Background. Many studies have shown that NLRC4 inflammasome polymorphisms are associated with a variety of autoimmune diseases, but the associations between NLRC4 polymorphisms and autoimmune thyroid diseases (AITDs) are unclear. Our research was aimed at identifying the correlations between NLRC4 polymorphisms and AITDs. Methods. Hi-SNP high-throughput genotyping technology was used for detecting four single-nucleotide polymorphisms (SNPs) of NLRC4 in 1005 AITDs patients (including 629 Graves’ disease...
Tue Aug 04, 2020 17:05
Background. Androgenetic alopecia (AGA) represents the most frequent clinical complaint encountered by dermatologists and is characterized by a progressive miniaturization of the hair follicle. However, the efficacy and safety of current medical treatment remain limited, and more personalized therapeutic approaches for AGA are needed. Therefore, the present study is aimed at investigating the efficacy and safety of botulinum toxin type A (BTA) in patients with AGA. Methods. 63 patients with AGA meeting...
Tue Aug 04, 2020 16:50
The within-sample relative expression orderings (REOs) of genes, which are stable qualitative transcriptional characteristics, can provide abundant information for a disease. Methods based on REO comparisons have been proposed for identifying differentially expressed genes (DEGs) at the individual level and for detecting disease-associated genes based on one-phenotype disease data by reusing data of normal samples from other sources. Here, we evaluated the effects of common potential confounding...
Tue Aug 04, 2020 16:35
Increasing evidence has shown competitive endogenous RNAs (ceRNAs) play key roles in numerous cancers. Nevertheless, the ceRNA network that can predict the prognosis of lung adenocarcinoma (LUAD) is still lacking. The aim of the present study was to identify the prognostic value of key ceRNAs in lung tumorigenesis. Differentially expressed (DE) RNAs were identified between LUAD and adjacent normal samples by limma package in R using The Cancer Genome Atlas database (TCGA). Gene ontology (GO) and...
Tue Aug 04, 2020 16:35
Background. Although the incidence and mortality of complicated skin and soft tissue infections have decreased, this infection is still relatively frequent and can be associated with lethal complications. In this study, the authors present our clinical experience of patients with complicated posterior cervical skin and soft tissue infections (CPCSSTIs) diagnosed and treated in a reconstructive unit in northeastern China. Methods. A retrospective chart review of patients diagnosed with CPCSSTIs from...
Tue Aug 04, 2020 16:20
Objective. The rate of neuronal apoptosis increases after spinal cord injury (SCI). Anastomosing the normal nerve roots above the SCI level to the injured sacral nerve roots can enhance the functional recovery of neurons. Therefore, we evaluated the effect of sacral nerve root transfer after SCI on pontine neuronal survival. Methods. Sprague–Dawley rats were randomly divided into three groups: Group A, reconstruction of afferent and efferent nerve pathways of the bladder after SCI; Group B, SCI only;...
Tue Aug 04, 2020 16:05
Background. The mechanisms that link obesity and cancer development are not well-defined. Investigation of leptin and leptin receptor expressions may help define some of the mechanisms. These proteins are known for associating with the immune response, angiogenesis and, signalling pathways such as JAK2/STAT3, PI3K, and AKT pathways. Tissue proteins can be easily detected with immunohistochemistry (IHC), a technique widely used both in diagnostic and research laboratories. The identification of altered...
Tue Aug 04, 2020 15:35
Background. This study is aimed at investigating natriuretic peptide B (NPPB) coexpression genes and their pathways involved in heart failure (HF) among patients both with and without type 2 diabetes mellitus (T2DM). Methods. The microarray dataset GSE26887, containing 19 postischemic HF patients’ peripheral blood samples (7 with T2DM and 12 without T2DM), was examined to detect the genes coexpressed with NPPB using the corr.test function in the R packet. Furthermore, using online analytical tools,...
Tue Aug 04, 2020 11:05
Rheumatoid arthritis (RA) is an autoimmune disease characterized by erosive arthritis, which has not been thoroughly cured yet, and standardized treatment is helpful for alleviating clinical symptoms. Here, various bioinformatics analysis tools were comprehensively utilized, aiming to identify critical biomarkers and possible pathogenesis of RA. Three gene expression datasets profiled by microarray were obtained from GEO database. Dataset GSE55235 and GSE55457 were merged for subsequent analyses....
