Biomolecules, Vol. 10, Pages 898: Transcriptomically Revealed Oligo-Fucoidan Enhances the Immune System and Protects Hepatocytes via the ASGPR/STAT3/HNF4A Axis Biomolecules doi: 10.3390/biom10060898 Authors: Chun-Chia Cheng Wan-Yu Yang Ming-Chen Hsiao Kuan-Hao Lin Hao-Wei Lee Chiou-Hwa Yuh Oligo-fucoidan, a sulfated polysaccharide extracted from brown seaweed, exhibits anti-inflammatory and anti-tumor effects. However, the knowledge concerning the detailed mechanism of...
Fri Jun 12, 2020 03:00
Biomolecules, Vol. 10, Pages 897: Agricultural Use of Copper and Its Link to Alzheimer’s Disease Biomolecules doi: 10.3390/biom10060897 Authors: Coelho Squitti Ventriglia Cerchiaro Daher Rocha Rongioletti Moonen Copper is an essential nutrient for plants, animals, and humans because it is an indispensable component of several essential proteins and either lack or excess are harmful to human health. Recent studies revealed that the breakdown of the regulation...
Fri Jun 12, 2020 03:00
Brain Sciences, Vol. 10, Pages 370: Relationship between Auditory Evoked Potentials and Circadian Preference in Patients with Major Depressive Episodes Brain Sciences doi: 10.3390/brainsci10060370 Authors: Young-Min Park Mood disorders often accompany circadian rhythm abnormalities. The serotonergic system (STS) is related to mood and circadian rhythm. This study aimed to test whether serotonergic neurotransmission, using the loudness dependence of auditory evoked potential (LDAEP),...
Fri Jun 12, 2020 03:00
Brain Sciences, Vol. 10, Pages 369: Pathophysiological Mechanisms of Cognitive Impairment and Neurodegeneration by Toxoplasma gondii Infection Brain Sciences doi: 10.3390/brainsci10060369 Authors: Gloria Ortiz-Guerrero Rodrigo E. Gonzalez-Reyes Alejandra de-la-Torre German Medina-Rincón Mauricio O. Nava-Mesa Toxoplasma gondii is an obligate intracellular parasite considered one of the most successful pathogens in the world, owing to its ability to produce long-lasting infections...
Fri Jun 12, 2020 03:00
Brain Sciences, Vol. 10, Pages 368: The Effects of the Early Start Denver Model for Children with Autism Spectrum Disorder: A Meta-Analysis Brain Sciences doi: 10.3390/brainsci10060368 Authors: Elizabeth A. Fuller Kelsey Oliver Sarah F. Vejnoska Sally J. Rogers This meta-analysis examined the effects of the Early Start Denver Model (ESDM) for young children with autism on developmental outcome measures. The 12 included studies reported results from 640 children with autism across...
Fri Jun 12, 2020 03:00
Brain Sciences, Vol. 10, Pages 367: Silence, Solitude, and Serotonin: Neural Mechanisms Linking Hearing Loss and Social Isolation Brain Sciences doi: 10.3390/brainsci10060367 Authors: Keesom Hurley For social animals that communicate acoustically, hearing loss and social isolation are factors that independently influence social behavior. In human subjects, hearing loss may also contribute to objective and subjective measures of social isolation. Although the behavioral relationship...
Fri Jun 12, 2020 03:00
Brain Sciences, Vol. 10, Pages 366: Variations in Values of State, Response Entropy and Haemodynamic Parameters Associated with Development of Different Epileptiform Patterns during Volatile Induction of General Anaesthesia with Two Different Anaesthetic Regimens Using Sevoflurane in Comparison with Intravenous Induct: A Comparative Study Brain Sciences doi: 10.3390/brainsci10060366 Authors: Stasiowski Duława Szumera Marciniak Niewiadomska Kaspera Krawczyk Ładziński...
Fri Jun 12, 2020 03:00
Brain Sciences, Vol. 10, Pages 365: Postnatal Guinea Pig Brain Development, as Revealed by Magnetic Resonance and Diffusion Kurtosis Imaging Brain Sciences doi: 10.3390/brainsci10060365 Authors: Roger J. Mullins Su Xu Jiachen Zhuo Steve Roys Edna F.R. Pereira Edson X. Albuquerque Rao P. Gullapalli This study used in vivo magnetic resonance imaging (MRI) to identify age dependent brain structural characteristics in Dunkin Hartley guinea pigs. Anatomical T2-weighted images,...
