Journal of International Medical Research, Volume 48, Issue 6, June 2020. ObjectivePeriarticular defect coverage remains challenging because multi-vector tension forces affect wound tensile strength. This study presents our experience with keystone design perforator island flap (KDPIF) reconstruction of non-oncological periarticular defects surrounded by the zone of injury and describes the expanding versatility of KDPIF reconstruction for periarticular defects.MethodsFrom June 2017 to July 2019,...
Fri Jun 12, 2020 12:07
Journal of International Medical Research, Volume 48, Issue 6, June 2020. ObjectiveTo explore associations between temperature, humidity and hand, foot and mouth disease (HFMD) incidence in Guangzhou, China from 2013 to 2017.MethodsA distributed lag non-linear model was applied to estimate the effects of daily temperature and humidity on HFMD incidence after adjusting for long-term trends, seasonal trends, and day of the week.ResultsIn total, 353,431 confirmed HFMD cases were reported in Guangzhou...
Fri Jun 12, 2020 11:35
Journal of International Medical Research, Volume 48, Issue 6, June 2020. ObjectiveThis study was performed to examine the clinical outcomes of epidural and intradural decompression for degenerative cervical myelopathy.MethodsThe data for 13 patients who underwent epidural and intradural decompression for treatment of degenerative cervical myelopathy (study group) and 20 patients who underwent only cervical laminoplasty, fusion, and epidural decompression (historical control group) were retrospectively...
Fri Jun 12, 2020 11:29
Journal of International Medical Research, Volume 48, Issue 6, June 2020. ObjectiveTo investigate the clinical features and outcomes of cryptococcal meningitis (CM) in HIV-negative patients with and without lung infections.MethodsWe retrospectively reviewed the medical records of HIV-negative patients with CM admitted to two university hospitals in Southwest China over the past 5 years.ResultsSeventy-one patients were included, of whom 35 (49.3%) had lung disease. Compared with patients without lung...
Fri Jun 12, 2020 11:20
Journal of International Medical Research, Volume 48, Issue 6, June 2020. ObjectiveNon-small cell lung cancer (NSCLC) accounts for approximately 80% of all lung cancers, but its pathogenesis has not been fully elucidated. Therefore, it is valuable to explore the pathogenesis of NSCLC to improve diagnosis and identify novel treatment biomarkers.MethodsCircular (circ)RNA, micro (mi)RNA, and gene expression datasets of NSCLC were analyzed to identify those that were differentially expressed between...
Fri Jun 12, 2020 11:13
Journal of International Medical Research, Volume 48, Issue 6, June 2020. ObjectiveTo investigate the possibility of combining tuberculosis (TB)-interferon (IFN)-γ release assays (IGRAs) with lymphocyte enumeration for diagnosis of Mycobacterium tuberculosis infection.MethodsWe performed a retrospective study of 166 TB patients [68 patients with pulmonary tuberculosis TB (PTB) and 98 patients with extra-pulmonary TB (EPTB)] diagnosed in our hospital between January 2016 and May 2018 along with 377...
Fri Jun 12, 2020 11:09
Journal of International Medical Research, Volume 48, Issue 6, June 2020. Acute graft-versus-host disease (aGvHD) reduces the efficiency and safety of allogeneic hematopoietic stem cell transplantation (allo-HSCT). In recent years, attempts have been made to transplant fecal microbiota from healthy donors to treat intestinal GvHD. This study presented two cases of patients undergoing allo-HSCT who were later selected for fecal microbiota transplantation (FMT). In the first patient, FMT resulted in...
Fri Jun 12, 2020 11:02
Journal of International Medical Research, Volume 48, Issue 6, June 2020. Patients in regional, rural and remote communities experience perennial difficulties accessing mental health treatments in a timely manner, which contributes to inequitable outcomes when compared with their metropolitan counterparts. This situation frequently stems from a shortage of specialised face-to-face psychotherapy services available in local areas. The recent development of digital psychotherapy as an alternative treatment...
Fri Jun 12, 2020 10:44
Journal of International Medical Research, Volume 48, Issue 6, June 2020. ObjectiveThis study aimed to explore the therapeutic effect of high-frequency repetitive transcranial magnetic stimulation (HF-rTMS) with two different inter-train intervals (ITIs) on upper limb motor function in the early period of stroke.MethodsWe recruited 48 post-stroke patients in the early period and randomly divided them into three cohorts: the sham group, the short ITI (8 s) group, and the long ITI (28 s) group. HF-rTMS...
Fri Jun 12, 2020 10:42
Journal of International Medical Research, Volume 48, Issue 6, June 2020. ObjectiveTo analyse the clinicopathological features of isolated pulmonary cryptococcosis in human immunodeficiency virus (HIV)-negative patients.MethodsThis retrospective study analysed the following data from HIV-negative patients diagnosed with pulmonary cryptococcosis: demographics, underlying diseases, clinical manifestations on admission, laboratory tests, imaging data, results of histopathology, treatment options and...
