Zusammenfassung Fettlebererkrankungen nehmen weltweit, insbesondere ernährungsbedingt, zu. Die Prävalenz liegt bereits bei 20–30 %. Ein weiterer Anstieg der Fallzahlen wird erwartet, wobei auch zunehmend Kinder betroffen sein werden. Die reine Einlagerung von Fett in die Hepatozyten bezeichnet man als Steatose bzw. bei nichtalkoholischer Genese als nichtalkoholische Fettleber (NAFL). Dabei handelt es sich um eine prinzipiell reversible Erkrankung, die sich aber durch fortwährende...
Fri Jun 12, 2020 03:00
Objective: To assess the efficacy of the combination of hyperbaric oxygen (HBO) and pharmacological treatment in patients with idiopathic sudden sensorineural hearing loss (ISSNHL) and define patients amenable for HBO therapy. Methods: Prospective, randomized, trial involving 136 cases with unilateral ISSNHL that were randomly divided into 2 groups: the pharmacological treatment (P) group and HBO + pharmacological treatment (HBO+P) group, which received additional HBO for 14 days besides the pharmacological...
Fri Jun 12, 2020 11:55
Related ArticlesThe way we were (and how we got here): fifty years of technology changes in dental and maxillofacial radiology. Dentomaxillofac Radiol. 2020 Jun 11;:20200133 Authors: Molteni R Abstract The history of the last 50 years (1970-2020) of technological changes and progresses for equipment and procedures in dental and maxillofacial radiology is related from the insider perspective of an industrial physicist and technologist who has been...
Fri Jun 12, 2020 16:58
Related ArticlesComparison of patulous Eustachian tube patients with and without a concave defect in the anterolateral wall of the tubal valve. J Laryngol Otol. 2020 Jun 11;:1-7 Authors: Choi SW, Park JH, Lee S, Oh SJ, Kong SK Abstract OBJECTIVE: Patulous Eustachian tube appears to be caused by a concave defect in the anterolateral wall of the tubal valve of the Eustachian tube. This study aimed to compare the clinical features of patulous Eustachian...
Fri Jun 12, 2020 16:47
Related ArticlesSilence of FOXD2-AS1 inhibited the proliferation and invasion of esophagus cells by regulating miR-145-5p/CDK6 axis. Histol Histopathol. 2020 Jun 11;:18232 Authors: Shi W, Gao Z, Song J, Wang W Abstract This study aimed to investigate the function of long non-coding RNA FOXD2 adjacent opposite strand RNA 1 (lncRNA FOXD2-AS1) during the progression of esophagus cancer (EC) and explore its underlying molecular mechanisms. The level of FOXD2-AS1...
Fri Jun 12, 2020 16:36
Related ArticlesHLA class-I and class-II restricted neoantigen loads predict overall survival in breast cancer. Oncoimmunology. 2020;9(1):1744947 Authors: Ren Y, Cherukuri Y, Wickland DP, Sarangi V, Tian S, Carter JM, Mansfield AS, Block MS, Sherman ME, Knutson KL, Lin Y, Asmann YW Abstract Tumors acquire numerous mutations during development and progression. When translated into proteins, these mutations give rise to neoantigens that can be recognized...
Fri Jun 12, 2020 16:25
Abstract Cranial nerve involvement is a finding often observed in patients infected with severe acute respiratory syndrome coronavirus 2 during the pandemic outbreak of coronavirus disease 2019 (COVID-19). To our knowledge, this is the first report of oropharyngeal dysphagia associated with COVID-19. A 70-year-old male developed dysphagia and consequent aspiration pneumonia during recovery from severe COVID-19. He had altered sense of taste and absent gag reflex. Videoendoscopy,...
Fri Jun 12, 2020 03:00
OBJECTIVE: The aim of this study was to explore the correlations of micro ribonucleic acid (miR)-146a and interleukin 1 receptor associated kinase 1 (IRAK1) gene polymorphisms with ankylosing spondylitis. PATIENTS AND METHODS: A total of 200 patients with ankylosing spondylitis in our hospital were enrolled in the disease group. The diagnosis of ankylosing spondylitis was in accordance with the 1984 New York Revised Criteria for Ankylosing Spondylitis. Meanwhile, 200 healthy people were taken as...
Fri Jun 12, 2020 15:48
The Journal of Antibiotics, Published online: 12 June 2020; doi:10.1038/s41429-020-0336-zIvermectin: a systematic review from antiviral effects to COVID-19 complementary regimen
Fri Jun 12, 2020 03:00
The Journal of Antibiotics, Published online: 12 June 2020; doi:10.1038/s41429-020-0334-1Antibacterial and cytotoxic metabolites of termite-associated Streptomyces sp. BYF63
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Abstract Purpose To investigate the efficacy and toxicity of cetuximab when added to radiochemotherapy for unresectable esophageal cancer. Methods This randomized phase 2 trial (clinicaltrials.gov, identifier NCT01787006) compared radiochemotherapy plus cetuximab (arm A) to radiochemotherapy (arm B) for unresectable esophageal cancer. Primary objective...
