Abstract Objective The purpose of this study was to evaluate the effect of simulated gastric acid solution on surface topography and bending properties of esthetic coated nickel-titanium (NiTi) archwires. Materials and methods Three brands of as-received white-coated superelastic NiTi upper archwires were used in this study: Dany, Perfect, and Nitanium. Uncoated...
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Abstract Objectives Genetic variants in multiple genes and loci have been associated with the risk of nonsyndromic cleft lip with or without cleft palate (NSCL ± P). However, the estimation of risk remains challenge, because most of these variants are population-specific rendering the identification of the underlying genetic risk difficult. Herein we examined the use of machine learning network in previously reported single nucleotide...
Thu Jul 02, 2020 03:00
Abstract Introduction The aim of this study was to experimentally investigate the potential of different light wavelengths to distinguish between healthy and carious tissue using a two-circle goniometer. Materials and methods Tooth slices were prepared from extracted human teeth that were caries free (n = 15) or had occlusal caries lesions (n = 10). The tooth...
Thu Jul 02, 2020 03:00
Abstract Diabetic nephropathy (DN), characterized by glomerular injury, is a common complication of both type 1 and type 2 diabetes, accompanied by massive proteinuria. Podocytes are reported to play pivotal roles in maintaining the glomerular filtration barrier. In addition, the expression of long non-coding RNAs (lncRNAs) ANRIL was upregulated in type 2 diabetes patients. Hence, the aim of this study was to investigate the underlying mechanisms implicated the role of LncRNA...
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Abstract Ulcerative colitis (UC) is a serious digestive system disease. Furthermore, the activation of C3a/C3aR axis promoted the expression of caspase-11. And higher levels of caspase-11 could induce the pyroptosis and inflammation of cells. However, some studies suggested that caspase-11 could promote and suppress the inflammation during the development of UC. In addition, whether C3a/C3aR axis could affect the development of UC by...
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Abstract Rhoifolin (ROF) is a main effective component in Citrus grandis ‘Tomentosa’. ROF has a potential anti-inflammatory activity, but its specific effects and mechanisms have not been studied. This study investigated the anti-inflammatory activity of ROF and searched for its possible molecular mechanisms. A mouse model of acute inflammation was induced by lipopolysaccharide, and the effects of ROF on pathological damages of the lung...
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Oncogenesis, Published online: 02 July 2020; doi:10.1038/s41389-020-00245-3Histoepigenetic analysis of the mesothelin network within pancreatic ductal adenocarcinoma cells reveals regulation of retinoic acid receptor gamma and AKT by mesothelin
Thu Jul 02, 2020 03:00
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Thu Jul 02, 2020 17:21
SUMMARY:Coronavirus disease 2019 (COVID-19) is associated with a severe inflammatory response. Inflammation affects atherosclerotic plaque vulnerability and promotes a thrombogenic environment. We report a series of 6 patients with COVID-19 with acute ischemic stroke due to intraluminal carotid artery thrombus presenting during an 8-day period. Six patients were included (5 men) with a mean age of 65.8 years (range, 55–78 years). COVID-19 was diagnosed by detection of Severe Acute Respiratory Syndrome...
Thu Jul 02, 2020 17:09
Thu Jul 02, 2020 16:52
SUMMARY:New York City has become the global epicenter of the coronavirus 2019 (COVID-19) pandemic. Despite a massive shift in health care resources, cerebrovascular disease continues to be a substantial burden. We review the first 10 patients undergoing thrombectomy following a series of governmental and institutional policy changes diverting resources to the care of critically ill patients with COVID-19. Ten patients with emergent large-vessel occlusion underwent thrombectomy between March 23 and...
Thu Jul 02, 2020 16:51
SUMMARY:We report a previously undescribed pattern of brain metastases in patients with epidermal growth factor receptor–mutated non-small-cell lung cancer treated with tyrosine kinase inhibitors and radiation therapy. These highly distinct lesions appear to spread focally within the leptomeninges, with invasion along the perivascular spaces (FLIP). The survival of patients with FLIP was significantly better compared with patients with classic leptomeningeal disease (median survival, 21 versus 3...
