Comparative Performance of Insulinoma-associated protein 1 (INSM1) and Routine Immunohistochemical Markers of Neuroendocrine Differentiation in the Diagnosis of Endocrine Mucin-Producing Sweat Gland Carcinoma. J Cutan Pathol. 2020 Aug 03;: Authors: Parra O, Linos K, Yan S, Lilo M, LeBlanc RE Abstract Endocrine Mucin-Producing Sweat Gland Carcinoma (EMPSGC) is a rare cutaneous adnexal malignancy with predilection for the eyelids of older adults....
Related Articles The role of sentinel lymph node mapping in lower genital tract melanoma. Minerva Ginecol. 2020 Aug 03;: Authors: Lopez S, Guerrisi R, Brusadelli C, Bogani G, Ditto A, Raspagliesi F Abstract INTRODUCTION: Vulvar and vaginal melanomas are rare cancers of the female genital tract and account for 1% to 3% of all melanomas diagnosed in women. Due to the rarity of the disease, few data are available on the clinical and pathologic...
Related Articles Salivary gland cancer in the era of immunotherapy: can we exploit tumor microenvironment? Expert Opin Ther Targets. 2020 Aug 01;: Authors: Theocharis S, Tasoulas J, Masaoutis C, Kokkali S, Klijanienko J Abstract INTRODUCTION: Salivary gland cancers (SGCs) consist a rare family of neoplasms with varying histology and biological behavior. Therapeutic regimens have been relatively unchanged for decades. The recent successes of...
Related Articles A case of inguinal cellular angiofibroma. IJU Case Rep. 2020 Mar;3(2):69-71 Authors: Kamitani R, Matsumoto K, Fujiwara S, Akita H, Mikami S, Kameyama K, Jinzaki M, Oya M Abstract Introduction: Cellular angiofibroma is a benign mesenchymal tumor that is rare and has a good prognosis. However, preoperative distinction of cellular angiofibroma from malignant tumors is difficult. Case presentation: A 77-year-old man complained...
Related Articles Secondary immune thrombocytopenic purpura with renal cell carcinoma. IJU Case Rep. 2019 Sep;2(5):250-252 Authors: Nakazawa S, Kawamura M, Nakano K, Ueda N, Kishikawa H, Kashiwagi H, Uemura M, Imamura R, Nishimura K, Nonomura N Abstract Introduction: Several types of cancers are reported to induce secondary immune thrombocytopenia resembling immune thrombocytopenic purpura-like syndrome. However, renal cell carcinoma-induced...
Related Articles Eosinophilic airway inflammation and eosinophilic chronic rhinosinusitis during nivolumab and ipilimumab. Respirol Case Rep. 2020 Oct;8(7):e00638 Authors: Watanabe H, Asada K, Shirai T, Torii H, Yoshimura K, Kusafuka K Abstract Immune-related adverse events (irAEs) are induced by immune checkpoint inhibitors (ICIs) which are administered for many cancers. There are many irAEs such as endocrine abnormalities, interstitial lung...
Related Articles Bloody Pericardial Effusion with a Huge Pericardial Mass: A Case Report. J Tehran Heart Cent. 2020 Jan;15(1):35-38 Authors: Zoroufian A, Shirzad M, Shahbazi N, Saheb Jam M, Rahnamoun Z, Shirani S, Davarpasand T Abstract Nowadays, the early diagnosis of tumoral diseases is more possible and accurate with multiple diagnostic imaging modalities such as chest X-ray, echocardiography, computed tomography, and magnetic resonance imaging,...
Related Articles Chemotherapy efficacy after first-line immunotherapy in 18 advanced melanoma patients. Medicine (Baltimore). 2020 Jul 17;99(29):e21329 Authors: Saint-Jean M, Fronteau C, Peuvrel L, Khammari A, Varey E, Quéreux G, Dréno B Abstract In BRAF wild type advanced melanoma, immune checkpoint blockers such as anti-PD1 (anti-programmed cell death 1) are usually continued beyond progression for a hypothetical rare further response. Chemotherapy...