Fri Jun 12, 2020 03:00
Related ArticlesEvaluating the effect of dorsal muscle biopsies on adult Atlantic salmon growth and marine return rates. Conserv Physiol. 2020;8(1):coz099 Authors: Bøe K, Robertson MJ, Fleming IA, Power M Abstract Increasing conservation and animal-welfare concerns have driven the development of non-lethal sampling of fish populations, with the use of muscle tissue biopsies now being routinely applied as a sampling method in the wild. Crucial to the...
Fri Jun 12, 2020 15:53
Related ArticlesAvian mortality risk during heat waves will increase greatly in arid Australia during the 21st century. Conserv Physiol. 2020;8(1):coaa048 Authors: Conradie SR, Woodborne SM, Wolf BO, Pessato A, Mariette MM, McKechnie AE Abstract Intense heat waves are occurring more frequently, with concomitant increases in the risk of catastrophic avian mortality events via lethal dehydration or hyperthermia. We quantified the risks of lethal hyperthermia...
Fri Jun 12, 2020 15:53
Related ArticlesHeat, health and hatchlings: associations of in situ nest temperatures with morphological and physiological characteristics of loggerhead sea turtle hatchlings from Florida. Conserv Physiol. 2020;8(1):coaa046 Authors: Fleming KA, Perrault JR, Stacy NI, Coppenrath CM, Gainsbury AM Abstract Incubation temperatures, in addition to an embryo's genetic makeup, are critical in many aspects of adequate sea turtle embryonic development. The effects...
Fri Jun 12, 2020 15:53
Related ArticlesLeveraging video telehealth for the transitional pain service in response to COVID-19. Reg Anesth Pain Med. 2020 Jun 09;: Authors: Hunter OO, Mariano ER, Harrison TK PMID: 32522866 [PubMed - as supplied by publisher]
Fri Jun 12, 2020 15:51
Related ArticlesThe intertransverse tissue complex: friend, foe, fallacies? Reg Anesth Pain Med. 2020 Jun 09;: Authors: Nielsen MV, Moriggl B, Børglum J PMID: 32522865 [PubMed - as supplied by publisher]
Fri Jun 12, 2020 15:51
Related ArticlesTime for reappraisal: in the light of scientific data. Reg Anesth Pain Med. 2020 Jun 09;: Authors: Coşarcan SK, Doğan AT, Gürkan Y, Erçelen Ö PMID: 32522864 [PubMed - as supplied by publisher]
Fri Jun 12, 2020 15:51
Related ArticlesUltrasound-guided maxillary nerve block via the pterygopalatine fossa: maxillary artery is the key. Reg Anesth Pain Med. 2020 Jun 09;: Authors: Anugerah A, Nguyen K, Nader A PMID: 32522863 [PubMed - as supplied by publisher]
Fri Jun 12, 2020 15:51
Related ArticlesUltrasound-guided maxillary nerve block via the pterygopalatine fossa: maxillary artery is the key. Reg Anesth Pain Med. 2020 Jun 09;: Authors: Qin X, Xie X PMID: 32522862 [PubMed - as supplied by publisher]
Fri Jun 12, 2020 15:51
Related ArticlesUltrasound-guided bilateral rectus sheath block with and without dexmedetomidine in pediatric umbilical hernia repairs: a retrospective interrupted time series analysis. Reg Anesth Pain Med. 2020 Jun 09;: Authors: Hartzell CJ, Long JB, White WM, Machado D, Austin TM PMID: 32522861 [PubMed - as supplied by publisher]
Fri Jun 12, 2020 15:51
Related ArticlesSelective trunk block (SeTB): a simple alternative to hybrid brachial plexus block techniques for proximal humeral fracture surgery during the COVID-19 pandemic. Reg Anesth Pain Med. 2020 Jun 09;: Authors: Sivakumar RK, Areeruk P, Karmakar MK PMID: 32522860 [PubMed - as supplied by publisher]
Fri Jun 12, 2020 15:51
Related ArticlesAntimicrobial Activities of Satureja khuzestanica Jamzad; A Review. Infect Disord Drug Targets. 2020 Jun 10;: Authors: Mahmoudvand H, Ezatpour B, Masoori L, Marzban A, Moghaddam A, Shahzamani K, Malekara V, Cheraghipour K Abstract Satureja khuzestanica Jamzad. is a species native to Iran, highly important in Southwestern regions. It belongs to the Lamiaceae family and grows in different climates. A number of pharmacological properties...