Fri Jun 12, 2020 10:39
Journal of International Medical Research, Volume 48, Issue 6, June 2020. ObjectiveThis study was performed to evaluate the capability of routine clinical indicators to predict the early outcome of embryos with cardiac activity in women with recurrent spontaneous abortion (RSA).MethodsA retrospective cohort study of pregnant women with a history of RSA in a Chinese tertiary hospital was performed using unadjusted and multivariable logistic regression.ResultsOf 789 pregnant women with RSA, 625 (79.21%)...
Fri Jun 12, 2020 10:35
Journal of International Medical Research, Volume 48, Issue 6, June 2020. ObjectivesTo analyze the clinical characteristics and perinatal outcomes of umbilical cord vascular rupture, and to investigate the diagnosis and treatment strategies for reducing adverse perinatal outcomes.MethodsClinical data of patients with a singleton pregnancy with umbilical cord rupture who were admitted to Fujian Maternity and Child Health Hospital were collected. The incidence, related factors, clinical features and...
Fri Jun 12, 2020 09:52
Journal of International Medical Research, Volume 48, Issue 6, June 2020. ObjectiveThis study was performed to assess the clinical value of measuring the intact parathyroid hormone (iPTH) concentration 1 day after total thyroidectomy to estimate the occurrence of permanent hypoparathyroidism (pHPP).MethodsData of 546 patients who underwent total thyroidectomy from February 2008 to December 2018 were retrospectively analyzed. Calcium and iPTH concentrations were collected preoperatively and at 1 day...
Fri Jun 12, 2020 09:46
Journal of International Medical Research, Volume 48, Issue 6, June 2020. ObjectiveTo assess ovarian reserve through antral follicle count (AFC) and ovarian volume (OV) determination after decapsulation (stripping technique) or CO2 laser vaporization in the surgical treatment of patients with bilateral ovarian endometriomas.MethodsThis prospective, randomized, blinded, self-controlled pilot study was set in a tertiary university hospital between January 2017 and December 2017, and included consecutive...
Fri Jun 12, 2020 09:44
Journal of International Medical Research, Volume 48, Issue 6, June 2020. ObjectiveThe aim of the study was to investigate knowledge of breaking bad news (BBN) among medical personnel in the emergency medical services (EMS).MethodsA cross-sectional survey was conducted of 148 individuals employed in EMS. An interview was conducted using a structured questionnaire.ResultsOf study participants, 89.2% were not aware of any formal BBN procedure and 58.1% had not participated in any form of training....
Thu Jun 11, 2020 11:33
Abstract The reconstructive techniques have been widely used in Veterinary Medicine. The post-operative adjuvants therapies like the low-level laser therapy (LLLT) are used to decrease inherent complications to reconstructive surgeries. This article purposed to define the LLLT effects on the healing, inflammation, and vascularization of the skin grafts in applicable time intervals to veterinary surgical routine. Forty rats (Rattus norvegicus albinus wistar) were used and each...
Sat Jun 13, 2020 09:51
Abstract Snakebites caused by the genus Bothrops are often associated with severe and complex local manifestations such as edema, pain, hemorrhage, and myonecrosis. Conventional treatment minimizes the systemic effects of venom; however, their local action is not neutralized. The purpose of this study was to evaluate the effect of photobiomodulation (PBM) on C2C12 muscle cells exposed to B. jararaca, B. jararacussu, and B. moojeni venoms on events involved in cell death and...
Sat Jun 13, 2020 09:51
Abstract This study investigated the combined effect of CO2 laser irradiation and Remin Pro paste on microhardness of enamel white spot lesions (WSLs). Seventy-eight intact premolars were randomly assigned into six groups and then stored in a demineralizing solution to create WSLs. Afterwards, the teeth in group 6 (negative control) remained untreated, while groups 1 and 4 were exposed to CO2 laser irradiation (20 Hz, 1 W, 30 s) and Remin Pro paste, respectively. In groups 2...
Sat Jun 13, 2020 09:51
Sat Jun 13, 2020 09:51
Abstract To explore the advantages and limitations of holmium laser resection of the bladder tumor (HOLRBT) versus standard transurethral resection of the bladder tumor (TURBT) in the treatment of non-muscle-invasive bladder cancer (NMIBC), the eligible studies were selected from the following databases: PubMed, Cochrane Library, and Embase. Studies comparing HOLRBT and TURBT for patients with NMIBC were included. The outcomes of interest were time of operation, catheterization...
Sat Jun 13, 2020 09:51
Abstract Purpose Acne scarring represents a common problem that negatively impacts patients’ quality of life. Different types of treatments are currently available for this dermatological condition. This study evaluates the efficacy of a new 675-nm laser source system on acne scars with the use of established parameters that guarantee minimum pain and the absence of side effects such as hyperpigmentation, hypopigmentation, and blistering....
Sat Jun 13, 2020 03:00
Abstract The aim of this study was to evaluate the efficacy and safety of 1064 nm neodymium-doped yttrium-aluminum-garnet laser treatment of melanocytic nevus of the external auditory canal. Retrospective chart review of 15 patients operated by 1064 nm Nd:YAG laser in single center. Data from charts and video documentation were collected and analyzed. Between November 2017 and November 2018, 15 patients underwent 1064 nm Nd:YAG laser treatment for melanocytic nevus of the external...
