Related Articles The development of the Compulsive Sexual Behavior Disorder Scale (CSBD-19): An ICD-11 based screening measure across three languages. J Behav Addict. 2020 Jun 16;: Authors: Bőthe B, Potenza MN, Griffiths MD, Kraus SW, Klein V, Fuss J, Demetrovics Z Abstract Background: Compulsive Sexual Behavior Disorder (CSBD) is included in the eleventh edition of The International Classification of Diseases (ICD-11) as an impulse-control...
Thu Jul 02, 2020 15:51
Related Articles Clinical applications of neurochemical and electrophysiological measurements for closed-loop neurostimulation. Neurosurg Focus. 2020 Jul;49(1):E6 Authors: Price JB, Rusheen AE, Barath AS, Rojas Cabrera JM, Shin H, Chang SY, Kimble CJ, Bennet KE, Blaha CD, Lee KH, Oh Y Abstract The development of closed-loop deep brain stimulation (DBS) systems represents a significant opportunity for innovation in the clinical application of...
Thu Jul 02, 2020 15:51
Related Articles Measuring the impact of epilepsy on families. Epilepsy Behav. 2020 Jun 28;111:107254 Authors: Dawes A, Attipoe S, Mittlesteadt J, Glynn P, Rust S, Debs A, Patel AD Abstract OBJECTIVE: Caring for a child with illness or a child with disability impacts family in various ways. The ability to assess the impact of this care on families is one way to proactively provide the necessary support and resources for impacted families. Accordingly,...
Thu Jul 02, 2020 15:51
Related Articles Lamotrigine add-on therapy for drug-resistant generalised tonic-clonic seizures. Cochrane Database Syst Rev. 2020 Jul 01;7:CD007783 Authors: Bresnahan R, Panebianco M, Marson AG Abstract BACKGROUND: This is an update of the Cochrane Review first published in 2010; it includes one additional study. Primary generalised tonic-clonic seizures are a type of generalised seizure. Other types of seizures include: absence, myoclonic,...
Thu Jul 02, 2020 15:51
Related Articles Interactions between cannabidiol and Δ9 -tetrahydrocannabinol in modulating seizure susceptibility and survival in a mousae model of Dravet syndrome. Br J Pharmacol. 2020 Jul 01;: Authors: Anderson LL, Low IK, McGregor IS, Arnold JC Abstract BACKGROUND AND PURPOSE: Extracts from the cannabis plant can dramatically improve the health of children suffering from refractory epilepsies such as Dravet syndrome. These extracts typically...
Thu Jul 02, 2020 15:51
Related Articles Neuronal α2δ proteins and brain disorders. Pflugers Arch. 2020 Jun 30;: Authors: Ablinger C, Geisler SM, Stanika RI, Klein CT, Obermair GJ Abstract α2δ proteins are membrane-anchored extracellular glycoproteins which are abundantly expressed in the brain and the peripheral nervous system. They serve as regulatory subunits of voltage-gated calcium channels and, particularly in nerve cells, regulate presynaptic and postsynaptic...
Thu Jul 02, 2020 15:51
Related Articles Psychogenic Non-Epileptic Seizures; a Narrative Review. Arch Acad Emerg Med. 2020;8(1):e10 Authors: Jafari A, Rezaei Tavirani M, Parvareshi Hamrah M, Ahmadi Karvigh S, Bashi Zadeh Fakhar H Abstract Psychogenic non-epileptic seizures (PNES) are paroxysmal changes that mimic epileptic seizures, so often misdiagnosed and treated for epilepsy. PNES are considered a psychiatric illness, personality pathology, and experiential and...
Thu Jul 02, 2020 15:51
Related Articles Cerebral Palsy: Current Opinions on Definition, Epidemiology, Risk Factors, Classification and Treatment Options. Neuropsychiatr Dis Treat. 2020;16:1505-1518 Authors: Sadowska M, Sarecka-Hujar B, Kopyta I Abstract Cerebral palsy (CP) is one of the most frequent causes of motor disability in children. According to the up-to-date definition, CP is a group of permanent disorders of the development of movement and posture, causing...
Thu Jul 02, 2020 15:51
Related Articles [Clinical characteristics of SLC35A2 gene variants related congenital disorders of glycosylation typeⅡ]. Zhonghua Er Ke Za Zhi. 2020 Jul 02;58(7):586-590 Authors: Lang CH, Yang Y, Niu XY, Yang XL, Chen Y, Zhang YH Abstract Objective: To summarize the clinical characteristics of children with SLC35A2 gene variants related congenital disorders of glycosylation (SLC35A2-CDG), so as to improve the clinicians' understanding of this...
