Bacteria evolve resistance to antibiotics by a multitude of mechanisms. A central, yet unsolved question is how resistance evolution affects cell growth at different drug levels. Here we develop a fitness model that predicts growth rates of common resistance mutants from their effects on cell metabolism. We map metabolic effects of resistance mutations in drug-free environments and under drug challenge; the resulting fitness trade-off defines a Pareto surface of resistance evolution. We predict evolutionary...
Thu Jul 02, 2020 03:00
Abstract Purpose The widespread use of gallium-68-labelled somatostatin analogue (SSA) PET, the current standard for somatostatin receptor (SSTR) imaging, is limited by practical and economic challenges that could be overcome by a fluorine-18-labelled alternative, such as the recently introduced [18F]AlF-NOTA-octreotide ([18F]AlF-OC). This prospective trial aimed to evaluate safety, dosimetry, biodistribution, pharmacokinetics and lesion...
Thu Jul 02, 2020 03:00
Abstract Purpose Prostate-specific membrane antigen (PSMA) positron emission tomography (PET)/computed tomography (CT) is used for (re)staging prostate cancer (PCa) and as a biomarker for evaluating response to therapy, but lacks established response criteria. A panel of PCa experts in nuclear medicine, radiology, and/or urology met on February 21, 2020, in Amsterdam, The Netherlands, to formulate criteria for PSMA PET/CT-based response...
Thu Jul 02, 2020 03:00
Type 2 diabetes typically originates in persons with obesity-induced insulin resistance, but the condition manifests clinically as hyperglycemia due to diminished capacity of beta cells to adapt by increasing insulin secretion. Chronic hyperglycemia is accompanied by both microvascular and…
Thu Jul 02, 2020 03:00
AbstractMetastatic salivary gland tumors are rare clinical entities of the head and neck. Parotid gland carcinoma with distant metastases heralds a poor prognosis with a median survival of 4.3–7.3 months. The lungs, long bones, liver and brain are the most common sites of metastasis for parotid gland cancer, along with a few reported cases describing metastasis to the ileum, spleen and iliac crest. We present the first case to our knowledge of parotid adenocarcinoma metastasis to the breast.
Thu Jul 02, 2020 03:00
A 78-year-old man with end-stage renal disease, diabetes mellitus, and microscopic polyangiitis, for which he was taking glucocorticoids, presented to the rheumatology clinic with fever, painful glossitis, and taste abnormalities that had persisted for 1 month. Examination of the tongue showed a…
Thu Jul 02, 2020 03:00
In the literature on vocal pedagogy we may find suggestions to increase the mouth opening when singing louder. It is known that sopranos tend to sing loud high notes with a wider mouth opening which raises the frequency of the first resonance of the vocal tract (fR1) to tune it close to the fundamental. Our experiment with classically trained male singers revealed that they also tended to raise the fR1 with the dynamics at pitches where the formant tuning does not seem relevant. The analysis by synthesis...
Thu Jul 02, 2020 03:00
The purpose of this study was to measure and compare the voice characteristics and vocal complaints and habits of musical theater actors and musical theater students.
Thu Jul 02, 2020 03:00
Teachers have been found to have a higher than normal risk to develop voice disorders. One common symptom of voice problems among teachers is the report and occurrence of vocal fatigue, often associated with different individual, physical, environmental, and professional factors.
Thu Jul 02, 2020 03:00
While the novel coronavirus outbreak has profoundly altered health care systems across the globe, it has also affected similar change and devastation on the social, educational and cultural communities upon which many rely, including communities of choral singers, solo performers, conductors, voice teachers and the professionals that collaborate with them. Even as citizens of the most heavily impacted countries took to their balconies to serenade first responders and health care workers, singers...
Wed Jul 01, 2020 03:00
Abstract Feeding disorders can have a significant impact on children and their families. Access to supportive multidisciplinary care is central to improving outcomes; however, there are numerous factors that can impact service access. Using a mixed methods design, the current study examined parents’ experiences and satisfaction with accessing a state-wide government-funded tertiary pediatric feeding clinic in Australia. Parents of 37 children (aged 7 weeks to 17 years) participated...