Related Articles Penile metastasis in rectal cancer with pathologic complete response after neoadjuvant chemoradiotherapy: The first case report and literature review. Medicine (Baltimore). 2020 Jul 17;99(29):e21215 Authors: Lee TG, Son SM, Kim MJ, Lee SJ Abstract RATIONALE: Penile metastasis in rectal cancer is very rare and often originates from prostatic or bladder cancer. The prognosis of penile metastasis is poor and its treatments are...
Related Articles 68Ga-NEB PET/CT can be a new method for diagnosing chylous fistula: Case reports of a rare complication after breast cancer surgery. Medicine (Baltimore). 2020 Jul 17;99(29):e21201 Authors: Peng L, Zhao J, Mao F, Sun Q Abstract RATIONALE: We hypothesize that with the determination of lymph fistula location 3-dimensionally, application of appropriate pressure would promote fistula healing, and a secondary surgery may be avoided....
Related Articles Intranasal glial heterotopia in a male infant: A case report. Medicine (Baltimore). 2020 Jul 17;99(29):e21200 Authors: Zhang W, Tang L, Wang P, Ge W, Ni X Abstract RATIONALE: Nasal glial heterotopia is a rare type of neoplasm consisting of meningothelial and/or neuroglial elements. PATIENT CONCERNS: A 2-month-old male was evaluated for treatment of a congenital mass in the right nasal cavity near the pharynx. ...
Related Articles Spindle cell lipoma of the larynx: A case report. Medicine (Baltimore). 2020 Jul 17;99(29):e21118 Authors: Qin-Ying W, Shui-Hong Z, Yong-Cai L, Hai-Hong C Abstract INTRODUCTION: Lipomas are rarely found in primary mesenchymal tumors of the hypopharynx and larynx. When they do appear, they often macroscopically resemble a retention cyst or laryngeal nodule. The laryngeal spindle cell lipoma, a variant, is extremely rare. ...
Related Articles Primary anaplastic large cell lymphoma of the central nervous system in a child: A case report. Medicine (Baltimore). 2020 Jul 17;99(29):e21115 Authors: Feng S, Chen Q, Chen J, Zheng P, Ma K, Tan B Abstract INTRODUCTION: To report the clinical characteristics of primary central nervous system T-cell lymphoma with anaplastic lymphoma kinase-1 (ALK-1) positive in an 8-year-old male. PATIENT CONCERNS: The patient presented...
Related Articles Schwannoma in the hepatoduodenal ligament with portal vein invasion: A case report. Medicine (Baltimore). 2020 Jul 17;99(29):e20940 Authors: Wang JK, Wu Q, Wu ZR, Liu F, Ran CD, Yin CH, Li FY Abstract RATIONALE: Schwannomas are mesenchymal tumors with low malignant potential that originate from Schwann cells. They can occur in most parts of the body, such as the head, neck, and extremities. Schwannoma in the hepatoduodenal...
Related Articles Synchronous primary pulmonary adenocarcinoma and extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue: A case report and literature review. Medicine (Baltimore). 2020 Jul 17;99(29):e20865 Authors: Sun L, Zhang B, Xuan K, Qi L, Wang J, Li Q, Liu J, Wang Y, Sun L, Li X, Ji H Abstract RATIONALE: Synchronous pulmonary lymphoma and carcinoma is relatively rare. And synchronous pulmonary lymphoma and adenocarcinoma...
Related Articles Normotensive hypokalemic primary hyperaldosteronism mimicking clinical features of anorexia nervosa in a young patient: A case report. Medicine (Baltimore). 2020 Jul 17;99(29):e20826 Authors: Huang YC, Tsai MH, Fang YW, Tu ML Abstract RATIONALE: The typical clinical presentations of patients with primary aldosteronism (PA) include generalized weakness, fatigue, high blood pressure, and potassium deficiency. However, normotensive...
Related Articles Multiple cavernous hemangiomas in the orbit: A case report and review of the literature. Medicine (Baltimore). 2020 Jul 17;99(29):e20670 Authors: Deng C, Hu W Abstract RATIONAL: Cavernous hemangiomas are one of the most common benign primary orbital lesions. These tumors are insidious in onset, slowly progressive and present more often in middle aged women. Multiple orbital cavernous hemangiomas are extremely rare, and only...
