IJMS, Vol. 21, Pages 4195: From Single Cell to Plants: Mesophyll Protoplasts as a Versatile System for Investigating Plant Cell Reprogramming International Journal of Molecular Sciences doi: 10.3390/ijms21124195 Authors: Pasternak Lystvan Betekhtin Hasterok Plants are sessile organisms that have a remarkable developmental plasticity, which ensures their optimal adaptation to environmental stresses. Plant cell totipotency is an extreme example of such plasticity, whereby...
Fri Jun 12, 2020 03:00
IJMS, Vol. 21, Pages 4197: Recombinant Adeno-Associated Viral Vectors (rAAV)-Vector Elements in Ocular Gene Therapy Clinical Trials and Transgene Expression and Bioactivity Assays International Journal of Molecular Sciences doi: 10.3390/ijms21124197 Authors: Buck Wijnholds Inherited retinal dystrophies and optic neuropathies cause chronic disabling loss of visual function. The development of recombinant adeno-associated viral vectors (rAAV) gene therapies in all disease fields have...
Fri Jun 12, 2020 03:00
IJMS, Vol. 21, Pages 4192: Silencing Core Spliceosome Sm Gene Expression Induces a Cytotoxic Splicing Switch in the Proteasome Subunit Beta 3 mRNA in Non-Small Cell Lung Cancer Cells International Journal of Molecular Sciences doi: 10.3390/ijms21124192 Authors: Maxime Blijlevens Malgorzata A. Komor Rocco Sciarrillo Egbert F. Smit Remond J. A. Fijneman Victor W. van Beusechem The core spliceosomal Sm proteins were recently proposed as cancer-selective lethal targets in...
Fri Jun 12, 2020 03:00
IJMS, Vol. 21, Pages 4193: Computer-Aided Ligand Discovery for Estrogen Receptor Alpha International Journal of Molecular Sciences doi: 10.3390/ijms21124193 Authors: Bafna Ban Rennie Singh Cherkasov Breast cancer (BCa) is one of the most predominantly diagnosed cancers in women. Notably, 70% of BCa diagnoses are Estrogen Receptor α positive (ERα+) making it a critical therapeutic target. With that, the two subtypes of ER, ERα and ERβ,...
Fri Jun 12, 2020 03:00
IJMS, Vol. 21, Pages 4191: Efflux Pump Inhibitors Against Nontuberculous Mycobacteria International Journal of Molecular Sciences doi: 10.3390/ijms21124191 Authors: Rindi Over the last years, nontuberculous mycobacteria (NTM) have emerged as important human pathogens. Infections caused by NTM are often difficult to treat due to an intrinsic multidrug resistance for the presence of a lipid-rich outer membrane, thus encouraging an urgent need for the development of new drugs for the treatment...
Fri Jun 12, 2020 03:00
IJNS, Vol. 6, Pages 49: Considerations for Newborn Screening for Critical Congenital Heart Disease in Low- and Middle-Income Countries International Journal of Neonatal Screening doi: 10.3390/ijns6020049 Authors: Bistra Zheleva Sreehari M Nair Adriana Dobrzycka Annamarie Saarinen We propose several considerations for implementation of critical congenital heart disease (CCHD) screening for low- and middle-income countries to assess health system readiness for countries that may...
Sun Jun 14, 2020 03:00
JCDD, Vol. 7, Pages 23: Validating the Paradigm That Biomechanical Forces Regulate Embryonic Cardiovascular Morphogenesis and Are Fundamental in the Etiology of Congenital Heart Disease Journal of Cardiovascular Development and Disease doi: 10.3390/jcdd7020023 Authors: Bradley B. Keller William J. Kowalski Joseph P. Tinney Kimimasa Tobita Norman Hu The goal of this review is to provide a broad overview of the biomechanical maturation and regulation of vertebrate cardiovascular...
