Abstract Objectives Alterations in adult hypothalamic–pituitary–adrenal (HPA) axis activity have increasingly been linked with early life stress and adult depression, but a limited number of studies have used longitudinal data to explore HPA axis dysregulation as an underlying mechanism driving the long‐term depressive impacts of early stressors. Here we address potential long‐term impacts of early life, family‐based stress on depressive symptoms among young adults in a longitudinal birth cohort...
Mon Aug 03, 2020 15:28
Abstract among patients with COVID‐19 who require treatment in intensive care for acute respiratory distress syndrome (ARDS), mortality rates have been reported between 16 – 78% (1). In patients who are discharged alive, an increased risk of sequelae from COVID‐19 is anticipated (2). The hyperinflammatory response induced by SARS‐CoV‐2 is pivotal in the pathogenesis of COVID‐19 and is accompanied by an upregulated expression of interleukin 6 (IL‐6) that correlates with disease severity (3). Tocilizumab,...
Mon Aug 03, 2020 12:24
Abstract Severely ill COVID‐19 patients have a high risk of admission to the intensive‐care unit (ICU) and requirement for mechanical ventilation (MV), with in‐hospital mortality reported as 18‐79% globally.1‐4. Among ICU patients in the United States (US), centers have reported 50% mortality.5,6 Tocilizumab, an IL‐6 receptor (IL‐6R) antagonist, is FDA approved for the management of CAR T‐cell related Cytokine Release Syndrome (CRS) and may have utility in treatment of some COVID‐19 patients. We...
Mon Aug 03, 2020 11:03
This protocol describes the use of 3D planning and printing for reconstruction of bony defects. We use segmentation tools to create 3D models followed by 3D design software to create patient specific implants for reconstruction purposes concomitant to ablative surgery or as a second stage.
Tue Aug 04, 2020 20:53
Publication date: November 2020Source: Medical Hypotheses, Volume 144Author(s): Emdormi Rymbai, Deepa Sugumar, J. Saravanan, S. Divakar
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Publication date: November 2020Source: Medical Hypotheses, Volume 144Author(s): Rachel K. Lim, Carlos G. Wambier, Andy Goren
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During integrated nutrient management involving poultry manure (PM) and urea fertilizer (UF) for maize (Zea mays L.), it is necessary to investigate the best time to apply UF that will optimize soil chemical properties, growth, and yield of maize. Hence, studies were carried out to investigate the effect of different rates of PM and single and split applications (SA) of UF on soil chemical properties, growth, and yield of maize. The treatment involved three levels of PM (0.0, 4.0, and 8.0 t·ha−1)...
Tue Aug 04, 2020 20:05
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