Related Articles Effective combinatorial immunotherapy for penile squamous cell carcinoma. Nat Commun. 2020 05 01;11(1):2124 Authors: Huang T, Cheng X, Chahoud J, Sarhan A, Tamboli P, Rao P, Guo M, Manyam G, Zhang L, Xiang Y, Han L, Shang X, Deng P, Luo Y, Lu X, Feng S, Ferrer MM, Alan Wang Y, DePinho RA, Pettaway CA, Lu X Abstract Penile squamous cell carcinoma (PSCC) accounts for over 95% of penile malignancies and causes significant mortality...
Related Articles Rapid formation and rupture of an infectious basilar artery aneurysm from meningitis following suprasellar region meningioma removal: a case report. BMC Neurol. 2020 Mar 14;20(1):94 Authors: Wang X, Chen G, Li M, Liang J, Guo H, Song G, Bao Y Abstract BACKGROUND: Infectious basilar artery (BA) aneurysm has been occasionally reported to be generated from meningitis following transcranial operation. However, infectious BA aneurysm...
Related Articles Cystic neutrophilic granulomatous mastitis: an update. J Clin Pathol. 2020 Aug;73(8):445-453 Authors: Wu JM, Turashvili G Abstract Cystic neutrophilic granulomatous mastitis (CNGM) is a rare subtype of granulomatous mastitis with a highly distinct histological pattern often associated with Corynebacterium species. CNGM is characterised by suppurative lipogranulomas that are composed of central lipid vacuoles rimmed by neutrophils...
Related Articles Primary hyperparathyroidism associated with non-Hodgkin lymphoma: a case report and literature review. Postgrad Med. 2020 May;132(4):398-401 Authors: Deng Y, Wang J, Liu H, Liu J, Xu J Abstract Primary hyperparathyroidism is the third most common endocrine disease, while primary hyperparathyroidism associated with non-Hodgkin lymphoma(NHL) is extremely rare. We report a case of primary hyperparathyroidism associated with NHL....
Related Articles Preclinical evaluation of drug combinations identifies co-inhibition of Bcl-2/XL/W and MDM2 as a potential therapy in uveal melanoma. Eur J Cancer. 2020 02;126:93-103 Authors: Decaudin D, Frisch Dit Leitz E, Nemati F, Tarin M, Naguez A, Zerara M, Marande B, Vivet-Noguer R, Halilovic E, Fabre C, Jochemsen A, Roman-Roman S, Alsafadi S Abstract INTRODUCTION: Uveal melanoma (UM) is a rare and malignant intraocular tumour with...
Related Articles Pangenomic Classification of Pituitary Neuroendocrine Tumors. Cancer Cell. 2020 01 13;37(1):123-134.e5 Authors: Neou M, Villa C, Armignacco R, Jouinot A, Raffin-Sanson ML, Septier A, Letourneur F, Diry S, Diedisheim M, Izac B, Gaspar C, Perlemoine K, Verjus V, Bernier M, Boulin A, Emile JF, Bertagna X, Jaffrezic F, Laloe D, Baussart B, Bertherat J, Gaillard S, Assié G Abstract Pituitary neuroendocrine tumors (PitNETs) are common,...
Related Articles Imaging Diagnosis of Epithelioid Hemangioendothelioma in Thoracic Vertebrae and Liver. Ann Thorac Surg. 2020 06;109(6):e407-e410 Authors: Zeng Y, Leng X, Chen P, Luo J, Zhou Z Abstract Epithelioid hemangioendothelioma (EHE) is a rare vascular tumor of uncertain biologic behavior. Most cases come out as a single lesion of the soft tissue but also may appear in the lung, liver, and other locations. EHE in bone, especially in...
Related Articles Schwannoma of the upper cervical spine--a case report. Chin J Traumatol. 2019 Dec;22(6):368-372 Authors: Airlangga PA, Prijambodo B, Hidayat AR, Benedicta S Abstract Upper cervical schwannoma is rare, and belongs to benign tumors that is usually asymptomatic. It accounted for only ten percent of schwannomas cases and mostly occurs in 40-50 years old patients. Aggressive and total resection is the treatment of choice for this...