Thu Jul 02, 2020 15:51
Related Articles Central Effects of Cranial Nerve Stimulation. Otolaryngol Clin North Am. 2020 Feb;53(1):45-55 Authors: Kohlberg GD, Samy RN Abstract The current literature on peripheral cranial nerve stimulation for the purpose of achieving therapeutic effects via altering brain activity is reviewed. Vagus nerve stimulation, which is approved for use in refractory epilepsy, is the most extensively studied cranial nerve stimulator that has...
Thu Jul 02, 2020 15:51
Related Articles Neuronal antibodies in adult patients with new-onset seizures: A prospective study. Brain Behav. 2019 11;9(11):e01442 Authors: Zelano J, Axelsson M, Constantinescu R, Malmeström C, Kumlien E Abstract OBJECTIVES: Immunotherapy in addition to antiepileptic drugs can improve seizure freedom rates in autoimmune epilepsy, highlighting the importance of early diagnosis. A diagnosis of autoimmune epilepsy can be supported by presence...
Thu Jul 02, 2020 15:51
Related Articles Neural Correlates of Music Listening and Recall in the Human Brain. J Neurosci. 2019 10 09;39(41):8112-8123 Authors: Ding Y, Zhang Y, Zhou W, Ling Z, Huang J, Hong B, Wang X Abstract Previous neuroimaging studies have identified various brain regions that are activated by music listening or recall. However, little is known about how these brain regions represent the time course and temporal features of music during listening...
Thu Jul 02, 2020 15:51
Related Articles Remedial dosing recommendations for delayed or missed doses of lamotrigine in pediatric patients with epilepsy using Monte Carlo simulations. Epilepsy Behav. 2019 07;96:132-140 Authors: Yu EQ, Jiao Z, Wang CY, Ding JJ, Zhang XH Abstract OBJECTIVE: This study investigated the effect of delayed or missed doses on the pharmacokinetics (PK) of lamotrigine (LTG) in children with epilepsy and established remedial dosing recommendations...
Thu Jul 02, 2020 15:51
Related Articles Time course of transient expression of pre-α-pro-GDNF and pre-β-pro-GDNF transcripts, and mGDNF mRNA region in Krushinsky-Molodkina rat brain after audiogenic seizures. Epilepsy Behav. 2019 07;96:87-91 Authors: Solius G, Panteleev D, Pustogarov N, Revishchin A, Poletaeva I, Pavlova G Abstract The expression of glial cell line-derived neurothrophic factor (GDNF) transcript forms pre-(α)pro-gdnf, pre-(β)pro-gdnf, and their common...
Thu Jul 02, 2020 15:51
Related Articles Transplantation of human meningioma stem cells loaded on a self-assembling peptide nanoscaffold containing IKVAV improves traumatic brain injury in rats. Acta Biomater. 2019 07 01;92:132-144 Authors: Sahab Negah S, Oliazadeh P, Jahanbazi Jahan-Abad A, Eshaghabadi A, Samini F, Ghasemi S, Asghari A, Gorji A Abstract Traumatic brain injury (TBI) can result in permanent brain function impairment due to the poor regenerative ability...
Thu Jul 02, 2020 15:51
Thu Jul 02, 2020 13:25
Related Articles Genomic discovery of an evolutionarily programmed modality for small-molecule targeting of an intractable protein surface. Proc Natl Acad Sci U S A. 2020 Jun 30;: Authors: Shigdel UK, Lee SJ, Sowa ME, Bowman BR, Robison K, Zhou M, Pua KH, Stiles DT, Blodgett JAV, Udwary DW, Rajczewski AT, Mann AS, Mostafavi S, Hardy T, Arya S, Weng Z, Stewart M, Kenyon K, Morgenstern JP, Pan E, Gray DC, Pollock RM, Fry AM, Klausner RD, Townson SA, Verdine GL...
Thu Jul 02, 2020 15:48
Related Articles X-ray processing of a realistic ice mantle can explain the gas abundances in protoplanetary disks. Proc Natl Acad Sci U S A. 2020 Jun 30;: Authors: Ciaravella A, Muñoz Caro GM, Jiménez-Escobar A, Cecchi-Pestellini C, Hsiao LC, Huang CH, Chen YJ Abstract The Atacama Large Millimeter Array has allowed a detailed observation of molecules in protoplanetary disks, which can evolve toward solar systems like our own. While CO, [Formula:...