Tue Aug 04, 2020 10:50
Background. Moyamoya disease (MMD) is a progressive occlusive cerebrovascular disease that is characterized by abnormal angiogenesis at the base of the brain. This pathological abnormal angiogenesis is susceptible to disturbances, including spontaneous hemorrhage and vasogenic edema. However, the underlying mechanisms of pathological angiogenesis and occurrence of hemorrhage are unclear. Angiopoietins play a fundamental role in the pathophysiology of central nervous system disorders in angiogenesis....
Tue Aug 04, 2020 10:35
Objective. Although noncoding RNAs, especially the microRNAs, have been found to play key roles in CRC development in intestinal tissue, the specific mechanism of these microRNAs has not been fully understood. Methods. GEO and TCGA database were used to explore the microRNA expression profiles of normal mucosa, adenoma, and carcinoma. And the differential expression genes were selected. Computationally, we built the SVM model and multivariable Cox regression model to evaluate the performance of tumorigenic...
Tue Aug 04, 2020 09:05
Fluid overload is a serious issue for critically ill patients. It can occur in a variety of situations, including as a result of acute kidney injury, and can also be an issue in critically ill COVID-19 patients. The condition requires prompt treatment to restore health fluid levels, and Medgadget recently featured an interview with CHF Solutions CEO John Erb about the Aquadex Ultrafiltration system, which is designed to safely restore fluid levels as an alternative to dialysis. Monitoring...
Tue Aug 04, 2020 23:29
eSight, a company based in Toronto, Canada, is releasing the latest version of its vision-improving electronic glasses for people with poor eyesight and even legal blindness. The eSight 4 sports two 1280×960 screens that display images captured and processed from the forward facing camera on the glasses. It’s indicated for people with all kinds of eye conditions that are characterized by substantial loss of central vision, such as diabetic retinopathy, macular degeneration, and Stargardt’s...
Tue Aug 04, 2020 19:49
Israel’s Rapid Medical has won European regulatory clearance to introduce its TIGERTRIEVER XL device for removing large ischemic stroke-causing clots from intracranial vessels. The company calls its line of devices “stentrievers,” as these look and operate similar to stents but can retrieve clots out of the body. Clot removed from the brain of the first stroke patient treated with Tigertriever XL at Bochum University Hospital The TIGERTRIEVER XL can be used to remove clots as big as...
Tue Aug 04, 2020 17:27
The gene encoding glucose oxidase from Aspergillus niger ZM-8 was cloned and transferred to Pichia pastoris GS115, a transgenic strain P. pastoris GS115-His-GOD constructed. The growth curve of P. pastoris GS115-His-GOD was consistent with that of Pichia pastoris GS115-pPIC9K under non-induced culture conditions. Under methanol induction conditions, the growth of the GOD-transgenic strain was significantly lowered than P. pastoris GS115-pPIC9K with the induced-culture time increase, and the optical...
Tue Aug 04, 2020 03:00
Background Forest plantations play an important role in carbon sequestration, helping to mitigate climate change. In this study, survival, biomass, growth rings and annual carbon content storage were evaluated in a mixed Pinus durangensis and P. cooperi plantation that was established after a clear-cutting. The plantation is eight years old and covers an area of 21.40 ha. Methods Sixteen sites of 100 m2 were distributed...
Tue Aug 04, 2020 03:00
Background Bayesian analyses offer many benefits for phylogenetic, and have been popular for analysis of amino acid alignments. It is necessary to specify a substitution and site model for such analyses, and often an ad hoc, or likelihood based method is employed for choosing these models that are typically of no interest to the analysis overall. Methods We present a method called OBAMA that averages over substitution...
Tue Aug 04, 2020 03:00
Background This study sought to investigate the occurrence of taxonomic patterns between semi-arid and humid regions, verifying how the taxonomic affiliation can influence the selection of plants for medicinal purposes and act as a selection criterion. Methods The relationship between the taxonomic affiliation and the selection of medicinal plants with four different communities was analyzed; two of them associated with a seasonally dry tropical forest and the other two associated with...