Fri Jun 12, 2020 15:43
Abstract Background Vestibular evoked myogenic potentials (VEMPs) are increasingly being used for testing otolith organ function. Objective This article provides an overview of the anatomical, biomechanical and neurophysiological principles underlying the evidence-based clinical application of ocular and cervical VEMPs (oVEMPs and cVEMPs). ...
Fri Jun 12, 2020 03:00
Related ArticlesThe enhanced treatment efficacy of invasive brain glioma by dual-targeted artemether plus paclitaxel micelles. Artif Cells Nanomed Biotechnol. 2020 Dec;48(1):983-996 Authors: Li X, Shi L, Li Y, Li Q, Duan X, Wang Y, Li Q Abstract High grade-gliomas are highly invasive and prone to metastasis, leading to poor survival and prognosis. Currently, we urgently need a new treatment strategy to effectively inhibit glioma. In this study, artemether...
Fri Jun 12, 2020 15:20
Related ArticlesLINC02163 promotes colorectal cancer progression via miR-511-3p/AKT3 axis. Artif Cells Nanomed Biotechnol. 2020 Dec;48(1):961-968 Authors: Ma J, Zhang L, Shang A, Song H, Huo J, Zhang M, Jiang L Abstract Long non-coding RNAs and microRNAs are functional regulators in tumour progression. Herein, we revealed the level LINC02163 was up-regulated in CRC tissues and cell lines, and the expression of LINC02163 negatively correlated with...
Fri Jun 12, 2020 15:20
Related ArticlesCorrection: miR146a-mediated targeting of FANCM during inflammation compromises genome integrity. Oncotarget. 2020 May 26;11(21):2024-2025 Authors: Sundaravinayagam D, Kim HR, Wu T, Kim HH, Lee HS, Jun S, Cha JH, Kee Y, You HJ, Lee JH Abstract [This corrects the article DOI: 10.18632/oncotarget.10275.].PMID: 32523656 [PubMed - in process]
Fri Jun 12, 2020 14:44
Related ArticlesDiagnostic value of microRNA panel in endometrial cancer: A systematic review. Oncotarget. 2020 May 26;11(21):2010-2023 Authors: Donkers H, Bekkers R, Galaal K Abstract PURPOSE: We conducted a systematic review to evaluate the overall diagnostic accuracy of miRNAs in detecting endometrial cancer. MATERIALS AND METHODS: A systematic search of Medline, Embase, Cinahl and the Cochrane Controlled Register of Trials was performed...
Fri Jun 12, 2020 14:44
Related ArticlesInfluence of the progression of pleural neoplasia on the outcome of pleurodesis in mice. Oncotarget. 2020 May 26;11(21):2002-2009 Authors: Sabbion RO, Terra RM, Teixeira LR, Acencio MMP, Augusto MC, Costa PB, Fernandes PMP Abstract PURPOSE: Experimental study aimed at evaluating whether pleural neoplastic disease is associated with the degree of pleural fibrosis over time caused by talc pleurodesis. The study describes changes in...
Fri Jun 12, 2020 14:44
Related ArticlesAmplifications of stemness genes and the capacity of breast tumors for metastasis. Oncotarget. 2020 May 26;11(21):1988-2001 Authors: Litviakov N, Ibragimova M, Tsyganov M, Kazantseva P, Deryusheva I, Pevzner A, Doroshenko A, Garbukov E, Tarabanovskaya N, Slonimskaya E Abstract INTRODUCTION: The phenomenon of non-CSC (cancer stem cell) to CSC plasticity has been previously described in multiple studies and occurs during the ectopic...
Fri Jun 12, 2020 14:44
Related ArticlesBCATc modulates crosstalk between the PI3K/Akt and the Ras/ERK pathway regulating proliferation in triple negative breast cancer. Oncotarget. 2020 May 26;11(21):1971-1987 Authors: Shafei MA, Forshaw T, Davis J, Flemban A, Qualtrough D, Dean S, Perks C, Dong M, Newman R, Conway ME Abstract The cytosolic branched chain aminotransferase (BCATc) protein has been found to be highly expressed in breast cancer subtypes, including triple...
Fri Jun 12, 2020 14:44
Related ArticlesTAK1 regulates the tumor microenvironment through inflammatory, angiogenetic and apoptotic signaling cascades. Oncotarget. 2020 May 26;11(21):1961-1970 Authors: Scarneo SA, Yang KW, Roques JR, Dai A, Eibschutz LS, Hughes P, Haystead TAJ Abstract Transforming growth factor beta-activated kinase 1 (TAK1) has been implicated for its role in inflammatory signaling and as an important mediator of cellular apoptosis and necroptosis in various...
