Abstract Background Adult‐onset asthma and chronic obstructive pulmonary disease (COPD) are heterogeneous diseases caused by complex gene‐environment interactions. A functional single nucleotide polymorphism of cadherin‐related family member 3 (CDHR3), known as a receptor of rhinovirus‐C, is associated with childhood‐onset asthma especially in atopic individuals. Objective Here, we identified risk factors for adult‐onset asthma and COPD, focusing on the impact of the CDHR3 variant in atopic...
Thu Jul 02, 2020 20:55
Publication date: Available online 2 July 2020Source: Annals of Allergy, Asthma & ImmunologyAuthor(s): Priya Mehta, Magee L. DeFelice, Christine Malloy, Jobayer Hossain, Hillary Gordon
Thu Jul 02, 2020 21:49
Publication date: Available online 1 July 2020Source: Annals of Allergy, Asthma & ImmunologyAuthor(s): Brian Lipworth, Rory Chan, Chris RuiWen Kuo
Thu Jul 02, 2020 21:49
Publication date: September 2020Source: European Journal of Cancer, Volume 136Author(s): Yves Rinaldi, Anne-Laure Pointet, Faiza Khemissa Akouz, Karine Le Malicot, Bidaut Wahiba, Samy Louafi, Alain Gratet, Laurent Miglianico, Hortense Laharie, Karine Bouhier Leporrier, Anne Thirot Bidault, Patrick Texereau, Romain Coriat, Eric Terrebonne, Marie-Claude Gouttebel, David Malka, Jean-Baptiste Bachet, Côme Lepage, Julien Taieb, Cécile Julien
Thu Jul 02, 2020 21:46
Publication date: September 2020Source: European Journal of Cancer, Volume 136Author(s): Maria Vittoria Dieci, Vassilena Tsvetkova, Gaia Griguolo, Federica Miglietta, Giulia Tasca, Carlo Alberto Giorgi, Enrico Cumerlato, Davide Massa, Marcello Lo Mele, Enrico Orvieto, Valentina Guarneri, Pierfranco Conte
Thu Jul 02, 2020 21:46
Publication date: Available online 1 July 2020Source: Critical Reviews in Oncology/HematologyAuthor(s): Eline Janssens, Jan P van Meerbeeck, Kevin Lamote
Thu Jul 02, 2020 21:41
Publication date: Available online 1 July 2020Source: Critical Reviews in Oncology/HematologyAuthor(s): C. Bisschop, E.C. de Heer, A.H. Brouwers, G.A.P. Hospers, M. Jalving
Thu Jul 02, 2020 21:41
Analyst, 2020, Accepted ManuscriptDOI: 10.1039/D0AN00865F, Paper Open Access This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Liam T. Wilson, William J. Tipping, Lauren E. Jamieson, Corinna Wetherill, Zoë Henley, Karen Faulds, Duncan Graham, Simon Mackay, Nicholas C O TomkinsonIntracellular pH (pHi) homeostasis is intertwined with a myriad of normal cellular behaviors as well as pathological pro-cesses. As such, small molecule probes for the measurement of pHi...
Thu Jul 02, 2020 02:00
Analyst, 2020, Advance ArticleDOI: 10.1039/D0AN00969E, PaperDaniel-Ralph Hermann, David Lilek, Christina Daffert, Ines Fritz, Simone Weinberger, Vanessa Rumpler, Birgit Herbinger, Katerina ProhaskaReproducible in situ SERS delivers a significantly reduced analysis time compared to HPLC, allowing timely decisions regarding Synechocystis PHB production.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry
Thu Jul 02, 2020 02:00
Analyst, 2020, Accepted ManuscriptDOI: 10.1039/D0AN00975J, CommunicationMengzhe Li, Mengmeng Liu, Cuiping Ma, Chao ShiWe reported a novel detection method named accelerated strand exchange amplification by employing Bst DNA polymerase and narrow-thermal-cycling firstly, achieving direct detection of 120 copies of DNA within 15 min...The content of this RSS Feed (c) The Royal Society of Chemistry
Thu Jul 02, 2020 02:00
Due to its rarity, little is known about the clinical presentations and responses to systemic chemotherapies in advanced and/or metastatic cases of paratesticular liposarcoma.