Tue Aug 04, 2020 03:00
The link between the gut microbiota and metabolic syndrome (MetS) has attracted widespread attention. Christensenellaceae was recently described as an important player in human health, while its distribution and relationship with MetS in Chinese population is still unknown. This study sought to observe the association between Christensenellaceae and metabolic indexes in a large sample of residents in South China. A total of 4,781 people from the GGMP project were included, and the fecal microbiota...
Tue Aug 04, 2020 03:00
Malaria is an infectious disease caused by Plasmodium parasites, transmitted through mosquito bites. Symptoms include fever, headache, and vomiting, and in severe cases, seizures and coma. The World Health Organization reports that there were 228 million cases and 405,000 deaths in 2018, with Africa representing 93% of total cases and 94% of total deaths. Rapid diagnosis and subsequent treatment are the most effective means to mitigate the progression into serious symptoms. However, many fatal cases...
Tue Aug 04, 2020 03:00
Background Lignosus tigris, a recently discovered species of the unique Lignosus family, has been traditionally used by the indigenous communities in Peninsular Malaysia to treat various ailments and as an alternative medicine for cancer treatment. The L. tigris cultivar sclerotia (Ligno TG-K) was found to contain numerous bioactive compounds with beneficial biomedicinal properties and the sclerotial extract exhibited potent antioxidant activity. However, the anticancer property...
Tue Aug 04, 2020 03:00
In this study, we analyze changing patterns of pesticide use in agriculture in Great Britain over the 1990–2016 period, with respect to the risk they pose to birds. The weight of pesticides applied decreased by 51% between 1990 and 2016, but the area treated increased by 63% over the same period. Over this period, there has been considerable turnover in the pesticides used. The European Union (including Great Britain until 2020) has restricted or banned many pesticides for agricultural use, including...
Tue Aug 04, 2020 03:00
Coral reefs support diverse communities, and relationships among organisms within these communities are quite complex. Among the relationships, clarifying the habitat association and foraging substrate selection relative to habitat characteristics is of central importance to ecology since these two aspects are the fundamentals for survival and growth of organisms. The aims of the present study were to investigate the spatial distribution and feeding substrate selection of 14 species of butterflyfishes...
Tue Aug 04, 2020 03:00
Publication date: Available online 4 August 2020Source: International Journal of Radiation Oncology*Biology*PhysicsAuthor(s): Ziqi Zhou, Jing Zhao, Ke Hu, Xiaorong Hou, Xiansong Sun, Xiaoli Pan, Xiaohui Wang, Nan Li, Zhiwei Yang, Fuquan Zhang, Qianqian Zhou, Linsheng Zhan
Tue Aug 04, 2020 15:10
Publication date: Available online 4 August 2020Source: International Journal of Radiation Oncology*Biology*PhysicsAuthor(s): Qiuying Tang, Lingyun Wu, Mengyou Xu, Danfang Yan, Jimin Shao, Senxiang Yan
Tue Aug 04, 2020 15:10
Publication date: Available online 3 August 2020Source: International Journal of Radiation Oncology*Biology*PhysicsAuthor(s): Davide Cusumano, Luca Boldrini, Poonam Yadav, Gao Yu, Bindu Musurunu, Giuditta Chiloiro, Antonio Piras, Jacopo Lenkowicz, Lorenzo Placidi, Sara Broggi, Angela Romano, Martina Mori, Brunella Barbaro, Luigi Azario, Maria Antonietta Gambacorta, Marco De Spirito, Micheal F. Bassetti, Yingli Yang, Claudio Fiorino, Vincenzo Valentini
Tue Aug 04, 2020 15:10
Publication date: Available online 3 August 2020Source: International Journal of Radiation Oncology*Biology*PhysicsAuthor(s): Jeffrey P. Gross, So-Youn Kim, Vinai Gondi, Mark Pankuch, Sarah Wagner, Allison Grover, Yi Luan, Teresa K. Woodruff
Tue Aug 04, 2020 15:10
Publication date: Available online 3 August 2020Source: International Journal of Radiation Oncology*Biology*PhysicsAuthor(s): Shuang Xing, Xing Shen, Jin-kun Yang, Xin-ru Wang, Hong-ling Ou, Xue-wen Zhang, Guo-lin Xiong, Ya-jun Shan, Yu-wen Cong, Qing-liang Luo, Zu-yin Yu
Tue Aug 04, 2020 15:10
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