Related ArticlesDouble Burden of Malnutrition and Nutrition Transition in Asia: A Case Study of 4 Selected Countries with Different Socioeconomic Development. Adv Nutr. 2020 Jun 12;: Authors: Gao L, Bhurtyal A, Wei J, Akhtar P, Wang L, Wang Y Abstract Disease burden and lifestyle patterns have changed rapidly worldwide, especially in some Asian countries over the past 2 decades. However, cross-country comparative research is limited. This study investigated...
Sat Jun 13, 2020 13:37
Related ArticlesVocal Cord and Diaphragmatic Paralysis in a Patient With Bilateral Mediastinal Neurofibromatosis Type 1. Ear Nose Throat J. 2020 Jun 12;:145561320933959 Authors: Choi SW, Kim WJ PMID: 32529900 [PubMed - as supplied by publisher]
Sat Jun 13, 2020 17:40
Related ArticlesDiode Laser for Laryngeal Cancer: "980 nm" and Beyond the Classic CO2. Ear Nose Throat J. 2020 Jun 12;:145561320932043 Authors: Karkos PD, Koskinas I, Stavrakas M, Triaridis S, Constantinidis J Abstract Lasers have been used in otolaryngology for more than 40 years and are widely considered an established way of addressing laryngeal pathology, benign and malignant. Carbon dioxide (CO2) laser is considered a gold standard, but over...
Sat Jun 13, 2020 17:40
Related ArticlesA "Leave Me Alone" Jaw Lesion. Ear Nose Throat J. 2020 Jun 12;:145561320933960 Authors: Omami G PMID: 32529846 [PubMed - as supplied by publisher]
Sat Jun 13, 2020 17:40
Related ArticlesA 3D Printed Model for Myringotomy and Grommet Insertion. Ear Nose Throat J. 2020 Jun 12;:145561320933963 Authors: Stavrakas M, Triaridis S, Bamidis P, Constantinidis J, Karkos PD PMID: 32527168 [PubMed - as supplied by publisher]
Sat Jun 13, 2020 13:35
Related ArticlesClinical and Diagnostic Aspect of Tongue Abscess. Ear Nose Throat J. 2020 Jun 12;:145561320933961 Authors: Mesolella M, Allosso S, Iorio B, Motta G PMID: 32527144 [PubMed - as supplied by publisher]
Sat Jun 13, 2020 13:35
Related ArticlesOffice Laser Laryngology: A Paradigm Shift. Ear Nose Throat J. 2020 Jun 11;:145561320930648 Authors: Hantzakos AG, Khan M Abstract OBJECTIVES: To present the value of office-based laryngological procedures as an effective alternative method to the treatment of benign and malignant laryngeal pathologies. METHODS: We have reviewed the technological advancements of fiber-guided laser systems, fiberoptic endoscopes, and high-definition...
Fri Jun 12, 2020 17:16
Related ArticlesIsolated Myxoma of the External Auditory Canal: A Case Report and Literature Review. Ear Nose Throat J. 2020 Jun 11;:145561320927913 Authors: Hasnaoui M, Masmoudi M, Belaid T, Mighri K Abstract Myxoma is a benign myxoid tumor of connective tissue that develops primarily in the heart. At the level of the external auditory canal, it is extremely rare. It can be isolated or associated with Carney syndrome. Only 5 cases of isolated myxoma...
Fri Jun 12, 2020 17:16
Related ArticlesRANK and RANKL Expression in Salivary Gland Tumors. Ear Nose Throat J. 2020 Jun 11;:145561320930640 Authors: Aslan F, Küçük Ü Abstract OBJECTIVES: The pathogenesis and molecular basis of salivary gland tumors (SGT) are not well understood. We investigated the expression of receptor activator of nuclear factor κB (RANK) and RANK ligand (RANKL) in benign and malignant SGTs and their relationship with clinicopathological features. ...
Fri Jun 12, 2020 17:16
Related ArticlesPlunging Ranula. Ear Nose Throat J. 2020 Jun 11;:145561320927828 Authors: Liman ARUA, Tuang GJ, Mansor M PMID: 32525702 [PubMed - as supplied by publisher]
Fri Jun 12, 2020 17:16
Related ArticlesEfficacy of Velopharyngeal Surgery for Positional Obstructive Sleep Apnea Hypopnea Syndrome. Ear Nose Throat J. 2020 Jun 11;:145561320931956 Authors: Sun N, Ye J, Zhang J, Kang D, Tai J, Wang S, Zhang J, Ni X Abstract BACKGROUND: Positional obstructive sleep apnea hypopnea syndrome (P-OSAHS) is a distinct OSAHS type. Whether velopharyngeal surgery is efficacious for patients with P-OSAHS remains unclear. AIM/OBJECTIVE: To...
Fri Jun 12, 2020 17:16
Related ArticlesA Closed Chamber ENT Examination Unit for Aerosol-Generating Endoscopic Examinations of COVID-19 Patients. Ear Nose Throat J. 2020 Jun 11;:145561320931216 Authors: Sayin İ, Devecioğlu İ, Yazıcı ZM PMID: 32525698 [PubMed - as supplied by publisher]
Fri Jun 12, 2020 17:16
Related ArticlesRemoval of Displaced Dental Implants in the Maxillary Sinus Using Endoscopic Approaches. Ear Nose Throat J. 2020 Jun 11;:145561320931304 Authors: Chang PH, Chen YW, Huang CC, Fu CH, Huang CC, Lee TJ Abstract With the broad indications for dental implantation, complications rates have increased. Dental implant displacement into the maxillary sinus, although rare, can occur during the restoration of maxillary posterior teeth. We performed...
