Abstract Fibroblast growth factor receptor 4 (FGFR4) is known to induce cancer cell proliferation, invasion, and anti‐apoptosis via activation of RAS/RAF/ERK and PI3K/AKT pathways, which are also known as major molecular bases of colon cancer carcinogenesis related with EGFR signaling. However, the interaction of FGFR4 and EGFR signaling in regard to colon cancer progression is unclear. Here, we investigated a potential crosstalk between FGFR4 and EGFR, and the effect of anti‐EGFR therapy in colon...
Sat Jun 13, 2020 11:54
Abstract Recent studies have revealed that metabolic reprogramming is closely associated with epithelial mesenchymal transition (EMT) during cancer progression. Aldolase A (ALDOA) is a key glycolytic enzyme and is highly expressed in several types of cancer. In this study, we found that ALDOA is highly expressed in uterine cervical adenocarcinoma and that high ALDOA expression promotes EMT to increase malignant potentials, such as metastasis and invasiveness, in cervical adenocarcinoma cells. In...
Fri Jun 12, 2020 16:15
Abstract Alternative splicing (AS) provides the primary mechanism for producing protein diversity. There is growing evidence that AS is involved in the development and progression of cancers. The rapid accumulation of high‐throughput sequencing technologies and clinical data sets offers an opportunity to systematically profile the relationship between mRNA variants and clinical outcomes. However, there is a lack of systematic analysis of alternative splicing in prostate cancer. Download RNA‐Seq...
Fri Jun 12, 2020 16:14
Abstract Malignant pleural mesothelioma (MPM) is an asbestos‐related aggressive malignant neoplasm. Due to the difficulty of achieving curative surgical resection in most patients with MPM, a combination chemotherapy of cisplatin and pemetrexed has been the only approved regimen proven to improve the prognosis of MPM. However, the median overall survival time is at most 12 months even with this regimen. There has been therefore a pressing need to develop a novel chemotherapeutic strategy to bring...
Fri Jun 12, 2020 16:09
Sat Jun 13, 2020 21:11
Abstract Background B cells play a crucial role during rhinovirus (RV) infections by production of virus‐neutralizing antibodies. A main feature of common variable immunodeficiency (CVID) is hypogammaglobulinemia (HG). HG patients have severely reduced levels of antibody‐producing B cells and suffer from prolonged virus infections. Here, we addressed whether antiviral response of peripheral blood lymphocytes differs between HG patients and healthy individuals during natural RV infection. ...
Sat Jun 13, 2020 12:35
Abstract Background The lack of a value set allowing the calculation of QALY is an important limitation when establishing the value of emerging therapies to treat food allergy. The aim of this study was to develop a Short‐Form Six‐Dimension version 2 (SF‐6Dv2) preference value set for the calculation of health utility from the Canadian food allergic population. Methods Two hundred ninety‐five parents of patients aged 0‐17 years old and 154 patients aged 12 years old and above with food...
Sat Jun 13, 2020 12:16
Abstract Background The Coronavirus disease 2019 (COVID‐19) has evolved as a pandemic infectious disease transmitted by the severe acute respiratory syndrome coronavirus (SARS‐CoV‐)2. Allergists and other health care providers (HCPs) in the field of allergies and associated airway diseases are in the front line, taking care of patients potentially infected with SARS‐CoV‐2. Hence, strategies and practices to minimize risks of infection for both HCPs and treated patients have to be developed and...
Fri Jun 12, 2020 21:24
Thu Jun 11, 2020 11:33
Coronavirus disease 2019 (COVID-19) is an acute respiratory syndrome which emerged in the city of Wuhan and rapidly spread through the world causing a global pandemic1. The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been identified as its causal agent1. Factors such as older age or presence of comorbidities are frequently identified as variables with a negative impact on patients’ prognosis2. If we focus on pre-existent respiratory conditions, a higher risk of developing a severe...
Sat Jun 13, 2020 03:00
Tropomyosin is the main allergen found in crustaceans, with high interspecies homology; it is found also in house dust mites (HDM).
Sat Jun 13, 2020 03:00
Physician burnout has been increasingly recognized as a public health crisis (1,2). American physicians have higher burnout rates compared with age, gender and lifestyle-matched adults who do not practice medicine. American physicians currently experience a higher suicide rate ( average approximately 1 per day) than any other group of professionals (3,4). Over 200 studies have been published in health-related journals on the topic of physician burnout with additional news, articles, and research...