Fri Jun 12, 2020 03:00
JCM, Vol. 9, Pages 1857: Reliability of Synthetic Brain MRI for Assessment of Ischemic Stroke with Phantom Validation of a Relaxation Time Determination Method Journal of Clinical Medicine doi: 10.3390/jcm9061857 Authors: Chia-Wei Li Ai-Ling Hsu Chi-Wen C. Huang Shih-Hung Yang Chien-Yuan Lin Charng-Chyi Shieh Wing P. Chan The reliability of relaxation time measures in synthetic magnetic resonance images (MRIs) of homemade phantoms were validated, and the diagnostic...
Sun Jun 14, 2020 03:00
JCM, Vol. 9, Pages 1855: Optimal Parameters of Deep Brain Stimulation in Essential Tremor: A Meta-Analysis and Novel Programming Strategy Journal of Clinical Medicine doi: 10.3390/jcm9061855 Authors: I. Daria Bogdan Teus van Laar D.L. Marinus Oterdoom Gea Drost J. Marc C. van Dijk Martijn Beudel The programming of deep brain stimulation (DBS) parameters for tremor is laborious and empirical. Despite extensive efforts, the end-result is often suboptimal. One reason for...
Sun Jun 14, 2020 03:00
JCM, Vol. 9, Pages 1856: Chronic Gastritis Is Associated with a Decreased High-Density Lipid Level: Histological Features of Gastritis Based on the Updated Sydney System Journal of Clinical Medicine doi: 10.3390/jcm9061856 Authors: Dong-Hoon Kim Byoung Kwan Son Kyueng-Whan Min Sang Kuk Han Ji Ung Na Pil Cho Choi Hack-Lyoung Kim Mi Jung Kwon Young Ha Oh Woon Yong Jung Ji-Yong Moon Sangmo Hong Ki-Wook Oh Young Seo Kim Chronic gastritis could activate...
Sun Jun 14, 2020 03:00
JCM, Vol. 9, Pages 1854: Exercise before, during, and after Hospitalization for Allogeneic Hematological Stem Cell Transplant: A Feasibility Randomized Controlled Trial Journal of Clinical Medicine doi: 10.3390/jcm9061854 Authors: Daniel Santa Mina Lianne B. Dolan Jeffrey H. Lipton Darren Au Encarna Camacho Pérez Alyssa Franzese Shabbir M. H. Alibhai Jennifer M. Jones Eugene Chang People with cancer who undergo allogeneic hematological stem cell transplant (allo-HSCT)...
Sun Jun 14, 2020 03:00
JCM, Vol. 9, Pages 1853: Non-Invasive Assessment of Breast Cancer Molecular Subtypes with Multiparametric Magnetic Resonance Imaging Radiomics Journal of Clinical Medicine doi: 10.3390/jcm9061853 Authors: Doris Leithner Marius E. Mayerhoefer Danny F. Martinez Maxine S. Jochelson Elizabeth A. Morris Sunitha B. Thakur Katja Pinker We evaluated the performance of radiomics and artificial intelligence (AI) from multiparametric magnetic resonance imaging (MRI) for the assessment...
Sun Jun 14, 2020 03:00
JCM, Vol. 9, Pages 1852: The Impact of Gastric Juice pH on the Intraluminal Therapy for Helicobacter pylori Infection Journal of Clinical Medicine doi: 10.3390/jcm9061852 Authors: Yu-Chio Wang Yen-Po Chen Cheng-Yu Ho Ting-Wen Liu Cheng-Hsin Chu Horng-Yuan Wang Tai-Cherng Liou Background: Helicobacter pylori (H. pylori) can be topically eradicated in stomach lumen on endoscopic examination. The procedures of intraluminal therapy for H. pylori infection (ILTHPI) include...