Related Articles Solitary plasmacytoma of the skull vault: A rare case report. Neurochirurgie. 2020 Feb;66(1):66-69 Authors: Bouali S, Taallah M, Bahri K, Zehani A, Abderrahmen K, Kallel J PMID: 31634509 [PubMed - indexed for MEDLINE]
Related Articles Pericardial effusion under nivolumab: case-reports and review of the literature. J Immunother Cancer. 2019 10 18;7(1):266 Authors: Saade A, Mansuet-Lupo A, Arrondeau J, Thibault C, Mirabel M, Goldwasser F, Oudard S, Weiss L Abstract BACKGROUND: Nivolumab, a programmed death-1 (PD-1) inhibitor, is an immune checkpoint inhibitor particularly used in the treatment of malignant melanoma, non-small cell lung cancer and renal cell...
Related Articles Seronegative autoimmune autonomic ganglionopathy from dual immune checkpoint inhibition in a patient with metastatic melanoma. J Immunother Cancer. 2019 10 17;7(1):262 Authors: Gao CA, Weber UM, Peixoto AJ, Weiss SA Abstract BACKGROUND: Immune checkpoint inhibitors have improved clinical outcomes including survival in several malignancies but have also been associated with a range of immune-related adverse events (irAEs)....
Related Articles A case of celiac disease with type I enteropathy-associated T-cell lymphoma in a Japanese male patient. Immunol Med. 2019 Sep;42(3):142-147 Authors: Hiraga H, Sakuraba H, Tanaka N, Watanabe R, Akemoto Y, Ota S, Kikuchi H, Sawaya M, Hiraga N, Chinda D, Hanabata N, Mikami T, Shimoyama T, Takahata T, Tanaka M, Fukuda S Abstract A 45-year-old Japanese male patient who was diagnosed with celiac disease (CeD) developed type I enteropathy-associated...
Related Articles Characteristics of Bone Destruction in Cranial Vault Lymphoma Compared with Other Skull Tumors. J UOEH. 2019;41(3):335-342 Authors: Umemura T, Nakano Y, Soejima Y, Saito T, Kitagawa T, Miyaoka R, Suzuki K, Yamamoto J Abstract Cranial vault lymphomas are rare and challenging to diagnose. We present herein two cases of cranial vault lymphoma. The first patient was a 72-year-old woman who presented with a large mass in the parietal...
Related Articles Phase II clinical trial of pembrolizumab efficacy and safety in advanced adrenocortical carcinoma. J Immunother Cancer. 2019 09 18;7(1):253 Authors: Habra MA, Stephen B, Campbell M, Hess K, Tapia C, Xu M, Rodon Ahnert J, Jimenez C, Lee JE, Perrier ND, Boraddus RR, Pant S, Subbiah V, Hong DS, Zarifa A, Fu S, Karp DD, Meric-Bernstam F, Naing A Abstract BACKGROUND: Adrenocortical carcinoma (ACC) is a rare malignancy without good...
Related Articles Late-differentiated effector neoantigen-specific CD8+ T cells are enriched in peripheral blood of non-small cell lung carcinoma patients responding to atezolizumab treatment. J Immunother Cancer. 2019 09 12;7(1):249 Authors: Fehlings M, Jhunjhunwala S, Kowanetz M, O'Gorman WE, Hegde PS, Sumatoh H, Lee BH, Nardin A, Becht E, Flynn S, Ballinger M, Newell EW, Yadav M Abstract BACKGROUND: There is strong evidence that immunotherapy-mediated...
Related Articles Complete NMR assignment and absolute configuration of k4610422, a norditerpenoid inhibitor of testosterone-5α-reductase originally from Streptosporangium: rediscovery from a thermophilic Actinomadura. J Antibiot (Tokyo). 2020 01;73(1):60-65 Authors: Akiyama H, Oku N, Harunari E, Panbangred W, Igarashi Y Abstract A norditerpenoid k4610422 (1), an inhibitor of testosterone-5α-reductase originally discovered from a mesophilic...
Related Articles Extra-abdominal desmoid tumours - further evidence for the watchful waiting policy. Swiss Med Wkly. 2019 Jul 15;149:w20107 Authors: Krieg AH, Wirth C, Lenze U, Kettelhack C, Coslovsky M, Baumhoer D, Klenke FM, Siebenrock KA, Exner GU, Bode-Lesniewska B, Fuchs B, Cherix S, Hefti F Abstract PURPOSE: Extra-abdominal desmoid tumours are benign and rare, and lead to a persistent treatment dilemma because of their high recurrence...