Sat Jun 13, 2020 03:00
Atopic dermatitis (AD) is associated with substantial variability of itch, skin pain1,2, sleep disturbance and fatigue3,4, variable lesional morphology5 and distribution6 and comorbid health disorders7-13. AD also has heterogeneity of triggers for itch, including heat, sweat, dryness, clothing and stress14,15. However, none of these triggers universally affected all AD patients. Yet little is known about which triggers of itch are most common in adults with AD and their predictors. In addition, little...
Sat Jun 13, 2020 03:00
The first large scale evaluation of prescribing patterns for imported fire ant (IFA) in a large US healthcare system was published by Haymore, et al. in 2009. In this first evaluation of prescriptions from 1990 - 2007, the most commonly prescribed maintenance IFA prescription was 0.5 ml of 1:200 w/v.
Sat Jun 13, 2020 03:00
Efficacy of Omalizumab in Chronic Spontaneous Urticaria Associated with Chronic Inducible Urticaria
Sat Jun 13, 2020 03:00
Abstract Purpose Klinefelter syndrome (KS) is characterized by late adolescence/young adulthood onset of primary hypogonadism. Hypogonadotropic hypogonadism (HH), when congenital, is usually associated with absent/incomplete puberty and low/normal gonadotropins. We report the clinical and genetic features of two subjects with KS and an unexpected HH hormone profile. Methods...
Sun Jun 14, 2020 03:00
Abstract Objectives The aim of this study was to evaluate the accuracy of cone beam computed tomography (CBCT), periapical radiograph, and intrasurgical linear measurements in the assessment of molars with furcation defects. Materials and methods This parallel, single-blinded, randomised controlled trial (RCT) consisted of 22 periodontitis patients who had...
Sun Jun 14, 2020 03:00
Abstract Objective The aim of this in vitro study was to evaluate the influence of bone type, drill diameter, drilling speed, and irrigation on heat generation while performing osteotomy for dental implants. Materials and methods Six polyurethane foam blocks simulating type I (dense) and type IV (soft) bone were selected for the study. Each block was subjected...
Sat Jun 13, 2020 03:00
Abstract Objective The purpose of this study was to evaluate and compare the effects of the immediate and delayed loading of strategic mini-implants (MIs) on the satisfaction of patients with removable partial dentures (RPDs). Materials and methods In this multi-center randomized clinical trial, strategic MIs were inserted under 79 RPDs in 76 participants....
Fri Jun 12, 2020 03:00
Abstract Epilepsy occurs in nearly all patients with tuberous sclerosis and is often refractory to medical treatment. The definition of surgical candidacy in these patients has broadened in recent years due to philosophical and technological advances. The goals of surgery have shifted to focusing on quality of life and maximizing neurodevelopmental potential in patients unable to obtain seizure freedom. Novel diagnostic, ablative, and neuromodulatory techniques have been developed...
Sat Jun 13, 2020 03:00
Abstract Purpose Tuberous sclerosis complex (TSC) is an autosomal dominant multisystem disorder characterized by hamartomas in multiple organ systems. The TSC1 and TSC2 genes have been identified as the genetic basis of TSC. Two gene tests were used for definitive genetic diagnosis. Methods In our study, the case of a Chinese pediatric patient with...
Fri Jun 12, 2020 03:00
Abstract Purpose Pediatric primary high-grade spinal glioma (p-HGSG) is an extremely rare disease process, with little data within the current literature. Akin to primary high-grade gliomas, this cancer has been exemplified by dismal prognosis and poor response to modern treatment paradigms. This study seeks to investigate the current trends affecting overall survival using the National Cancer Database (NCDB). ...
Fri Jun 12, 2020 03:00
Abstract Purpose An estimated 5–11% of patients with neurofibromatosis type 1 (NF1) harbour NF1 microdeletions encompassing the NF1 gene and its flanking regions. The purpose of this study was to evaluate the clinical phenotype in children and adolescents with NF1 microdeletions. Methods We retrospectively analysed 30 children and adolescents with...
