Cancers, Vol. 12, Pages 1761: Preclinical and Clinical Immunotherapeutic Strategies in Epithelial Ovarian Cancer Cancers doi: 10.3390/cancers12071761 Authors: Alejandra Martinez Jean-Pierre Delord Maha Ayyoub Christel Devaud In the past 20 years, the immune system has increasingly been recognized as a major player in tumor cell control, leading to considerable advances in cancer treatment. While promising with regards to melanoma, renal cancer and non-small cell lung cancer,...
Thu Jul 02, 2020 03:00
Cancers, Vol. 12, Pages 1765: The CCL5/CCR5 Axis in Cancer Progression Cancers doi: 10.3390/cancers12071765 Authors: Donatella Aldinucci Cinzia Borghese Naike Casagrande Tumor cells can “hijack” chemokine networks to support tumor progression. In this context, the C-C chemokine ligand 5/C-C chemokine receptor type 5 (CCL5/CCR5) axis is gaining increasing attention, since abnormal expression and activity of CCL5 and its receptor CCR5 have been found in hematological...
Thu Jul 02, 2020 03:00
Cancers, Vol. 12, Pages 1766: Endocrine Risk Factors of Endometrial Cancer: Polycystic Ovary Syndrome, Oral Contraceptives, Infertility, Tamoxifen Cancers doi: 10.3390/cancers12071766 Authors: Atanas Ignatov Olaf Ortmann Endometrial cancer is the most common gynecologic cancer and is predominantly endocrine-related. The role of unopposed estrogen in the development of endometrial cancer has been investigated in numerous studies. Different reproductive factors such as younger age at...
Thu Jul 02, 2020 03:00
Cancers, Vol. 12, Pages 1764: Macrophages in Oral Carcinomas: Relationship with Cancer Stem Cell Markers and PD-L1 Expression Cancers doi: 10.3390/cancers12071764 Authors: Faustino J. Suárez-Sánchez Paloma Lequerica-Fernández Julián Suárez-Canto Juan P. Rodrigo Tania Rodriguez-Santamarta Francisco Domínguez-Iglesias Juana M. García-Pedrero Juan C. de Vicente Tumor-associated macrophages (TAMs) can be polarized into antitumoral M1 and protumoral and immunosuppressive...
Thu Jul 02, 2020 03:00
Cancers, Vol. 12, Pages 1763: Cancer Immune Therapy for Philadelphia Chromosome-Negative Chronic Myeloproliferative Neoplasms Cancers doi: 10.3390/cancers12071763 Authors: Morten Orebo Holmström Hans Carl Hasselbalch Mads Hald Andersen Philadelphia chromosome-negative chronic myeloproliferative neoplasms (MPN) are neoplastic diseases of the hematopoietic stem cells in the bone marrow. MPN are characterized by chronic inflammation and immune dysregulation. Of interest, the potent...
Thu Jul 02, 2020 03:00
Cancers, Vol. 12, Pages 1758: Recent Advances and Challenges in the Treatment of Rhabdomyosarcoma Cancers doi: 10.3390/cancers12071758 Authors: Shinji Miwa Norio Yamamoto Katsuhiro Hayashi Akihiko Takeuchi Kentaro Igarashi Hiroyuki Tsuchiya Rhabdomyosarcoma, the most common soft tissue sarcoma noted in childhood, requires multimodality treatment, including chemotherapy, surgical resection, and/or radiation therapy. The majority of the patients with localized rhabdomyosarcoma...
Thu Jul 02, 2020 03:00
Cancers, Vol. 12, Pages 1762: EpCAM-Binding DARPins for Targeted Photodynamic Therapy of Ovarian Cancer Cancers doi: 10.3390/cancers12071762 Authors: Dirk van den Brand Sanne A. M. van Lith Jelske M. de Jong Mark A. J. Gorris Valentina Palacio-Castañeda Stijn T. Couwenbergh Mark R. G. Goldman Inge Ebisch Leon F. Massuger William P. J. Leenders Roland Brock Wouter P. R. Verdurmen Ovarian cancer is the most lethal gynecological malignancy due to late detection...