Fri Jun 12, 2020 17:16
Related ArticlesHypersensitivity reaction of the gingiva to chlorhexidine: case report and literature review. Oral Surg Oral Med Oral Pathol Oral Radiol. 2020 Jun 08;: Authors: Kotsailidi EA, Kalogirou EM, Michelogiannakis D, Vlachodimitropoulos D, Tosios KI Abstract OBJECTIVE: The aim of this case report was to document a case of delayed-type hypersensitivity reaction of the gingiva to chlorhexidine and review the literature on oral mucosal hypersensitivity...
Sat Jun 13, 2020 13:27
Related ArticlesA cross-sectional study of temporomandibular joint coronal plane disk position: imaging reliability and clinical utility. Oral Surg Oral Med Oral Pathol Oral Radiol. 2020 Jun 08;: Authors: Kurup S, Crow H, Gonzalez Y, Schiffman ES, Truelove ET, Ohrbach R Abstract OBJECTIVES: The aim of this study was to assess the reliability, frequency, and clinical significance of temporomandibular joint (TMJ) medial and lateral disk positions,...
Fri Jun 12, 2020 17:02
Related ArticlesOral and maxillofacial disease: a model for interprofessional education and care. Oral Surg Oral Med Oral Pathol Oral Radiol. 2020 Jun 07;: Authors: Sardiña LA, Pinto A, Elston CA, Bergfeld WF, Stojanov IJ PMID: 32522533 [PubMed - as supplied by publisher]
Fri Jun 12, 2020 17:02
Publication date: Available online 12 June 2020Source: Journal of the American College of SurgeonsAuthor(s): Jansen N. Seheult, Anupamaa Seshadri, Matthew D. Neal
Sat Jun 13, 2020 13:26
Publication date: Available online 11 June 2020Source: Journal of the American College of SurgeonsAuthor(s): Sricharan Chalikonda, Hope Waltenbaugh, Sara Angelilli, Tiffany Dumont, Curt Kvasager, Timothy Sauber, Nino Servello, Anil Singh, Rafael Diaz-Garcia
Fri Jun 12, 2020 21:29
Related ArticlesAssessment of cerebral and renal autoregulation using near-infrared spectroscopy under normal, hypovolaemic and postfluid resuscitation conditions in a swine model: An observational study. Eur J Anaesthesiol. 2019 Jul;36(7):531-540 Authors: Kurita T, Kawashima S, Morita K, Nakajima Y Abstract BACKGROUND: The impact of blood pressure changes on tissue oxygenation differs between vital organs and with blood volume conditions. ...
Sat Jun 13, 2020 13:24
Related ArticlesEvaluation of the sequence method as a tool to assess spontaneous baroreflex in reptiles. J Exp Zool A Ecol Integr Physiol. 2019 08;331(7):374-381 Authors: Filogonio R, Orsolini KF, Castro SA, Oda GM, Rocha GC, Tavares D, Abe AS, Leite CAC Abstract The sequence method is an alternative to the traditional pharmacological approach (i.e., the Oxford technique) used to calculate baroreflex gain (G) in mammals. Although the sequence method...
Sat Jun 13, 2020 13:24
Related ArticlesEffects of leptin on norepinephrine in acute ischemic stroke. Pharmazie. 2019 08 01;74(8):477-480 Authors: Tao P, Jing Z, Shou-Hong G, Shu-Juan P, Jian-Peng J, Wen-Quan L, Wan-Sheng C Abstract Stroke is a multifactorial disease and a consequence of morbidities of diabetes, obesity, hypertension, and heart diseases. Leptin is a major adipokine that regulates weight balance and energy homeostasis, the level of which has been considered...
Fri Jun 12, 2020 13:45
Related ArticlesDietary choline is positively related to overall and cause-specific mortality: results from individuals of the National Health and Nutrition Examination Survey and pooling prospective data. Br J Nutr. 2019 12 14;122(11):1262-1270 Authors: Mazidi M, Katsiki N, Mikhailidis DP, Banach M Abstract Little is known about the association between dietary choline intake and mortality. We evaluated the link between choline consumption and overall...
Fri Jun 12, 2020 13:45
To the Editor: Neurologic symptoms, including headache, altered mental status, and anosmia, occur in many patients with Covid-19. We report the neuropathological findings from autopsies of 18 consecutive patients with SARS-CoV-2 infection who died in a single teaching hospital between April 14 and…
Fri Jun 12, 2020 03:00
Abstract Introduction Tumor Treating Fields (TTFields; antimitotic treatment) delivers low-intensity, intermediate-frequency, alternating electric fields through skin-applied transducer arrays. TTFields (200 kHz) was FDA-approved in glioblastoma (GBM), based on the phase 3 EF-11 (recurrent GBM, rGBM) and EF-14 (newly diagnosed GBM, ndGBM) trials. The most common TTFields-related adverse event (AE) in both trials was array-associated...
Sat Jun 13, 2020 03:00
New England Journal of Medicine, Ahead of Print.
Fri Jun 12, 2020 07:13
New England Journal of Medicine, Ahead of Print.
Fri Jun 12, 2020 07:03
New England Journal of Medicine, Ahead of Print.