Fri Jun 12, 2020 14:44
Related ArticlesThe role of EGFR mutations in predicting recurrence in early and locally advanced lung adenocarcinoma following definitive therapy. Oncotarget. 2020 May 26;11(21):1953-1960 Authors: Galvez C, Jacob S, Finkelman BS, Zhao J, Tegtmeyer K, Chae YK, Mohindra N, Salgia R, Jovanovic B, Behdad A, Villaflor V Abstract INTRODUCTION: Roughly one third of new non-small cell lung cancer (NSCLC) is diagnosed at early stages. While lobectomy can...
Fri Jun 12, 2020 14:44
Related ArticlesPhase I study of vemurafenib in children with recurrent or progressive BRAFV600E mutant brain tumors: Pacific Pediatric Neuro-Oncology Consortium study (PNOC-002). Oncotarget. 2020 May 26;11(21):1942-1952 Authors: Nicolaides T, Nazemi KJ, Crawford J, Kilburn L, Minturn J, Gajjar A, Gauvain K, Leary S, Dhall G, Aboian M, Robinson G, Long-Boyle J, Wang H, Molinaro AM, Mueller S, Prados M Abstract Background: BRAFV600E mutation is present...
Fri Jun 12, 2020 14:44
Related ArticlesAn exploratory study of metformin with or without rapamycin as maintenance therapy after induction chemotherapy in patients with metastatic pancreatic adenocarcinoma. Oncotarget. 2020 May 26;11(21):1929-1941 Authors: Bever KM, Borazanci EH, Thompson EA, Durham JN, Pinero K, Jameson GS, Vrana A, Liu M, Wilt C, Wu AA, Fu W, Wang H, Yin Y, Leal JP, Jesus-Acosta A, Zheng L, Laheru DA, Von Hoff DD, Jaffee EM, Powell JD, Le DT Abstract ...
Fri Jun 12, 2020 14:44
Abstract Introduction Osteonecrosis of the femoral head (ONFH) is a disease in which the blood supply of the femoral head is interrupted or damaged, resulting in joint dysfunction. Hypoxic environments increase the expression of EPO, VEGF, and HIF causes vascular proliferation and increases the blood supply. It also causes the organism to be in a state of hypercoagulability and increases thrombosis. Therefore, the purpose of this study...
Fri Jun 12, 2020 03:00
Conditions: Astrocytoma; Brain Cancer; Brain Metastases; Bladder Cancer; Breast Cancer; Cervical Cancer; Cholangiocarcinoma; Colorectal Cancer; Esophagus Cancer; Gastric Cancer; Head and Neck Cancer; Kidney Cancer; Liver Cancer; Lung Cancer; Melanoma; Ovarian Cancer; Pancreatic Cancer; Pleural Mesothelioma; Prostate Cancer; Sarcoma; Tongue Cancer; Thymic Carcinoma; Urinary Tract CancerIntervention: Drug: QBS10072SSponsors: Quadriga Biosciences, Inc.;...
Fri Jun 12, 2020 14:35
Condition: Severe Eosinophilic Chronic Sinusitis Without Nasal PolyposisInterventions: Drug: Dupilumab 300 MG/2 ML Subcutaneous Solution [DUPIXENT]; Other: PlaceboSponsor: University of South FloridaNot yet recruiting
Fri Jun 12, 2020 14:35
Conditions: TNBC - Triple-Negative Breast Cancer; Head and Neck Squamous Cell Carcinoma; Squamous Cell Carcinoma of Anal Canal; Uveal Melanoma; Glioblastoma; Colorectal Cancer; Chordoma; Squamous Cell Carcinoma of the Lung; KRAS G12D; KRAS G13D; EGFR Amplification; Epithelial Ovarian Cancer; Hepatocellular Carcinoma; Anaplastic Thyroid Cancer; Pancreas CancerInterventions: Drug: BCA101; Drug: PembrolizumabSponsor: Bicara TherapeuticsRecruiting
Fri Jun 12, 2020 14:35
Related ArticlesUtilization of Invasive Procedures for Adult Eustachian Tube Dysfunction. Otolaryngol Head Neck Surg. 2020 Jun 11;:194599820931467 Authors: McCoul ED, Weinreich HM, Mulder H, Man LX, Schulz K, Shin JJ Abstract OBJECTIVE: Eustachian tube dysfunction (ETD) is a common diagnosis among adults presenting for outpatient care. We sought to determine national utilization and the associated cost of invasive procedures for adult ETD. ...
Fri Jun 12, 2020 14:23
Related ArticlesCortical Auditory Event-Related Potentials and Categorical Perception of Voice Onset Time in Children With an Auditory Neuropathy Spectrum Disorder. Front Hum Neurosci. 2020;14:184 Authors: McFayden TC, Baskin P, Stephens JDW, He S Abstract Objective: This study evaluated cortical encoding of voice onset time (VOT) in quiet and noise, and their potential associations with the behavioral categorical perception of VOT in children with auditory...