Related Articles Phenotype evolution and health issues of adults with Beckwith-Wiedemann syndrome. Am J Med Genet A. 2019 09;179(9):1691-1702 Authors: Gazzin A, Carli D, Sirchia F, Molinatto C, Cardaropoli S, Palumbo G, Zampino G, Ferrero GB, Mussa A Abstract BACKGROUND: Beckwith-Wiedemann syndrome (BWS) phenotype usually mitigates with age and data on adulthood are limited. Our study aims at reporting phenotype evolution and health issues...
Related Articles Mosaic paternal haploidy in a patient with pancreatoblastoma and Beckwith-Wiedemann spectrum. Am J Med Genet A. 2019 09;179(9):1878-1883 Authors: Lee CT, Tung YC, Hwu WL, Shih JC, Lin WH, Wu MZ, Kuo KT, Yang YL, Chen HL, Chen M, Su YN, Jong YJ, Liu SY, Tsai WY, Lee NC Abstract Pancreatoblastoma is a rare type of pancreatic cancer in children. Here, we describe a case in which Beckwith-Wiedemann syndrome (BWS) was first suspected...
Related Articles Helicobacter suis infection is associated with nodular gastritis-like appearance of gastric mucosa-associated lymphoid tissue lymphoma. Cancer Med. 2019 08;8(9):4370-4379 Authors: Takigawa H, Masaki S, Naito T, Yuge R, Urabe Y, Tanaka S, Sentani K, Matsuo T, Matsuo K, Chayama K, Kitadai Y Abstract Most patients with gastric mucosa-associated lymphoid tissue (MALT) lymphoma are infected with Helicobacter pylori, and eradication...
Related Articles Anal adenocarcinoma: Treatment outcomes and trends in a rare disease entity. Cancer Med. 2019 07;8(8):3855-3863 Authors: Wegner RE, White RJ, Hasan S, Raj M, Monga D, Finley G, Kirichenko AV, McCormick J Abstract IMPORTANCE: Primary Adenocarcinoma of the anus is a rare disease with a poor prognosis and thus tends to have a more aggressive treatment algorithm, typically involving a surgical approach. Prior to 2001, a few retrospective...
Related Articles Outcome of patients aged 60-75 years with newly diagnosed secondary acute myeloid leukemia: A single-institution experience. Cancer Med. 2019 07;8(8):3846-3854 Authors: Bertoli S, Tavitian S, Bories P, Luquet I, Delabesse E, Comont T, Sarry A, Huguet F, Bérard E, Récher C Abstract A recent phase 3 trial showed that outcome of older patients with secondary acute myeloid leukemia (AML) may be improved by a liposomal encapsulation...
Related Articles Clinical analysis of 547 patients with neuroendocrine tumors in a Chinese population: A single-center study. Cancer Med. 2019 07;8(8):3729-3737 Authors: Song L, Zhai X, Yu S, Ma Y, Wang F, Yu X, Tao S, Lian Y, Yang M, Tao W, Fan Q Abstract BACKGROUND: Neuroendocrine tumors (NETs) are rare, which has resulted in a lack of published data on their epidemiology and clinical features. We therefore aimed to investigate the epidemiology,...
Related Articles The propensity of invasive circulating tumor cells (iCTCs) in metastatic progression and therapeutic responsiveness. Cancer Med. 2019 07;8(8):3864-3874 Authors: Dong H, Tulley S, Zhao Q, Cho L, Chen D, Pearl ML, Chen WT Abstract Circulating tumor cells (CTCs) are important clinical indicators of metastatic progression and treatment efficacy. However, because of their low number and heterogeneity, reliable patient-derived CTC...
Related Articles EAA clinical practice guidelines-gynecomastia evaluation and management. Andrology. 2019 11;7(6):778-793 Authors: Kanakis GA, Nordkap L, Bang AK, Calogero AE, Bártfai G, Corona G, Forti G, Toppari J, Goulis DG, Jørgensen N Abstract BACKGROUND: Gynecomastia (GM) is a benign proliferation of the glandular tissue of the breast in men. It is a frequent condition with a reported prevalence of 32-65%, depending on the age and the...
