
Thu Jul 02, 2020 03:00
Atmosphere, Vol. 11, Pages 707: Idealized Simulations of City-Storm Interactions in a Two-Dimensional Framework Atmosphere doi: 10.3390/atmos11070707 Authors: Jason Naylor Numerous studies have identified spatial variability in convective parameters such as rainfall totals and lightning flashes in the vicinity of large urban areas, yet many questions remain regarding the storm-scale processes that are altered during interaction with a city as well as which urban features are most responsible...
Thu Jul 02, 2020 03:00
Atmosphere, Vol. 11, Pages 706: Importance Evaluation Based on Random Forest Algorithms: Insights into the Relationship between Negative Air Ions Variability and Environmental Factors in Urban Green Spaces Atmosphere doi: 10.3390/atmos11070706 Authors: Linghao Luo Wen Sun Yujie Han Wenwen Zhang Chunjiang Liu Shan Yin Negative air ions (NAIs) exert positive effects on human health. Urban green spaces produce NAIs and perform valuable ecological functions; this phenomenon...
Thu Jul 02, 2020 03:00
Atmosphere, Vol. 11, Pages 705: Evaluation of Rainfall Forecasts by Three Mesoscale Models during the Mei-Yu Season of 2008 in Taiwan. Part III: Application of an Object-Oriented Verification Method Atmosphere doi: 10.3390/atmos11070705 Authors: Chung-Chieh Wang Sahana Paul Dong-In Lee In this study, the performances of Mei-yu (May–June) quantitative precipitation forecasts (QPFs) in Taiwan by three mesoscale models: the Cloud-Resolving Storm Simulator (CReSS), the Central...
Thu Jul 02, 2020 03:00
Atmosphere, Vol. 11, Pages 704: Climatology of Tropospheric Relative Humidity over the Korean Peninsula from Radiosonde and ECMWF Reanalysis Atmosphere doi: 10.3390/atmos11070704 Authors: Hwan-Jin Song Sunyoung Kim Hyesook Lee Ki-Hoon Kim Conventional radiosondes can be used to measure the relative humidity over liquid (RHL) by assuming a saturated vapor pressure over the liquid. However, this assumption results in significant errors with respect to measurements in the upper...
Thu Jul 02, 2020 03:00
Bioengineering, Vol. 7, Pages 67: Adipose-Derived Stromal Cells Seeded on Integra® Dermal Regeneration Template Improve Post-Burn Wound Reconstruction Bioengineering doi: 10.3390/bioengineering7030067 Authors: Marcin Piejko Karolina Radziun Sylwia Bobis-Wozowicz Agnieszka Waligórska Eliza Zimoląg Michał Nessler Anna Chrapusta Zbigniew Madeja Justyna Drukała Fibrosis of burn-related wounds remains an unresolved clinical issue that leads to patient disability. The...
Thu Jul 02, 2020 03:00
Biology, Vol. 9, Pages 150: Heterometrus Spinifer: An Untapped Source of Anti-Tumor Molecules Biology doi: 10.3390/biology9070150 Authors: Morhanavallee Soopramanien Naveed Ahmed Khan Ajnish Ghimire Kuppusamy Sagathevan Ruqaiyyah Siddiqui Despite intensive research, cancer incidence and mortality continue to rise. Consequently, the necessity to develop effective anti-cancer therapy is apparent. We have recently shown that the gut bacteria of animals living in polluted environments,...
Thu Jul 02, 2020 03:00
Biology, Vol. 9, Pages 151: A Selective PPARγ Modulator Reduces Hepatic Fibrosis Biology doi: 10.3390/biology9070151 Authors: Benita L. McVicker Frederick G. Hamel Ronda L. Simpson Robert G. Bennett Hepatic fibrosis is the accumulation of excess collagen as a result of chronic liver injury. If left unabated, hepatic fibrosis can lead to the disruption of the liver architecture, portal hypertension, and increased risk of progression to cirrhosis and hepatocellular carcinoma....
