IJMS, Vol. 21, Pages 4234: Mono-PEGylation of a Thermostable Arginine-Depleting Enzyme for the Treatment of Lung Cancer International Journal of Molecular Sciences doi: 10.3390/ijms21124234 Authors: Sai-Fung Chung Chi-Fai Kim Sui-Yi Kwok Suet-Ying Tam Yu Wai Chen Hiu-Chi Chong Siu-Lun Leung Pui-Kin So Kwok-Yin Wong Yun-Chung Leung Wai-Hung Lo L-arginine (L-Arg) depletion induced by randomly PEGylated arginine deiminase (ADI-PEG20) can treat arginosuccinate...
Sun Jun 14, 2020 03:00
IJMS, Vol. 21, Pages 4233: Structure, Function, and Regulation of the SRMS Tyrosine Kinase International Journal of Molecular Sciences doi: 10.3390/ijms21124233 Authors: Chakia J. McClendon W. Todd Miller Src-related kinase lacking C-terminal regulatory tyrosine and N-terminal myristoylation sites (SRMS) is a tyrosine kinase that was discovered in 1994. It is a member of a family of nonreceptor tyrosine kinases that also includes Brk (PTK6) and Frk. Compared with other tyrosine kinases,...
Sun Jun 14, 2020 03:00
IJMS, Vol. 21, Pages 4232: An Inhibitor of the Sodium–Hydrogen Exchanger-1 (NHE-1), Amiloride, Reduced Zinc Accumulation and Hippocampal Neuronal Death after Ischemia International Journal of Molecular Sciences doi: 10.3390/ijms21124232 Authors: Beom Seok Kang Bo Young Choi A Ra Kho Song Hee Lee Dae Ki Hong Jeong Hyun Jeong Dong Hyeon Kang Min Kyu Park Sang Won Suh Acidosis in the brain plays an important role in neuronal injury and is a common feature of several...
Sun Jun 14, 2020 03:00
IJMS, Vol. 21, Pages 4231: An Integrative Synthetic Biology Approach to Interrogating Cellular Ubiquitin and Ufm Signaling International Journal of Molecular Sciences doi: 10.3390/ijms21124231 Authors: Chuanyin Li Tianting Han Rong Guo Peng Chen Chao Peng Gali Prag Ronggui Hu Global identification of substrates for PTMs (post-translational modifications) represents a critical but yet dauntingly challenging task in understanding biology and disease pathology. Here we...
Sun Jun 14, 2020 03:00
IJMS, Vol. 21, Pages 4229: Molecular Effects of FDA-Approved Multiple Sclerosis Drugs on Glial Cells and Neurons of the Central Nervous System International Journal of Molecular Sciences doi: 10.3390/ijms21124229 Authors: Kim M. A. De Kleijn Gerard J. M. Martens Multiple sclerosis (MS) is characterized by peripheral and central inflammatory features, as well as demyelination and neurodegeneration. The available Food and Drug Administration (FDA)-approved drugs for MS have been designed...
Sat Jun 13, 2020 03:00
IJMS, Vol. 21, Pages 4230: New Determinants of Aminoglycoside Resistance and Their Association with the Class 1 Integron Gene Cassettes in Trueperella pyogenes International Journal of Molecular Sciences doi: 10.3390/ijms21124230 Authors: Ewelina Kwiecień Ilona Stefańska Dorota Chrobak-Chmiel Agnieszka Sałamaszyńska-Guz Magdalena Rzewuska Trueperella pyogenes is an important opportunistic animal pathogen. Different antimicrobials, including aminoglycosides, are used to treat...