Thu Jul 02, 2020 03:00
Publication date: Available online 1 July 2020Source: Brain Research BulletinAuthor(s): Fang Yang, Hong Wang, Huali Chen, Dongzhi Ran, Qiang Tang, Ping Wong, Yuzhuo Sun, Wengao Jiang
Thu Jul 02, 2020 21:22
Publication date: Available online 1 July 2020Source: British Journal of Oral and Maxillofacial SurgeryAuthor(s): P.A. Brennan, M. Davidson
Thu Jul 02, 2020 21:18
Publication date: Available online 1 July 2020Source: British Journal of Oral and Maxillofacial SurgeryAuthor(s): N. Kolsuz, O. Atali, A. Varol
Thu Jul 02, 2020 21:18
Publication date: Available online 1 July 2020Source: British Journal of Oral and Maxillofacial SurgeryAuthor(s): M. Schlund, G. Raoul, L. Marti-Flich, R. Nicot
Thu Jul 02, 2020 21:18
Publication date: Available online 1 July 2020Source: British Journal of Oral and Maxillofacial SurgeryAuthor(s): C. von Wilmowsky, M.G. Schwertner, E. Nkenke, T. Moest, W. Adler, T. Ebker
Thu Jul 02, 2020 21:18
Publication date: Available online 1 July 2020Source: British Journal of Oral and Maxillofacial SurgeryAuthor(s): J.N. Farrier, S. Farrier, S. Haworth, A.N. Beech
Thu Jul 02, 2020 21:18
Publication date: Available online 1 July 2020Source: British Journal of Oral and Maxillofacial SurgeryAuthor(s): H. Ong, J. Spellman, A. Kanatas
Thu Jul 02, 2020 21:18
Publication date: Available online 1 July 2020Source: British Journal of Oral and Maxillofacial SurgeryAuthor(s): B.H.J. Rapaport, J.S. Brown
Thu Jul 02, 2020 21:18
Abstract Introduction The prognostic role of racial and socioeconomic factors in patients with glioblastoma is controversially debated. We aimed to evaluate how these factors may affect survival outcomes in an overall and cause-specific manner using large, national cancer registry cohort data in the temozolomide chemoradiation era. Methods The National...
Thu Jul 02, 2020 03:00
Species’ vulnerability to climate change depends on the most temperature-sensitive life stages, but for major animal groups such as fish, life cycle bottlenecks are often not clearly defined. We used observational, experimental, and phylogenetic data to assess stage-specific thermal tolerance metrics for 694 marine and freshwater fish species from all climate zones. Our analysis shows that spawning adults and embryos consistently have narrower tolerance ranges than larvae and nonreproductive adults...
Thu Jul 02, 2020 20:34
During sexual transmission, the high genetic diversity of HIV-1 within an individual is frequently reduced to one founder variant that initiates infection. Understanding the drivers of this bottleneck is crucial to developing effective infection control strategies. Little is known about the importance of the source partner during this bottleneck. To test the hypothesis that the source partner affects the number of HIV founder variants, we developed a phylodynamic model calibrated using genetic and...
Thu Jul 02, 2020 20:34
The direct-current (dc) Josephson effect provides a phase-sensitive tool for investigating superfluid order parameters. We report on the observation of dc Josephson supercurrents in strongly interacting fermionic superfluids across a tunneling barrier in the absence of any applied potential difference. For sufficiently strong barriers, we observed a sinusoidal current-phase relation, in agreement with Josephson’s seminal prediction. We mapped out the zero-resistance state and its breakdown as a function...
Thu Jul 02, 2020 20:34
The CRISPR RNA (crRNA)–guided nuclease Cas13 recognizes complementary viral transcripts to trigger the degradation of both host and viral RNA during the type VI CRISPR-Cas antiviral response. However, how viruses can counteract this immunity is not known. We describe a listeriaphage (LS46) encoding an anti-CRISPR protein (AcrVIA1) that inactivates the type VI-A CRISPR system of Listeria seeligeri. Using genetics, biochemistry, and structural biology, we found that AcrVIA1 interacts with the guide-exposed...
Thu Jul 02, 2020 20:34
The coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has resulted in an unprecedented public health crisis. Because of the novelty of the virus, there are currently no SARS-CoV-2–specific treatments or vaccines available. Therefore, rapid development of effective vaccines against SARS-CoV-2 are urgently needed. Here, we developed a pilot-scale production of PiCoVacc, a purified inactivated SARS-CoV-2 virus vaccine candidate, which...
