Related Articles European genetic ancestry associated with risk of childhood ependymoma. Neuro Oncol. 2020 Jun 02;: Authors: Zhang C, Ostrom QT, Hansen HM, Gonzalez-Maya J, Hu D, Ziv E, Morimoto L, de Smith AJ, Muskens IS, Kline CN, Vaksman Z, Hakonarson H, Diskin SJ, Kruchko C, Barnholtz-Sloan JS, Ramaswamy V, Ali-Osman F, Bondy ML, Taylor MD, Metayer C, Wiemels JL, Walsh KM Abstract BACKGROUND: Ependymoma is a histologically defined central...
Thu Jul 02, 2020 13:58
Related Articles Nanoscale Metal-Organic Frameworks Generate Reactive Oxygen Species for Cancer Therapy. ACS Cent Sci. 2020 Jun 24;6(6):861-868 Authors: Ni K, Lan G, Lin W Abstract In the past 15 years, enormous progress has been made in cancer nanotechnology, and a several nanoparticles have entered clinical testing for cancer treatment. Among these nanoparticles are nanoscale metal-organic frameworks (nMOFs), a class of organic-inorganic hybrid...
Thu Jul 02, 2020 13:58
Related Articles Immunotherapy in Colorectal Cancer: Potential of Fecal Transplant and Microbiota-augmented Clinical Trials. Curr Colorectal Cancer Rep. 2020 Aug;16(4):81-88 Authors: Park R, Umar S, Kasi A Abstract Purpose of review: This review summarizes the role of the microbiome in colorectal cancer (CRC) in the setting of immunotherapy and emphasizes the potential of microbiota-influencing strategies with a focus on the use of fecal microbiota...
Thu Jul 02, 2020 13:58
Related Articles Icotinib as Adjuvant Treatment for Stage II-IIIA Lung Adenocarcinoma Patients with EGFR Mutation (ICWIP Study): Study Protocol for a Randomised Controlled Trial. Cancer Manag Res. 2020;12:4633-4643 Authors: Liu YT, Hao XZ, Liu DR, Cheng G, Zhang SC, Xiao WH, Hu Y, Liu JF, He M, Ding CM, Zhang L, Wang J, Li H, Dong GL, Zhi XY, Li J, Shi YK Abstract The efficacy and possible role of epidermal growth factor receptor tyrosine kinase...
Thu Jul 02, 2020 13:58
Related Articles Proteomic Applications in Antimicrobial Resistance and Clinical Microbiology Studies. Infect Drug Resist. 2020;13:1785-1806 Authors: Khodadadi E, Zeinalzadeh E, Taghizadeh S, Mehramouz B, Kamounah FS, Khodadadi E, Ganbarov K, Yousefi B, Bastami M, Kafil HS Abstract Sequences of the genomes of all-important bacterial pathogens of man, plants, and animals have been completed. Still, it is not enough to achieve complete information...
Thu Jul 02, 2020 13:58
Related Articles The Role of Erastin in Ferroptosis and Its Prospects in Cancer Therapy. Onco Targets Ther. 2020;13:5429-5441 Authors: Zhao Y, Li Y, Zhang R, Wang F, Wang T, Jiao Y Abstract Erastin was initially discovered as a small molecule compound that selectively kills tumor cells expressing ST and RASV12 and was later widely investigated as an inducer of ferroptosis. Ferroptosis is a recently discovered form of cell death caused by peroxidation...
Thu Jul 02, 2020 13:58
Related Articles Management of Refractory Pediatric Sarcoma: Current Challenges and Future Prospects. Onco Targets Ther. 2020;13:5093-5112 Authors: Pushpam D, Garg V, Ganguly S, Biswas B Abstract Paediatric sarcomas are a heterogeneous group of disorders constituting bone sarcoma and various soft tissue sarcomas. Almost one-third of these presents with metastasis at baseline and another one-third recur after initial curative treatment. There...
Thu Jul 02, 2020 13:58
Related Articles Development of the NIH Patient-Reported Outcomes Measurement Information System (PROMIS) Medication Adherence Scale (PMAS). Patient Prefer Adherence. 2020;14:971-983 Authors: Peipert JD, Badawy SM, Baik SH, Oswald LB, Efficace F, Garcia SF, Mroczek DK, Wolf M, Kaiser K, Yanez B, Cella D Abstract Poor medication adherence is associated with reduced drug effectiveness, poor health-related quality of life, increased morbidity and...
Thu Jul 02, 2020 13:58
Related Articles B-cell maturation antigen expression across hematologic cancers: a systematic literature review. Blood Cancer J. 2020 Jun 30;10(6):73 Authors: Dogan A, Siegel D, Tran N, Fu A, Fowler J, Belani R, Landgren O Abstract B-cell maturation antigen (BCMA) plays a critical role in regulating B-cell proliferation and survival. There is evidence for BCMA expression in various hematologic malignancies, suggesting that BCMA may play an...
Thu Jul 02, 2020 13:58
Related Articles Risk factors for bleeding in haemato-oncology patients-a nested case-control study: The BITE study protocol (Bleeding In Thrombocytopenia Explained). BMJ Open. 2020 Jun 30;10(6):e034710 Authors: Cornelissen LL, Caram-Deelder C, van der Bom JG, Middelburg RA, Zwaginga JJ Abstract INTRODUCTION: Haemato-oncological patients often receive platelet count driven prophylactic platelet transfusions to prevent bleeding. However, many...