Thu Jul 02, 2020 15:48
Related Articles Sir2 takes affirmative action to ensure equal opportunity in replication origin licensing. Proc Natl Acad Sci U S A. 2020 Jun 30;: Authors: Lengronne A, Pasero P PMID: 32606246 [PubMed - as supplied by publisher]
Thu Jul 02, 2020 15:48
Related Articles Poverty, work, and welfare: Cutting the Gordian knot. Proc Natl Acad Sci U S A. 2020 Jun 30;: Authors: Duncan GJ, Smeeding T, Le Menestrel S PMID: 32606245 [PubMed - as supplied by publisher]
Thu Jul 02, 2020 15:48
Related Articles The E3 ubiquitin ligase MARCH1 regulates antimalaria immunity through interferon signaling and T cell activation. Proc Natl Acad Sci U S A. 2020 Jun 30;: Authors: Wu J, Xia L, Yao X, Yu X, Tumas KC, Sun W, Cheng Y, He X, Peng YC, Singh BK, Zhang C, Qi CF, Bolland S, Best SM, Gowda C, Huang R, Myers TG, Long CA, Wang RF, Su XZ Abstract Malaria infection induces complex and diverse immune responses. To elucidate the mechanisms...
Thu Jul 02, 2020 15:48
Related Articles Turning up the heat on HIV-1. Proc Natl Acad Sci U S A. 2020 Jun 30;: Authors: Chen IP, Ott M PMID: 32606243 [PubMed - as supplied by publisher]
Thu Jul 02, 2020 15:48
Related Articles Applications of Traditional Chinese Medicine in Antiviral and Anticancer Drug Development: An Interview with Dr. Yung-Chi (Tommy) Cheng, PhD. Yale J Biol Med. 2020 06;93(2):381-384 Authors: Li H PMID: 32607097 [PubMed - in process]
Thu Jul 02, 2020 15:40
Related Articles Plants Go to War: A Botanical History of World War II: An Interview with Judith Sumner, PhD. Yale J Biol Med. 2020 06;93(2):375-379 Authors: Cassell K PMID: 32607096 [PubMed - in process]
Thu Jul 02, 2020 15:40
Related Articles Using Plants as a Source of Potential Therapeutics for the Treatment of Alzheimer's Disease. Yale J Biol Med. 2020 06;93(2):365-373 Authors: Maher PA Abstract Alzheimer's disease (AD) is the most common form of dementia with the numbers expected to increase dramatically as our society ages. There are no treatments to cure, prevent, or slow down the progression of the disease. Age is the single greatest risk factor for AD. However,...
Thu Jul 02, 2020 15:40
Related Articles Aristolochia Herbs and Iatrogenic Disease: The Case of Portland's Powders. Yale J Biol Med. 2020 06;93(2):355-363 Authors: Tomlinson T, Fernandes A, Grollman AP Abstract Aristolochia herbals have a 2500-year history of medicinal use. We focused this article on Portland's Powders, an 18th-century British gout medicine containing Aristolochia herbs. The powders constitute an 18th-century iteration of an herbal remedy, which was...
Thu Jul 02, 2020 15:40
Related Articles Herbal Medicines in Glaucoma Treatment. Yale J Biol Med. 2020 06;93(2):347-353 Authors: Ige M, Liu J Abstract Glaucoma is the leading cause of irreversible blindness worldwide. Optimizing treatment is important to protecting vision. The current standard of therapy for glaucoma involves lowering the intraocular pressure (IOP) through medical, laser, and/or surgical therapy. Nevertheless, there are an increasing number of glaucoma...
Thu Jul 02, 2020 15:40
Related Articles A Critical Review to Identify the Domains Used to Measure the Effect and Outcome of Adaptogenic Herbal Medicines. Yale J Biol Med. 2020 06;93(2):327-346 Authors: Gerontakos SE, Casteleijn D, Shikov AN, Wardle J Abstract Background: Phytoadaptogens are considered to be herbal medicines with a multi-target effect that strengthen organ systems compromised by stress. Although animal and laboratory studies have identified numerous...
Thu Jul 02, 2020 15:40
Related Articles Antidiabetic Potential of Syzygium sp.: An Overview. Yale J Biol Med. 2020 06;93(2):307-325 Authors: Zulcafli AS, Lim C, Ling AP, Chye S, Koh R Abstract Diabetes, characterized by hyperglycemia, is one of the most significant metabolic diseases, reaching alarming pandemic proportions. It can be due to the defects in insulin action, or secretion, or both. The global prevalence of diabetes is estimated at 425 million people in...