Fri Jun 12, 2020 07:00
Technology in Cancer Research &Treatment, Volume 19, Issue , January-December 2020. Purpose:The current study was intended to research the functional role and regulatory mechanism of microRNA-96-5p in the progression of cervical cancer.Methods:MicroRNA-96-5p expression in cervical cancer tissues was assessed by quantitative real-time polymerase chain reaction. The association between microRNA-96-5p expression and clinicopathological features of patients with cervical cancer was analyzed. MTT,...
Fri Jun 12, 2020 11:08
Abstract Bladder cancer (BCa) is an exophytic tumor that presents as either noninvasive confined to the mucosa (NMIBC) or invading the detrusor muscle (MIBC), and was recently further subgrouped into molecular subtypes. Arylamines, major BCa environmental and occupational risk factors, are mainly metabolized by the genetically polymorphic N ‐acetyltransferases 1, NAT1 and NAT2 . In this study, we investigated the association between N ‐acetyltransferases genetic polymorphism and key MIBC and NMIBC...
Fri Jun 12, 2020 22:48
Using a semi‐automated workflow called NMJ‐morph to quantify features of neuromuscular junction (NMJ) architecture across several different muscles and timepoints, Mech et al . reveal that post‐synaptic morphology is more variable between muscles than the pre‐synaptic structure of innervating motor neuron terminals. Moreover, the developing NMJ shows greater diversity than the mature synapse, perhaps caused by the observed distinctions in synaptic growth. Abstract The neuromuscular junction (NMJ)...
Sat Jun 13, 2020 11:59
By analysing the complete drilling cycle of the parasitic wasp Diachasmimorpha longicaudata we determined the actuation mechanism and muscle forces that move the ovipositor elements in an alternating movement during probing for hosts. The muscle forces are sufficient for substrate penetration, and may cause buckling without the push–pull mechanism and enveloping sheaths to prevent this. Abstract Parasitic wasps use specialized needle‐like structures, ovipositors, to drill into substrates to reach...
Sat Jun 13, 2020 11:59
Abstract Purpose Intrathecal gadolinium-enhanced MR cisternography (IGE-MRC) has a high sensitivity to detect accurate localization of cerebrospinal fluid (CSF) leakage in otorhinorrhea patients. Our purpose in this study was to describe our experience in analyzing clinically suspected CSF leakage by IGE-MRC by using gadobutrol with emphasis on its safety and diagnostic performance. ...
Sat Jun 13, 2020 03:00
Abstract Diagnosis of cerebrovascular disease (CVD) at early stages is essential for preventing sequential complications. CVD is often associated with abnormal cerebral microvasculature, which may impact cerebral‐autoregulation (CA). A novel hybrid near‐infrared diffuse optical instrument and a finger plethysmograph were used to simultaneously detect low‐frequency oscillations (LFOs) of cerebral blood flow (CBF), oxy‐hemoglobin concentration ([HbO2]), deoxy‐hemoglobin concentration ([Hb]), and mean...
Sat Jun 13, 2020 11:57
Abstract Introduction The antenatal diagnosis of sagittal craniosynostosis can be challenging, but there are several published papers describing a traumatic outcome to both the affected foetus and the mother during delivery of a scaphocephalic child. The antenatal imaging from affected children was collected along with the mother’s obstetric history. The aim of this study was to identify antenatal ultrasound features that may assist the diagnosis of sagittal synostosis before birth, to enable...
Fri Jun 12, 2020 17:56
Fri Jun 12, 2020 15:32
Sepsis is associated with a strong inflammatory reaction triggering a complex and prolonged immune response. Septic patients have been shown to develop sustained immunosuppression due to a reduced responsiveness of leukocytes to pathogens. Changes in cellular metabolism of leukocytes have been linked to this phenomenon and contribute to the ongoing immunological derangement. However, the underlying mechanisms of these phenomena are incompletely understood. In cell culture models, we mimicked LPS...
Sat Jun 13, 2020 06:35
Inflammatory bowel disease (IBD) is a chronic inflammatory disorder of the gastrointestinal tract resulting from the homeostasis imbalance of intestinal microenvironment, immune dysfunction, environmental and genetic factors, and so on. This disease is associated with multiple immune cells including regulatory T cells (Tregs). Tregs are a subset of T cells regulating the function of various immune cells to induce immune tolerance and maintain intestinal immune homeostasis. Tregs are correlated with...
Fri Jun 12, 2020 15:20
Summary We assessed the pharmacokinetics and safety of a single oral administration of selatinib to healthy Chinese subjects and evaluated the potential bioavailability advantage of selatinib relative to lapatinib. Healthy subjects aged 18–40 years were enrolled in this two-part study: Part 1, a single ascending dose (50–500 mg), randomized, double-blind, placebo-control study with 64 subjects; and Part 2, an open-label, positive control, randomized, three-treatment, three-period,...
Sat Jun 13, 2020 03:00
Summary Kinesin family member 4A (KIF4A) is located in the human chromosome band Xq13.1. It has a highly conserved kinesin motor region at its N-terminus, which is followed by a central coiled-coil region and a C-terminus cargo-binding domain that contains a cysteine-rich motif. It is aberrantly expressed in a variety of cancers. Our study aimed to determine the expression of KIF4A in renal cell carcinoma (RCC) and to gain new insights into the underlying molecular mechanisms...
Fri Jun 12, 2020 03:00
Abstract Our understanding of the rises of animal and cancer multicellularity face the same conceptual hurdles: what makes the clade originate and what makes it diversify. Between the events of origination and diversification lies complex tissue organization that gave rise to novel functionality for organisms and, unfortunately, for malignant transformation in cells. Tissue specialization with distinctly separated cell fates allowed novel functionality at organism level, such...