Thu Jul 02, 2020 03:00
Biology, Vol. 9, Pages 149: Ranacyclin-NF, a Novel Bowman–Birk Type Protease Inhibitor from the Skin Secretion of the East Asian Frog, Pelophylax nigromaculatus Biology doi: 10.3390/biology9070149 Authors: Tao Wang Yangyang Jiang Xiaoling Chen Lei Wang Chengbang Ma Xinping Xi Yingqi Zhang Tianbao Chen Chris Shaw Mei Zhou Serine protease inhibitors are found in plants, animals and microorganisms, where they play important roles in many physiological and pathological...
Thu Jul 02, 2020 03:00
Biology, Vol. 9, Pages 148: A Novel Antimicrobial Peptide (Kassinatuerin-3) Isolated from the Skin Secretion of the African Frog, Kassina senegalensis Biology doi: 10.3390/biology9070148 Authors: Hui Wang Haoyang He Xiaoling Chen Mei Zhou Minjie Wei Xinping Xi Chengbang Ma Qiang Du Tianbao Chen Chris Shaw Lei Wang Amphibian skin secretions are remarkable sources of novel bioactive peptides. Among these, antimicrobial peptides have demonstrated an outstanding...
Thu Jul 02, 2020 03:00
Biomedicines, Vol. 8, Pages 191: Orthosiphon stamineus Proteins Alleviate Pentylenetetrazol-Induced Seizures in Zebrafish Biomedicines doi: 10.3390/biomedicines8070191 Authors: Yin-Sir Chung Brandon Kar Meng Choo Pervaiz Khalid Ahmed Iekhsan Othman Mohd. Farooq Shaikh The anticonvulsive potential of proteins extracted from Orthosiphon stamineus leaves (OSLP) has never been elucidated in zebrafish (Danio rerio). This study thus aims to elucidate the anticonvulsive potential...
Thu Jul 02, 2020 03:00
Biomedicines, Vol. 8, Pages 190: Thickness of Intraretinal Layers in Patients with Type 2 Diabetes Mellitus Depending on a Concomitant Diabetic Neuropathy: Results of a Cross-Sectional Study Using Deviation Maps for OCT Data Analysis Biomedicines doi: 10.3390/biomedicines8070190 Authors: Ruby Kala Prakasam Aleksandra Matuszewska-Iwanicka Dagmar-Christiane Fischer Heidrun Schumann Diethelm Tschöpe Bernd Stratmann Hans-Joachim Hettlich Rudolf F. Guthoff Oliver Stachs...
Thu Jul 02, 2020 03:00
Biomolecules, Vol. 10, Pages 997: CMH-Small Molecule Docks into SIRT1, Elicits Human IPF-Lung Fibroblast Cell Death, Inhibits Ku70-deacetylation, FLIP and Experimental Pulmonary Fibrosis Biomolecules doi: 10.3390/biom10070997 Authors: Jenya Konikov-Rozenman Raphael Breuer Naftali Kaminski Shulamit B. Wallach-Dayan Regenerative capacity in vital organs is limited by fibrosis propensity. Idiopathic pulmonary fibrosis (IPF), a progressive lung disease linked with aging, is a classic...
Thu Jul 02, 2020 03:00
Biomolecules, Vol. 10, Pages 996: SIRT1 Deficiency, Specifically in Fibroblasts, Decreases Apoptosis Resistance and Is Associated with Resolution of Lung-Fibrosis Biomolecules doi: 10.3390/biom10070996 Authors: Raanan Bulvik Raphael Breuer Mona Dvir-Ginzberg Eli Reich Neville Berkman Shulamit B. Wallach-Dayan In contrast to normal regenerating tissue, resistance to Fas- and FasL-positive T cell-induced apoptosis were detected in myofibroblasts from fibrotic-lungs of humans...
Thu Jul 02, 2020 03:00
Biomolecules, Vol. 10, Pages 995: Hydrogen Sulfide Alleviates Anxiety, Motor, and Cognitive Dysfunctions in Rats with Maternal Hyperhomocysteinemia via Mitigation of Oxidative Stress Biomolecules doi: 10.3390/biom10070995 Authors: Olga Yakovleva Ksenia Bogatova Renata Mukhtarova Aleksey Yakovlev Viktoria Shakhmatova Elena Gerasimova Guzel Ziyatdinova Anton Hermann Guzel Sitdikova Hydrogen sulfide (H2S) is endogenously produced from sulfur containing amino acids,...