Fri Jun 12, 2020 03:00
Cancers, Vol. 12, Pages 1574: Cotargeting of XPO1 Enhances the Antileukemic Activity of Midostaurin and Gilteritinib in Acute Myeloid Leukemia Cancers doi: 10.3390/cancers12061574 Authors: Lindsey T. Brinton Steven Sher Katie Williams Daniel Canfield Shelley Orwick Ronni Wasmuth Casey Cempre Jordan Skinner Amy Lehman James S. Blachly John C. Byrd Rosa Lapalombella Acute myeloid leukemia (AML) is a hematopoietic stem-cell-derived leukemia with often successive...
Sun Jun 14, 2020 03:00
Cancers, Vol. 12, Pages 1573: New Therapeutics in HER2-Positive Advanced Breast Cancer: Towards a Change in Clinical Practices?pi Cancers doi: 10.3390/cancers12061573 Authors: Mezni Vicier Guerin Sabatier Bertucci Gonçalves Over the last few decades, improved knowledge of oncogenic activation mechanisms of HER2 protein has led to the development of HER2 targeted therapies that are currently commonly used in HER2-positive advanced breast cancer, such as trastuzumab,...
Sun Jun 14, 2020 03:00
Cancers, Vol. 12, Pages 1572: Quantitative Analysis of Differential Expression of HOX Genes in Multiple Cancers Cancers doi: 10.3390/cancers12061572 Authors: Orit Adato Yaron Orenstein Juri Kopolovic Tamar Juven-Gershon Ron Unger Transcription factors encoded by Homeobox (HOX) genes play numerous key functions during early embryonic development and differentiation. Multiple reports have shown that mis-regulation of HOX gene expression plays key roles in the development of...
Sun Jun 14, 2020 03:00
Cancers, Vol. 12, Pages 1571: BRAF Mutated Colorectal Cancer: New Treatment Approaches Cancers doi: 10.3390/cancers12061571 Authors: Javier Molina-Cerrillo María San Román Javier Pozas Teresa Alonso-Gordoa Miguel Pozas Elisa Conde Marta Rosas Enrique Grande María Laura García-Bermejo Alfredo Carrato Colon cancer is one of the most frequently diagnosed malignancies in adults, considering both its incidence and prevalence. Anatomically, the right colon is considered...
Sun Jun 14, 2020 03:00
Cancers, Vol. 12, Pages 1570: Src Inhibitors Pyrazolo[3,4-d]pyrimidines, Si306 and Pro-Si306, Inhibit Focal Adhesion Kinase and Suppress Human Glioblastoma Invasion In Vitro and In Vivo Cancers doi: 10.3390/cancers12061570 Authors: Marija Nešović Aleksandra Divac Rankov Ana Podolski-Renić Igor Nikolić Goran Tasić Arianna Mancini Silvia Schenone Milica Pešić Jelena Dinić Glioblastoma (GBM), as the most aggressive brain tumor, displays a high expression of Src tyrosine...
Sun Jun 14, 2020 03:00
Cancers, Vol. 12, Pages 1567: Role and Therapeutic Potential of Melatonin in the Central Nervous System and Cancers Cancers doi: 10.3390/cancers12061567 Authors: Gurunathan Kang Kim Melatonin (MLT) is a powerful chronobiotic hormone that controls a multitude of circadian rhythms at several levels and, in recent times, has garnered considerable attention both from academia and industry. In several studies, MLT has been discussed as a potent neuroprotectant, anti-apoptotic, anti-inflammatory,...
Sat Jun 13, 2020 03:00
Cancers, Vol. 12, Pages 1568: Well-Differentiated Papillary Mesothelioma of the Peritoneum Is Genetically Distinct from Malignant Mesothelioma Cancers doi: 10.3390/cancers12061568 Authors: Raunak Shrestha Noushin Nabavi Stanislav Volik Shawn Anderson Anne Haegert Brian McConeghy Funda Sar Sonal Brahmbhatt Robert Bell Stephane Le Bihan Yuzhuo Wang Colin Collins Andrew Churg Well-differentiated papillary mesothelioma (WDPM) is an uncommon mesothelial...
Sat Jun 13, 2020 03:00
Cancers, Vol. 12, Pages 1566: Circulating Tumor DNA as a Novel Biomarker Optimizing Chemotherapy for Colorectal Cancer Cancers doi: 10.3390/cancers12061566 Authors: Hiroki Osumi Eiji Shinozaki Kensei Yamaguchi Liquid biopsy is a minimally invasive method for detecting soluble factors, including circulating tumor DNA (ctDNA), in body fluids. ctDNA carrying tumor-specific genetic or epigenetic alterations is released into circulation from tumor cells. ctDNA in the plasma contains...