Sat Jun 13, 2020 03:00
IJMS, Vol. 21, Pages 4225: Targeting NF-κB by the Cell-Permeable NEMO-Binding Domain Peptide Improves Albuminuria and Renal Lesions in an Experimental Model of Type 2 Diabetic Nephropathy International Journal of Molecular Sciences doi: 10.3390/ijms21124225 Authors: Lucas Opazo-Ríos Anita Plaza Yenniffer Sánchez Matus Susana Bernal Laura Lopez-Sanz Luna Jimenez-Castilla Daniel Carpio Alejandra Droguett Sergio Mezzano Jesús Egido Carmen Gomez-Guerrero Diabetic...
Sat Jun 13, 2020 03:00
IJMS, Vol. 21, Pages 4228: Microorganisms and Their Metabolic Capabilities in the Context of the Biogeochemical Nitrogen Cycle at Extreme Environments International Journal of Molecular Sciences doi: 10.3390/ijms21124228 Authors: Rosa María Martínez-Espinosa Extreme microorganisms (extremophile) are organisms that inhabit environments characterized by inhospitable parameters for most live beings (extreme temperatures and pH values, high or low ionic strength, pressure, or scarcity of...
Sat Jun 13, 2020 03:00
IJMS, Vol. 21, Pages 4227: Seed Germination in Oil Palm (Elaeis guineensis Jacq.): A Review of Metabolic Pathways and Control Mechanisms International Journal of Molecular Sciences doi: 10.3390/ijms21124227 Authors: Jing Cui Emmanuelle Lamade Guillaume Tcherkez Oil palm is an oil-producing crop of major importance at the global scale. Oil palm mesocarp lipids are used for myriads industrial applications, and market demand has been growing for decades. In addition, oil palm seeds...
Sat Jun 13, 2020 03:00
IJMS, Vol. 21, Pages 4226: Extracellular Vesicles-Loaded Fibrin Gel Supports Rapid Neovascularization for Dental Pulp Regeneration International Journal of Molecular Sciences doi: 10.3390/ijms21124226 Authors: Siyuan Zhang Anja Lena Thiebes Franziska Kreimendahl Stephan Ruetten Eva Miriam Buhl Michael Wolf Stefan Jockenhoevel Christian Apel Rapid vascularization is required for the regeneration of dental pulp due to the spatially restricted tooth environment. Extracellular...
Sat Jun 13, 2020 03:00
IJMS, Vol. 21, Pages 4215: 1,25(OH)2D3 Alleviates Aβ(25-35)-Induced Tau Hyperphosphorylation, Excessive Reactive Oxygen Species, and Apoptosis Through Interplay with Glial Cell Line-Derived Neurotrophic Factor Signaling in SH-SY5Y Cells International Journal of Molecular Sciences doi: 10.3390/ijms21124215 Authors: Ching-I Lin Yi-Chen Chang Ning-Jo Kao Wei-Ju Lee Tzu-Wen Cross Shyh-Hsiang Lin Amyloid beta (Aβ) accumulation in the brain is one of the major pathological...
Sat Jun 13, 2020 03:00
IJMS, Vol. 21, Pages 4220: Structural and Functional Annotation of Transposable Elements Revealed a Potential Regulation of Genes Involved in Rubber Biosynthesis by TE-Derived siRNA Interference in Hevea brasiliensis International Journal of Molecular Sciences doi: 10.3390/ijms21124220 Authors: Shuangyang Wu Romain Guyot Stéphanie Bocs Gaëtan Droc Fetrina Oktavia Songnian Hu Chaorong Tang Pascal Montoro Julie Leclercq The natural rubber biosynthetic pathway is...
Sat Jun 13, 2020 03:00
IJMS, Vol. 21, Pages 4224: GO/Bi2S3 Doped PVDF/TPU Nanofiber Membrane with Enhanced Photothermal Performance International Journal of Molecular Sciences doi: 10.3390/ijms21124224 Authors: Yang Li Feng Hou Wang Yang Hu Zhang Ramakrishna Photothermal conversion materials have attracted wide attention due to their efficient utilization of light energy. In this study, a (GO)/Bi2S3-PVDF/TPU composite nanofiber membrane was systematically developed, comprising...