Sat Jun 13, 2020 03:00
Abstract Background The objective of this study was to characterize the incidence and prognostic correlation of perineural invasion in oral squamous cell carcinoma and determine whether nerve growth factor and its receptor tyrosine Kinase A expression could be used as biological markers for perineural invasion. Methods A retrospective review of pathology reports of 430 patients with oral squamous cell carcinoma who were treated from 1992 to 2014 in Tayside, Scotland was carried out. The...
Fri Jun 12, 2020 21:44
Abstract Background Accumulating evidences suggest that lncRNA FOXD2‐AS1 plays an important role in tumor progression, however, its function in tongue squamous cell carcinoma (TSCC) remains unknown. This research aims to investigate the function and mechanism of FOXD2‐AS1 in the modulation of tongue squamous cell carcinoma progression. Methods Expression of FOXD2‐AS1 was detected in TSCC tissues and TCGA data. Receiver operating characteristic curves (ROCs) analysis and bioinformatic analysis...
Fri Jun 12, 2020 13:29
Abstract This study aimed to synthetize and critically appraise available evidence regarding mucoepidermoid carcinoma (MEC) prevalence among intraoral minor salivary gland tumors (MiSGT). Five main electronic databases and three grey literature databases were searched. The risk of bias (RoB) was assessed using the Joanna Briggs Institute Critical Appraisal Checklist for Studies Reporting Prevalence Data. Proportion meta‐analyses were performed. From 1321 studies identified, 82 were included in qualitative...
Fri Jun 12, 2020 13:28
Abstract Background Adenosine triphosphate (ATP) and glutamate are associated with some headache conditions, and purinergic (P2X) and glutamatergic N ‐methyl‐D‐aspartate (NMDA) receptor‐related processes in the medulla can modulate the effects of trigeminal nociceptive afferent inputs into the brainstem on craniofacial sensorimotor circuits. This study aimed to test whether neck muscle activity can be induced in rats by noxious stimulation of the frontal dura or superior sagittal sinus that involves...
Fri Jun 12, 2020 13:24
Abstract Physiotherapists can manage chronic pain patients by using technical interventions such as mobility, strengthening, manual therapy, or flexibility in a specific and functional manner, being a key component of a multidisciplinary team. Dentists are involved in the management of different chronic pain conditions such as temporomandibular disorders and sleep disorders such as obstructive sleep apnea, but they are frequently unaware of the benefits of collaboration with physical therapists....
Fri Jun 12, 2020 13:20
Abstract Background While the psychosocial morbidity of orofacial pain (OFP) is widely recognised, the differential impact of musculoskeletal, neuropathic and neurovascular symptoms on pain and psychosocial function in individuals with and without coexisting OFP conditions is unclear. Materials and methods This was a comparative cross‐sectional study of 350 consecutive patients attending an OFP clinic; 244 completed standardized self‐report measures of pain experience, mood, and generic...
Fri Jun 12, 2020 13:18
Abstract Background Music is used to evoke audio analgesia during dental procedures, but it is unknown if experimental pain and music interact. This study aimed to explore the multi‐sensory interaction between contrasting types of music and experimentally‐induced muscle pain. Methods In 20 healthy women 0.3 ml sterile hypertonic saline (5.8%) was injected into the masseter muscle during three sessions while contrasting music (classical and black metal) or no music was played in the background....
Fri Jun 12, 2020 12:54
Abstract As reported by the National Institute of Dental and Craniofacial Research, temporomandibular disorders (TMD) are the most prevalent orofacial pain conditions for which patients seek treatment. TMD, a chronic disease that affects between 5‐12% of the adult population, is characterized by pain in the muscles and temporomandibular joint (TMJ) associated with mastication
Fri Jun 12, 2020 12:48
ABSTRACT Background Autoimmune muco‐cutaneous blistering diseases (AMBDs) represent a heterogeneous group of organ‐specific and potentially life‐threatening diseases. We sought to determine the relationship between clinical remission and therapeutic regimens with clinical type and phenotype of AMBDs, as well as clinical outcomes achieved based on different therapeutic regimens. Methods A retrospective single‐center study on 169 AMBDs patients, including pemphigus vulgaris (PV), mucous membrane...
Fri Jun 12, 2020 12:28
Abstract Background Burning mouth syndrome (BMS) is a chronic pain disorder affecting the oral cavity. Previous work has shown promising analgesic results of bodily illusions in other chronic pain conditions. The aim of this proof‐of‐concept, pilot study was to investigate whether bodily illusions reduce pain in BMS patients. Methods Nine participants diagnosed with BMS underwent bodily illusions using a MIRAGE‐mediated reality system. All participants completed 4 conditions and performed...
Fri Jun 12, 2020 12:21
Abstract Background Orofacial pain is a common complaint, with an estimated 75% of cases caused by dental disease, specifically a diseased pulp. A small percentage of orofacial pain cases will require specialist referral most commonly to oral medicine specialists or oral and maxillofacial surgeons from a dental perspective, or otolaryngologists or neurologists from a medical perspective. Imaging Modalities Following a thorough history and clinical examination, imaging is often required...