Fri Jun 12, 2020 03:00
Abstract Background Treatment approaches for voice therapy are diverse, yet their differential effects are not well understood. Evaluations of treatment effects across approaches are important for clinical guidance and evidence‐based practice. Objective of review To quantify the evidence of treatment effectiveness on the outcome measure Voice Handicap Index with the 30‐items(VHI‐30) from existing randomized controlled/clinical trials (RCT) of voice therapy using the statistical approach...
Sat Jun 13, 2020 12:19
Abstract Interleukin (IL)-35, which has an anti-inflammatory role in acute respiratory distress syndrome (ARDS)/acute lung injury (ALI), is relatively promising as a drug target. Studies have shown that curcumin may play a therapeutic role in ALI and enhance the suppressive function of regulatory T cells (Tregs). To illustrate the effect of curcumin on the regulation of Treg cell differentiation and expression of IL-35, we built a cecal...
Sun Jun 14, 2020 03:00
Abstract Hemidesmus indicus (L.) R. Br. ex Schult is commonly known as anantmul or Indian sarsaparilla. The roots of this plant, which display a wide range of medicinal, biological, and phytopharmaceutical properties, are used in the pharmaceutical and food industries. Conventionally, the plant is propagated by seed germination or vegetatively, but the efficacy of traditional methods has some limitations: plants derived from seed germination are prone...
Sun Jun 14, 2020 02:23
Abstract Toxin-antitoxin systems (TASs) have attracted much attention due to their important physiological functions. These small genetic factors have been widely studied mostly in commensal Escherichia coli strains, whereas the role of TASs in the probiotic E. coli Nissle 1917 (EcN) is still elusive. Here, the physiological role of chromosomally encoded type II TASs in EcN was examined. We showed that gene pair ECOLIN_00240-ECOLIN_00245 and ECOLIN_08365-ECOLIN_08370 were two...
Sat Jun 13, 2020 03:00
Abstract Cyclo(Phe-Pro) (cFP), produced by the Vibrio species, plays the dual roles of being a signaling molecule and a virulence factor. Acting modes of this compound have recently been characterized at the molecular level. Nevertheless, the method by which this compound passes across biological membranes remains obscure. Using radiolabeled cFP, we examined the kinetics of transport for this compound across membranes using V. vulnificus, Escherichia coli,...
Sat Jun 13, 2020 03:00
Abstract High temperature is a major threat to Pleurotus ostreatus cultivation. In this study, a potential mechanism by which P. ostreatus mycelia growth is inhibited under heat stress was explored. Lactate, as a microbial fermentation product, was found unexpectedly in the mycelia of P. ostreatus under heat stress, and the time-dependent accumulation and corresponding inhibitory effect of lactate on mycelial growth was further confirmed. The addition of a glycolysis inhibitor,...
Fri Jun 12, 2020 03:00
Abstract Modernisation of our households created novel opportunities for microbial growth and thus changed the array of microorganisms we come in contact with. While many studies have investigated microorganisms in the air and dust, tap water, another major input of microbial propagules, has received far less attention. The quality of drinking water in developed world is strictly regulated to prevent immediate danger to human health. However, fungi, algae,...
Fri Jun 12, 2020 03:00
Abstract Ribose-5-phosphate isomerase (Rpi, EC 5.3.1.6) is widespread in microorganisms, animals, and plants. It has a pivotal role in the pentose phosphate pathway and responsible for catalyzing the isomerization between d-ribulose 5-phosphate and d-ribose 5-phosphate. In recent years, Rpi has received considerable attention as a multipurpose biocatalyst for production of rare sugars, including d-allose, l-rhamnulose, l-lyxose, and l-tagatose. Besides, it has been thought of...
Fri Jun 12, 2020 03:00
Retrobulbar haemorrhage (RBH) is a potentially blinding consequence of craniofacial trauma, but timely ophthalmic evaluation is difficult to obtain in some settings and clear standards for canthotomy/cantholysis are lacking. We have sought to develop an algorithm to identify vision-threatening traumatic RBH that requires emergent decompression. We retrospectively reviewed 42 consecutive consultations for RBH at a level-one trauma centre. Charts and imaging studies were analysed with attention to...
Sat Jun 13, 2020 03:00
We investigated the possibilities of angioprotection and the reduction of osteonecrosis in rats that had been given bisphosphonates. In our experiment, 27 rats were divided into three groups: Group 1 was injected with saline; Group 2 was given zoledronic acid for six weeks; and Group 3 was given zoledronic acid for six weeks, with added doses of sulodexide after three weeks. After that we constructed a model of how the teeth should be extracted. The velocity of linear blood flow in the periodontal...