Sat Jun 13, 2020 03:00
Cancers, Vol. 12, Pages 1569: Circulating Plasma Gelsolin: A Predictor of Favorable Clinical Outcomes in Head and Neck Cancer and Sensitive Biomarker for Early Disease Diagnosis Combined with Soluble Fas Ligand Cancers doi: 10.3390/cancers12061569 Authors: Chen-Tzu Chiu Pei-Wen Wang Meshach Asare-Werehene Benjamin K. Tsang Dar-Bin Shieh Head and neck cancer (HNC) accounts for more than 330,000 cancer deaths annually worldwide. Despite late diagnosis being a major factor contributing...
Sat Jun 13, 2020 03:00
Cancers, Vol. 12, Pages 1564: What Are Young Women Living Conditions after Breast Cancer? Health-Related Quality of Life, Sexual and Fertility Issues, Professional Reinsertion Cancers doi: 10.3390/cancers12061564 Authors: Emerline L. F. Assogba Ariane Mamguem Kamga Helène Costaz Clémentine Jankowski Agnès Dumas Patrick Roignot Geneviève Jolimoy Charles Coutant Patrick Arveux Tienhan Sandrine Dabakuyo-Yonli In recent decades, the living conditions of young breast...
Fri Jun 12, 2020 03:00
Cancers, Vol. 12, Pages 1565: Management of Drug Resistance in Mantle Cell Lymphoma Cancers doi: 10.3390/cancers12061565 Authors: Gaël Roué Brigitte Sola Mantle cell lymphoma (MCL) is a rare but aggressive B-cell hemopathy characterized by the translocation t(11;14)(q13;q32) that leads to the overexpression of the cell cycle regulatory protein cyclin D1. This translocation is the initial event of the lymphomagenesis, but tumor cells can acquire additional alterations allowing the...
Fri Jun 12, 2020 03:00
Cancers, Vol. 12, Pages 1562: Novel Molecular Targets for Tumor-Specific Imaging of Epithelial Ovarian Cancer Metastases Cancers doi: 10.3390/cancers12061562 Authors: Lysanne D.A.N. de Muynck Katja N. Gaarenstroom Cornelis F.M. Sier Maurice van Duijvenvoorde Tjalling Bosse J. Sven D. Mieog Cornelis D. de Kroon Alexander L. Vahrmeijer Inge T.A. Peters In epithelial ovarian cancer (EOC), the strongest prognostic factor is the completeness of surgery. Intraoperative...
Fri Jun 12, 2020 03:00
Cancers, Vol. 12, Pages 1561: Radiation-Induced Lung Fibrosis: Preclinical Animal Models and Therapeutic Strategies Cancers doi: 10.3390/cancers12061561 Authors: Hee Jin Youngjo Yoo Younghwa Kim Yeijin Kim Jaeho Cho Yun-Sil Lee Radiation-induced lung injury (RILI), including acute radiation pneumonitis and chronic radiation-induced lung fibrosis, is the most common side effect of radiation therapy. RILI is a complicated process that causes the accumulation, proliferation,...
Fri Jun 12, 2020 03:00
Cancers, Vol. 12, Pages 1560: New Use for Old Drugs: The Protective Effect of Risperidone on Colorectal Cancer Cancers doi: 10.3390/cancers12061560 Authors: Vincent Chin-Hung Chen Yi-Hsuan Hsieh Tzu-Chin Lin Mong-Liang Lu Yin-To Liao Yao-Hsu Yang Tsai-Ching Hsu Robert Stewart Jun-Cheng Weng Min-Jing Lee Wei-Che Chiu Bor-Show Tzang Background: The potential of old drugs in novel indications is being greatly valued. We propose a triple-model study involving...
Fri Jun 12, 2020 03:00
Cancers, Vol. 12, Pages 1563: Restoration of MHC-I on Tumor Cells by Fhit Transfection Promotes Immune Rejection and Acts as an Individualized Immunotherapeutic Vaccine Cancers doi: 10.3390/cancers12061563 Authors: María Pulido Virginia Chamorro Irene Romero Ignacio Algarra Alba S-Montalvo Antonia Collado Federico Garrido Angel M. Garcia-Lora The capacity of cytotoxic-T lymphocytes to recognize and destroy tumor cells depends on the surface expression by tumor cells...