Sat Jun 13, 2020 03:00
Abstract Photobiomodulation (PBM) therapy is used to stimulate cell proliferation and metabolism, as well as reduce inflammatory cytokine synthesis, which plays a main role in the long-term stability of implants. This study assessed the response of gingival fibroblasts cultured on titanium (Ti) and zirconia (ZrO2), submitted to PBM and exposed to lipopolysaccharide (LPS). Cells seeded on Ti and ZrO2 were irradiated (InGaAsP; 780 nm, 25 mW) 3 times, using 0.5, 1.5, and 3.0 J/cm2...
Fri Jun 12, 2020 03:00
Abstract The Research Training Opportunities for Outstanding Leaders (ReTOOL) program was implemented in 2012 to increase the representation of racial and ethnic minorities in the biomedical workforce. Specifically, the ReTOOL program aims to foster the capacity for scientific research among underserved populations as well as address the cultural appropriateness of research projects. This paper describes the impact of the ReTOOL program in enhancing the research training of underrepresented...
Sat Jun 13, 2020 03:00
Abstract After a diagnosis of cancer (or other serious disease), patients may be asked to consider joining a clinical trial. Because most people are unfamiliar with the scientific concepts that are necessary to the provision of meaningful informed consent, patient education is necessary. Increasing knowledge alone is not sufficient; understanding how clinical trial participation aligns with personal circumstances and knowledge is central to the decision-making process. In this...
Sat Jun 13, 2020 03:00
Abstract Public health concerns regarding opioids and marijuana have implications for their medical use. This study examined use motives and perceived barriers in relation to opioid and marijuana use and interest in use among US adult cancer survivors. Self-administered surveys were distributed using social media to assess use motives and perceived barriers among participants living with cancer. Overall, 40.9% of cancer survivors reported current (past 30-day) use of opioids,...
Fri Jun 12, 2020 03:00
Abstract Purpose To study the influence of the access window dimensions on the healing at the antrostomy and within the augmented maxillary sinus. Material and methods A maxillary sinus augmentation was performed in twenty-four albino New Zealand rabbits. Antrostomies of 3 × 6 mm (small) or 5 × 6 mm (large) in dimensions were randomly prepared in each...
Sat Jun 13, 2020 03:00
Abstract In this reply to a letter, the Authors discuss the raised points regarding the nomenclature and management of Lymphatic Malformations / Lymphangiomas.
Fri Jun 12, 2020 03:00
Abstract Eruption sequestrum (ES) is a single or even multiple, small whitish calcified masses found within the soft tissue of the opercula overlying the crown of erupting permanent molars of children. We herein report a well-documented case of ES, offering a review of published cases in the English literature. An otherwise healthy 6-year-old girl was seen for routine dental examination. A fragment of hard whitish tissue was observed in the gingiva overlying the erupting lower...
Fri Jun 12, 2020 03:00
Abstract Background When evaluating patients’ profile, surgeons usually note the lack of the chin projection and may suggest chin augmentation, but they rarely discuss reduction of an over-projecting chin. This is unfortunate, since there are quite many individuals who have macrogenia and would aesthetically benefit from corrective surgery, but the chin reduction is seldom offered. The reason for this is the lack of experience, lack...
Fri Jun 12, 2020 03:00
Analytical ChemistryDOI: 10.1021/acs.analchem.0c01263
Fri Jun 12, 2020 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c04695
Fri Jun 12, 2020 07:00
[ASAP] Thiophene-Based Two-Dimensional Dion–Jacobson Perovskite Solar Cells with over 15% Efficiency
Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c03363
Fri Jun 12, 2020 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c04328
Fri Jun 12, 2020 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c02956
Fri Jun 12, 2020 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c03990
Fri Jun 12, 2020 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c01880
Fri Jun 12, 2020 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c04252
Fri Jun 12, 2020 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c01671
Fri Jun 12, 2020 07:00
Abstract The hyoid contributes to a range of functional behaviors such as breathing, swallowing, and vocalization. Among nonhuman primates, hyoid morphology and position show taxonomic differences. For example, cercopithecoid hyoids are more anatomically constrained than hominoid hyoids, which may influence their morphology. While most of the existing literature on the hyoid in nonhuman primates compares morphological differences among species, studies of intraspecific hyoid morphological...
Sat Jun 13, 2020 03:00
A research collaboration has demonstrated the function of a genetic pathway for anther development, with this pathway proven in 2019 work to be present widely in the flowering plants that evolved over 200 million years ago.
Thu Jun 11, 2020 22:14
Despite continuous updates of the human reference genome, there are still hundreds of unresolved gaps which account for ~5% of the total sequence length. Given the availability of whole genome de novo assemblies, especially those derived from long-read sequencing data, gap-closing sequences can be determined. By comparing 17 de novo long-read sequencing assemblies with the human reference genome, we identified a total of 1,125 gap-closing sequences for 132 (16.9% of 783) gaps and added up to 2.2...
Fri Jun 12, 2020 23:57
Tilapia are amongst the most important farmed fish species worldwide, and are fundamental for the food security of many developing countries. Several genetically improved Nile tilapia (Oreochromis niloticus) strains exist, such as the iconic Genetically Improved Farmed Tilapia (GIFT), and breeding programmes typically follow classical pedigree-based selection. The use of genome-wide single-nucleotide polymorphism (SNP) data can enable an understanding of the genetic architecture of economically important...