Fri Jun 12, 2020 03:00
Publication date: August 2020Source: Cancer Epidemiology, Volume 67Author(s): Tor Åge Myklebust, Therese Andersson, Aude Bardot, Sally Vernon, Anna Gavin, Deirdre Fitzpatrick, Marianne Brenn Jerm, Mark Rutherford, D. Maxwell Parkin, Peter Sasieni, Melina Arnold, Isabelle Soerjomataram, Freddie Bray, Paul C Lambert, Bjørn Møller
Sun Jun 14, 2020 00:00
Publication date: August 2020Source: Cancer Epidemiology, Volume 67Author(s): Tomohiro Matsuda, Young-Joo Won, RuRu Chun-ju Chiang, Jiwon Lim, Kumiko Saika, Keisuke Fukui, Wen-Chung Lee, Laura Botta, Alice Bernasconi, Annalisa Trama
Fri Jun 12, 2020 18:04
Publication date: August 2020Source: Cancer Epidemiology, Volume 67Author(s): Patrick Muller, Laura Woods, Sarah Walters
Fri Jun 12, 2020 18:04
Abstract Background The majority of patients with advanced gastrointestinal stromal tumor (GIST) develop resistance to imatinib, and subsequent treatments have limited efficacy. Ilixadencel (allogeneic inflammatory dendritic cells) is a cell-based immune primer injected intratumorally that previously has been clinically investigated in metastatic renal cell carcinoma and hepatocellular carcinoma. ...
Sat Jun 13, 2020 03:00
Publication date: Available online 12 June 2020Source: BrachytherapyAuthor(s): Harjot Kaur Bajwa, Rohith Singareddy, Anil Kumar Talluri, Rajeev Guntupalli, Alluri Krishnam Raju, Madhusudhana Sresty, Ameer Ahmed
Sat Jun 13, 2020 23:46
Abstract Rationale and objective Estradiol decline has been associated with depression and anxiety in post-menopausal women. Agomelatine (Ago) is an agonist of the melatonergic MT1/MT2 receptors and an antagonist of the serotonergic 5-HT2c receptors. The present study aimed to evaluate the effects of combining Ago with 17β-estradiol (E2) on ovariectomy (OVX)-induced depressive- and anxiety-like behaviors in young adult female rats. ...
Sat Jun 13, 2020 03:00
Abstract Rationale Selective serotonin reuptake inhibitor (SSRI) antidepressants are increasingly prescribed during pregnancy. Changes in serotonergic signaling during human fetal development have been associated with changes in brain development and with changes in affective behavior in adulthood. The suprachiasmatic nucleus (SCN) is known to be modulated by serotonin and it is therefore assumed that SSRIs may affect circadian rhythms....
Fri Jun 12, 2020 03:00
Health practitioners from different professions, and with differing competencies, need to collaborate to provide quality care. Competencies in interprofessional working need developing in undergraduate educati...
Fri Jun 12, 2020 03:00
There is no consensus on the role of inflammatory markers in identifying chorioamnionitis in preterm prelabour rupture of membranes (PPROM). We set out to evaluate the accuracy of maternal blood C-reactive pro...
Fri Jun 12, 2020 03:00
A model that can predict treatment response for a patient with specific baseline characteristics would help decision-making in personalized medicine. The aim of the study is to develop such a model in the trea...
Fri Jun 12, 2020 03:00
US opioid prescribing and use escalated over the last two decades, with parallel increases in opioid misuse, opioid-related deaths, and concerns about diversion. Postoperatively prescribed opioids contribute t...
Thu Jun 11, 2020 03:00
Scientists have screened almost 163,000 DNA mutations in 2,700 C. elegans roundworms to shed light on DNA damage. The results, published in Nature Communications, lead to the conclusion that mutation patterns seen in cancer are more complicated than we previously thought.
Mon Jun 08, 2020 17:47
Researchers have investigated the contributions that symbiotic bacteria make to the unusual life cycle and diet of reed beetles.
Fri Jun 12, 2020 18:14
A research collaboration has demonstrated the function of a genetic pathway for anther development, with this pathway proven in 2019 work to be present widely in the flowering plants that evolved over 200 million years ago.