Fri Jun 12, 2020 12:10
Abstract Oral dysaesthesia is a condition characterised by persistent alteration to oral sensation, perceived by the patient to be abnormal and unpleasant, in the absence of mucosal pathology. Its aetiology remains uncertain. The condition was attributed as a psychosomatic disease for much of the 20th century, but with newer technologies, recent literature has mostly focused on a possible peripheral or central neuropathic aetiology to oral dysaesthesia. Despite this, psychotropic medications and...
Fri Jun 12, 2020 12:05
Abstract Background Temporomandibular Disorders (TMD) are recognised as the most common chronic orofacial pain condition, with prevalence figures ranging from 3% to 12%. Patients referred to tertiary orofacial pain clinics for the management of TMD often experience delays in receiving treatment. The objective of the present study was to assess a group treatment program to deliver effective earlier intervention for patients with chronic TMD. Methods Forty‐two patients with TMD seen at the...
Fri Jun 12, 2020 12:04
Abstract Background Pain is a common symptom of head and neck cancers. In some instances pain may not resolve with conventional modalities and become refractory. Chemical neurolysis is a technique that utilizes chemical neurolytic agents to temporarily denervate a targeted nerve and provide relief in pain‐related symptoms. The aim of this investigation was to determine the effectiveness, safety, and predictors of chemical neurolysis procedures for management of refractory head and neck cancer...
Fri Jun 12, 2020 11:14
Abstract Background The objective of this study was to explore the psychometric properties of the Mouth Handicap in Systemic Sclerosis (MHISS) specifically exploring aspects of validity and reliability of MHISS in UK SSc patients. Methods 150 questionnaires were distributed in this study at the Oral Medicine Department of UCLHT Eastman Dental Hospital, the Outpatient Rheumatology Clinic of the Royal Free Hospital and Scleroderma Family Day. Participants were asked to complete three questionnaires...
Fri Jun 12, 2020 11:10
Abstract Following a request from the European Commission, the Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) was asked to deliver a scientific opinion on the efficacy of iron chelates of lysine and glutamic acid (Iron‐LG) as nutritional feed additive for all animal species. The European Commission request followed an opinion of the FEEDAP Panel published in 2019; in that opinion the Panel could not conclude on the efficacy of the additive. The applicant submitted additional...
Fri Jun 12, 2020 11:10
Abstract Following a request from the European Commission, the EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP ) was asked to deliver a scientific opinion on the safety and efficacy of turmeric extract, turmeric oil, turmeric oleoresin and turmeric tincture from Curcuma longa L. rhizome when used as sensory additives in feed and in water for drinking for all animal species. The FEEDAP Panel concludes that the additives under consideration are safe at the maximum...
Fri Jun 12, 2020 11:10
Abstract Background The role of retrospective analysis has been evolved greatly in cancer research. We undertook this meta‐analysis to evaluate the diagnostic value of Neural networks (NNs) in Fine needle aspiration cytological (FNAC) image of cancer. Methods We systematically retrieved 396 literatures on cytodiagnosis of NNs from Cochrane, PubMed, and EMBASE. After screening, only six studies were included in meta‐analysis finally. Data was comprehensively analyzed by RevMan and meta‐Disc...
Fri Jun 12, 2020 16:10
Abstract Background Promoter hypermethylation is common in Breast Cancer (BC) with studies mainly in histological specimens showing frequent methylation of tumor suppressor genes (TSGs) compared with normal tissues. The aim of this study was to estimate the frequency of promoter methylation of RAR‐β2 and RASSF1A genes in breast FNAB material aiming to evaluate the methylation status of these two genes as biomarker for detecting BC in Greek population. Methods FNAB material from 104 patients...
Fri Jun 12, 2020 16:07
Journal of Cutaneous Medicine and Surgery, Ahead of Print. BackgroundTumor necrosis factor (TNF) alpha inhibitors (anti-TNF) are effective in the treatment of inflammatory bowel disease (IBD) as well as psoriasis. Their increasing use has raised the identification of cutaneous side effects (CSEs). Evidence in children is limited.ObjectivesThe objective of this study is to describe CSEs of anti-TNF treatment in a pediatric population with IBD.MethodsThis is a retrospective single-center study of children...
Fri Jun 12, 2020 09:04
Journal of Cutaneous Medicine and Surgery, Ahead of Print. BackgroundSurgical excision is considered standard treatment for nodular basal cell carcinoma (nBCC). However, patients who reject or are unsuited for surgery may benefit from imiquimod (IMQ) 5% cream as an alternative treatment.ObjectivesThe objective of this study was to conduct a systematic review on the efficacy and safety of IMQ for the treatment of nBCC.Materials and MethodsThe terms basal cell carcinoma AND imiquimod OR Aldara were...
Fri Jun 12, 2020 09:03
Background and Objectives To investigate whether optical coherence tomography (OCT) could be utilized to characterize blood flow and vessel dimensions of facial telangiectasias before and during consecutive intense pulsed light (IPL) treatment. Study Design/Materials and methods Dynamic OCT (D‐OCT) was used to image telangiectasia immediately before and after, 1–3 days after, and 1 month after IPL treatment. Measurements included vessel width and depth, blood flow, and attenuation. Vessel...
Fri Jun 12, 2020 20:25
Background and Objective To take major advantage of erbium‐doped yttrium aluminium garnet (Er:YAG) lasers in osteotomy—like freedom of cutting geometries and high accuracy—the integration and miniaturization of the robot, laser, and navigation technology was tried and applied to minipigs. The investigators hypothesized laser osteotomy would render acceptable bone healing based on the intraoperative findings and postoperative cut surface analysis. Study Design/Materials and Methods We designed...