Thu Jul 02, 2020 03:00
Cancers, Vol. 12, Pages 1759: Natural History and Prognostic Factors at First Relapse in Multiple Myeloma Cancers doi: 10.3390/cancers12071759 Authors: Chen Wang Cinnie Yentia Soekojo Sanjay de Mel Melissa Ooi Yunxin Chen Allan Zhi Kai Goh Chandramouli Nagarajan Wee Joo Chng The prognosis of multiple myeloma has considerably improved due to the introduction of novel agents in the upfront setting. However, the great majority of patients ultimately relapse, and choosing...
Thu Jul 02, 2020 03:00
Cancers, Vol. 12, Pages 1760: MHC Class I Downregulation in Cancer: Underlying Mechanisms and Potential Targets for Cancer Immunotherapy Cancers doi: 10.3390/cancers12071760 Authors: Annelisa M. Cornel Iris L. Mimpen Stefan Nierkens In recent years, major advances have been made in cancer immunotherapy. This has led to significant improvement in prognosis of cancer patients, especially in the hematological setting. Nonetheless, translation of these successes to solid tumors was...
Thu Jul 02, 2020 03:00
Cancers, Vol. 12, Pages 1757: Tumor Cell-Intrinsic Immunometabolism and Precision Nutrition in Cancer Immunotherapy Cancers doi: 10.3390/cancers12071757 Authors: Elisabet Cuyàs Sara Verdura Begoña Martin-Castillo Tomás Alarcón Ruth Lupu Joaquim Bosch-Barrera Javier A. Menendez One of the greatest challenges in the cancer immunotherapy field is the need to biologically rationalize and broaden the clinical utility of immune checkpoint inhibitors (ICIs). The balance between...
Thu Jul 02, 2020 03:00
Cells, Vol. 9, Pages 1608: Latest Developed Strategies to Minimize the Off-Target Effects in CRISPR-Cas-Mediated Genome Editing Cells doi: 10.3390/cells9071608 Authors: Muhammad Naeem Saman Majeed Mubasher Zahir Hoque Irshad Ahmad Gene editing that makes target gene modification in the genome by deletion or addition has revolutionized the era of biomedicine. Clustered regularly interspaced short palindromic repeats (CRISPR)/Cas9 emerged as a substantial tool due to its simplicity...
Thu Jul 02, 2020 03:00
Cells, Vol. 9, Pages 1607: KLF4 Acts as a wt-CFTR Suppressor through an AKT-Mediated Pathway Cells doi: 10.3390/cells9071607 Authors: Luis Sousa Ines Pankonien Luka A Clarke Iris Silva Karl Kunzelmann Margarida D Amaral Cystic Fibrosis (CF) is caused by >2000 mutations in the CF transmembrane conductance regulator (CFTR) gene, but one mutation—F508del—occurs in ~80% of patients worldwide. Besides its main function as an anion channel, the CFTR...
Thu Jul 02, 2020 03:00
Cells, Vol. 9, Pages 1605: IL-6 Trans-Signaling in the Brain Influences the Metabolic Phenotype of the 3xTg-AD Mouse Model of Alzheimer’s Disease Cells doi: 10.3390/cells9071605 Authors: Anna Escrig Amalia Molinero Brenda Méndez Mercedes Giralt Gemma Comes Paula Sanchis Olaya Fernández-Gayol Lydia Giménez-Llort Christoph Becker-Pauly Stefan Rose-John Juan Hidalgo Alzheimer’s disease (AD) is a neurodegenerative disorder that causes the most prevalent...
Thu Jul 02, 2020 03:00
Cells, Vol. 9, Pages 1606: The Role of Hyaluronic Acid in Cartilage Boundary Lubrication Cells doi: 10.3390/cells9071606 Authors: Weifeng Lin Zhang Liu Nir Kampf Jacob Klein Hydration lubrication has emerged as a new paradigm for lubrication in aqueous and biological media, accounting especially for the extremely low friction (friction coefficients down to 0.001) of articular cartilage lubrication in joints. Among the ensemble of molecules acting in the joint, phosphatidylcholine...
Thu Jul 02, 2020 03:00
Cells, Vol. 9, Pages 1609: Show Me Your Friends and I Tell You Who You Are: The Many Facets of Prion Protein in Stroke Cells doi: 10.3390/cells9071609 Authors: Berta Puig Denise Yang Santra Brenna Hermann Clemens Altmeppen Tim Magnus Ischemic stroke belongs to the leading causes of mortality and disability worldwide. Although treatments for the acute phase of stroke are available, not all patients are eligible. There is a need to search for therapeutic options to promote...