Sat Jun 13, 2020 03:00
IJMS, Vol. 21, Pages 4222: Pleiotropic Functions of FoxN1: Regulating Different Target Genes during Embryogenesis and Nymph Molting in the Brown Planthopper International Journal of Molecular Sciences doi: 10.3390/ijms21124222 Authors: Ye Zhang FoxN1 gene belongs to the forkhead box gene family that comprises a diverse group of “winged helix” transcription factors that have been implicated in a variety of biochemical and cellular processes. In the brown planthopper...
Sat Jun 13, 2020 03:00
IJMS, Vol. 21, Pages 4221: Can Physical Activity Support the Endocannabinoid System in the Preventive and Therapeutic Approach to Neurological Disorders? International Journal of Molecular Sciences doi: 10.3390/ijms21124221 Authors: Tomasz Charytoniuk Hubert Zywno Karolina Konstantynowicz-Nowicka Klaudia Berk Wiktor Bzdega Adrian Chabowski The worldwide prevalence of neurological and neurodegenerative disorders, such as depression or Alzheimer’s disease, has...
Sat Jun 13, 2020 03:00
IJMS, Vol. 21, Pages 4223: Focus on the Role of NLRP3 Inflammasome in Diseases International Journal of Molecular Sciences doi: 10.3390/ijms21124223 Authors: Roberta Fusco Rosalba Siracusa Tiziana Genovese Salvatore Cuzzocrea Rosanna Di Paola Inflammation is a protective reaction activated in response to detrimental stimuli, such as dead cells, irritants or pathogens, by the evolutionarily conserved immune system and is regulated by the host. The inflammasomes are recognized...
Sat Jun 13, 2020 03:00
IJMS, Vol. 21, Pages 4219: Aspirin Induced Glioma Apoptosis through Noxa Upregulation International Journal of Molecular Sciences doi: 10.3390/ijms21124219 Authors: Cheng-Yi Chang Ping-Ho Pan Jian-Ri Li Yen-Chuan Ou Jiaan-Der Wang Su-Lan Liao Wen-Ying Chen Wen-Yi Wang Chun-Jung Chen Clinically, high cyclooxygenase-2 expression in malignant glioma correlates well with poor prognosis and the use of aspirin is associated with a reduced risk of glioma. To extend the...
Sat Jun 13, 2020 03:00
IJMS, Vol. 21, Pages 4218: Berberine Derivatives Suppress Cellular Proliferation and Tumorigenesis In Vitro in Human Non-Small-Cell Lung Cancer Cells International Journal of Molecular Sciences doi: 10.3390/ijms21124218 Authors: Jia-Ming Chang Kam-Hong Kam Wen-Ying Chao Pei-Wen Zhao Shu-Hsin Chen Hui-Chen Chung Yi-Zhen Li Jin-Yi Wu Ying-Ray Lee Lung cancer is the leading cause of death in the world, and the most common type of lung cancer is non-small-cell lung...
Sat Jun 13, 2020 03:00
IJMS, Vol. 21, Pages 4217: Transcriptome, Spliceosome and Editome Expression Patterns of the Porcine Endometrium in Response to a Single Subclinical Dose of Salmonella Enteritidis Lipopolysaccharide International Journal of Molecular Sciences doi: 10.3390/ijms21124217 Authors: Lukasz Paukszto Anita Mikolajczyk Jan P. Jastrzebski Marta Majewska Kamil Dobrzyn Marta Kiezun Nina Smolinska Tadeusz Kaminski Endometrial infections at a young age can lead to fertility issues...
Sat Jun 13, 2020 03:00
IJMS, Vol. 21, Pages 4216: Hepatoma-Derived Growth Factor: An Overview and Its Role as a Potential Therapeutic Target Molecule for Digestive Malignancies International Journal of Molecular Sciences doi: 10.3390/ijms21124216 Authors: Hirayuki Enomoto Hideji Nakamura Hiroki Nishikawa Shuhei Nishiguchi Hiroko Iijima Hepatoma-derived growth factor (HDGF) was identified in research seeking to find a novel growth factor for hepatoma cells. Subsequently, four HDGF-related proteins...