Thu Jun 11, 2020 19:21
Background and Objectives Fractional ablative 10,600‐nm carbon dioxide (CO2) laser has well‐demonstrated safety and efficacy in resurfacing treatment of scars in the adult population and in the treatment of pediatric burn scars. However, there is a paucity of literature regarding laser resurfacing of traumatic and surgical scars for cosmetic benefit in the pediatric population, and in majority of cases previously reported, this was done under general anesthesia. Study Design/Materials and Methods...
Thu Jun 11, 2020 19:21
Background and Objectives Photodynamic therapy (PDT) is an antitumor procedure clinically approved for the treatment of different cancer types. Despite strong efforts and promising results in this field, PDT has not yet been approved by any regulatory authority for the treatment of colorectal cancer, one of the most prevalent gastrointestinal tumors. In the search of novel therapeutic strategies, we examined the in vivo effect of PDT with a lipophilic phthalocyanine (Pc9) encapsulated into polymeric...
Thu Jun 11, 2020 13:14
Ali R Al-Khatib, Lamiaa A Hasan, Mohammed Najeeb Abdullah Alrawi, Emad Hazim Kasim AlhajarJournal of Orofacial Sciences 2020 12(1):41-46 Introduction: The asymmetry of mandibular ascending ramus leads to serious orthodontic problems in the dentofacial complex. This study was aimed to assess the effects of gender bone properties difference on biomechanics of distraction osteogenesis that used for ascending ramus lengthening with different forces. Materials and Methods: A 3D mandibular model was...
Fri Jun 12, 2020 00:00
Mel Mupparapu, Angela Denise LoJournal of Orofacial Sciences 2020 12(1):3-8 Introduction: This study evaluates the trends in the disinfection of the dental X-ray machines in North American dental schools. The methods of disinfection were compared to the Centers for Disease Control (CDC) guidelines. Materials and Methods: A survey posed the question of whether plastic barrier wrap, bag, disinfecting wipes, or a combination were used for infection control of the tube head. Additional information...
Fri Jun 12, 2020 00:00
Eric Todd StooplerJournal of Orofacial Sciences 2020 12(1):1-2
Fri Jun 12, 2020 00:00
Viswa Chaitanya Chandu, Vydehi Mullapudi, Srinivas Pachava, Vadapalli ViswanathJournal of Orofacial Sciences 2020 12(1):9-12 Introduction: Majority of rural dental outreach programs focus on screening the subjects attending the programs and providing oral health education for them. There has only been limited emphasis on the provision of care as a part of the outreach activities for the geographically disadvantaged rural population. The objective of this study is to check whether the basic clinical...
Fri Jun 12, 2020 00:00
Radhika Manoj Bavle, Konda Paremala, Makarala Sowmya, Muniswamappa Sudhakara, Venugopal Reshma, Sreelatha HosthorJournal of Orofacial Sciences 2020 12(1):52-60 Introduction: Oral submucous fibrosis (OSMF) is a pre-malignant condition highly prevalent in India with a malignant transformation rate of 2–8%. Its incidence amongst younger population has risen due to increased consumption of commercial preparations of areca. p63, a homolog of p53, has a role in epithelial proliferation and is frequently...
Fri Jun 12, 2020 00:00
Thavarajah Rooban, Immanuel Joseph, Selvan Preetha, Joshua Elizabeth, Umadevi Krishna Mohan Rao, Kannan RanganathanJournal of Orofacial Sciences 2020 12(1):13-23 Introduction: Head and neck squamous cell cancer (HNSCC) is a common cancer worldwide. It has been associated with TP53 mutation and chronic inflammation. The control genes of inflammation, Tumor Necrosis Factor Receptor Superfamily (TNFRSF) in HNSCC has not been widely reported. The impact of the TNFRSF and survival and cell death regulation...
Fri Jun 12, 2020 00:00
Nasrollah Saghravanian, Narges Ghazi, Amirhosein Habibollahi, Mohammad Taghi ShakeriJournal of Orofacial Sciences 2020 12(1):35-40 Introduction: Ameloblastoma is the most common neoplasm of odontogenic epithelium with locally aggressive behavior resulting in recurrence and malignant transformation. Odontogenic cysts are common lesions of the jaws with different biological behavior. Odontogenic keratocyst (OKC) and calcifying odontogenic cyst (COC) with ameloblastoma-like epithelium (ameloblastic...
Fri Jun 12, 2020 00:00
Abad Bocangel Salcedo-Alcaychahua, Aron Aliaga-Del Castillo, Luis Ernesto Arriola-GuillénJournal of Orofacial Sciences 2020 12(1):24-29 Introduction: The aim of this study was to compare the shear bond strength at the resin/bracket interface of metal brackets sandblasted with aluminum oxide particles of 25 µm, 50 µm and 110 µm. Materials and Methods: Sixty metal brackets were recycled and randomly assigned into four groups according to the aluminum oxide (Al2O3) particle size (µm) used during sandblasting....
Fri Jun 12, 2020 00:00
Angelita Leonarda Carpio Contreras, Abraham Meneses López, Luis Ernesto Arriola-GuillénJournal of Orofacial Sciences 2020 12(1):47-51 Introduction: The aim of this study was to compare the effect of four different salivary pH levels on the shear bond strength (SBS) of two orthodontic adhesive systems for bracket placement. Materials and Methods: This in-vitro experimental study was performed on 72 premolars extracted for orthodontic reasons. They were randomly assigned into two groups according...