Thu Jul 02, 2020 03:00
Cells, Vol. 9, Pages 1604: The Diversity of Intermediate Filaments in Astrocytes Cells doi: 10.3390/cells9071604 Authors: Maja Potokar Mitsuhiro Morita Gerhard Wiche Jernej Jorgačevski Despite the remarkable complexity of the individual neuron and of neuronal circuits, it has been clear for quite a while that, in order to understand the functioning of the brain, the contribution of other cell types in the brain have to be accounted for. Among glial cells, astrocytes have multiple...
Thu Jul 02, 2020 03:00
Cells, Vol. 9, Pages 1602: Roles of miR-640 and Zinc Finger Protein 91 (ZFP91) in Angiopoietin-1-Induced In Vitro Angiogenesis Cells doi: 10.3390/cells9071602 Authors: Sharon Harel Veronica Sanchez-Gonzalez Raquel Echavarria Dominique Mayaki Sabah NA Hussain Angiopoietin-1 (Ang-1) is a ligand of Tie-2 receptors that promotes angiogenesis. It has been established that regulatory loops exist between angiogenic growth factors and distinct pro or anti-angiogenic miRNAs, but the...
Thu Jul 02, 2020 03:00
Cells, Vol. 9, Pages 1601: Extracellular Vesicles as Delivery Vehicles of Specific Cellular Cargo Cells doi: 10.3390/cells9071601 Authors: Bilal Mir Claudia Goettsch Extracellular vesicles (EVs) mediate cell-to-cell communication via the transfer of biomolecules locally and systemically between organs. It has been elucidated that the specific EV cargo load is fundamental for cellular response upon EV delivery. Therefore, revealing the specific molecular machinery that functionally...
Thu Jul 02, 2020 03:00
Cells, Vol. 9, Pages 1603: Expression of miR-135b in Psoriatic Skin and Its Association with Disease Improvement Cells doi: 10.3390/cells9071603 Authors: Pablo Chicharro Pedro Rodríguez-Jiménez Mar Llamas-Velasco Nuria Montes Ancor Sanz-García Danay Cibrian Alicia Vara Manuel J Gómez María Jiménez-Fernández Pedro Martínez-Fleta Inés Sánchez-García Marta Lozano-Prieto Juan C Triviño Rebeca Miñambres Francisco Sánchez-Madrid Hortensia de la Fuente...
Thu Jul 02, 2020 03:00
Chemosensors, Vol. 8, Pages 50: Some Energy Issues for a Nanoscale Electrostatic Potential Well in Saline Solutions Chemosensors doi: 10.3390/chemosensors8030050 Authors: Jingkun Guo Zijin Lei Fan Wang Jingjing Xu Shengyong Xu An electrostatic potential well may be applied to trap and manipulate charged micro- and nanoparticles. An electrostatic potential well obtained from a certain charge distribution may be used to mimic the electrostatic interactions among biomolecules...
Thu Jul 02, 2020 03:00
Chemosensors, Vol. 8, Pages 49: Sulfide Detection by Gold-Amalgam Microelectrodes in Artificial Wastewater Chemosensors doi: 10.3390/chemosensors8030049 Authors: Jonas M. S. Andrich Uwe Schröder Gold amalgam microelectrodes (GAMEs) have been characterized and successfully calibrated to measure >1.5 mM (30 mg L−1) sulfide in artificial wastewater (AWW) using cathodic stripping voltammetry (CSV). Microbial sulfide generation in two types of AWW was traced. Artificial...
Thu Jul 02, 2020 03:00
Children, Vol. 7, Pages 72: Simple Method for the Objective Activity Type Assessment with Preschoolers, Children and Adolescents Children doi: 10.3390/children7070072 Authors: Jan Christian Brønd Anders Grøntved Lars Bo Andersen Daniel Arvidsson Line Grønholt Olesen Background: The objective and accurate assessment of children’s sedentary and physical behavior is important for investigating their relation to health. The purpose of this study is to validate a simple...
Thu Jul 02, 2020 03:00
Children, Vol. 7, Pages 71: Predicting Tobacco and Alcohol Consumption Based on Physical Activity Level and Demographic Characteristics in Romanian Students Children doi: 10.3390/children7070071 Authors: Georgian Badicu Seyed Hojjat Zamani Sani Zahra Fathirezaie Background: This study aims to assess the relationships between alcohol and tobacco consumption, physical activity (PA) and demographic characteristics in Romanian students. Methods: There were 253 participants in this...