Fri Jun 12, 2020 23:57
Single-cell RNA sequencing (scRNA-seq) is a recent technology that enables fine-grained discovery of cellular subtypes and specific cell states. It routinely uses machine learning methods, such as feature learning, clustering, and classification, to assist in uncovering novel information from scRNA-seq data. However, current methods are not well suited to deal with the substantial amounts of noise that is created by the experiments or the variation that occurs due to differences in the cells of the...
Fri Jun 12, 2020 18:19
Total metabolic tumor volume (TMTV), calculated from 18F-labeled fluoro-2-deoxyglucose (18F-FDG) positron-emission tomography–computed tomography (PET/CT) baseline studies, is a prognostic factor in diffuse large B-cell lymphoma (DLBCL) whose measurement requires the segmentation of all malignant foci throughout the body. No consensus currently exists regarding the most accurate approach for such segmentation. Further, all methods still require extensive manual input from an experienced reader. We...
Sat Jun 13, 2020 02:23
Redirecting the immune system in cancer treatment has led to remarkable responses in a subset of patients. Natural killer (NK) cells are innate lymphoid cells being explored as they engage tumor cells in different mechanisms compared to T cells, which could be exploited for treatment of nonresponders to current immunotherapies. NK cell therapies are monitored through measuring peripheral NK cell concentrations or changes in tumor volume over time. The former does not detect NK cells at the tumor...
Sat Jun 13, 2020 02:23
Introduction: Fixed-dose pembrolizumab (200 mg abs., d1, q3w) for the treatment of malignant pleural mesothelioma did not result in survival benefit in the phase 3 PROMISE-meso trial compared to 2nd-line chemotherapy. Due to lack of validated imaging response criteria, responder-subgroups with potential survival benefit have not yet been identified. Here, we administered high-dose pembrolizumab (10 mg/kg, d1, q2w) considering the KEYNOTE-028 trial and assessed the prognostic value of PET metabolic...
Sat Jun 13, 2020 02:23
Τα ευρήματα άρθρου που πραγματεύεται τις προκλήσεις των ψευδώς αρνητικών διαγνωστικών ελέγχων για τον κορωνοϊό και που δημοσιεύτηκε στο επιστημονικό περιοδικό New England Journal of Medicine, συνοψίζουν οι γιατροί της Θεραπευτικής Κλινικής της Ιατρικής Σχολής του ΕΚΠΑ. Από τα συμπεράσματα προκύπτει ότι τα ψευδώς αρνητικά αποτελέσματα ακόμη και σε υψηλής ευαισθησίας τεστ δεν μπορούν να αποκλείσουν την ύπαρξη λοίμωξης, ενώ ενδεχομένως επαναλαμβανόμενα τεστ σε άτομα πολύ υψηλής κλινικής υποψίας να...
Fri Jun 12, 2020 21:48
Στις 29 Ιουνίου παρέπεμψε ο υπουργός Μεταφορών, Γκραντ Σαπς, για ο,τιδήποτε νεότερο αφορά την καραντίνα 14 ημερών που ισχύει για τους επισκέπτες στη Βρετανία, καθώς μέχρι τότε δεν θα ανακοινωθεί κάτι περεταίρω που ενδεχομένως να αφορά συνομιλίες με άλλες χώρες για τη δημιουργία αεροδιαδρόμων, οι οποίοι θα διευκολύνουν τα αεροπορικά ταξίδια. «Θα προχωρήσουμε στις αερογέφυρες όταν θα είναι ασφαλές να το κάνουμε» είπε, στη διάρκεια της ενημέρωσης από την κυβέρνηση για την πανδημία του κορωνοϊού. Υπενθύμισε...
Fri Jun 12, 2020 20:23
Πρόσφατα συγκριτικά (head-to-head) δεδομένα Φάσης 3b καταδεικνύουν υψηλότερα ποσοστά κάθαρσης του δέρματος για το risankizumab-rzaa έναντι του secukinumab την 52η εβδομάδα, όπως προκύπτει από τη μελέτη IMMerge. Η IMMerge είναι μία Φάσης 3b, πολυκεντρική, τυχαιοποιημένη, ανοικτή (και τα δύο σκέλη) μελέτη τυφλής αξιολόγησης αποτελεσματικότητας με ενεργό συγκριτικό παράγοντα που σχεδιάστηκε για την αξιολόγηση της ασφάλειας και της αποτελεσματικότητας του risankizumab-rzaa σε σύγκριση με το secukinumab...
Fri Jun 12, 2020 15:44
Η σεροτονίνη, χημική ουσία γνωστή για τον ρόλο της στην πρόκληση ευφορίας και ευτυχίας στον εγκέφαλο, μπορεί να μειώσει την ικανότητα κάποιων παθογόνων στο έντερο να προκαλέσουν σοβαρές λοιμώξεις, σύμφωνα με μία νέα έρευνα επιστημόνων του Πανεπιστημίου Southwestern. Τα ευρήματα, που δημοσιεύθηκαν στο Cell Host & Microbe, θα μπορούσαν να προσφέρουν ένα νέο τρόπο αντιμετώπισης των λοιμώξεων για τις οποίες υπάρχουν ελάχιστες πραγματικά αποτελεσματικές θεραπείες. Παρόλο που η μεγάλη πλειοψηφία...