Thu Jun 11, 2020 22:14
Abstract This study was done to identify the effect that environmental noises have on consonant perception of individuals with normal hearing sensitivity. The objectives were to find out the effect of white noise and environmental noises on consonant identification and to find the effect of noises on consonant features. Adult with normal hearing in both ears whose mother tongue was Odia were included. Initially the participants underwent pure tone audiometry, speech audiometry,...
Sat Jun 13, 2020 03:00
Abstract Nose is very important in standards of beauty because of its central location on face, making any slightest alteration in its appearance vulnerable to appreciation as well as criticism. Osteotomy is one of main steps of rhinoplasty which brings appreciably drastic change in the appearance of the individual after appropriate correction. Many approaches and instruments have since been used for proper correction of width of nasal bridge. Sometimes wrong use of force can...
Sat Jun 13, 2020 03:00
Abstract Facial nerve paralysis is one of the most common symptom an otology surgeon comes across. Aim of this article is to review the literature, to study the important causes, pathogenesis and to know the common sites of involvement in different types of facial paralysis with importance of imaging in identifying the site of lesion and role of surgery and outcome of conservative management in case of infranuclear facial paralysis. This is a prospective study of 23 cases...
Sat Jun 13, 2020 03:00
Abstract Post-auricular incisions used for ear surgeries have their distinct advantages and disadvantages. Numbness in post-auricular region or over pinna is a symptom encountered in many patients following surgery via post-auricular incision. We performed this study to investigate this phenomenon of aural numbness in terms of frequency and severity. Design: Prospective study. Setting: This study was conducted in our hospital from 1st December 2015 to 30th November 2016 for a...
Sat Jun 13, 2020 03:00
Abstract Purpose Elevated serum levels of carbohydrate antigen 19.9 (CA19.9), a well-established tumor marker in pancreatic neoplasms, has been proposed as a prognostic marker of tumor aggressiveness in medullary thyroid carcinoma (MTC). A hypothesis of C-cell dedifferentiation has been raised. Here, we evaluated the expression of CA19.9 and CD133, a stem cell marker, in MTC tissues. ...
Sat Jun 13, 2020 03:00
Abstract Purpose Differentiated thyroid cancer (DTC) has an increasing incidence in childhood and adolescence but long-term outcome data are limited. We aimed to identify possible risk factors associated with disease persistence, with special focus on the usefulness of ATA risk stratification system and pre-ablation stimulated thyroglobulin (Tg) levels. Methods ...
Sat Jun 13, 2020 03:00
Fri Jun 12, 2020 03:00
Background. Sestrins (Sesns), a group of oxidative stress-related proteins, have been reported to be involved in various cardiovascular diseases, including aortic dissection and chronic heart failure. This study is aimed at investigating the level of circulating Sesn1, Sesn2, and Sesn3 in hypertension patients. Methods. Plasma levels of Sesn1, Sesn2, and Sesn3 in 400 hypertensive patients and 100 normotensive subjects were detected using enzyme-linked immunosorbent assay (ELISA) kits. The hypertension...
Sat Jun 13, 2020 11:35
The prevalence of heart failure (HF) due to cardiac remodelling after acute myocardial infarction (AMI) does not decrease regardless of implementation of new technologies supporting opening culprit coronary artery and solving of ischemia-relating stenosis with primary percutaneous coronary intervention (PCI). Numerous studies have examined the diagnostic and prognostic potencies of circulating cardiac biomarkers in acute coronary syndrome/AMI and heart failure after AMI, and even fewer have depicted...
Fri Jun 12, 2020 19:05
Abstract Irreversible electroporation (IRE) is primarily a nonthermal ablative technology that uses a series of high-voltage and ultra-short pulses with high-frequency electrical energy to induce cell death. This paper presents the influence of cholesterol on the IRE-induced probability of pore formation and the rate constant of pore formation in giant unilamellar vesicles (GUVs). The GUVs are prepared by a mixture of dioleoylphosphatidylglycerol (DOPG), dioleoylphosphatidylcholine...
Sat Jun 13, 2020 03:00
AbstractGastric neuroendocrine tumors (NET) are rare tumors with a broad spectrum of symptoms; in recent years, the number of cases has increased due to the growing number of upper endoscopies. Obesity has become a worldwide epidemic and bariatric surgery one of the most effective therapies to control this illness. As more surgeries are performed, the number of histopathological samples will also increase. Incidental discoveries on these histopathological specimens are difficult situations to encounter...