Thu Jul 02, 2020 03:00
Biomolecules, Vol. 10, Pages 994: The Phytochemical Indicaxanthin Synergistically Enhances Cisplatin-Induced Apoptosis in HeLa Cells via Oxidative Stress-Dependent p53/p21waf1 Axis Biomolecules doi: 10.3390/biom10070994 Authors: Mario Allegra Antonella D’Anneo Anna Frazzitta Ignazio Restivo Maria Antonia Livrea Alessandro Attanzio Luisa Tesoriere Combining phytochemicals with chemotherapics is an emerging strategy to treat cancer to overcome drug toxicity and resistance...
Thu Jul 02, 2020 03:00
Biomolecules, Vol. 10, Pages 993: Effects of NAD+ in Caenorhabditis elegans Models of Neuronal Damage Biomolecules doi: 10.3390/biom10070993 Authors: Yuri Lee Hyeseon Jeong Kyung Hwan Park Kyung Won Kim Nicotinamide adenine dinucleotide (NAD+) is an essential cofactor that mediates numerous biological processes in all living cells. Multiple NAD+ biosynthetic enzymes and NAD+-consuming enzymes are involved in neuroprotection and axon regeneration. The nematode Caenorhabditis...
Thu Jul 02, 2020 03:00
Biomolecules, Vol. 10, Pages 992: Implication of Opioid Receptors in the Antihypertensive Effect of a Novel Chicken Foot-Derived Peptide Biomolecules doi: 10.3390/biom10070992 Authors: Anna Mas-Capdevila Lisard Iglesias-Carres Anna Arola-Arnal Gerard Aragonès Begoña Muguerza Francisca Isabel Bravo The peptide AVFQHNCQE demonstrated to produce nitric oxide-mediated antihypertensive effect. This study investigates the bioavailability and the opioid-like activity of this...
Thu Jul 02, 2020 03:00
Biomolecules, Vol. 10, Pages 991: A Short Review on the Valorization of Green Seaweeds and Ulvan: FEEDSTOCK for Chemicals and Biomaterials Biomolecules doi: 10.3390/biom10070991 Authors: D. Shanthana Lakshmi Sivashunmugam Sankaranarayanan Tejal K Gajaria Guoqiang Li Wojciech Kujawski Joanna Kujawa Rodrigo Navia This short review analyzed the recent trend towards, progresses towards the preparation of chemicals of, and value-added biomaterials from marine macroalgae...
Thu Jul 02, 2020 03:00
Brain Sciences, Vol. 10, Pages 422: Prospective Memory, Sleep, and Age Brain Sciences doi: 10.3390/brainsci10070422 Authors: Miranda Occhionero Lorenzo Tonetti Marco Fabbri Michele Boreggiani Monica Martoni Sara Giovagnoli Vincenzo Natale It is reported that sleep enhances prospective memory (PM), but it remains to be understood whether this influence is moderated by age, since sleep changes across the lifespan. To this end, we performed a retrospective study in a naturalistic...
03:00
Brain Sciences, Vol. 10, Pages 421: Science Runs and the Debate Brakes: Somatic Gene-Editing as a New Tool for Gender-Specific Medicine in Alzheimer’s Disease Brain Sciences doi: 10.3390/brainsci10070421 Authors: Pamela Tozzo Silvia Zullo Luciana Caenazzo Gender-specific medicine is a discipline that studies the influence of sex and gender on physiology, pathophysiology, and diseases. One example in light of how a genetic-based disease among other diseases, that impact on sex,...
Thu Jul 02, 2020 03:00
Brain Sciences, Vol. 10, Pages 420: Atrial Fibrillation on Patients with Vascular Dementia: A Fundamental Target for Correct Management Brain Sciences doi: 10.3390/brainsci10070420 Authors: Giovanna Viticchi Lorenzo Falsetti Marco Burattini Vincenzo Zaccone Laura Buratti Marco Bartolini Gianluca Moroncini Mauro Silvestrini Background: Atrial fibrillation (AF) is a risk factor for cerebrovascular diseases and vascular dementia (VAD). The aim of this study was to evaluate...