Thu Jul 02, 2020 03:00
Diagnostics, Vol. 10, Pages 447: COVID-19 Assessment with Bedside Lung Ultrasound in a Population of Intensive Care Patients Treated with Mechanical Ventilation and ECMO Diagnostics doi: 10.3390/diagnostics10070447 Authors: Hasse Møller-Sørensen Jakob Gjedsted Vibeke Lind Jørgensen Kristoffer Lindskov Hansen The COVID-19 pandemic has increased the need for an accessible, point-of-care and accurate imaging modality for pulmonary assessment. COVID-19 pneumonia is mainly monitored...
Thu Jul 02, 2020 03:00
Diversity, Vol. 12, Pages 265: Molecular Diversity of Nematode Parasites in Afrotropical Reed Frogs (Hyperolius spp.) Diversity doi: 10.3390/d12070265 Authors: Sinsch Dehling Scheid Balczun The diversity of nematodes infecting amphibians is understudied in tropical Africa and unknown in Rwanda. Diversity assessment is hampered by the fact that species descriptions refer mostly to morphological features that are unlinked to DNA sequences of marker genes available in public...
Thu Jul 02, 2020 03:00
Foods, Vol. 9, Pages 868: Enhancement of Immune Activities of Mixtures with Sasa quelpaertensis Nakai and Ficus erecta var. sieboldii Foods doi: 10.3390/foods9070868 Authors: Kwon Choi Han Men Jang Choi Kim Kang Cho Lee The objective of the present study was to develop a concoction of natural products that could dramatically improve immune function with minimal possible side effects. Sasa quelpaertensis Nakai and Ficus erecta var. sieboldii are plants...
Thu Jul 02, 2020 03:00
Foods, Vol. 9, Pages 862: Flash Gas Chromatography in Tandem with Chemometrics: A Rapid Screening Tool for Quality Grades of Virgin Olive Oils Foods doi: 10.3390/foods9070862 Authors: Sara Barbieri Chiara Cevoli Alessandra Bendini Beatriz Quintanilla-Casas Diego Luis García-González Tullia Gallina Toschi This research aims to develop a classification model based on untargeted elaboration of volatile fraction fingerprints of virgin olive oils (n = 331) analyzed by flash...
Thu Jul 02, 2020 03:00
Foods, Vol. 9, Pages 866: Can Health Perceptions, Credibility, and Physical Appearance of Low-Fat Foods Stimulate Buying Intentions? Foods doi: 10.3390/foods9070866 Authors: Inés Küster-Boluda Natalia Vila This study examines the influence of labelling and packaging strategies on perceived product health and overall attitudes to low-fat products in the field of healthy food claims among young consumers. The aim was to determine if these aspects can influence buying intentions. After...
Thu Jul 02, 2020 03:00
Foods, Vol. 9, Pages 867: Seasonal Changes in Free Amino Acid and Fatty Acid Compositions of Sardines, Sardina pilchardus (Walbaum, 1792): Implications for Nutrition Foods doi: 10.3390/foods9070867 Authors: Vida Šimat Imen Hamed Sandra Petričević Tanja Bogdanović The aim of this study was to clarify the seasonal variation in the proximate composition of the free amino acid (AA) and fatty acid (FA) profiles of the European sardine (Sardina pilchardus) from the Adriatic Sea and...
Thu Jul 02, 2020 03:00
Foods, Vol. 9, Pages 864: Regulatory Effect of Lactobacillus brevis Bmb6 on Gut Barrier Functions in Experimental Colitis Foods doi: 10.3390/foods9070864 Authors: Mi-Young Shin Cheng-Chung Yong Sejong Oh The integrity of gut barrier functions is closely associated with the pathogenesis of colitis. It is speculated that Lactobacillus brevis Bmb6 alleviates colitis by improving the tight junction (TJ) of the inflamed intestinal epithelial layer. In the present study, the regulatory...