Fri Jun 12, 2020 14:09
Related ArticlesAtypical processing of tones and phonemes in Rett Syndrome as biomarkers of disease progression. Transl Psychiatry. 2020 Jun 10;10(1):188 Authors: Sysoeva OV, Molholm S, Djukic A, Frey HP, Foxe JJ Abstract Due to severe motor impairments and the lack of expressive language abilities seen in most patients with Rett Syndrome (RTT), it has proven extremely difficult to obtain accurate measures of auditory processing capabilities in this...
Fri Jun 12, 2020 14:09
Related ArticlesSARS-CoV-2-related paediatric inflammatory multisystem syndrome, an epidemiological study, France, 1 March to 17 May 2020. Euro Surveill. 2020 Jun;25(22): Authors: Belot A, Antona D, Renolleau S, Javouhey E, Hentgen V, Angoulvant F, Delacourt C, Iriart X, Ovaert C, Bader-Meunier B, Kone-Paut I, Levy-Bruhl D Abstract End of April 2020, French clinicians observed an increase in cases presenting with paediatric inflammatory multisystem syndrome...
Fri Jun 12, 2020 18:06
Related ArticlesInfection prevention guidelines and considerations for paediatric risk groups when reopening primary schools during COVID-19 pandemic, Norway, April 2020. Euro Surveill. 2020 Jun;25(22): Authors: Johansen TB, Astrup E, Jore S, Nilssen H, Dahlberg BB, Klingenberg C, Berg AS, Greve-Isdahl M Abstract In response to the coronavirus disease (COVID-19) pandemic, most countries implemented school closures. In Norway, schools closed on 13 March...
Fri Jun 12, 2020 18:06
Related ArticlesAuthor's correction for Euro Surveill. 2020;25(10). Euro Surveill. 2020 Jun;25(22): Authors: Eurosurveillance editorial team PMID: 32524952 [PubMed - in process]
Fri Jun 12, 2020 18:06
Related ArticlesHigh impact of COVID-19 in long-term care facilities, suggestion for monitoring in the EU/EEA, May 2020. Euro Surveill. 2020 Jun;25(22): Authors: ECDC Public Health Emergency Team, Danis K, Fonteneau L, Georges S, Daniau C, Bernard-Stoecklin S, Domegan L, O'Donnell J, Hauge SH, Dequeker S, Vandael E, Van der Heyden J, Renard F, Sierra NB, Ricchizzi E, Schweickert B, Schmidt N, Abu Sin M, Eckmanns T, Paiva JA, Schneider E Abstract Residents...
Fri Jun 12, 2020 18:06
Related Articles2017/18 and 2018/19 seasonal influenza vaccine safety surveillance, Canadian National Vaccine Safety (CANVAS) Network. Euro Surveill. 2020 Jun;25(22): Authors: Bettinger JA, De Serres G, Valiquette L, Vanderkooi OG, Kellner JD, Coleman BL, Top KA, Isenor JE, McCarthy AE, Canadian Immunization Research Network Abstract BackgroundThe Canadian National Vaccine Safety (CANVAS) network monitors the safety of seasonal influenza vaccines in...
Fri Jun 12, 2020 18:06
Related ArticlesGenetic structure of SARS-CoV-2 reflects clonal superspreading and multiple independent introduction events, North-Rhine Westphalia, Germany, February and March 2020. Euro Surveill. 2020 Jun;25(22): Authors: Walker A, Houwaart T, Wienemann T, Vasconcelos MK, Strelow D, Senff T, Hülse L, Adams O, Andree M, Hauka S, Feldt T, Jensen BE, Keitel V, Kindgen-Milles D, Timm J, Pfeffer K, Dilthey AT Abstract We whole-genome sequenced 55 SARS-CoV-2...
Fri Jun 12, 2020 18:06
Nature Communications, Published online: 12 June 2020; doi:10.1038/s41467-020-16786-5Tropomyosin receptor kinase B (TrkB), encoded by the neurotrophic tyrosine receptor kinase 2 (NTRK2) gene, exhibits intricate splicing patterns and post-translational modifications. Here, the authors perform whole gene and transcript-level analyses and report the TrkB.T1 splice variant enhances PDGF-driven gliomas in vivo and augments PI3K signaling cascades in vitro.
Fri Jun 12, 2020 03:00
Nature Communications, Published online: 12 June 2020; doi:10.1038/s41467-020-16767-8Atom-photon interaction and their coupling are important to understand correlated and quantum matter. Here the authors show strong coupling between degenerate interacting Fermi gas of 6Li atoms and photons.