Fri Jun 12, 2020 12:55
Τα μικρόβια, από τα βακτήρια έως τους ιούς και τους μύκητες, βρίσκονται παντού, συμπεριλαμβανομένου του ανθρώπινου οργανισμού. Θα μπορούσαν να απουσιάζουν από μια συσκευή όπως το πλυντήριο πιάτων; Την αρνητική απάντηση στο παραπάνω ερώτημα έδωσε έρευνα που δημοσιεύτηκε στο Applied and Environmental Microbiology, η οποία εξέτασε ποια βακτήρια και μύκητες κατοικούν στα πλυντήρια πιάτων καθώς και τους παράγοντες που ευνοούν τον εποικισμό τους. Σύμφωνα με την Erica Hartmann, Επίκουρη Καθηγήτρια Μικροβιολογίας...
Fri Jun 12, 2020 12:43
Μια διεθνής ομάδα ερευνητών υπό την επίβλεψη του Πανεπιστημίου McMaster βρήκε ότι ενώ η υψηλότερη θερμοκρασία και η υγρασία μπορούν να καθυστερήσουν την εξάπλωση της COVID-19, οι περισσότερες ώρες ηλιοφάνειας σχετίζονται με αυξημένη συχνότητα εμφάνισης της νόσου, σημάδι ότι οι ημέρες με λιακάδα μπορούν να δελεάσουν περισσότερο τους ανθρώπους να βγουν έξω, ακόμα κι αν αυτό σημαίνει υψηλότερο κίνδυνο μόλυνσης. Τα ευρήματα, που δημοσιεύθηκαν στο Geographical Analysis, ενημερώνουν τον εκτεταμένο επιστημονικό...
Fri Jun 12, 2020 08:44
Πόσο ασφαλής είναι η κολύμβηση στη θάλασσα ή την πισίνα κατά τη διάρκεια της πανδημίας του νέου κορωνοϊού; Σύμφωνα με τις οδηγίες των υγειονομικών αρχών, δεν υπάρχει κάποιος κίνδυνος, εφόσον τηρείται το μέτρο της απόστασης μεταξύ των κολυμβητών μέσα και έξω από το νερό. Ωστόσο, παρά την καθησυχαστική γραμμή των ειδικών, ο φόβος πιθανής μόλυνσης από τον ιό δεν φαίνεται να υποχωρεί. Εξ ου και η επαναλειτουργία πισινών και οργανωμένων παραλιών συνοδεύεται από προσωρινούς κανόνες που περιορίζουν την...
Fri Jun 12, 2020 08:20
Image description: A man with short hair wearing a long-sleeved, button-down shirt sits at a desk and smiles.1954–2020 Steven Alec Weber passed away quietly, surrounded by family on January 14, 2020, from ALS, a disease he lived with for several years that he once described to me as a “new life experience.” That characterization of a crippling disease accurately reflects Weber’s upbeat personality. Not one to be overwhelmed or depressed by his condition, he embraced it and lived with it to the end,...
Sat Jun 13, 2020 00:03
Image description: A light-skinned woman with short-cropped white and grey hair is sitting in a chair outdoors and looks at the camera. 1945–2019 After a prolonged struggle with cancer, Marilyn Silverman passed away in Toronto, Canada, on June 18, 2019. She joined York University in 1971, becoming full professor in 1996. Silverman was born (April 30, 1945), brought up, and educated in Montreal, Quebec. Her undergraduate and graduate degrees in anthropology were all taken at McGill, where she was...
Sat Jun 13, 2020 00:03
1935–2018 Roderick (Rod) Earl Burchard, a cultural anthropologist known for his perceptive and groundbreaking analyses of coca chewing in the Andes, passed away on December 21, 2018, in Victoria, BC. Burchard was born September 9, 1935, in Granville, Ohio, to Frederick Ralph Burchard and Mary Marguerite “Maggie” Yingling Burchard. He is survived by his spouse, Andrea Foster Burchard, sons John and Paul Burchard, and four grandchildren—Ellie and Erin Burchard (John) and Toby and Lily-Jane Burchard...
Sat Jun 13, 2020 00:01
Caption: Ira E. Harrison at the Association of Black Anthropologists’ celebration of St.Clair Drake’s life’s work and 75th birthday, during the American Anthropological Association Annual Meeting in Washington DC, December 1985. Image description: A dark-skinned man wearing glasses and a suit smiles at the camera, hand on his chin. 1933–2020 Ira E. Harrison, activist, poet, pioneer, mentor, and professor emeritus of anthropology at the University of Tennessee, Knoxville (UTK), passed away on April...
Sat Jun 13, 2020 00:01
Image description: A light-skinned woman with shoulder-length white hair smiles at the camera. She wears a black long-sleeved shirt and clasps her hands in front of her.1931–2020 Sarah Milledge Nelson (November 29, 1931–April 27, 2020) enjoyed a remarkable career establishing contemporary archaeological practice in Korea, launching a series of books on archaeological recognition of women and gender, and leading scientific programs in the University of Denver. She published eight books on archaeology,...