Fri Jun 12, 2020 00:00
Sofiya Juliet, Ganesh Jeevanandan, Lavanya Govindaraju, Vignesh Ravindran, Erulappan Muthuganapathy SubramanianJournal of Orofacial Sciences 2020 12(1):30-34 Introduction: There are many available Nickel Titanium (Ni-Ti) rotary systems that are used for canal cleaning and shaping of the permanent teeth. The new emerging concept in pediatric dentistry is the use of rotary files for canal instrumentation in primary teeth. In literature, there are no clinical studies comparing three different rotary...
Fri Jun 12, 2020 00:00
Mohammed Bindakhil, Mel MupparapuJournal of Orofacial Sciences 2020 12(1):61-63 Maxillary sinus hypoplasia (MSH) is a rare condition characterized by underdevelopment or decrease in the volume of the maxillary sinus. It is thought that MSH may be embryological in origin but acquired etiologies have also been discussed in the literature. MSH is usually detected upon radiographic examination of the maxillofacial area. Three types have been described based on variations in sinus anatomy. A case of...
Fri Jun 12, 2020 00:00
Abstract Structural eye disorders are increasingly recognised as having a genetic basis, although current genetic testing is limited in its success. De novo missense variants in WDR37 are a recently described cause of a multisystemic syndromic disorder featuring ocular coloboma. This study characterizes the phenotypic spectrum of this disorder and reports 2 de novo heterozygous variants (p.Thr115Ile, p.Ser119Tyr) in three unrelated Caucasian individuals. All had a clinical phenotype consisting...
Fri Jun 12, 2020 14:40
Journal of International Medical Research, Volume 48, Issue 6, June 2020. ObjectiveTo investigate the prevalence of hyperuricemia in patients at different stages of chronic kidney disease (CKD) and the association of serum uric acid (SUA) with several clinical factors in a retrospective cross-sectional study of non-dialysis CKD patients at two hospitals in Shanghai, China.MethodsThe prevalence of hyperuricemia in CKD patients and the association of SUA with other clinical factors were examined using...
Fri Jun 12, 2020 15:03
Journal of International Medical Research, Volume 48, Issue 6, June 2020. ObjectiveTo investigate drug resistance features and homology among penicillin-intermediate Streptococcus pneumoniae isolates from Wenzhou City, China.MethodsFifty-one penicillin-intermediate S. pneumoniae isolates were obtained from respiratory samples of infants and children hospitalized with lung infections. An antimicrobial susceptibility test was used to assess drug resistance. Polymerase chain reaction and agarose gel...
Fri Jun 12, 2020 14:36
Journal of International Medical Research, Volume 48, Issue 6, June 2020. ObjectiveHepatocellular carcinoma (HCC) is the most common cause of primary liver cancer. A major part of diagnostic HCC work-up is based on imaging findings from sonography, computed tomography (CT), or magnetic resonance imaging (MRI) scans. Contrast-enhanced ultrasound (CEUS) allows for the dynamic assessment of the microperfusion pattern of suspicious liver lesions. This study aimed to evaluate the diagnostic value of CEUS...
Fri Jun 12, 2020 14:34
Journal of International Medical Research, Volume 48, Issue 6, June 2020. ObjectiveDisulfiram is commonly used for alcohol abuse; however, recent studies have revealed its potential as an anti-cancer treatment. This study investigated the effects of disulfiram on gastric cancer and its underlying mechanisms of action.MethodsThe gastric cancer cell lines MKN-45 and SGC-7901 were used for all experiments. Cell proliferation was investigated using cell counting kit-8, cell migration and invasion were...
Fri Jun 12, 2020 14:31
Journal of International Medical Research, Volume 48, Issue 6, June 2020. ObjectiveTo investigate the anti-metastatic effects of Babao Dan (BBD) on gastric cancer (GC) cells (AGS and MGC80-3) and explore the underlying molecular mechanisms by which it inhibits epithelial–mesenchymal transition (EMT).MethodsAGS and MGC80-3 cells were treated with BBD. In addition, cells were treated with the EMT inducer transforming growth factor-β1 (TGF-β1). Cell viability was determined using the MTT assay, and...
Fri Jun 12, 2020 14:27
Journal of International Medical Research, Volume 48, Issue 6, June 2020. ObjectiveTo evaluate the efficacy and safety of adjunctive alpha-blocker therapy before ureteroscopy in the management of ureteral stones.MethodsThe databases MEDLINE®, EMBASE and The Cochrane Controlled Trail Register of Controlled Trials were searched between January 1980 and June 2019 to identify randomized controlled trials (RCTs) that referred to the use of alpha-blockers as adjunctive therapy before ureteroscopy for the...
Fri Jun 12, 2020 14:25
Journal of International Medical Research, Volume 48, Issue 6, June 2020. ObjectiveStatins have been shown to be beneficial for the prevention of cardiovascular events. In elderly individuals, the efficacy of statins remains controversial and the comparative effect of statins has not been assessed.MethodsMEDLINE, Embase, and the Cochrane Central database were searched for randomized controlled trials that assessed statins in older patients.ResultsSeventeen trials were analyzed. When used for secondary...