Fri Jun 12, 2020 03:00
Nature Communications, Published online: 12 June 2020; doi:10.1038/s41467-020-16689-5Many neurodegenerative disorders are characterised by the accumulation of protein aggregates in neurons. Here, the authors show that the lysosomal protein TECPR1 selectively recruits mature autophagosomes via an interaction with LC3C to break down protein aggregates in neural stem cells.
Fri Jun 12, 2020 03:00
Nature Communications, Published online: 12 June 2020; doi:10.1038/s41467-020-16736-1Structural variants (SVs) contribute to the genetic architecture of many brain-related disorders. Here, the authors integrate SV calls from genome sequencing (n = 755) with RNA-seq data (n = 629) from post-mortem dorsal lateral prefrontal cortex to annotate the gene regulatory effects of SVs in the human brain and their potential to contribute to disease.
Fri Jun 12, 2020 03:00
Nature Communications, Published online: 12 June 2020; doi:10.1038/s41467-020-16776-7Northeast Atlantic climate shifted into the Quaternary Ice Age around 2.6 Myr ago. Here, the authors use 3D seismic data from the northern North Sea to document detailed changes in continental-margin sedimentary architecture spanning the transition from a fluvially dominated environment to an icehouse world.
Fri Jun 12, 2020 03:00
Nature Communications, Published online: 12 June 2020; doi:10.1038/s41467-020-16802-8The DNA cytosine deaminases APOBEC3A and APOBEC3B have emerged from cancer genomics studies as drivers of mutation in cancers and tumor heterogeneity. Here the authors present a computational approach to identify the RNA mutations specifically driven by APOBEC3A, and developed an RNA mutation-based assay to quantify ongoing APOBEC3A activity in tumor cells.
Fri Jun 12, 2020 03:00
Nature Communications, Published online: 12 June 2020; doi:10.1038/s41467-020-16795-4Fat uptake and storage in subcutaneous adipose tissue (SAT) prevents ectopic fat accumulation and associated metabolic complications, however, the underlying mechanisms are incompletely understood. Here, the authors show that adipose angiopoietin-2 (Angpt2) enhances SAT size via increased endothelial fatty acid transport.
Fri Jun 12, 2020 03:00
Nature Communications, Published online: 12 June 2020; doi:10.1038/s41467-020-16746-zExcited charge carriers, such as photoelectrons, play an important role in fundamental and technological fields. Here the authors employ an ultrafast electron microscope to directly visualize the cyclotron oscillations and oblate-to-prolate shape change of a photoemitted electron gas from a laser-excited copper surface.
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Related ArticlesHow effective are nonalcoholic fatty liver disease models for drug discovery? Expert Opin Drug Discov. 2020 Jun 11;:1-4 Authors: Hundertmark J, Tacke F Abstract The spectrum of nonalcoholic fatty liver disease (NAFLD) ranges from simple steatosis to nonalcoholic steatohepatitis (NASH) with hepatic fibrosis up to liver cirrhosis and hepatocellular carcinoma, displaying a global health problem with no effective therapy yet. Multiple preclinical...
Fri Jun 12, 2020 17:53
Related ArticlesLetter to the editor: "Cavernous sinus and abducens nerve in human fetuses near term". Surg Radiol Anat. 2020 Jun 10;: Authors: Akkaya S, Özveren MF PMID: 32524186 [PubMed - as supplied by publisher]
Fri Jun 12, 2020 13:18
Cataract formation is a slow accumulative process due to protein aggregates promoted by different factors over time. Zinc and copper ions have been reported to induce the formation of aggregates opaque to light in the human gamma D crystallin (HγD) in a concentration and temperature dependent manner. In order to gain insight into the mechanism of metal-induced aggregation of HγD under conditions that mimic more closely the slow, accumulative process of the disease, we have studied the non-equilibrium...
Fri Jun 12, 2020 03:00
The western pond turtle (WPT), recently separated into two paripatrically distributed species (Emys pallida and Emys marmorata), is experiencing significant reductions in its range and population size. In addition to habitat loss, two potential causes of decline are female-biased road mortality and high juvenile mortality from non-native predatory bullfrogs (Rana catesbeiana). However, quantitative analyses of these threats have never been conducted for either species of WPT. We used a combination...
Fri Jun 12, 2020 03:00
Background Untreated wastewater carries substantial amount of heavy metals and causes potential ecological risks to the environment, food quality, soil health and sustainable agriculture. Methodology In order to reduce the incidence of nickel (Ni2+) contamination in soils, two separate experiments (incubation and greenhouse) were conducted to investigate the potentials of rice straw biochar and elemental sulfur in remediating...
Fri Jun 12, 2020 03:00
A decline in soil biodiversity is generally considered to be the reduction of forms of life living in soils, both in terms of quantity and variety. Where soil biodiversity decline occurs, it can significantly affect the soils’ ability to function, respond to perturbations and recover from a disturbance. Several soil threats have been identified as having negative effects on soil biodiversity, including human intensive exploitation, land-use change and soil organic matter decline. In this review we...