Thu Jul 02, 2020 03:00
Cancers, Vol. 12, Pages 1772: The ATF6-EGF Pathway Mediates the Awakening of Slow-Cycling Chemoresistant Cells and Tumor Recurrence by Stimulating Tumor Angiogenesis Cancers doi: 10.3390/cancers12071772 Authors: Jaebeom Cho Hye-Young Min Honglan Pei Xuan Wei Jeong Yeon Sim Shin-Hyung Park Su Jung Hwang Hyo-Jong Lee Sungyoul Hong Young Kee Shin Ho-Young Lee Slow-cycling cancer cells (SCCs) with a quiescence-like phenotype are believed to perpetrate cancer...
Thu Jul 02, 2020 03:00
Cancers, Vol. 12, Pages 1770: FIGO 2018 Staging for Cervical Cancer: Influence on Stage Distribution and Outcomes in the 3D-Image-Guided Brachytherapy Era Cancers doi: 10.3390/cancers12071770 Authors: Kento Tomizawa Takuya Kaminuma Kazutoshi Murata Shin-ei Noda Daisuke Irie Takuya Kumazawa Takahiro Oike Tatsuya Ohno Recent widespread use of three-dimensional image-guided brachytherapy (3D-IGBT) has improved radiotherapy outcomes of cervical cancer dramatically. In...
Thu Jul 02, 2020 03:00
Cancers, Vol. 12, Pages 1768: IGF-1R/mTOR Targeted Therapy for Ewing Sarcoma: A Meta-Analysis of Five IGF-1R-Related Trials Matched to Proteomic and Radiologic Predictive Biomarkers Cancers doi: 10.3390/cancers12071768 Authors: Hesham M. Amin Ajaykumar C. Morani Najat C. Daw Salah-Eddine Lamhamedi-Cherradi Vivek Subbiah Brian A. Menegaz Deeksha Vishwamitra Ghazaleh Eskandari Bhawana George Robert S. Benjamin Shreyaskumar Patel Juhee Song Alexander J. Lazar...
Thu Jul 02, 2020 03:00
Cancers, Vol. 12, Pages 1769: Zebrafish Xenografts Unveil Sensitivity to Olaparib beyond BRCA Status
Cancers, Vol. 12, Pages 1769: Zebrafish Xenografts Unveil Sensitivity to Olaparib beyond BRCA Status Cancers doi: 10.3390/cancers12071769 Authors: Ana Beatriz Varanda Ana Martins-Logrado Miguel Godinho Ferreira Rita Fior Poly (ADP-ribose) polymerase (PARP) inhibition in BRCA-mutated cells results in an incapacity to repair DNA damage, leading to cell death caused by synthetic lethality. Within the treatment options for advanced triple negative breast cancer, the PARP inhibitor...
Thu Jul 02, 2020 03:00
Cancers, Vol. 12, Pages 1767: Multiparametric MRI for Prostate Cancer Characterization: Combined Use of Radiomics Model with PI-RADS and Clinical Parameters Cancers doi: 10.3390/cancers12071767 Authors: Piotr Woźnicki Niklas Westhoff Thomas Huber Philipp Riffel Matthias F. Froelich Eva Gresser Jost von Hardenberg Alexander Mühlberg Maurice Stephan Michel Stefan O. Schoenberg Dominik Nörenberg Radiomics is an emerging field of image analysis with potential...
Thu Jul 02, 2020 03:00
Cancers, Vol. 12, Pages 1771: Cell-Mediated Release of Nanoparticles as a Preferential Option for Future Treatment of Melanoma Cancers doi: 10.3390/cancers12071771 Authors: Anastasia Chillà Francesca Margheri Alessio Biagioni Tommaso Del Rosso Gabriella Fibbi Mario Del Rosso Anna Laurenzana Targeted and immune therapies have unquestionably improved the prognosis of melanoma patients. However the treatment of this neoplasm still requires approaches with a higher therapeutic...
Thu Jul 02, 2020 03:00
Δεν υπάρχουν σχόλια:
Δημοσίευση σχολίου