Thu Jul 02, 2020 03:00
Abstract Larry David, the co‐creator and producer of Seinfeld, when asked by a reporter from the New York Times about what he fears the most while quarantining during the COVID 19 Epidemic, responded “Anarchy and a potential dental emergency — and not necessarily in that order”(Dowd, 2020).The pandemic introduced a new layer of challenges on how to provide care, alleviate pain. Restrictions have been implemented by the majority of governments, as SARS‐CoV‐2 has been detected in saliva samples and...
Thu Jul 02, 2020 12:10
Abstract The detection of SARS‐CoV‐2 in the saliva of patients with coronavirus disease (COVID‐19) has made this biological fluid relevant in terms of the diagnosis and transmission of the infection (To et al, 2020a; Azzi et al, 2020a). As a result, the dental clinic is considered an environment of risk for dental healthcare personnel and their patients, particularly due to the potential transmission of the virus through droplets and aerosols (Peng et al, 2020).
Thu Jul 02, 2020 12:09
Abstract In December 2019 an outbreak of a new corona virus was reported in the city Wuhan, China. End of January, the WHO declared this development as a public health emergency of international concern (WHO, 2020). Germany reported a rapidly increasing number of 186,461 infected persons in the period from February to June (Robert‐Koch‐Institut, 2020). This pandemic, caused by a respiratory disease, presents the dental profession with an unprecedented challenge in terms of dental care for the population.
Thu Jul 02, 2020 12:03
Abstract Background Periodontitis and osteoporosis are most popular among aging population and both conditions might be linked, even though, this suggestion still until now debated. Objectives A meta‐analysis on previous investigations has been used to evaluate the correlation between periodontitis and osteoporosis to determine whether osteoporosis is a local indicator of bone loss, or whether it is depending on or related to periodontitis causes. Methods The literature database,...
Thu Jul 02, 2020 11:59
Abstract The novel coronavirus disease 2019 (COVID‐19) had caused major disruptions in medical and dental care across the world, affecting secondary care services that had to rapidly adapt to new circumstances. Postponed and delayed oral medicine (OM) care, deferring non‐urgent follow‐ups in case of patients because of COVID‐19 crisis, and limited access to health care, may have lead serious consequences fororal and systemic health (Arduino et al, 2020; Jones et al, 2020). Deferred diagnosis of...
Thu Jul 02, 2020 15:47
Abstract Tri-spine horseshoe crabs (HSCs) Tachypleus tridentatus have been facing the threat of population depletion for decades, and the physiology and microbiology of their early life stages are lacking. To explore what directs the change of juvenile T. tridentatus gut microbiota and how gut microbiota change, by using 16S rRNA sequencing of gut samples we detected the intestinal microbiome of juvenile HSCs and compared the impact of initial molting and initial feeding, as well...
Thu Jul 02, 2020 03:00
Human periodontal ligament stromal cells (hPDLSCs) and gingival mesenchymal stromal cells (hGMSCs) are resident mesenchymal stromal cells (MSCs) of the periodontal tissue. The lipopolysaccharide (LPS) from Porphyromonas gingivalis is structurally distinct from that of other Gram-negative bacteria, and earlier studies linked this structural difference to a distinct virulence activity and the ability to activate toll-like receptor 2 (TLR-2), besides TLR-4 as commonly occurring upon LPS challenge. Later...
Thu Jul 02, 2020 15:35
Abstract As the most common cardiac arrhythmia, atrial fibrillation (AF) is a major risk factor for stroke, heart failure, and premature death with considerable associated costs. However, no available treatment options have optimal benefit-harm profiles currently, reflecting an incomplete understanding of the biological mechanisms underlying this complex arrhythmia. Recently, molecular epidemiological studies, especially genome-wide association studies, have emphasized the substantial...
Thu Jul 02, 2020 03:00
Abstract CRISPR-Cas9 are widely used for gene targeting in mice and rats. The non-homologous end-joining (NHEJ) repair pathway, which is dominant in zygotes, efficiently induces insertion or deletion (indel) mutations as gene knockouts at targeted sites, whereas gene knock-ins (KIs) via homology-directed repair (HDR) are difficult to generate. In this study, we used a double-stranded DNA (dsDNA) donor template with Cas9 and two single guide RNAs, one designed to cut the targeted...