Fri Jun 12, 2020 03:00
Understanding relationships between animals and their habitat is a central goal in ecology with important implications for conservation. Misidentified habitat requirements can have serious repercussions because land protection or reintroductions might occur in less than optimal habitat. Studies of resource selection have greatly facilitated an understanding of ecological relationships but can be improved when vital yet infrequently utilized habitat features are more fully described. A critical element...
Fri Jun 12, 2020 03:00
A previous study found that use of the traditional halibut hook (čibu.d) of the Makah Tribe in present day recreational Pacific halibut (Hippoglossus stenolepis) fisheries significantly reduced bycatch compared to paired 8/0 circle hooks. The study also found that the čibu.d had a significantly reduced catch of halibut, but that the reduction may have been due to manufacturing flaws in the čibu.d used in the study. In this two-phased study, we first compared the fishing performance of redesigned...
Fri Jun 12, 2020 03:00
Epiphytic bryophytes (EB) are some of the most commonly found plant species in tropical montane cloud forests, and they play a disproportionate role in influencing the terrestrial hydrological and nutrient cycles. However, it is difficult to estimate the abundance of EB due to the nature of their “epiphytic” habitat. This study proposes an allometric scaling approach implemented in twenty-one 30 × 30 m plots across an elevation range in 16,773 ha tropical montane cloud forests of northeastern Taiwan...
Fri Jun 12, 2020 03:00
Rice false smut (RFS), caused by Ustilaginoidea virens, is one of the most detrimental rice fungal diseases and pose a severe threat to rice production and quality. Effectors in U. virens often act as a set of essential virulence factors that play crucial roles in the interaction between host and the pathogen. Thus, the functions of each effector in U. virens need to be further explored. Here, we performed multiple alignment analysis and demonstrated a small secreted hypersensitive response-inducing...
Fri Jun 12, 2020 03:00
Pleurotus ostreatus is one of the most widely cultivated mushrooms in China. The regulatory mechanisms of fruiting body formation and the response to heat stress in P. ostreatus are main research focuses. The Zn(II)2Cys6 family is one of the largest families of transcriptional factors and plays important roles in multiple biological processes in fungi. In this study, we identified 66 zinc cluster proteins in P. ostreatus (PoZCPs) through a genome-wide search. The PoZCPs were classified into 15 types...
Fri Jun 12, 2020 03:00
Publication date: September 2020Source: Photodiagnosis and Photodynamic Therapy, Volume 31Author(s): Darakhshan Qaiser, Anubhuti Sood, Deepika Mishra, OP Kharbanda, Anurag Srivastava, Siddhartha Datta Gupta, RM Pandey, Rahul Yadav, Krushna Bhatt, Ramniwas Kumawat
Fri Jun 12, 2020 12:30
Abstract Purpose of Review Since the discovery of its very first member in 1974, the IL-1 family has expanded into a group of 11 potent molecules which are essential in both innate and acquired immunity. Pro-inflammatory cytokines IL-36α, IL-36β, and IL-36γ and their receptor antagonists IL-36Ra and IL-38, which belong to the IL-36 subfamily, are some of the most recently identified members. Recent studies show that these members...
Fri Jun 12, 2020 03:00
Abstract Background Dentine hypersensitivity (DH) could occur or intensify after non-surgical periodontal therapy because of the exposure of dentine tubules, but currently no gold standard exists to treat DH. It has been demonstrated that nano-sized particles presented potential for dentine tubules blocking and remineralization. This randomized controlled trial aimed to investigate the efficacy of dentifrice containing nano-carbonate...
Fri Jun 12, 2020 03:00
Abstract Background Recent preventive strategies for dental caries focus on targeting the mechanisms underlying biofilm formation, including the inhibition of bacterial adhesion. A promising approach to prevent bacterial adhesion is to modify the composition of acquired salivary pellicle. This in vitro study investigated the effect and possible underlying mechanism of pellicle modification by casein phosphopeptide (CPP) on Streptococcus...
Fri Jun 12, 2020 03:00
ObjectivesExposure to high-molecular-weight polycyclic aromatic hydrocarbons (PAHs) may cause cancer in chimney sweeps and creosote-exposed workers, however, knowledge about exposure to low-molecular-weight PAHs in relation to cancer risk is limited. In this study, we aimed to investigate occupational exposure to the low-molecular-weight PAHs phenanthrene and fluorene in relation to different cancer biomarkers. MethodsWe recruited 151 chimney sweeps, 19 creosote-exposed workers and 152 unexposed...