Thu Jul 02, 2020 16:50
SUMMARY:We recently observed a type of MR imaging artifact that consistently mimics an abnormal appearance of the cerebral cortex, leading to initial misinterpretation and repeat scans. The artifact is caused by malfunction of part of the multichannel phased array head coil and is manifested by irregularity of cortical surface and gray-white matter junctions. The presence of such an artifact can be confirmed by assessing the background noise of the MR images and checking the coil element status on...
Thu Jul 02, 2020 16:49
SUMMARY:"Encephalopathy" is a vague term that encompasses varying definitions, often with a nonspecific clinical presentation and numerous possible pathophysiologic causes. Hence, MR imaging plays a crucial role in the early diagnosis and treatment by identifying imaging patterns when there is limited clinical history in such patients with acute encephalopathy. The aim of this review was to aid in remembrance of etiologies of potentially reversible acute encephalopathic syndromes on MR imaging. The...
Thu Jul 02, 2020 16:48
BACKGROUND AND PURPOSE:Neurotransmitter changes in youth addicted to the Internet and smartphone were compared with normal controls and in subjects after cognitive behavioral therapy. In addition, the correlations between neurotransmitters and affective factors were investigated.MATERIALS AND METHODS:Nineteen young people with Internet and smartphone addiction and 19 sex- and age-matched healthy controls (male/female ratio, 9:10; mean age, 15.47 ± 3.06 years) were included. Twelve teenagers with...
Thu Jul 02, 2020 16:46
BACKGROUND AND PURPOSE:Pediatric acute toxic leukoencephalopathy is a clinicoradiologic entity comprising various etiologies. This study aimed to identify the MR imaging appearance of pediatric acute toxic leukoencephalopathy from various etiologies and determine whether the etiology correlates with clinical outcome.MATERIALS AND METHODS:We retrospectively reviewed the electronic records of patients with pediatric acute toxic leukoencephalopathy younger than 19 years of age who had MR imaging within...
Thu Jul 02, 2020 16:45
BACKGROUND AND PURPOSE:Duchenne muscular dystrophy is an X-linked disorder characterized by progressive muscle weakness and prominent nonmotor manifestations, such as a low intelligence quotient and neuropsychiatric disturbance. We investigated WM integrity in patients with Duchenne muscular dystrophy using DTI.MATERIALS AND METHODS:Fractional anisotropy and mean, axial, and radial diffusivity (DTI measures) were used to assess WM microstructural integrity along with neuropsychological evaluation...
Thu Jul 02, 2020 16:44
SUMMARY:The appropriate imaging of patients with headache presents a number of important and vexing challenges for clinicians. Despite a number of guidelines and studies demonstrating a lack of cost-effectiveness, clinicians continue to image patients with chronic nonfocal headaches, and the trend toward imaging is increasing. The reasons are complex and include the fear of missing a clinically significant lesion and litigation, habitual and standard of care practices, lack of tort reform, regulatory...
Thu Jul 02, 2020 16:43
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Introduction. Duration of first remission is important for the survival of multiple myeloma (MM) patients. Methods. From the CoMMpass study (NCT01454297), 926 newly diagnosed MM patients, characterized by next-generation sequencing, were analyzed to evaluate those who experienced early progressive disease (PD) (time to progression, TTP≤18 months). Results. After a median follow-up of 39 months, early PD was detected in 191/926 (20.6%) patients, 228/926 (24.6%) patients had late PD (TTP>18...
Thu Jul 02, 2020 16:30
Purpose: AT13148 is an oral AGC kinase inhibitor, which potently inhibits ROCK and AKT kinases. In preclinical models, AT13148 has been shown to have anti-metastatic and anti-proliferative activity. Experimental Design: The trial followed a rolling six design during dose escalation. An intra-patient dose escalation arm to evaluate tolerability and a biopsy cohort to study pharmacodynamic (PD) effects were later added. AT13148 was administered orally three days a week (Mon-Wed-Fri) in 28-day...
Thu Jul 02, 2020 16:30
Background: Using next-generation sequencing (NGS), we recently documented T cell oligoclonality in treatment-naive chronic lymphocytic leukemia (CLL), with evidence indicating T cell selection by restricted antigens. Experimental Design: Here, we sought to comprehensively assess T cell repertoire changes during treatment in relation to: (i) treatment type [fludarabine-cyclophosphamide-rituximab (FCR) versus ibrutinib (IB) versus rituximab-idelalisib (R-ID)], and (ii) clinical response, by combining...