Thu Jul 02, 2020 03:00
Foods, Vol. 9, Pages 865: Combined Experimental and CFD Approach of Two-Phase Flow Driven by Low Thermal Gradients in Wine Tanks: Application to Light Lees Resuspension Foods doi: 10.3390/foods9070865 Authors: Fabien Bogard Fabien Beaumont Yann Vasserot Florica Simescu-Lazar Blaise Nsom Gérard Liger-Belair Guillaume Polidori In winemaking, clarification and stabilization are the processes by which insoluble matter suspended in the wine (called lees) is removed before...
Thu Jul 02, 2020 03:00
Heritage, Vol. 3, Pages 649-670: Collaborative Archaeology, Relational Memory, and Stakeholder Action at Three Henequen Haciendas in Yucatan, Mexico Heritage doi: 10.3390/heritage3030037 Authors: Mario Zimmermann Héctor Hernández Álvarez Lilia Fernández Souza Joaquín Venegas de la Torre Luis Pantoja Díaz In the Mexican state of Yucatán, the Industrial Revolution is intimately linked to the cultivation and commercialization of henequen (Agave fourcroydes). The second...
Thu Jul 02, 2020 03:00
Humanities, Vol. 9, Pages 56: The Anthropocene, Technology and Fictional Literature Humanities doi: 10.3390/h9030056 Authors: Münster In the Geosciences, the new concept of the Anthropocene has been well established. Today, in the Humanities, it is increasingly also accepted as centrally relevant because it allows us to describe our present world in a more accurate fashion. The critical question of this study is what opportunities result from literature and literary studies in order...
Thu Jul 02, 2020 03:00
Humanities, Vol. 9, Pages 57: Senegal, the African Slave Trade, and the Door of No Return: Giving Witness to Gorée Island Humanities doi: 10.3390/h9030057 Authors: Fofana Recently, the Senegalese people have learned to speak more openly of their history. But, as late as the 1980s—the years of my youth and early schooling—the wounds of colonialism were still fresh. I contend that slavery had been so powerful a blow to the Senegalese ethos that we—my family,...
Thu Jul 02, 2020 03:00
IJERPH, Vol. 17, Pages 4778: The Relationship between Psychological Well-Being and Psychosocial Factors in University Students International Journal of Environmental Research and Public Health doi: 10.3390/ijerph17134778 Authors: Morales-Rodríguez Espigares-López Brown Pérez-Mármol Determining what factors influence the psychological well-being of undergraduate university students may provide valuable information to inform the development of intervention programs and targeted...
Thu Jul 02, 2020 03:00
IJERPH, Vol. 17, Pages 4779: Effects of Covid-19 Lockdown on Mental Health and Sleep Disturbances in Italy International Journal of Environmental Research and Public Health doi: 10.3390/ijerph17134779 Authors: Gualano Lo Moro Voglino Bert Siliquini Italy was the first European country that entered a nationwide lockdown during the COVID-19 pandemic. Since quarantine can impact on mental health, this study aimed to estimate the prevalence of depressive symptoms, anxiety...
Thu Jul 02, 2020 03:00
IJERPH, Vol. 17, Pages 4777: Analyzing the Association Between Hyperuricemia and Periodontitis: A Cross-Sectional Study Using KoGES HEXA Data International Journal of Environmental Research and Public Health doi: 10.3390/ijerph17134777 Authors: Byun Yoo Lee Choi Hyperuricemia arises from the buildup of excessive uric acid in the blood, and it is implicated in the development of periodontitis. The objective of this study was to investigate the association between hyperuricemia...
Thu Jul 02, 2020 03:00
IJERPH, Vol. 17, Pages 4776: Bullying Experience among Adolescents with a Turkish Migration Background in Germany: Ethnic Class Composition, Integration, and Religiosity as Protective Factors? International Journal of Environmental Research and Public Health doi: 10.3390/ijerph17134776 Authors: Demmrich Akgül Bullying is a worldwide problem that has serious effects on the mental health of both victims and perpetrators. Although bullying seems related to increasing globalization...
Thu Jul 02, 2020 03:00
IJERPH, Vol. 17, Pages 4774: Real-World Goal Setting and Use of Outcome Measures According to the International Classification of Functioning, Disability and Health: A European Survey of Physical Therapy Practice in Multiple Sclerosis International Journal of Environmental Research and Public Health doi: 10.3390/ijerph17134774 Authors: Řasová Martinková Soler Freeman Cattaneo Jonsdottir Smedal Romberg Henze Santoyo-Medina Feys Goal setting is...
Thu Jul 02, 2020 03:00
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