Fri Jun 12, 2020 18:20
ObjectivesCommon mental disorders (CMDs) are among the main causes of sickness absence and can lead to suffering and high costs for individuals, employers and the society. The occupational health service (OHS) can offer work-directed interventions to support employers and employees. The aim of this study was to evaluate the effect on sickness absence and health of a work-directed intervention given by the OHS to employees with CMDs or stress-related symptoms. MethodsRandomisation was conducted...
Fri Jun 12, 2020 18:20
Dear Editor, We read with great interest the editorial by Reynolds and Blanc1 on "forging effective surveillance for work-related lung disease". On its 30th anniversary, the authors cleverly looked at initial objectives of Surveillance of Work-related and Occupational Respiratory Disease (SWORD) programme and how these objectives have been met over the last three decades. There is one point that we would like to add to what Reynolds and Blanc1 wrote about SWORD. This is the potential to globalise...
Fri Jun 12, 2020 18:20
ObjectivesThe aim of this clustered, randomised controlled trial was to assess the effectiveness of a lumbopelvic postural feedback device for changing postural behaviour in a group of healthcare workers. We hypothesised that workers exposed to auditory postural feedback would reduce the number of times forward bending posture is adopted at work. MethodsThis was a participant and assessor blinded, randomised, sham-controlled trial with blocked cluster random allocation. We recruited healthcare...
Fri Jun 12, 2020 18:20
In response to the COVID-19 pandemic, many countries have adopted a broad spectrum of containment measures, from recommendations to stay at home to quarantines of large geographic regions. As part of this response, corporations and governments alike have strongly encouraged workers to telecommute where possible. More than 3.4 billion people in 84 countries have been confined to their homes, as estimated in late March 2020, which potentially translates to many millions of workers temporarily exposed...
Fri Jun 12, 2020 18:20
Analyst, 2020, Accepted ManuscriptDOI: 10.1039/D0AN01040E, PaperHongkun Li, Guifen JieA novel versatile dendritical amplification photoelectric (PEC) biosensing platform using Bi2S3 nanorods and perylenebased polymer (PTC-NH2) as double signal probes is proposed for detection of trace target DNA. Bi2S3 nanorods...The content of this RSS Feed (c) The Royal Society of Chemistry
Fri Jun 12, 2020 02:00
Analyst, 2020, Accepted ManuscriptDOI: 10.1039/D0AN00930J, PaperWene Liu, Lili Tian, Jie Du, Jiangmin Wu, Yongmei Liu, Guofan Wu, Xiaoquan LuAbstract :Developing a rapid, low-cost, and multimode detection method for heavy metal ions remains a compelling goal for many applications, including food safety, environmental and biological analysis. This study investigated...The content of this RSS Feed (c) The Royal Society of Chemistry
Fri Jun 12, 2020 02:00
Detailed MR imaging assessment of endolymphatic hydrops in patients with <em>SLC26A4</em> mutations.
Publication date: Available online 12 June 2020Source: Auris Nasus LarynxAuthor(s): Keita Tsukada, Shin-ichi Usami
Fri Jun 12, 2020 18:32
Publication date: Available online 12 June 2020Source: Auris Nasus LarynxAuthor(s): Antoniu-Oreste Gostian, Johannes Loeser, Christian Tholen, Philipp Wolber, Martin Otte, David Schwarz, Ludwig Maximilian Heindl, Matthias Balk, Magdalena Gostian
Fri Jun 12, 2020 18:32
Publication date: Available online 11 June 2020Source: Auris Nasus LarynxAuthor(s): Mirko Gabelica, Robert Tafra, Marina Krnić Martinić, Mirko Kontić, Joško Markić, Tanja Kovačević, Ivana Čulo Čagalj, Željko Ninčević
Fri Jun 12, 2020 18:32
Publication date: Available online 11 June 2020Source: Auris Nasus LarynxAuthor(s): Seiichiro Makihara, Shin Kariya, Mitsuhiro Okano, Tomoyuki Naito, Munechika Tsumura, Kazunori Nishizaki
Fri Jun 12, 2020 18:32
Publication date: Available online 11 June 2020Source: Auris Nasus LarynxAuthor(s): So Young Jeon, Oh Eun Kwon, Jin Woo Jang, Sang Yoon Kang, Jin-Young Min, Sung Wan Kim
Fri Jun 12, 2020 18:32
Publication date: Available online 11 June 2020Source: Auris Nasus LarynxAuthor(s): Takeshi Suzuki, Yosuke Seki, Tomoaki Matsumura, Jun Ikari, Makoto Arai, Toyoyuki Hanazawa, Yoshitaka Okamoto, Haruhiko Suzuki, Yoshimoti Kurokawa, Akiko Umezawa, Kazunori Kasama, Toshitaka Hoppo
Fri Jun 12, 2020 18:32
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