Fri Jun 12, 2020 03:00
Cancers, Vol. 12, Pages 1553: Tissue-Resident NK Cells: Development, Maturation, and Clinical Relevance Cancers doi: 10.3390/cancers12061553 Authors: Elaheh Hashemi Subramaniam Malarkannan Natural killer (NK) cells belong to type 1 innate lymphoid cells (ILC1) and are essential in killing infected or transformed cells. NK cells mediate their effector functions using non-clonotypic germ-line-encoded activation receptors. The utilization of non-polymorphic and conserved activating receptors...
Fri Jun 12, 2020 03:00
Cancers, Vol. 12, Pages 1558: SRC Kinase in Glioblastoma News from an Old Acquaintance Cancers doi: 10.3390/cancers12061558 Authors: Claudia Cirotti Claudia Contadini Daniela Barilà Glioblastoma multiforme (GBM) is one of the most recalcitrant brain tumors characterized by a tumor microenvironment (TME) that strongly supports GBM growth, aggressiveness, invasiveness, and resistance to therapy. Importantly, a common feature of GBM is the aberrant activation...
Fri Jun 12, 2020 03:00
Cancers, Vol. 12, Pages 1557: Personalised Dosimetry in Radioembolisation for HCC: Impact on Clinical Outcome and on Trial Design Cancers doi: 10.3390/cancers12061557 Authors: Etienne Garin Xavier Palard Yan Rolland Selective internal radiation therapy (SIRT) of hepatocellular carcinoma (HCC) has been used for many years, usually without any specific dosimetry endpoint. Despite good clinical results in early phase studies or in cohort studies, three randomized trials in locally...
Fri Jun 12, 2020 03:00
Cancers, Vol. 12, Pages 1556: Optimization of the Enrichment of Circulating Tumor Cells for Downstream Phenotypic Analysis in Patients with Non-Small Cell Lung Cancer Treated with Anti-PD-1 Immunotherapy Cancers doi: 10.3390/cancers12061556 Authors: Maria A Papadaki Afroditi I Sotiriou Christina Vasilopoulou Maria Filika Despoina Aggouraki Panormitis G Tsoulfas Christina A Apostolopoulou Konstantinos Rounis Dimitrios Mavroudis Sofia Agelaki The current study...
Fri Jun 12, 2020 03:00
Cancers, Vol. 12, Pages 1555: Proteomic Profiling of Retinoblastoma-Derived Exosomes Reveals Potential Biomarkers of Vitreous Seeding Cancers doi: 10.3390/cancers12061555 Authors: Angela Galardi Marta Colletti Chiara Lavarello Virginia Di Paolo Paolo Mascio Ida Russo Raffaele Cozza Antonino Romanzo Paola Valente Rita De Vito Luisa Pascucci Hector Peinado Angel M. Carcaboso Andrea Petretto Franco Locatelli Angela Di Giannatale Retinoblastoma...
Fri Jun 12, 2020 03:00
Cancers, Vol. 12, Pages 1554: Monoclonal Gammopathy of Undetermined Significance (MGUS)—Not So Asymptomatic after All Cancers doi: 10.3390/cancers12061554 Authors: Oliver C. Lomas Tarek H. Mouhieddine Sabrin Tahri Irene M. Ghobrial Monoclonal Gammopathy of Undetermined Significance (MGUS) is considered to be a benign precursor condition that may progress to a lymphoproliferative disease or multiple myeloma. Most patients do not progress to an overt condition, but nevertheless,...
Fri Jun 12, 2020 03:00
Cancers, Vol. 12, Pages 1559: Unraveling the Genomic-Epigenomic Interaction Landscape in Triple Negative and Non-Triple Negative Breast Cancer Cancers doi: 10.3390/cancers12061559 Authors: Jiande Wu Tarun Karthik Kumar Mamidi Lu Zhang Chindo Hicks Background: The recent surge of next generation sequencing of breast cancer genomes has enabled development of comprehensive catalogues of somatic mutations and expanded the molecular classification of subtypes of breast cancer. However,...
Fri Jun 12, 2020 03:00
Cancers, Vol. 12, Pages 1549: Integrated Analysis of Key Differentially Expressed Genes Identifies DBN1 as a Predictive Marker of Response to Endocrine Therapy in Luminal Breast Cancer Cancers doi: 10.3390/cancers12061549 Authors: Alfarsi El Ansari Masisi Parks Mohammed Ellis Rakha Green Endocrine therapy is the mainstay of adjuvant treatment for patients with luminal breast cancer. Despite ongoing advances in endocrine therapy to date, a proportion of patients...