Sat Jun 13, 2020 03:00
Publication date: Available online 12 June 2020Source: Autoimmunity ReviewsAuthor(s): Saeed Mohammadian Haftcheshmeh, Amir Abbas Momtazi-Borojeni
Sat Jun 13, 2020 20:08
Publication date: Available online 12 June 2020Source: Autoimmunity ReviewsAuthor(s): Maria Infantino, Teresa Carbone, Mariangela Manfredi, Valentina Grossi, Antonio Antico, Maria Piera Panozzo, Ignazio Brusca, Maria Grazia Alessio, Giulia Previtali, Stefan Platzgummer, Luigi Cinquanta, Giusy Paura, Gaia Deleonardi, Maria Teresa Trevisan, Antonella Radice, Caterina Castiglione, Tiziana Imbastaro, Martina Fabris, Giampaola Pesce, Brunetta Porcelli
Sat Jun 13, 2020 20:08
Publication date: Available online 12 June 2020Source: Autoimmunity ReviewsAuthor(s): Cesare Mazzaro, Luigino Dal Maso, Endri Mauro, Marcella Visentini, Maurizio Tonizzo, Valter Gattei, Pietro Andreone, Gabriele Pozzato
Sat Jun 13, 2020 20:08
Publication date: Available online 12 June 2020Source: Autoimmunity ReviewsAuthor(s): Benjamin Terrier, Sébastien Humbert, Laure-Hélène Preta, Laure Delage, Jérôme Razanamahery, Sara Laurent-Roussel, Raphaële Mestiri, Lauren Beaudeau, Paul Legendre, François Goupil, Jérôme Hadjadj, Marie-Claude Stolzenberg, Jean-Marc Treluyer, Virginie Westeel, Marie-Blanche Valnet-Rabier, Marie Wislez, Luc Mouthon, Laurent Chouchana
Sat Jun 13, 2020 20:08
Publication date: Available online 12 June 2020Source: Autoimmunity ReviewsAuthor(s): Philipp Klemm, Ulf Müller-Ladner, Ingo H. Tarner, Uwe Lange, Ole Hudowenz
Fri Jun 12, 2020 20:17
Publication date: Available online 11 June 2020Source: Autoimmunity ReviewsAuthor(s): Yves Allenbach, Céline Anquetil, Ali Manouchehri, Olivier Benveniste, Olivier Lambotte, Bénédicte Lebrun-Vignes, Jean-Philippe Spano, Stéphane Ederhy, David Klatzmann, Michelle Rosenzwajg, Bruno Fautrel, Jacques Cadranel, Douglas B. Johnson, Javid J. Moslehi, Joe-Elie Salem
Fri Jun 12, 2020 20:17
Publication date: Available online 11 June 2020Source: Autoimmunity ReviewsAuthor(s): Francesca Angileri, Sébastien Legare, Antonella Marino Gammazza, Everly Conway de Macario, Alberto JL Macario, Francesco Cappello
Sun Jun 14, 2020 18:00
Publication date: Available online 11 June 2020Source: Autoimmunity ReviewsAuthor(s): Michael Ehrenfeld, Angela Tincani, Laura Andreoli, Marco Cattalini, Assaf Greenbaum, Darja Kanduc, Jaume Alijotas-Reig, Vsevolod Zinserling, Natalia Semenova, Howard Amital, Yehuda Shoenfeld
Fri Jun 12, 2020 20:17
High-dose methotrexate (HD-MTX) is commonly used in the treatment of solid tumors and hematological malignancies. Severe toxicities are frequent, leading to organ dysfunction and death. Risk–benefit ratio of u...
Sat Jun 13, 2020 03:00
Endotoxins can induce an excessive inflammatory response and result in microcirculatory dysfunction. Polymyxin-B hemoperfusion (PMX-HP) has been recognized to effectively remove endotoxins in patients with sep...
Fri Jun 12, 2020 03:00
Although many techniques have been introduced to facilitate nasogastric tube (NGT) insertion using anatomic landmarks and a group of devices, there is a lack of general consensus regarding a standard method. T...