Thu Jul 02, 2020 03:00
Abstract While pralatrexate has been successfully developed for the treatment of T‐cell lymphoma, the mechanistic basis for its T‐cell selectivity and acquired resistance remains elusive. In an effort to potentially identify synergistic combinations that might circumnavigate or delay acquired pralatrexate resistance, we generated resistant cells lines over a broad concentration range. Pralatrexate‐resistant cell lines H9‐12 and H9‐200 were developed, each exhibiting an IC50 of 35 and over 1000 nM,...
Thu Jul 02, 2020 19:29
Abstract We describe a family severely affected by colorectal cancer (CRC) where whole‐exome sequencing identified the coinheritance of the germline variants encoding MSH6 p.Thr1100Met and MUTYH p.Tyr179Cys in, at least, three CRC patients diagnosed before 60 years of age. Digenic inheritance of monoallelic MSH6 variants of uncertain significance and MUTYH variants has been suggested to predispose to Lynch syndrome‐associated cancers, however cosegregation with disease in the familial setting...
Thu Jul 02, 2020 19:24
Carl ZimmerSe calcula que casi tres cuartas partes de la tierra están cubiertas por océanos, y que estos contienen casi la totalidad del agua disponible (más del 95%). La vida se originó en el agua, y aún se encuentra en todas sus diversas manifestaciones y tamaños en ella. Y en ella también se hayan los representantes más variopintos genéticamente de la biosfera...pero no están vivos, en un sentido estricto. Sólo penetrando las células de los seres propiamente vivos y apropiándose de su maquinaria...
Thu Jul 02, 2020 23:45
Publication date: Available online 1 July 2020Source: Archives of Oral BiologyAuthor(s): Bina Kashyap, Arja M. Kullaa
00:05
Publication date: Available online 2 July 2020Source: Journal of the American College of SurgeonsAuthor(s): Jinyoung Park, Hyung Sun Kim, Jung Hyun Park, Yoon Ghil Park, Sanghoon Shin, Jae Eun Park, Sangwon Hwang, So Young Jun, Joon Seong Park
00:04
Sagittal split ramus osteotomy (SSRO) is one of the most common maxillofacial operations, and the technique relies on a directed fracture involving different biomechanical variables. The aim of this study was to find out the biomechanical characteristics involved during each step of sagittal split osteotomy. We sampled eight fully dentate human mandibles and used the right side for hardness tests and the left side for a traction-to-fracture test within an unfinished SSRO. Right sides were sampled...
Thu Jul 02, 2020 03:00
Complications with bilateral sagittal split osteotomy (BSSO) can sometimes result from surgical inexperience. Our aim was to present a 3-dimensional printed mandibular model for BSSO training in a maxillofacial surgical education programme. A polymethacrylate mandibular model obtained from mandibular cone-beam computed tomographic (CT) images was designed and printed for use in training. Twenty-four residents were each asked to do a BSSO according to the Epker/Dal-Pont technique. The session was...
Thu Jul 02, 2020 03:00
Excellence in teaching and learning is fundamental to the provision of quality training for doctors and for this a sound knowledge of the principles of adult learning theory is important. We present an educational course in head and neck trauma skills for emergency medicine (EM) registrars, using the pedagogical principle of active learning. Our aim was to provide trainees with skills in the evaluation and management of hard and soft tissue injuries to the head, neck, and mouth. Active learning has...
Thu Jul 02, 2020 03:00
In October 2016, the Health Secretary announced an expansion of medical school places from September 2018, which meant that a total of 1500 extra places will be funded in existing and new medical schools.
Thu Jul 02, 2020 03:00
Exercise is now widely accepted as a safe, cost-efficient, and effective intervention for survivors of cancer.1–3 Considerable scientific evidence supports its efficacy in improving the quality of life of survivors,3 as it helps to prevent and manage comorbidities,2 and reduces cancer-specific and all-cause mortality.4 Evidence-based guidelines have been published to inform medical and allied health professionals about how best to prescribe it,5–9 but an important issue is the current lack of specific...
Thu Jul 02, 2020 03:00
We appreciate the opportunity to respond to the interesting letter about the treatment alternatives for mandibular third molars with mild pericoronitis that related to our recent article.1
Thu Jul 02, 2020 03:00
Abstract Humans can rapidly categorise visual objects when presented in isolation. However, in everyday life we encounter multiple objects at the same time. Far less is known about how simultaneously active object representations interact. We examined such interactions by asking participants to categorise a target object at the basic (Experiment 1) or the superordinate (Experiment 2) level while the representation of another object was still active. We found that the ‘prime’ object strongly modulated...