Thu Jul 02, 2020 16:30
The COVID-19 global pandemic has drastically impacted cancer care, posing challenges in treatment and diagnosis. There is increasing evidence that cancer patients, particularly those who have advanced age, significant comorbidities, metastatic disease, and/or are receiving active immunosuppressive therapy may be at higher risk of COVID-19 severe complications. Controlling viral spread from asymptomatic carriers in cancer centres is paramount, and appropriate screening methods need to be established....
Thu Jul 02, 2020 16:30
Dear Colleagues, The current COVID-19 pandemic has continued to impact our scholarly community in multiple ways. We are particularly aware of and concerned about the forms of financial hardship that are hitting members who are underemployed and unemployed. To support members whose livelihood has been significantly impacted, or outright lost, due to the impacts of the pandemic, the Society for Linguistic Anthropology is inviting applications for the Society for Linguistic Anthropology...
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British Journal of Cancer, Published online: 03 July 2020; doi:10.1038/s41416-020-0975-7Multicentre biomarker cohort study on the efficacy of nivolumab treatment for gastric cancer
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British Journal of Cancer, Published online: 03 July 2020; doi:10.1038/s41416-020-0966-8Fewer tumour-specific PD-1+CD8+ TILs in high-risk “Infiltrating” HPV− HNSCC
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British Journal of Cancer, Published online: 02 July 2020; doi:10.1038/s41416-020-0880-0Referee acknowledgement for 2019
Thu Jul 02, 2020 03:00
To evaluate prostate intrafraction motion using MRI during the full course of online adaptive MR-Linac radiotherapy (RT) fractions, in preparation of MR-guided extremely hypofractionated RT.
Thu Jul 02, 2020 03:00
Combined modality treatment (CMT) with brief chemotherapy followed by radiation therapy (RT) secures local control and high cure rates in patients with early-stage classical Hodgkin lymphoma (ESHL) [1–5]. To reduce the risk of severe late effects of treatment, RT for ESHL has changed over time[6–9] and the use of advanced imaging and highly conformal RT techniques has allowed dramatic reductions in the irradiated tissue volume [10]. Currently, only the initially macroscopically involved lymph nodes...
Thu Jul 02, 2020 03:00
Magnetic resonance (MR) imaging is widely used in radiotherapy to better delineate the tumor target and organs at risk owing to its superior soft-tissue contrast compared with that of computed tomography (CT) imaging [1]. Developing a novel radiotherapy modality based solely on MR simulation, i.e., MR-only radiotherapy, is becoming a common research focus [2], because this eliminates extra CT imaging and thus reduces patient radiation exposure. However, implementing MR-only radiotherapy requires...
Thu Jul 02, 2020 03:00
Internal organs at risk volumes (IRV) represent the propagation of organs at risk (OARs) in 4DCT.Sixty consecutive patients that underwent 4DCT for thoracic stereotactic radiotherapy were analyzed and IRVs for heart, trachea, esophagus, bronchial tree, great vessels, and spinal cord were calculated. IRVs were then tested for the respect of dose constraints.IRVs were significantly bigger than standard OARs (p-value<0,001 for all the IRVs).IRVs that did not respect the dose constraints were, respectively,...
Thu Jul 02, 2020 03:00
Measuring circulating-free-deoxyribonucleic-acid (cfDNA) has created a new framework for personalized treatment in oncology. The aim of this study was to analyze the relation between cfDNA and risk factors and outcome in squamous cell carcinoma of the anus (SCCA).
Thu Jul 02, 2020 03:00
For patients with medically inoperable, early-stage non-small cell lung cancer (NSCLC), stereotactic body radiotherapy (SBRT) is an effective treatment modality. Prospective studies demonstrate high rates of tumor control that are improved compared to conventionally fractionated radiotherapy (CFRT) with the distinct advantages of shortened treatment times, improved toxicity, and potentially greater survival when compared to CFRT [1–5]. A critical step in properly staging patients with NSCLC is determining...
Thu Jul 02, 2020 03:00
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