Fri Jun 12, 2020 03:00
Abstract ECG-based representation of atrial fibrillation (AF) progression is currently limited. We propose a novel framework for a more sensitive noninvasive characterization of the AF substrate during persistent AF. An atrial activity (AA) recurrence signal is computed from body surface potential map (BSPM) recordings, and a set of characteristic indices is derived from it which captures the short- and long-term recurrent behaviour in the AA patterns. A novel measure of short-...
Sat Jun 13, 2020 03:00
Abstract Epileptic seizure detection and classification in clinical electroencephalogram data still is a challenge, and only low sensitivity with a high rate of false positives has been achieved with commercially available seizure detection tools, which usually are patient non-specific. Epilepsy patients suffer from severe detrimental effects like physical injury or depression due to unpredictable seizures. However, even in hospitals due to the high rate of false positives, the...
Fri Jun 12, 2020 03:00
Abstract Nowadays, acoustic emission (AE) has its applications in various areas, including mechanical, civil, underwater acoustics, and biomedical engineering. It is a non-destructive evaluation (NDE) and a non-intrusive method to detect active damage mechanisms such as crack growth, delamination, and processes such as friction, continuous wear, etc. The application of AE in orthopedics, especially in hip implant monitoring, is an emerging research field. This article presents...
Fri Jun 12, 2020 03:00
To the Editor: Information on the natural history of asymptomatic infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) remains scarce. The outbreak of coronavirus disease 2019 (Covid-19) on the cruise ship Diamond Princess led to 712 persons being infected with SARS-CoV-2…
Fri Jun 12, 2020 03:00
In Minnesota, where black Americans account for 6% of the population but 14% of Covid-19 cases and 33% of Covid-19 deaths, George Floyd died at the hands of police. "Please — I can’t breathe." He was a black man detained on suspicion of forgery, an alleged offense that was never litigated or even…
Wed Jun 10, 2020 03:00
Abstract The chromosomal region critical in Down syndrome has long been analyzed through genotype–phenotype correlation studies using data from many patients with partial trisomy 21. Owing to that, a relatively small region of human chromosome 21 (35.9 ~ 38.0 Mb) has been considered as Down syndrome critical region (DSCR). In this study, microarray-based comparative genomic hybridization analysis identified complex rearrangements of chromosome 21 in a patient manifesting clinical...
Sat Jun 13, 2020 03:00
Abstract The fragile X premutation is defined by the expansion of the CGG trinucleotide repeat at the 5′ UTR of the FMR1 gene to between 55 and 200 repeats, while repeat tracks longer than 200 are defined as full mutations. Men carrying a premutation are at increased risk for fragile X-associated tremor/ataxia syndrome (FXTAS); those with > 200 repeats have fragile X syndrome, a common genetic form of intellectual disabilities. In our study, we tested the hypothesis that men...
Fri Jun 12, 2020 03:00
Abstract Vascular anomalies (VAs), comprising wide subtypes of tumors and malformations, are often caused by variants in multiple tyrosine kinase (TK) receptor signaling pathways including TIE2, PIK3CA and GNAQ/11. Yet, a portion of individuals with clinical features of VA do not have variants in these genes, suggesting that there are undiscovered pathogenic factors underlying these patients and possibly with overlapping phenotypes. Here, we identified one rare non-synonymous...
Fri Jun 12, 2020 03:00
Ginger (Zingiber officinale Rosc) (Zingiberaceae) is a livelihood and commercial crop in Ethiopia. But, the availability of clean and healthy planting materials has become a problem due to wilt disease, caused by Ralstonia solanacearum Biovar 3 Race 4. This problem obliged growers to seek for tens of millions of vigorous and disease-free planting materials very quickly via in vitro micropropagation of shoot tip explants. For this purpose, protocols of sterilizing shoot tip explants and controlling...
Sat Jun 13, 2020 12:35
Reliable sources of CO2 that are relatively cheap, obtainable, and easy to sustain are immediately required for scaling up of odor-baited mosquito surveillance and control devices. Several odor-baited devices are in the pipeline; however, their scale-up against residual malaria transmission, particularly in resource poor areas, is limited by the unavailability of reliable sources of CO2 and reliance on electrical power sources among other factors. We evaluated the use of granular cyclopentanone as...