Sun Jun 14, 2020 03:00
JCM, Vol. 9, Pages 1851: Involvement of the 14-3-3 Gene Family in Autism Spectrum Disorder and Schizophrenia: Genetics, Transcriptomics and Functional Analyses Journal of Clinical Medicine doi: 10.3390/jcm9061851 Authors: Bàrbara Torrico Ester Antón-Galindo Noèlia Fernàndez-Castillo Eva Rojo-Francàs Sadaf Ghorbani Laura Pineda-Cirera Amaia Hervás Isabel Rueda Estefanía Moreno Janice M. Fullerton Vicent Casadó Jan K. Buitelaar Nanda Rommelse Barbara Franke...
Sat Jun 13, 2020 03:00
JCM, Vol. 9, Pages 1848: SKINREMS—A New Method for Assessment of the Niacin Skin Flush Test Response in Schizophrenia Journal of Clinical Medicine doi: 10.3390/jcm9061848 Authors: Hanna Karakula-Juchnowicz Joanna Rog Piotr Wolszczak Kamil Jonak Ewa Stelmach Paweł Krukow Schizophrenia has been considered a disorder linked with faulty lipid homeostasis, and the proposed tool for assessment of these disruptions is the niacin skin flush test. The aims of the study were: 1....
Sat Jun 13, 2020 03:00
JCM, Vol. 9, Pages 1850: Phase 2 and Later of COVID-19 Lockdown: Is it Possible to Perform Remote Diagnosis and Intervention for Autism Spectrum Disorder? An Online-Mediated Approach Journal of Clinical Medicine doi: 10.3390/jcm9061850 Authors: Antonio Narzisi COVID-19 is still in phase 2. The lockdown has been significantly reduced compared to phase 1. The centers and institutions that deal with the diagnosis and intervention of children with autism spectrum disorder (ASD) require rapid...
Sat Jun 13, 2020 03:00
JCM, Vol. 9, Pages 1849: Effects of Prolonged Type 2 Diabetes on the Inner Retinal Layer and Macular Microvasculature: An Optical Coherence Tomography Angiography Study Journal of Clinical Medicine doi: 10.3390/jcm9061849 Authors: Min-Woo Lee Woo-Hyuk Lee Cheon-Kuk Ryu Tae-Yeon Kim Hyung-Bin Lim Young-Hoon Lee Jung-Yeul Kim Purpose: To identify the effects of prolonged type 2 diabetes (T2DM) on macular microcirculation and the inner retinal layer in diabetic eyes without...
Sat Jun 13, 2020 03:00
JCM, Vol. 9, Pages 1847: Deterioration of Retinal Blood Flow Parameters in Branch Retinal Vein Occlusion Measured by Doppler Optical Coherence Tomography Flowmeter Journal of Clinical Medicine doi: 10.3390/jcm9061847 Authors: Kengo Takahashi Youngseok Song Kenji Sogawa Takafumi Yoshioka Tomofumi Tani Satoshi Ishiko Akitoshi Yoshida Background: Doppler optical coherence tomography (DOCT) flowmeter can be used to measure retinal blood flow (RBF) parameters, including...
Sat Jun 13, 2020 03:00
JCM, Vol. 9, Pages 1846: Altered Cortical Thickness-Based Individualized Structural Covariance Networks in Patients with Schizophrenia and Bipolar Disorder Journal of Clinical Medicine doi: 10.3390/jcm9061846 Authors: Sungkean Kim Yong-Wook Kim Hyeonjin Jeon Chang-Hwan Im Seung-Hwan Lee Structural covariance is described as coordinated variation in brain morphological features, such as cortical thickness and volume, among brain structures functionally or anatomically interconnected...
Sat Jun 13, 2020 03:00
JCM, Vol. 9, Pages 1845: Metatarsal Head Resections in Diabetic Foot Patients: A Systematic Review Journal of Clinical Medicine doi: 10.3390/jcm9061845 Authors: Irene Sanz-Corbalán Aroa Tardáguila-García Josep M. García-Alamino Yolanda García-Álvarez Francisco Javier Álvaro-Afonso José Luis Lázaro-Martínez A systematic review and proportional meta-analysis were carried out to investigate the complications that occur after surgical metatarsal head resection in diabetic...