Sat Jun 13, 2020 03:00
IJMS, Vol. 21, Pages 4214: Pleiotropic Role of Notch Signaling in Human Skin Diseases International Journal of Molecular Sciences doi: 10.3390/ijms21124214 Authors: Rossella Gratton Paola Maura Tricarico Chiara Moltrasio Ana Sofia Lima Estevão de Oliveira Lucas Brandão Angelo Valerio Marzano Luisa Zupin Sergio Crovella Notch signaling orchestrates the regulation of cell proliferation, differentiation, migration and apoptosis of epidermal cells by strictly interacting...
Sat Jun 13, 2020 03:00
IJMS, Vol. 21, Pages 4213: Augmentation of Bone Regeneration by Depletion of Stress-Induced Senescent Cells Using Catechin and Senolytics International Journal of Molecular Sciences doi: 10.3390/ijms21124213 Authors: Yoshitomo Honda Anqi Huang Tomonari Tanaka Xiaoyu Han Beiyuan Gao Haitao Liu Xinchen Wang Jianxin Zhao Yoshiya Hashimoto Kazuyo Yamamoto Naoyuki Matsumoto Shunsuke Baba Makoto Umeda Despite advances in bone regenerative medicine, the relationship...
Sat Jun 13, 2020 03:00
IJMS, Vol. 21, Pages 4212: Identification of Substrates of Cytoplasmic Peptidyl-Prolyl Cis/Trans Isomerases and Their Collective Essentiality in Escherichia coli International Journal of Molecular Sciences doi: 10.3390/ijms21124212 Authors: Gracjana Klein Pawel Wojtkiewicz Daria Biernacka Anna Stupak Patrycja Gorzelak Satish Raina Protein folding often requires molecular chaperones and folding catalysts, such as peptidyl-prolyl cis/trans isomerases (PPIs). The Escherichia...
Sat Jun 13, 2020 03:00
IJMS, Vol. 21, Pages 4210: β3-Adrenoreceptor Blockade Reduces Hypoxic Myeloid Leukemic Cells Survival and Chemoresistance International Journal of Molecular Sciences doi: 10.3390/ijms21124210 Authors: Maura Calvani Annalisa Dabraio Gennaro Bruno Veronica De Gregorio Marcella Coronnello Costanza Bogani Sara Ciullini Giancarlo la Marca Marina Vignoli Paola Chiarugi Margherita Nardi Alessandro Maria Vannucchi Luca Filippi Claudio Favre β-adrenergic...
Fri Jun 12, 2020 03:00
IJMS, Vol. 21, Pages 4209: The Recent Progress in Nanotoxicology and Nanosafety from the Point of View of Both Toxicology and Ecotoxicology International Journal of Molecular Sciences doi: 10.3390/ijms21124209 Authors: Wu Ho Wang Wang This editorial aims to summarize the 14 scientific papers contributed to the Special Issue “Nanotoxicology and nanosafety 2.0 from the point of view of both toxicology and ecotoxicology”.
Fri Jun 12, 2020 03:00
IJMS, Vol. 21, Pages 4211: Targeted Metabolomic Analysis of a Mucopolysaccharidosis IIIB Mouse Model Reveals an Imbalance of Branched-Chain Amino Acid and Fatty Acid Metabolism International Journal of Molecular Sciences doi: 10.3390/ijms21124211 Authors: Valeria De De Pasquale Marianna Caterino Michele Costanzo Roberta Fedele Margherita Ruoppolo Luigi Michele Pavone Mucopolysaccharidoses (MPSs) are inherited disorders of the glycosaminoglycan (GAG) metabolism. The defective...