Sat Jun 13, 2020 00:00
I typed out the phrase and then paused, my finger hovering over the delete key. “I’ll be praying for you and your family.” This was not something I said aloud, much less wrote. It was certainly not something I wrote to a student. Too personal, I thought. Too much like what folks back home might say. In the United States, ”praying for” signals Christian identity and devotion. Typing it out felt like donning some ill-fitting garment. Besides, I had often heard the phrase as an “out” for those who wished...
Fri Jun 12, 2020 21:30
AbstractCancer is often treated with broad-spectrum cytotoxic drugs that not only eradicate cancerous cells, but also have detrimental side effects. One of these side-effects, disruption of the olfactory system, impedes a patient’s ability to smell, perceive flavor, and ultimately may interfere with their nutritional intake and recovery from cancer. Recent studies reported that the chemotherapy drug, cyclophosphamide (CYP), can damage gustatory epithelia and disrupt cell proliferation in olfactory...
Fri Jun 12, 2020 03:00
AbstractThis longitudinal study aimed to evaluate qualitative (parosmia) and quantitative (hyposmia/anosmia) olfaction 2-4 weeks (baseline) and six months (follow-up) after a mild traumatic brain injury (mTBI). We further evaluated the predictive value of baseline depression, anxiety and olfaction scores on depression and anxiety at follow-up. At baseline, olfactory function and affective state were assessed in 107 participants (53 patients with mild TBI; 54 healthy controls). At follow-up, data...
Tue Jun 09, 2020 03:00
Opinion statement Recent phase II clinical trials suggest that stereotactic ablative radiation therapy (SABR) can potentially improve survival for patients with oligometastatic cancer. However, these studies have mostly enrolled primaries other than gynecologic malignancies. While level I evidence is limited, recent publications exploring the use of SABR for oligometastatic gynecologic cancers have indicated a potential role for this treatment in para-aortic lymph node recurrences,...
Fri Jun 12, 2020 03:00
Purpose: Combination immunotherapy with anti-CTLA-4 and anti-PD-1 blockade has demonstrated significant clinical activity across several tumour types. Neuroendocrine tumors (NETs) are a heterogeneous group of rare tumors with limited treatment options. CA209-538 is a clinical trial of combination immunotherapy with ipilimumab and nivolumab in rare cancers, including advanced NETs. Experimental Design: CA209-538 is a prospective multicentre clinical trial in patients with advanced rare cancers....
Fri Jun 12, 2020 16:43
Purpose: Pancreatic cancer is one of the most lethal solid tumors, mainly because of its intrinsic chemoresistance. We identified TAK1 as a central hub sustaining this resistance. Nanoliposomal irinotecan (nal-IRI)is a novel treatment for metastatic gemcitabine-refractory pancreatic cancer. We endeavored to identify circulating markers for TAK1 activation predicting chemoresistance in this setting. Experimental design: In vivo activity of nal-IRI was validated in an orthotopic nude murine model...
Fri Jun 12, 2020 16:43
Purpose: We sought to improve upon frontline bendamustine/rituximab (BR) induction therapy followed by rituximab maintenance in untreated high-risk follicular lymphoma (FL). Patients and Methods: Patients were randomized to BR induction followed by 2-year rituximab maintenance (BR-R), BR with bortezomib and rituximab maintenance (BVR-R), or BR followed by lenalidomide (1 year) with rituximab maintenance (BR-LR). Dual primary objectives were complete remission (CR) rate and 1-year disease-free survival...
Fri Jun 12, 2020 16:43
Purpose: We report efficacy and safety with extended follow-up, and exploratory biomarker analyses from the phase II CheckMate 275 trial to identify biomarkers of response to nivolumab in platinum-resistant metastatic or unresectable urothelial carcinoma (mUC). Patients and Methods: Patients received nivolumab 3 mg/kg Q2W until disease progression, unacceptable toxicity, or other protocol-defined reasons. The primary endpoint was ORR per blinded independent review committee (BIRC; using RECIST v1.1)...
Fri Jun 12, 2020 16:43
Abstract Purpose To evaluate the effect of N-Acetylcysteine (NAC) in newborn rats submitted to hypoxia and reoxygenation (H/R) conditions in an experimental model of necrotizing enterocolitis. Methods Eight pregnant rats and their 70 cubs were used (5 groups) and exposed to H/R conditions and received NAC at different times. The animals in the H/R groups were placed in a gas chamber (100% CO2) for 10 minutes and then reoxygenated for 10 minutes (100% O2), twice a day for the first three days...
Fri Jun 12, 2020 20:05
Abstract Purpose To analyze the effect of calcitriol treatment on acute colitis in an experimental rat model. Methods A total of 24 adult Sprague Dawley albino rats were randomly separated into 3 equal groups: control group (n:8), colitis group (n:8), calcitriol administered group (n:8). A single dose of acetic acid (1 ml of 4% solution) was administered intrarectally to induce colitis. Group 1 was given 1 ml/kg 0.9% NaCl intraperitoneally; rats belonging to Group 2 were administered calcitriol...