Related Articles Management of giant cell hepatitis associated with chronic lymphocytic leukemia - a case series and review of the literature. Cancer Biol Ther. 2019;20(8):1136-1140 Authors: Rhodes JM, Schuster SJ, Furth EE, Kennard K, Nasta SD, Svoboda J, Porter DL, Mato AR Abstract Giant cell hepatitis (GCH) is a rare diagnosis in adults that is found in 0.25% of liver biopsies. GCH has been associated with multiple causes including drugs...
Related Articles Potential of Helicobacter pylori-uninfected signet ring cell carcinoma to invade the submucosal layer. J Gastroenterol Hepatol. 2019 Nov;34(11):1955-1962 Authors: Yorita N, Ito M, Boda T, Kotachi T, Nagasaki N, Abuduwaili M, Hata K, Hiyama Y, Oka S, Yoshihara M, Kitadai Y, Tanaka S, Chayama K Abstract BACKGROUND AND AIM: The typical histology of Helicobacter pylori-uninfected gastric cancer is signet ring cell carcinoma (SRCC)...
Related Articles NUT midline carcinoma in the right orbit: a case report. Cancer Biol Ther. 2019;20(8):1091-1096 Authors: Ding T, Wang Y, Zhao T, Xu Z, Gao W, Cui Z, Du Y Abstract Nuclear protein in testis (NUT) midline carcinoma (NMC) is a rare malignant tumor defined by a unique chromosomal translocation of the NUT gene on chromosome 15q14. This very rare tumor is usually located in midline structures, especially in the head and neck region....
Related Articles The in cis compound EGFR mutations in Chinese advanced non-small cell lung cancer patients. Cancer Biol Ther. 2019;20(8):1097-1104 Authors: Li M, Zhou CZ, Yang JJ, Lu S, Zheng D, Hu J, Zeng H, Lu Y, Lu KH, Li SA, Mao XR, Han-Zhang H, Lizaso A, Ye JY, Hu CP Abstract Literatures regarding the prevalence and clinical significance of compound EGFR mutations are limited. Until now, none of retrospective or prospective research...
Related Articles Intra-Articular Synovial Fibroma of the Knee in a Young Boy. Kathmandu Univ Med J (KUMJ). 2019 Apr-Jun;17(66):148-150 Authors: Vaidya RK, Shrestha A, Vaidya KM Abstract Synovial fibroma, a benign fibro collagenous soft tissue tumour, arising in the knee joint is a rare entity. It is even rarer in the paediatric age group. The clinical symptoms, investigations, diagnosis, and treatment with the literature reviews are presented...
Related Articles The First Reported Case of Gluteal Implant-Associated Anaplastic Large Cell Lymphoma (ALCL). Aesthet Surg J. 2019 06 21;39(7):NP253-NP258 Authors: Shauly O, Gould DJ, Siddiqi I, Patel KM, Carey J Abstract Anaplastic large-cell lymphoma (ALCL) is a very rare but life-threatening complication that has largely been demonstrated to be associated with breast implants (BIA-ALCL). Patients are at risk of BIA-ALCL with the placement...
Related Articles Postmenopausal androgen-secreting ovarian tumors: challenging differential diagnosis in two cases. Climacteric. 2019 08;22(4):324-328 Authors: Arteaga E, Martinez A, Jaramilo J, Villaseca P, Cuello M, Valenzuela P, Gejman R, Blumel JE Abstract Postmenopausal hyperandrogenism constitutes a very rare condition of tumoral or non-tumoral origin primarily residing either in the ovary or in the adrenal glands. We present herein two...
Related Articles Cancer stem cells: Road to therapeutic resistance and strategies to overcome resistance. Biochim Biophys Acta Mol Basis Dis. 2020 04 01;1866(4):165339 Authors: Makena MR, Ranjan A, Thirumala V, Reddy AP Abstract Unlike other normal cells, a subpopulation of cells often termed as "stem cells" are long-lived and generate cellular progeny throughout life. Cancer stem cells (CSCs) are rare immortal cells within a tumor that can...
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