Fri Jun 12, 2020 03:00
IJMS, Vol. 21, Pages 4208: Comparing a Query Compound with Drug Target Classes Using 3D-Chemical Similarity International Journal of Molecular Sciences doi: 10.3390/ijms21124208 Authors: Sang-Hyeok Lee Sangjin Ahn Mi-hyun Kim 3D similarity is useful in predicting the profiles of unprecedented molecular frameworks that are 2D dissimilar to known compounds. When comparing pairs of compounds, 3D similarity of the pairs depends on conformational sampling, the alignment method, the...
Fri Jun 12, 2020 03:00
IJMS, Vol. 21, Pages 4206: Pre-Growth Culture Conditions Affect Type 1 Fimbriae-Dependent Adhesion of Salmonella International Journal of Molecular Sciences doi: 10.3390/ijms21124206 Authors: Beata Klasa Anna Ewa Kędzierska Krzysztof Grzymajło Among various fimbrial structures used by Salmonella enterica to colonize host tissues, type 1 fimbriae (T1F) are among the most extensively studied. Although some experiments have shown the importance of T1F in the initial stages of Salmonella...
Fri Jun 12, 2020 03:00
IJMS, Vol. 21, Pages 4207: Insight into the Regulatory Relationships between the Insulin-Like Androgenic Gland Hormone Gene and the Insulin-Like Androgenic Gland Hormone-binding Protein Gene in Giant Freshwater Prawns (Macrobrachium rosenbergii) International Journal of Molecular Sciences doi: 10.3390/ijms21124207 Authors: Guang Yang Zhijie Lu Zhendong Qin Lijuan Zhao Gan Pan Haiyang Shen Menglan Zhang Rishen Liang Li Lin Kai Zhang Giant freshwater prawns (Macrobrachium...
Fri Jun 12, 2020 03:00
IJMS, Vol. 21, Pages 4205: Molecular Interactions Stabilizing the Promatrix Metalloprotease-9·Serglycin Heteromer International Journal of Molecular Sciences doi: 10.3390/ijms21124205 Authors: Rangita Dawadi Nabin Malla Beate Hegge Imin Wushur Eli Berg Gunbjørg Svineng Ingebrigt Sylte Jan-Olof Winberg Previous studies have shown that THP-1 cells produced an SDS-stable and reduction-sensitive complex between proMMP-9 and a chondroitin sulfate proteoglycan (CSPG) core...
Fri Jun 12, 2020 03:00
IJMS, Vol. 21, Pages 4203: Bright Fluorescent Vacuolar Marker Lines Allow Vacuolar Tracing Across Multiple Tissues and Stress Conditions in Rice International Journal of Molecular Sciences doi: 10.3390/ijms21124203 Authors: Yiran Cao Wenguo Cai Xiaofei Chen Mingjiao Chen Jianjun Chu Wanqi Liang Staffan Persson Zengyu Liu Dabing Zhang The vacuole is indispensable for cells to maintain their water potential and to respond to environmental changes. Nevertheless,...
Fri Jun 12, 2020 03:00
IJMS, Vol. 21, Pages 4204: Cartilage Trauma Induces Necroptotic Chondrocyte Death and Expulsion of Cellular Contents International Journal of Molecular Sciences doi: 10.3390/ijms21124204 Authors: Josef Stolberg-Stolberg Meike Sambale Uwe Hansen Alexandra Schäfer Michael Raschke Jessica Bertrand Thomas Pap Joanna Sherwood Necroptotic cell death is characterized by an activation of RIPK3 and MLKL that leads to plasma membrane permeabilization and the release of immunostimulatory...