Thu Jul 02, 2020 20:34
Direct activation of gaseous hydrocarbons remains a major challenge for the chemistry community. Because of the intrinsic inertness of these compounds, harsh reaction conditions are typically required to enable C(sp3)–H bond cleavage, barring potential applications in synthetic organic chemistry. Here, we report a general and mild strategy to activate C(sp3)–H bonds in methane, ethane, propane, and isobutane through hydrogen atom transfer using inexpensive decatungstate as photocatalyst at room temperature....
Thu Jul 02, 2020 20:34
Microbial communities are essential to fundamental processes on Earth. Underlying the compositions and functions of these communities are nutritional interdependencies among individual species. One class of nutrients, cobamides (the family of enzyme cofactors that includes vitamin B12), is widely used for a variety of microbial metabolic functions, but these structurally diverse cofactors are synthesized by only a subset of bacteria and archaea. Advances at different scales of study—from individual...
Thu Jul 02, 2020 20:34
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can cause coronavirus disease 2019 (COVID-19), an influenza-like disease that is primarily thought to infect the lungs with transmission through the respiratory route. However, clinical evidence suggests that the intestine may present another viral target organ. Indeed, the SARS-CoV-2 receptor angiotensin-converting enzyme 2 (ACE2) is highly expressed on differentiated enterocytes. In human small intestinal organoids (hSIOs), enterocytes...
Thu Jul 02, 2020 20:34
Eukaryotic histone H3-H4 tetramers contain a putative copper (Cu2+) binding site at the H3-H3' dimerization interface with unknown function. The coincident emergence of eukaryotes with global oxygenation, which challenged cellular copper utilization, raised the possibility that histones may function in cellular copper homeostasis. We report that the recombinant Xenopus laevis H3-H4 tetramer is an oxidoreductase enzyme that binds Cu2+ and catalyzes its reduction to Cu1+ in vitro. Loss- and gain-of-function...
Thu Jul 02, 2020 20:34
Bacterial biofilms represent a basic form of multicellular organization that confers survival advantages to constituent cells. The sequential stages of cell ordering during biofilm development have been studied in the pathogen and model biofilm-former Vibrio cholerae. It is unknown how spatial trajectories of individual cells and the collective motions of many cells drive biofilm expansion. We developed dual-view light-sheet microscopy to investigate the dynamics of biofilm development from a founder...
Thu Jul 02, 2020 20:34
Dielectric capacitors can store and release electric energy at ultrafast rates and are extensively studied for applications in electronics and electric power systems. Among various candidates, thin films based on relaxor ferroelectrics, a special kind of ferroelectric with nanometer-sized domains, have attracted special attention because of their high energy densities and efficiencies. We show that high-energy ion bombardment improves the energy storage performance of relaxor ferroelectric thin films....
Thu Jul 02, 2020 20:34
The role of reduced dimensionality in high-temperature superconductors is still under debate. Recently, ultracold atoms have emerged as an ideal model system to study such strongly correlated two-dimensional (2D) systems. Here, we report on the realization of a Josephson junction in an ultracold 2D Fermi gas. We measure the frequency of Josephson oscillations as a function of the phase difference across the junction and find excellent agreement with the sinusoidal current phase relation of an ideal...
Thu Jul 02, 2020 20:34
Longevity has been a long-standing concern for hybrid perovskite photovoltaics. We demonstrate high-resilience positive-intrinsic-negative perovskite solar cells by incorporating a piperidinium-based ionic compound into the formamidinium-cesium lead-trihalide perovskite absorber. With the bandgap tuned to be well suited for perovskite-on-silicon tandem cells, this piperidinium additive enhances the open-circuit voltage and cell efficiency. This additive also retards compositional segregation into...
Thu Jul 02, 2020 20:34
Cancer treatments are often more successful when the disease is detected early. We evaluated the feasibility and safety of multicancer blood testing coupled with positron emission tomography–computed tomography (PET-CT) imaging to detect cancer in a prospective, interventional study of 10,006 women not previously known to have cancer. Positive blood tests were independently confirmed by a diagnostic PET-CT, which also localized the cancer. Twenty-six cancers were detected by blood testing. Of these,...
Thu Jul 02, 2020 20:34
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