Sat Jun 13, 2020 03:00
JCM, Vol. 9, Pages 1843: Urinary Dimethylamine (DMA) and Its Precursor Asymmetric Dimethylarginine (ADMA) in Clinical Medicine, in the Context of Nitric Oxide (NO) and Beyond Journal of Clinical Medicine doi: 10.3390/jcm9061843 Authors: Tsikas Asymmetric protein-arginine dimethylation is a major post-translational modification (PTM) catalyzed by protein-arginine methyltransferase (PRMT). Regular proteolysis releases asymmetric dimethylarginine (ADMA). Of the daily produced ADMA, about...
Fri Jun 12, 2020 03:00
JCM, Vol. 9, Pages 1844: High-Throughput MicroRNA Profiling of Vitreoretinal Lymphoma: Vitreous and Serum MicroRNA Profiles Distinct from Uveitis Journal of Clinical Medicine doi: 10.3390/jcm9061844 Authors: Minezaki Usui Asakage Takanashi Shimizu Nezu Narimatsu Tsubota Umazume Yamakawa Kuroda Goto Purpose: Vitreoretinal lymphoma (VRL) is a non-Hodgkin lymphoma of the diffuse large B cell type (DLBCL), which is an aggressive cancer causing...
Fri Jun 12, 2020 03:00
JCM, Vol. 9, Pages 1842: Feasibility of Gynaecologist Led Lynch Syndrome Testing in Women with Endometrial Cancer Journal of Clinical Medicine doi: 10.3390/jcm9061842 Authors: Neil AJ Ryan Louise Donnelly Katie Stocking D Gareth Evans Emma J Crosbie A barrier to Lynch syndrome testing is the need for prior genetic counselling, a resource demanding process for both patients and healthcare services. We explored the impact of gynaecologist led Lynch syndrome testing in women...
Fri Jun 12, 2020 03:00
JCM, Vol. 9, Pages 1841: Characterization of Intervertebral Disc Changes in Asymptomatic Individuals with Distinct Physical Activity Histories Using Three Different Quantitative MRI Techniques Journal of Clinical Medicine doi: 10.3390/jcm9061841 Authors: Daniel L. Belavy Helena Brisby Benjamin Douglas Hanna Hebelka Matthew J. Quittner Patrick J. Owen Timo Rantalainen Guy Trudel Kerstin M. Lagerstrand (1) Background: Assessments of intervertebral disc (IVD) changes,...
Fri Jun 12, 2020 03:00
JCM, Vol. 9, Pages 1839: Deep Learning for Automated Detection of Cyst and Tumors of the Jaw in Panoramic Radiographs Journal of Clinical Medicine doi: 10.3390/jcm9061839 Authors: Hyunwoo Yang Eun Jo Hyung Jun Kim In-ho Cha Young-Soo Jung Woong Nam Jun-Young Kim Jin-Kyu Kim Yoon Hyeon Kim Tae Gyeong Oh Sang-Sun Han Hwiyoung Kim Dongwook Kim Patients with odontogenic cysts and tumors may have to undergo serious surgery unless the lesion is properly...
Fri Jun 12, 2020 03:00
JCM, Vol. 9, Pages 1840: The Accuracy of Jaws Repositioning in Bimaxillary Orthognathic Surgery with Traditional Surgical Planning Compared to Digital Surgical Planning in Skeletal Class III Patients: A Retrospective Observational Study Journal of Clinical Medicine doi: 10.3390/jcm9061840 Authors: Martina Barone Alberto De De Stefani Ugo Baciliero Giovanni Bruno Antonio Gracco Background: Technological progress has led to the transition to digital methods to perform surgical...