Fri Jun 12, 2020 03:00
IJMS, Vol. 21, Pages 4201: In Vivo Metabolic Regulation of Alternative Oxidase under Nutrient Deficiency—Interaction with Arbuscular Mycorrhizal Fungi and Rhizobium Bacteria International Journal of Molecular Sciences doi: 10.3390/ijms21124201 Authors: José Ortíz Carolina Sanhueza Antònia Romero-Munar Javier Castro Luisa Bascuñán-Godoy Teodoro Coba de la Peña Miguel López-Gómez Igor Florez-Sarasa Néstor Del-Saz The interaction of the alternative oxidase (AOX)...
Fri Jun 12, 2020 03:00
IJMS, Vol. 21, Pages 4202: Impaired Expression of Chloroplast HSP90C Chaperone Activates Plant Defense Responses with a Possible Link to a Disease-Symptom-Like Phenotype International Journal of Molecular Sciences doi: 10.3390/ijms21124202 Authors: Shaikhul Islam Sachin Ashok Bhor Keisuke Tanaka Hikaru Sakamoto Takashi Yaeno Hidetaka Kaya Kappei Kobayashi RNA-seq analysis of a transgenic tobacco plant, i-hpHSP90C, in which chloroplast HSP90C genes can be silenced in...
Fri Jun 12, 2020 03:00
IJMS, Vol. 21, Pages 4200: Role of Oxidative Stress in the Genesis of Ventricular Arrhythmias International Journal of Molecular Sciences doi: 10.3390/ijms21124200 Authors: Adriana Adameova Anureet K. Shah Naranjan S. Dhalla Ventricular arrhythmias, mainly lethal arrhythmias, such as ventricular tachycardia and fibrillation, may lead to sudden cardiac death. These are triggered as a result of cardiac injury due to chronic ischemia, acute myocardial infarction and various stressful...
Fri Jun 12, 2020 03:00
IJMS, Vol. 21, Pages 4199: CCR5-Mediated Signaling Is Involved in Invasion of Glioblastoma Cells in Its Microenvironment International Journal of Molecular Sciences doi: 10.3390/ijms21124199 Authors: Novak Koprivnikar Krajnc Hrastar Breznik Majc Mlinar Rotter Porčnik Mlakar Stare Pestell Lah Turnšek The chemokine CCL5/RANTES is a versatile inflammatory mediator, which interacts with the receptor CCR5, promoting cancer cell interactions within...
Fri Jun 12, 2020 03:00
IJMS, Vol. 21, Pages 4198: Discovery of the Involvement in DNA Oxidative Damage of Human Sperm Nuclear Basic Proteins of Healthy Young Men Living in Polluted Areas International Journal of Molecular Sciences doi: 10.3390/ijms21124198 Authors: Gennaro Lettieri Giovanni D’Agostino Elena Mele Carolina Cardito Rosa Esposito Annalinda Cimmino Antonella Giarra Marco Trifuoggi Salvatore Raimondo Tiziana Notari Ferdinando Febbraio Luigi Montano Marina Piscopo ...
Fri Jun 12, 2020 03:00
IJMS, Vol. 21, Pages 4194: UV-Pre-Treated and Protein-Adsorbed Titanium Implants Exhibit Enhanced Osteoconductivity International Journal of Molecular Sciences doi: 10.3390/ijms21124194 Authors: Yoshihiko Sugita Juri Saruta Takashi Taniyama Hiroaki Kitajima Makoto Hirota Takayuki Ikeda Takahiro Ogawa Titanium materials are essential treatment modalities in the medical field and serve as a tissue engineering scaffold and coating material for medical devices. Thus, there...
Fri Jun 12, 2020 03:00
IJMS, Vol. 21, Pages 4196: The Role of Deubiquitinating Enzymes in the Various Forms of Autophagy International Journal of Molecular Sciences doi: 10.3390/ijms21124196 Authors: Tamás Csizmadia Péter Lőw Deubiquitinating enzymes (DUBs) have an essential role in several cell biological processes via removing the various ubiquitin patterns as posttranslational modification forms from the target proteins. These enzymes also contribute to the normal cytoplasmic ubiquitin pool during the...
Fri Jun 12, 2020 03:00
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