Fri Jun 12, 2020 20:05
Abstract Purpose To investigate the effects of Chemically Extracted Acellular Nerves (CEANs) when combined with Adipose-Derived mesenchymal Stem Cell (ADSC) transplantation on the repair of sciatic nerve defects in rabbits. Methods A total of 71 six-month-old Japanese rabbit were used in this study. Twenty rabbits served as sciatic nerve donors, while the other 51 rabbits were randomly divided into Autologous Nerve Transplantation Group (ANT, n=17), CEAN group (n=17) and CEAN-ADSCs group (n=17)....
Fri Jun 12, 2020 20:05
Abstract Purpose To evaluate whether silicone foam implants have a different evolution pattern compared to conventional texture implants. Methods Fifty-eight female patients underwent surgery. They were divided into two groups (silicone foam – Lifesil® – and microtexturized silicone – Lifesil®). The evolution was analyzed in postoperative consultations, with physical examination, photographic documentation and filling in a satisfaction questionnaire, in the postoperative period of one month,...
Fri Jun 12, 2020 20:05
Abstract Purpose To evaluate the analgesic effect of esmolol in patients submitted to laparoscopic gastroplasty. Methods Forty patients aged between 18 and 50 years with American Society of Anesthesiologists (ASA) physical status scores of II and III who underwent gastric bypass were allocated to two groups. Group 1 patients received a 0.5-mg/kg bolus of esmolol in 30 mL of saline before induction of anesthesia, followed by an infusion at 15 µg/kg/min until the end of surgery. Group 2 patients...
Fri Jun 12, 2020 20:05
Microfluidic devices are analogous to circuit boards, and they can be programmed to perform all kinds of laboratory tasks on a small scale. They have the potential to perform all kinds of medical tests involving body fluids in a short time and using very small samples. While circuit boards pass electricity, which can be abstracted and quantified as bits, microfluidic devices tend to work with liquids that can mix with one another and contaminate each other. For microfluidic devices...
Fri Jun 12, 2020 19:40
To the Editor: There is a bidirectional relationship between Covid-19 and diabetes. On the one hand, diabetes is associated with an increased risk of severe Covid-19. On the other hand, new-onset diabetes and severe metabolic complications of preexisting diabetes, including diabetic ketoacidosis…
Fri Jun 12, 2020 03:00
We are writing with respect to three recently published papers1–3 that address the global burden of disease due to occupational exposures. This work by the Global Burden of Disease (GBD) 2016 Occupational Risk Factors Collaborators presents what appear to be precise estimates of the global burden of death and disease due to occupational exposure, for example, 2.8% of deaths and 3.2% of disability-adjusted life years (DALYs) from all causes.1 For cancer, the estimates are 3.9% of all cancer deaths...
Fri Jun 12, 2020 19:00
Publication date: Available online 11 June 2020Source: Reports of Practical Oncology & RadiotherapyAuthor(s): Marta Adamczyk, Marta Kruszyna-Mochalska, Anna Rucińska, Tomasz Piotrowski
Fri Jun 12, 2020 19:30
Publication date: August 2020Source: Brain and Language, Volume 207Author(s): Nathalie Giroud, Shari R. Baum, Annie C. Gilbert, Natalie A. Phillips, Vincent Gracco
Fri Jun 12, 2020 19:14
Publication date: Available online 11 June 2020Source: Annales de Chirurgie Plastique EsthétiqueAuthor(s): D. Sawan, R. Bosc, S. La Padula, E. Leblanc, F. Narducci, C. Touboul, J.-P. Meningaud, B. Hersant
Fri Jun 12, 2020 19:14
Publication date: Available online 12 June 2020Source: Clinical ImagingAuthor(s): Nassier Harfouch, Jonathan Stern, Varun Chowdhary, Yuly Arias, Seleshi Demissie, Jonathan Scheiner, Boris Khodorkovsky, Morris Hayim
Fri Jun 12, 2020 19:13
Publication date: Available online 11 June 2020Source: Clinical ImagingAuthor(s): Katerina Dodelzon, Geraldine McGinty, Amy Melsaether
Fri Jun 12, 2020 19:13
This study aims to assess the relationship between Food and Nutrition Literacy (FNLIT) and dietary diversity score (DDS); FNLIT and nutrient adequacy (NAR%, MAR%) in school-age children in Iran.
Fri Jun 12, 2020 03:00
Musculoskeletal pain is often caused by injury to the bones, muscles, tendons, ligaments or nerves. Symptoms can be localized or generalized. Mild-moderate symptoms are treated with topical/oral over the count...
Fri Jun 12, 2020 03:00
Adenosine has an analgesic and anti-inflammatory role and its injections are used for perioperative pain management. We aimed to study efficacy of intrathecal injection of adenosine for post-operative radicula...
Fri Jun 12, 2020 03:00
The influence of physical activity (PA) on the immune system has emerged as a new field of research. Regular PA may promote an anti-inflammatory state in the body, thus contributing to the down-regulation of p...