Thu Jul 02, 2020 15:40
Related Articles Essential Oils and Health. Yale J Biol Med. 2020 06;93(2):291-305 Authors: Ramsey JT, Shropshire BC, Nagy TR, Chambers KD, Li Y, Korach KS Abstract Essential oils (EOs) have risen in popularity over the past decade. These oils function in society as holistic integrative modalities to traditional medicinal treatments, where many Americans substitute EOs in place of other prescribed medications. EOs are found in a multitude of...
Thu Jul 02, 2020 15:40
Related Articles The Potential for Kratom as an Antidepressant and Antipsychotic. Yale J Biol Med. 2020 06;93(2):283-289 Authors: Johnson LE, Balyan L, Magdalany A, Saeed F, Salinas R, Wallace S, Veltri CA, Swogger MT, Walsh Z, Grundmann O Abstract Mitragyna speciosa, otherwise known as kratom, is a plant in the coffee family (Rubiaceae) native to Southeast Asia and Thailand whose leaves have been shown to cause opioid-like and stimulant responses...
Thu Jul 02, 2020 15:40
Related Articles Resolution of Recurrent Oro-facial Herpes Simplex Using a Topical Botanical Gel: A Case Report. Yale J Biol Med. 2020 06;93(2):277-281 Authors: Nelson EO, Ruiz GG, Kozin AF, Turner TC, Langland EV, Langland JO Abstract Oral herpes labialis, more commonly known as cold sores, are a common encountered viral infection involving herpes simplex virus-1 (HSV-1). Although relatively benign, these lesions can be both unsightly and clinically...
Thu Jul 02, 2020 15:40
Related Articles Chemical Evaluation of the Effects of Storage Conditions on the Botanical Goldenseal using Marker-based and Metabolomics Approaches. Yale J Biol Med. 2020 06;93(2):265-275 Authors: Khin M, Cech NB, Kellogg JJ, Caesar LK Abstract Hydrastis canadensis, commonly known as goldenseal, is a botanical native to the southeastern United States that has been used for the treatment of infection. The activity of goldenseal is often attributed...
Thu Jul 02, 2020 15:40
Related Articles The Effectiveness of Cannabis Flower for Immediate Relief from Symptoms of Depression. Yale J Biol Med. 2020 06;93(2):251-264 Authors: Li X, Diviant JP, Stith SS, Brockelman F, Keeling K, Hall B, Vigil JM Abstract Objective: Scientific research on how consumption of whole, natural Cannabis flower affects low mood and behavioral motivations more generally is largely nonexistent, and few studies to date have measured how common...
Thu Jul 02, 2020 15:40
Related Articles The Role of Endophytic/Epiphytic Bacterial Constituents in the Immunostimulatory Activity of the Botanical, Astragalus membranaceus. Yale J Biol Med. 2020 06;93(2):239-250 Authors: Koehler H, Puchalski K, Ruiz G, Jacobs B, Langland J Abstract Astragalus membranaceus is a staple of Traditional Chinese Medicine being one of the oldest medicinal herbs listed in the material medica of Chinese herbal medicine. Chinese herbalists...
Thu Jul 02, 2020 15:40
Related Articles Kratom and Pain Tolerance: A Randomized, Placebo-Controlled, Double-Blind Study. Yale J Biol Med. 2020 06;93(2):229-238 Authors: Vicknasingam B, Chooi WT, Rahim AA, Ramachandram D, Singh D, Ramanathan S, Yusof NSM, Zainal H, Murugaiyah V, Gueorguieva R, Mansor SM, Chawarski MC Abstract Background: Kratom has a long history of traditional medicine use in Southeast Asia. Consumption of kratom products has also been reported in...
Thu Jul 02, 2020 15:40
Related Articles Tumor Radiation-absorbed Dose: The Missing Link in Radioembolization. Radiology. 2020 Jun 30;:202354 Authors: Sofocleous CT, Vasiniotis Kamarinos N PMID: 32609061 [PubMed - as supplied by publisher]
Thu Jul 02, 2020 15:40
Related Articles Three-dimensional US Measurements of Blood Flow: One Step Closer to Clinical Practice. Radiology. 2020 Jun 30;:202419 Authors: Forsberg F PMID: 32609060 [PubMed - as supplied by publisher]
Thu Jul 02, 2020 15:40
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