Thu Jul 02, 2020 13:58
Related Articles The Value of Multiparametric Magnetic Resonance Imaging Sequences to Assist in the Decision Making of Muscle-invasive Bladder Cancer. Eur Urol Oncol. 2020 Jun 27;: Authors: Bandini M, Calareso G, Raggi D, Marandino L, Colecchia M, Gallina A, Giannatempo P, Pederzoli F, Gandaglia G, Fossati N, Capitanio U, Colombo R, Salonia A, Briganti A, Montorsi F, De Cobelli F, Messina A, Necchi A Abstract Interim data from the PURE-01 study,...
Thu Jul 02, 2020 13:58
Related Articles Cardiac Mast Cells: Underappreciated Immune Cells in Cardiovascular Homeostasis and Disease. Trends Immunol. 2020 Jun 27;: Authors: Varricchi G, Marone G, Kovanen PT Abstract Mast cells are multifarious immune cells with complex roles in tissue homeostasis and disease. They produce a plethora of mediators that play roles in inflammation, angiogenesis, lymphangiogenesis, and tissue remodeling. Recent insights into the heterogeneity...
Thu Jul 02, 2020 13:58
Related Articles KRAS G12C Metastatic Colorectal Cancer: Specific Features of a New Emerging Target Population. Clin Colorectal Cancer. 2020 May 12;: Authors: Schirripa M, Nappo F, Cremolini C, Salvatore L, Rossini D, Bensi M, Businello G, Pietrantonio F, Randon G, Fucà G, Boccaccino A, Bergamo F, Lonardi S, Dei Tos AP, Fassan M, Loupakis F Abstract BACKGROUND: Kirsten rat sarcoma viral oncogene (KRAS) G12C mutation occurs in about 4% of colorectal...
Thu Jul 02, 2020 13:58
Related Articles Mesothelin-Targeted Recombinant Immunotoxins for Solid Tumors. Biomolecules. 2020 Jun 28;10(7): Authors: Hagerty BL, Pegna GJ, Xu J, Tai CH, Alewine C Abstract Mesothelin (MSLN) is a cell surface glycoprotein normally expressed only on serosal surfaces, and not found in the parenchyma of vital organs. Many solid tumors also express MSLN, including mesothelioma and pancreatic adenocarcinoma. Due to this favorable expression profile,...
Thu Jul 02, 2020 13:58
Related Articles Tumor Volume Dynamics as an Early Biomarker for Patient-Specific Evolution of Resistance and Progression in Recurrent High-Grade Glioma. J Clin Med. 2020 Jun 27;9(7): Authors: Glazar DJ, Grass GD, Arrington JA, Forsyth PA, Raghunand N, Yu HM, Sahebjam S, Enderling H Abstract Recurrent high-grade glioma (HGG) remains incurable with inevitable evolution of resistance and high inter-patient heterogeneity in time to progression...
Thu Jul 02, 2020 13:58
Related Articles Antisense Oligonucleotides: An Emerging Area in Drug Discovery and Development. J Clin Med. 2020 Jun 26;9(6): Authors: Dhuri K, Bechtold C, Quijano E, Pham H, Gupta A, Vikram A, Bahal R Abstract Antisense oligonucleotides (ASOs) bind sequence specifically to the target RNA and modulate protein expression through several different mechanisms. The ASO field is an emerging area of drug development that targets the disease source...
Thu Jul 02, 2020 13:58
Related Articles Periodontal Ligament Stem Cells: Current Knowledge and Future Perspectives. Stem Cells Dev. 2019 08 01;28(15):995-1003 Authors: Trubiani O, Pizzicannella J, Caputi S, Marchisio M, Mazzon E, Paganelli R, Paganelli A, Diomede F Abstract Teeth represent a fascinating area of study in regenerative medicine, because of their unique and complex developmental origin. Several types of mesenchymal stem cells (MSCs) have been characterized...
Thu Jul 02, 2020 13:58
Related Articles Corrigendum to "Factors Associated With Intubation and Prolonged Intubation in Hospitalized Patients With COVID-19". Otolaryngol Head Neck Surg. 2020 Jul;163(1):NP1 Authors: PMID: 32609073 [PubMed - as supplied by publisher]
Thu Jul 02, 2020 13:56
Related Articles Diet and sedentary behaviour in relation to mortality in US adults with a cardiovascular condition. Results from the National Health and Nutrition Examination Survey linked to the US mortality registry. Br J Nutr. 2020 Jun 30;:1-21 Authors: Ricci C, Leitzmann MF, Freisling H, Schutte AE, Schutte R, Kruger SH, Smuts CM, Pieters M Abstract Cardiovascular disease (CVD) is the most common chronic condition and the highest cause...
Thu Jul 02, 2020 13:54
Related Articles The Influence of Different Foods and Food Ingredients on Acute Postprandial Triglyceride Response: A Systematic Literature Review and Meta-Analysis of Randomized Controlled Trials. Adv Nutr. 2020 Jul 01;: Authors: Lee DPS, Low JHM, Chen JR, Zimmermann D, Actis-Goretta L, Kim JE Abstract The use of postprandial triglyceride (ppTG) as a cardiovascular disease risk indicator has gained recent popularity. However, the influence...
Thu Jul 02, 2020 13:52
Objectives: To investigate the predictive factors for changes in the quality of life (GO-QoL) of patients with Graves’ orbitopathy (GO) prior to and after specific treatment. Methods: A prospective follow-up study was conducted at an academic tertiary referral orbital center with a joint thyroid-eye clinic on 100 consecutive patients with GO. Before and after the standard 12-week course of weekly intravenous methylprednisolone (cumulative dose 4.5 g), the GO-QoL questionnaire provided by the European...
Thu Jul 02, 2020 13:04
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