Fri Jun 12, 2020 03:00
JCM, Vol. 9, Pages 1837: Effectiveness of Percutaneous Electrolysis in Supraspinatus Tendinopathy: A Single-Blinded Randomized Controlled Trial Journal of Clinical Medicine doi: 10.3390/jcm9061837 Authors: Manuel Rodríguez-Huguet Jorge Góngora-Rodríguez Pablo Rodríguez-Huguet Alfonso Javier Ibañez-Vera Daniel Rodríguez-Almagro Rocío Martín-Valero Ángeles Díaz-Fernández Rafael Lomas-Vega Supraspinatus tendinopathy is one of the most common causes of shoulder pain....
Fri Jun 12, 2020 03:00
JCM, Vol. 9, Pages 1836: Effects of Four-Week Rehabilitation Program on Hemostasis Disorders in Patients with Spinal Cord Injury Journal of Clinical Medicine doi: 10.3390/jcm9061836 Authors: Magdalena Mackiewicz-Milewska Małgorzata Cisowska-Adamiak Danuta Rość Iwona Głowacka-Mrotek Iwona Świątkiewicz Background: Patients with spinal cord injury (SCI) exhibit hemostasis disorders. This study aims at assessing the effects of a 4-week rehabilitation program on hemostasis disorders...
Fri Jun 12, 2020 03:00
JCM, Vol. 9, Pages 1838: Differential Expression of MicroRNAs in Silent and Functioning Corticotroph Tumors Journal of Clinical Medicine doi: 10.3390/jcm9061838 Authors: Araceli García-Martínez Antonio C. Fuentes-Fayos Carmen Fajardo Cristina Lamas Rosa Cámara Beatriz López-Muñoz Ignacio Aranda Raúl M. Luque Antonio Picó The potential role of miRNAs in the silencing mechanisms of pituitary neuroendocrine tumors (PitNETs) has not been addressed. The aim of the...
Fri Jun 12, 2020 03:00
JCM, Vol. 9, Pages 1834: Serum Klotho in Living Kidney Donors and Kidney Transplant Recipients: A Meta-Analysis Journal of Clinical Medicine doi: 10.3390/jcm9061834 Authors: Charat Thongprayoon Javier A. Neyra Panupong Hansrivijit Juan Medaura Napat Leeaphorn Paul W. Davis Wisit Kaewput Tarun Bathini Sohail Abdul Salim Api Chewcharat Narothama Reddy Aeddula Saraschandra Vallabhajosyula Michael A. Mao Wisit Cheungpasitporn α-Klotho is a...
Fri Jun 12, 2020 03:00
JCM, Vol. 9, Pages 1835: Should We Perform Old-for-Old Kidney Transplantation during the COVID-19 Pandemic? The Risk for Post-Operative Intensive Stay Journal of Clinical Medicine doi: 10.3390/jcm9061835 Authors: Philip Zeuschner Urban Sester Michael Stöckle Matthias Saar Ilias Zompolas Nasrin El‑Bandar Lutz Liefeldt Klemens Budde Robert Öllinger Paul Ritschl Thorsten Schlomm Janine Mihm Frank Friedersdorff Health care systems worldwide have been facing...
Fri Jun 12, 2020 03:00
JCM, Vol. 9, Pages 1833: Recommendations for Dental Care during COVID-19 Pandemic Journal of Clinical Medicine doi: 10.3390/jcm9061833 Authors: Katarzyna Gurzawska-Comis Kathrin Becker Giulia Brunello Agata Gurzawska Frank Schwarz Dental clinics were suspected to be a hotspot for nosocomial transmission of coronavirus disease 19 (COVID-19), yet there has been no clear recommendation about emergency dental care and appropriate personal protective equipment during pandemics....