Sat Jun 13, 2020 11:20
Fri Jun 12, 2020 16:50
Related ArticlesThe current clinical approach to newly diagnosed uterine cancer. Expert Rev Anticancer Ther. 2020 Jun 12;: Authors: Filippova O, Leitao MM Abstract INTRODUCTION: Uterine cancer is the most common gynecologic malignancy, although fortunately, 75% of women present with early-stage disease. A major area of controversy regarding the management of the disease concerns postoperative therapy for both women with early- and advanced-stage endometrial...
Sat Jun 13, 2020 18:49
Related ArticlesEfficacy and safety of afatinib for non-small-cell lung cancer: state-of-the-art and future perspectives. Expert Rev Anticancer Ther. 2020 Jun 12;:1-12 Authors: Sartori G, Belluomini L, Lombardo F, Avancini A, Trestini I, Vita E, Tregnago D, Menis J, Bria E, Milella M, Pilotto S Abstract INTRODUCTION: Afatinib is a second-generation epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor, acting as an irreversible and multitarget...
Sat Jun 13, 2020 18:49
Related ArticlesRare Bilateral Caudate Infarction in a Patient with a Common Circle of Willis Variant. Can J Neurol Sci. 2019 09;46(5):593-594 Authors: Anello MG, Miao TL, Pandey SK, Mandzia JL Abstract A 62-year-old male presented to hospital with acute aphasia. His past medical history was significant for a previous left middle cerebral artery stroke, from which he fully recovered, hypertension, dyslipidemia, coronary artery disease, one episode of...
Sat Jun 13, 2020 18:40
Dual transcranial direct current stimulation (tDCS) to the bilateral primary motor cortices (M1s) has potential benefits in chronic stroke, but its effects in subacute stroke, when behavioural effects might be...
Thu Jun 11, 2020 03:00
To the Editor: There is a bidirectional relationship between Covid-19 and diabetes. On the one hand, diabetes is associated with an increased risk of severe Covid-19. On the other hand, new-onset diabetes and severe metabolic complications of preexisting diabetes, including diabetic ketoacidosis…
Fri Jun 12, 2020 03:00
To the Editor: Neurologic symptoms, including headache, altered mental status, and anosmia, occur in many patients with Covid-19. We report the neuropathological findings from autopsies of 18 consecutive patients with SARS-CoV-2 infection who died in a single teaching hospital between April 14 and…
Fri Jun 12, 2020 03:00
Internal Target Volume (ITV) is one of the most common strategies to passively manage tumour motion in Radiotherapy (RT).
Fri Jun 12, 2020 03:00
Chemoradiotherapy remains the standard of care for locally advanced rectal cancer. Efforts to intensify treatment and increase response rates have yet to yield practice changing results due to increased toxici...
Fri Jun 12, 2020 03:00
Retrospective analysis of volumetric modulated arc therapy treatment plans to investigate qualitative, possible, clinical consequences of the use of AAA versus AXB in nasopharyngeal cancer (NPC) cases.
Fri Jun 12, 2020 03:00
Publication date: Available online 13 June 2020Source: Journal of Bodywork and Movement TherapiesAuthor(s): Tracy Hellem, Young-Hoon Sung, Hayden Ferguson, Laura Hildreth
Sat Jun 13, 2020 16:53
Publication date: Available online 13 June 2020Source: The Journal of Prosthetic DentistryAuthor(s): Caroline Vieira Maluf, Camilla Alves Janott-Sarlo, Martinna de Mendonça Bertolini, Lívia Rodrigues Menezes, Eduardo José Veras Lourenço, Daniel de Moraes Telles
Sat Jun 13, 2020 16:47
Publication date: Available online 12 June 2020Source: The Journal of Prosthetic DentistryAuthor(s): Jan K. Mitchell, David E. Urbanawiz, John C. Morgan
Sat Jun 13, 2020 16:47
Related ArticlesCorrigendum. Future Oncol. 2020 Jun 12;: Authors: PMID: 32530299 [PubMed - as supplied by publisher]
Sat Jun 13, 2020 16:36
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Sat Jun 13, 2020 16:27
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Sat Jun 13, 2020 16:27
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Fri Jun 12, 2020 16:52
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Fri Jun 12, 2020 16:52
Application of Principal Component Analysis to Newborn Screening for Congenital Adrenal Hyperplasia.
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Fri Jun 12, 2020 16:52
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Fri Jun 12, 2020 16:52
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Fri Jun 12, 2020 16:52
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Fri Jun 12, 2020 16:52
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Fri Jun 12, 2020 16:52
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