Thu Jun 11, 2020 03:00
COVID-19 arise global attention since their first public reporting. Infection prevention and control (IPC) is critical to combat COVID-19, especially at the early stage of pandemic outbreak. This study aimed t...
Thu Jun 11, 2020 03:00
Publication date: Available online 11 June 2020Source: Hearing ResearchAuthor(s): B.D. Richardson, S.Y. Sottile, D.M. Caspary
Fri Jun 12, 2020 18:51
Publication date: Available online 11 June 2020Source: Hearing ResearchAuthor(s): Martin Eklöf, Filip Asp, Erik Berninger
Fri Jun 12, 2020 18:51
Related ArticlesUpper airway volumetric changes of obstructive sleep apnoea patients treated with oral appliances: a systematic review and meta-analysis. Eur J Orthod. 2020 Jun 11;: Authors: Dontsos VK, Chatzigianni A, Papadopoulos MA, Nena E, Steiropoulos P Abstract BACKGROUND: Obstructive sleep apnoea (OSA) is a common sleep-related breathing disorder, attributed to the collapse of the pharyngeal walls and the subsequent complete or partial upper airway...
Fri Jun 12, 2020 18:44
After seven busy and very enjoyable, although sometimes challenging, years as editor-in-chief (EIC) of Occupational and Environmental Medicine (OEM), it is time for me to move on and allow someone new to take over the leadership of the journal. The new EIC is my colleague and friend, Professor Hans Kromhout, from the Institute for Risk Assessment Sciences at the University of Utrecht in the Netherlands. Hans will be very well known to OEM readers, having been an associate editor for many years, as...
Fri Jun 12, 2020 18:20
This systematic review was conducted to help clarify the effect of lifting at work on pregnancy outcome, by focusing on specific exposure categories. A search in Medline and Embase identified 51 articles reporting association of spontaneous abortion (SA), preterm delivery (PTD) or small-for-gestational-age (SGA) infant with exposure to occupational lifting. A global validity score was assigned to each study and six potential sources of bias were considered in sensitivity analyses. For each exposure–outcome...
Fri Jun 12, 2020 18:20
The 2019 bushfire catastrophe in Australia is only the most recent example of the increasing duration and intensity of wildfire events. In the past decade, the USA experienced 67 000 wildfires annually with an average 7 million acres burned. Over 34 000 US wildland firefighters (WLFFs) are engaged in arduous, high-risk duty, yet several features of this occupation limit our ability to understand the associated short-term and long-term health risks. For example, wildfire suppression activities are...
Fri Jun 12, 2020 18:20
ObjectivesThe determinants of poor functioning and subsequent early exit from work are well established but very little is known about the positive determinants of maintaining good functioning among the ageing workforce. We investigated modifiable determinants of maintaining good mental and physical health functioning. MethodsWe used prospective survey data collected across four waves among the midlife employees of the City of Helsinki, Finland, 2000–2017 (n=3342). Health functioning was repeatedly...
Fri Jun 12, 2020 18:20
ObjectivesIn order to make recommendations to protect wildland firefighters (WLFFs) from heat-related illness, the role physical exertion plays on core body temperature (Tc) in the work environment needs to be considered. We aimed to estimate the association of time-varying job tasks with differing exertion levels on change in Tc, among WLFFs engaged in fire management activities, while controlling for ambient conditions and individual characteristics. In addition, we examined whether duration of...
Fri Jun 12, 2020 18:20
The link between seasonal variation and viral outbreaks is a topic of much debate.1 It is postulated that cold temperatures increase viral half-lives and that low relative humidity (RH) adversely influences natural processes that otherwise lead to viral inactivation.2 3 As such, there is a growing interest in whether indoor temperature and RH may be modifiable risk factors for aerial transmission of viruses. Indeed, preclinical studies and observational data suggest that high temperature as well...
Fri Jun 12, 2020 18:20
ObjectiveHigh-risk opioid prescribing practices in workers’ compensation (WC) settings are associated with excess opioid-related morbidity, longer work disability and higher costs. This study characterises the burden of prescription opioid-related hospitalisations among injured workers. MethodsHospital discharge data for eight states (Arizona, Colorado, Michigan, New Jersey, New York, South Carolina, Utah and Washington) were obtained from the State Inpatient Databases, Healthcare Cost and Utilization...
Fri Jun 12, 2020 18:20
ObjectiveTo determine whether step-downs, which cut the rate of compensation paid to injured workers after they have been on benefits for several months, are effective as a return to work incentive. MethodsWe aggregated administrative claims data from seven Australian workers’ compensation systems to calculate weekly scheme exit rates, a proxy for return to work. Jurisdictions were further subdivided into four injury subgroups: fractures, musculoskeletal, mental health and other trauma. The effect...
Fri Jun 12, 2020 18:20
ObjectivesExposure to high altitude can affect human health, including the development of adverse cardiovascular effects. This study aimed to investigate alterations in cardiac morphology and function in high-altitude workers and to identify risk factors associated with cardiac abnormalities. MethodsA retrospective cohort study was conducted with 286 Qinghai-Tibetan Railroad maintenance workers. Participant data were collected from company personnel records. Data on echocardiography and diagnosis...
Fri Jun 12, 2020 18:20
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