Thu Jul 02, 2020 11:36
Journal of Adolescent and Young Adult Oncology, Ahead of Print.
Tue Jun 30, 2020 10:00
Journal of Adolescent and Young Adult Oncology, Ahead of Print.
Tue Jun 30, 2020 10:00
Thu Jul 02, 2020 23:41
Publication date: Available online 2 July 2020Source: European Journal of Vascular and Endovascular SurgeryAuthor(s): Rutger H.A. Welling, Gert J. de Borst, Daniel A.F. van den Heuvel, Daniela Branzan, Andrej Schmidt, Dierk Scheinert, Olaf J. Bakker
Thu Jul 02, 2020 23:51
Publication date: July 2020Source: European Journal of Vascular and Endovascular Surgery, Volume 60, Issue 1Author(s): Stavros Kakkos
Thu Jul 02, 2020 23:51
Publication date: July 2020Source: European Journal of Vascular and Endovascular Surgery, Volume 60, Issue 1Author(s): Michael S. Conte, Andrew W. Bradbury, Philippe Kolh, John V. White, Florian Dick, Robert Fitridge, Joseph L. Mills, Jean-Baptiste Ricco, Kalkunte R. Suresh, M. Hassan Murad, Victor Aboyans, Murat Aksoy, Vlad-Adrian Alexandrescu, David Armstrong, Nobuyoshi Azuma, Jill Belch, Michel Bergoeing, Martin Bjorck, Nabil Chakfé, Stephen Cheng
Thu Jul 02, 2020 23:51
Publication date: July 2020Source: European Journal of Vascular and Endovascular Surgery, Volume 60, Issue 1Author(s): Jonathan R. Boyle
Thu Jul 02, 2020 23:51
Publication date: July 2020Source: European Journal of Vascular and Endovascular Surgery, Volume 60, Issue 1Author(s):
Thu Jul 02, 2020 23:51
Publication date: July 2020Source: European Journal of Vascular and Endovascular Surgery, Volume 60, Issue 1Author(s):
Thu Jul 02, 2020 23:51
Publication date: July 2020Source: European Journal of Vascular and Endovascular Surgery, Volume 60, Issue 1Author(s):
Thu Jul 02, 2020 23:51
Publication date: July 2020Source: European Journal of Vascular and Endovascular Surgery, Volume 60, Issue 1Author(s):
Thu Jul 02, 2020 23:51
Not long after he ascended to the throne in 1999, King Abdullah II began a project of economic development and reform in Jordan. Following the suggestions of his economic advisors as well as the recommendations of the International Monetary Fund (IMF) and World Bank, the king privatized national industries to remake the country into a regional destination for economic investment. Amman, the capital, was central to his vision for a new Jordan. With Bahaa Hariri, the multibillionaire developer and...
Thu Jul 02, 2020 23:30
Heat is everywhere. We are born with it. It is used by the physiotherapist to minimize the pain in our body. The muscle relaxants we use also emit heat on the surface of our skin. Heat can be seen and felt. We live on an overheated planet with glaciers melting, floods and droughts increasing, and a number of other examples of ecological crisis. The heat of the planet can be seen as the pulse of our social condition. Can heat also be a mirror to look at our life in the wake of the social crisis created...
Thu Jul 02, 2020 21:30
Racism permeates the academy. We will need more than performative allyship and symbolic statements condemning racism in society if we are to build a more inclusive anthropology. Black bodies have always been and continue to be under social, economic, and physical siege in the United States. Glimpses of widespread protests against racism and police brutality from coastal Georgia, Central Park, Louisville, Minneapolis, and Atlanta coupled with the disproportionately deadly impact of COVID-19 have...
Thu Jul 02, 2020 19:32
We do not sit outside of the world in which we live. The current fight over the fate of Confederate monuments in US life is a direct struggle that calls for direct action by us all against racism. Are symbols of the Old South memorials? Living museums of interactive racism, filled with exhibits of monuments to hate. Whether etched in stone or ingrained in knots, placards mark the spots the present never forgot. Historical reenactments of unspeakable acts, performed again and again to bring...
Thu Jul 02, 2020 19:30
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