Fri Jun 12, 2020 03:00
Cancers, Vol. 12, Pages 1551: Low-Dose Aspirin Use Significantly Improves the Survival of Late-stage NPC: A Propensity Score-Matched Cohort Study in Taiwan Cancers doi: 10.3390/cancers12061551 Authors: Luo Chen Wu Yang Li Fang Huang Wang Chiu Wu Background: Aspirin use has been associated with improved survival rates in various cancers. However, it remains unclear if aspirin confers a survival benefit on patients with nasopharyngeal carcinoma (NPC)....
Fri Jun 12, 2020 03:00
Cancers, Vol. 12, Pages 1547: Reciprocal Regulation Between Indoleamine 2,3-Dioxigenase 1 and Notch1 Involved in Radiation Response of Cervical Cancer Stem Cells Cancers doi: 10.3390/cancers12061547 Authors: Low Lee Lee Wang Chen Chien Li Chang Cervical cancer is the fourth most common cancer in women around the world. Cancer stem cells (CSCs) are responsible for cancer initiation, as well as resistance to radiation therapy, and are considered as the effective...
Fri Jun 12, 2020 03:00
Cancers, Vol. 12, Pages 1550: Clinical Applications of Molecular Biomarkers in Prostate Cancer Cancers doi: 10.3390/cancers12061550 Authors: Couñago López-Campos Díaz-Gavela Almagro Fenández-Pascual Henríquez Lozano Linares Espinós Gómez-Iturriaga de Velasco Quintana Franco Rodríguez-Melcón López-Torrecilla Spratt Guerrero Martínez-Salamanca del Cerro There is clinically relevant molecular heterogeneity in prostate cancer...
Fri Jun 12, 2020 03:00
Cancers, Vol. 12, Pages 1548: Protein Stability of Pyruvate Kinase Isozyme M2 Is Mediated by HAUSP Cancers doi: 10.3390/cancers12061548 Authors: Hae-Seul Choi Chang-Zhu Pei Jun-Hyeok Park Soo-Yeon Kim Seung-Yeon Song Gyeong-Jin Shin Kwang-Hyun Baek The ubiquitin–proteasome system (UPS) is responsible for proteasomal degradation, regulating the half-life of the protein. Deubiquitinating enzymes (DUBs) are components of the UPS and inhibit degradation by removing...
Fri Jun 12, 2020 03:00
Cancers, Vol. 12, Pages 1552: Should the Number of Metastatic Pelvic Lymph Nodes be Integrated into the 2018 Figo Staging Classification of Early Stage Cervical Cancer? Cancers doi: 10.3390/cancers12061552 Authors: Luigi Pedone Anchora Vittoria Carbone Valerio Gallotta Francesco Fanfani Francesco Cosentino Luigi Carlo Turco Camilla Fedele Nicolò Bizzarri Giovanni Scambia Gabriella Ferrandina Introduction: Lymph node status has become part of the new staging...
Fri Jun 12, 2020 03:00
Cancers, Vol. 12, Pages 1546: Radiation Dose Escalation is Crucial in Anti-CTLA-4 Antibody Therapy to Enhance Local and Distant Antitumor Effect in Murine Osteosarcoma Cancers doi: 10.3390/cancers12061546 Authors: Takenaka Takahashi Tamari Minami Katsuki Seo Isohashi Koizumi Ogawa We previously reported that a combination of 10 Gy of X-ray irradiation and dual immune checkpoint blockade with anti-CTLA-4 (C4) and anti-PD-L1 antibodies produced a significant...
Fri Jun 12, 2020 03:00
Cells, Vol. 9, Pages 1462: TAZ Controls Helicobacter pylori-Induced Epithelial–Mesenchymal Transition and Cancer Stem Cell-Like Invasive and Tumorigenic Properties Cells doi: 10.3390/cells9061462 Authors: Camille Tiffon Julie Giraud Silvia Elena Molina-Castro Sara Peru Lornella Seeneevassen Elodie Sifré Cathy Staedel Emilie Bessède Pierre Dubus Francis Mégraud Philippe Lehours Océane C.B. Martin Christine Varon Helicobacter pylori infection, the main...
Sat Jun 13, 2020 03:00
Cells, Vol. 9, Pages 1461: Reaction Cycles of Halogen Species in the Immune Defense: Implications for Human Health and Diseases and the Pathology and Treatment of COVID-19 Cells doi: 10.3390/cells9061461 Authors: Lu There is no vaccine or specific antiviral treatment for COVID-19, which is causing a global pandemic. One current focus is drug repurposing research, but those drugs have limited therapeutic efficacies and known adverse effects. The pathology of COVID-19 is essentially unknown....
Sat Jun 13, 2020 03:00
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