Fri Jun 12, 2020 03:00
JCM, Vol. 9, Pages 1832: A Minimal PKPD Interaction Model for Evaluating Synergy Effects of Combined NSCLC Therapies Journal of Clinical Medicine doi: 10.3390/jcm9061832 Authors: Clara Mihaela Ionescu Maria Ghita Dana Copot Eric Derom Dirk Verellen This paper introduces a mathematical compartmental formulation of dose-effect synergy modelling for multiple therapies in non small cell lung cancer (NSCLC): antiangiogenic, immuno- and radiotherapy. The model formulates the dose-effect...
Fri Jun 12, 2020 03:00
JFB, Vol. 11, Pages 41: CaSiO3-HAp Structural Bioceramic by Sol-Gel and SPS-RS Techniques: Bacteria Test Assessment Journal of Functional Biomaterials doi: 10.3390/jfb11020041 Authors: Papynov Shichalin Buravlev Belov Portnyagin Mayorov Merkulov Kaidalova Skurikhina Turkutyukov Fedorets Apanasevich The article presents an original way of getting porous and mechanically strong CaSiO3-HAp ceramics, which is highly desirable for bone-ceramic...
Fri Jun 12, 2020 03:00
JoF, Vol. 6, Pages 86: Role of CpALS4790 and CpALS0660 in Candida parapsilosis Virulence: Evidence from a Murine Model of Vaginal Candidiasis Journal of Fungi doi: 10.3390/jof6020086 Authors: Marina Zoppo Fabrizio Fiorentini Cosmeri Rizzato Mariagrazia Di Luca Antonella Lupetti Daria Bottai Marisa Colone Annarita Stringaro Flavia De Bernardis Arianna Tavanti The Candida parapsilosis genome encodes for five agglutinin-like sequence (Als) cell-wall glycoproteins...
Fri Jun 12, 2020 03:00
JoF, Vol. 6, Pages 85: NO Candida auris: Nitric Oxide in Nanotherapeutics to Combat Emerging Fungal Pathogen Candida auris Journal of Fungi doi: 10.3390/jof6020085 Authors: Cleare Li Abuzeid Nacharaju Friedman Nosanchuk Candida auris (C. auris) is an emerging pathogenic fungal species that is especially worrisome due to its high mortality rates and widespread antifungal resistance. Previous studies have demonstrated the efficacy of nitric oxide (NO) nanoparticles...
Fri Jun 12, 2020 03:00
JoF, Vol. 6, Pages 84: Clinical Relevance and Characteristics of Aspergillus calidoustus and Other Aspergillus Species of Section Usti Journal of Fungi doi: 10.3390/jof6020084 Authors: Emmanouil Glampedakis Véronique Erard Frederic Lamoth The Aspergilli of section Usti (group ustus) are represented by over 20 species, of which Aspergillus calidoustus is the most relevant human pathogen. Invasive aspergillosis (IA) caused by these fungi is rare but could represent an emerging issue...
Fri Jun 12, 2020 03:00
J. Imaging, Vol. 6, Pages 49: Image Processing Technique and Hidden Markov Model for an Elderly Care Monitoring System Journal of Imaging doi: 10.3390/jimaging6060049 Authors: Swe Nwe Nwe Htun Thi Thi Zin Pyke Tin Advances in image processing technologies have provided more precise views in medical and health care management systems. Among many other topics, this paper focuses on several aspects of video-based monitoring systems for elderly people living independently. Major concerns...
Sat Jun 13, 2020 03:00
J. Imaging, Vol. 6, Pages 48: A Versatile Machine Vision Algorithm for Real-Time Counting Manually Assembled Pieces Journal of Imaging doi: 10.3390/jimaging6060048 Authors: Paola Pierleoni Alberto Belli Lorenzo Palma Luisiana Sabbatini The Industry 4.0 paradigm is based on transparency and co-operation and, hence, on monitoring and pervasive data collection. In highly standardized contexts, it is usually easy to gather data using available technologies, while, in complex environments,...
Sat Jun 13, 2020 03:00
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