Fri Jun 12, 2020 14:23
Journal of International Medical Research, Volume 48, Issue 6, June 2020. Numerous risk factors for heart disease or dementia harbor over 10% valine plus glycine content. Interestingly, TDP-43 contains 6.0% valine and 13.3% glycine, and the buildup of this protein in the brains of patients with limbic-predominant age-related TDP-43 encephalopathy has dire consequences. The two γ-methyl groups in valine enable hyperconjugation, which enhances the van der Waals interaction between its side group and...
Fri Jun 12, 2020 14:22
Journal of International Medical Research, Volume 48, Issue 6, June 2020. ObjectiveCephalic arch stenosis (CAS) causes repeated dysfunction and failure of arteriovenous access. Percutaneous transluminal angioplasty is the standard initial treatment for CAS, but its outcome is unsatisfactory. This study aimed to evaluate the outcome of stent graft placement for CAS in patients on hemodialysis.MethodsA retrospective chart review from a tertiary medical center was performed in patients receiving stent...
Fri Jun 12, 2020 14:10
Journal of International Medical Research, Volume 48, Issue 6, June 2020. ObjectiveThis study investigated the effects of leptin on intestinal flora and inflammation in mice with high-fat diet (HFD)-induced obesity.MethodsMice were fed an HFD for 8 weeks; some were concurrently administered oral leptin for 4 weeks. Pathological changes in adipose tissue were detected using hematoxylin–eosin staining; endotoxin content in adipose tissue was measured by enzyme-linked immunosorbent assay. Intestinal...
Fri Jun 12, 2020 12:28
Journal of International Medical Research, Volume 48, Issue 6, June 2020. ObjectiveMeasurement of positive end-expiratory pressure (PEEP)-induced recruitment lung volume using passive spirometry is based on the assumption that the functional residual capacity (FRC) is not modified by the PEEP changes. We aimed to investigate the influence of PEEP on FRC in different models of acute respiratory distress syndrome (ARDS).MethodsA randomized crossover study was performed in 12 pigs. Pulmonary (n = 6)...
Fri Jun 12, 2020 12:26
Journal of International Medical Research, Volume 48, Issue 6, June 2020. ObjectiveTo investigate the effects of tanshinone IIA on the transforming growth factor-β1 (TGF-β1)/Smads signaling pathway in angiotensin II-treated hepatic stellate cells (HSCs).MethodsHSCs were cultured and treated with angiotensin II (10 μM) or angiotensin II (10 μM) plus tanshinone IIA (3, 10, or 30 μM). Cells were incubated for 48 hours and proliferation was determined with the Cell Counting Kit-8. The relative mRNA expression...
Fri Jun 12, 2020 12:25
Journal of International Medical Research, Volume 48, Issue 6, June 2020. IntroductionPatients treated with direct oral anticoagulants (DOACs) are at increased bleeding risk. It is therefore of increasing interest to identify predictors of bleeding episodes to increase safety during treatment with DOACs.MethodsThis retrospective cohort study systematically reviewed medical records of 235 patients treated with either apixaban, rivaroxaban or dabigatran for non-valvular atrial fibrillation or venous...
Fri Jun 12, 2020 12:22
Journal of International Medical Research, Volume 48, Issue 6, June 2020. Renal cell carcinoma (RCC) is a malignant tumor and the third most common urinary disease. It was estimated that RCC affected over 350,000 individuals in 2013, and there are nearly 140,000 deaths annually due to this disease. The initial masses in RCC patients are mostly confined to a single organ. However, due to the metastatic spread of cancer cells through the circulatory system, more than 30% of RCC patients relapse after...
Fri Jun 12, 2020 12:17
Journal of International Medical Research, Volume 48, Issue 6, June 2020. ObjectivePostoperative delirium (POD) has rarely been investigated in breast cancer patients. Herein, we assessed the association between serum levels of the inflammatory biomarker translocator protein (TP) and the occurrence of POD in breast cancer patients.MethodsIn this prospective, observational study, TP levels were detected in preoperative and postoperative serum samples from 152 elderly breast cancer patients, samples...
Fri Jun 12, 2020 12:15
Journal of International Medical Research, Volume 48, Issue 6, June 2020. ObjectiveAsymmetric and symmetric dimethylarginines (ADMA and SDMA) are endothelial dysfunction markers. ADMA inhibits synthesis of nitric oxide. We aimed to analyze both markers in patients with coronary artery disease (CAD) who were referred for stress/rest myocardial perfusion scintigraphy (MPS).MethodsAll patients underwent a 2-day dipyridamole (DP) stress/rest protocol. Thereafter, patients with transient myocardial perfusion...
Fri Jun 12, 2020 12:13
Journal of International Medical Research, Volume 48, Issue 6, June 2020. Gestational gigantomastia (GGM) is a rare complication of pregnancy. The etiology of GGM is yet to be fully established. Treatment methods for GGM include medical therapy and surgery. If medical treatment is unsuccessful, surgery may be required. Currently available surgical interventions are either breast reduction or mastectomy with delayed reconstruction. We report a case of a 25-year-old woman (G1P1) who presented with...
Fri Jun 12, 2020 12:11
Journal of International Medical Research, Volume 48, Issue 6, June 2020. ObjectiveThe deficient placental blood perfusion caused by the attenuated infiltration of trophoblast cells is a key factor in the occurrence of preeclampsia (PE). Furthermore, the long noncoding (lnc)RNA SNHG12 (small nucleolar RNA host gene 12) can promote the proliferation and metastasis of multiple tumor cells. However, whether lncRNA SNHG12 affects proliferation and metastasis of trophoblast cells is unclear.MethodsWe...
Fri Jun 12, 2020 12:09
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