Related ArticlesBridging bronchus (pseudocarina) and left pulmonary artery sling: A case report and literature review. Int J Pediatr Otorhinolaryngol. 2020 Jun 03;136:110158 Authors: Yang CJ, Yang C, Farhat L, Gray RT, Guerrero GY, Peek GJ, Shifteh K Abstract Congenital airway malformations can present with respiratory distress, cyanosis, and difficulty feeding in the neonate or infant. Clinical presentation may vary from asymptomatic to fatal airway...
Sun Jun 14, 2020 17:08
Related ArticlesOutcomes of voice therapy in children with benign vocal fold lesions. Int J Pediatr Otorhinolaryngol. 2020 May 16;136:110121 Authors: Braden M, Thibeault SL Abstract OBJECTIVE: This study aims to examine the effect of voice therapy on dysphonia on children with benign vocal fold lesions, as measured by perceptual evaluation using the Consensus Auditory Perceptual Evaluation of Voice (CAPE-V) and acoustic and aerodynamic measures (jitter,...
Sat Jun 13, 2020 17:18
Related ArticlesPediatric otolaryngology workflow changes in a community hospital setting to decrease exposure to novel coronavirus. Int J Pediatr Otorhinolaryngol. 2020 Jun 05;136:110169 Authors: Mukerji SS, Liu YC, Musso MF Abstract OBJECTIVES: To develop a workflow algorithm for physicians and staff to decrease cross contamination and minimize exposure to Coronavirus Disease -19 (COVID-19) in pediatric otolaryngology at a community pediatric hospital....
Fri Jun 12, 2020 17:21
Related ArticlesThe Effectiveness of Voice Therapy on Voice-Related Handicap: A Network Meta-Analysis. Clin Otolaryngol. 2020 Jun 13;: Authors: Barsties V Latoszek B, Watts CR, Neumann K Abstract BACKGROUND: Treatment approaches for voice therapy are diverse, yet their differential effects are not well understood. Evaluations of treatment effects across approaches are important for clinical guidance and evidence-based practice. OBJECTIVE OF...
Sun Jun 14, 2020 17:07
Related ArticlesStereotactic Ablative Radiotherapy for Recurrent or Metastatic Gynecological Cancer: Extending Lives? Curr Treat Options Oncol. 2020 Jun 12;21(7):58 Authors: Zhang TW, Palma D, D'Souza D, Velker V, Mendez LC Abstract OPINION STATEMENT: Recent phase II clinical trials suggest that stereotactic ablative radiation therapy (SABR) can potentially improve survival for patients with oligometastatic cancer. However, these studies have mostly...
Sun Jun 14, 2020 13:06
Related Articles[PJI-TNM as new classification system for periprosthetic joint infections : An evaluation of 20 cases]. Orthopade. 2020 Jun 12;: Authors: Rupp M, Kerschbaum M, Freigang V, Bärtl S, Baumann F, Trampuz A, Alt V Abstract BACKGROUND: Current classifications for periprosthetic joint infections (PJIs) often lack a detailed description of the overall underlying situation of a patient. The PJI-TNM classification uses the principles of the TNM...
Sun Jun 14, 2020 13:06
Related ArticlesTime trajectory of cardiac function and its relation with survival in patients with light-chain cardiac amyloidosis. Eur Heart J Cardiovasc Imaging. 2020 Jun 12;: Authors: Hwang IC, Koh Y, Park JB, Yoon YE, Kim HL, Kim HK, Kim YJ, Cho GY, Sohn DW, Lee SP Abstract AIMS : We aimed to analyse the time-serial change of cardiac function in light-chain (AL) cardiac amyloidosis patients undergoing active chemotherapy and its relationship with...
Sun Jun 14, 2020 13:06
Related ArticlesVolumetric PET response assessment outperforms conventional criteria in patients receiving high-dose pembrolizumab for malignant mesothelioma. J Nucl Med. 2020 Jun 12;: Authors: Ferdinandus J, Barbato F, Chodyla M, Fendler WP, Kessler L, Pomykala KL, Metzenmacher M, Krefting F, Hager T, Umutlu L, Herrmann K, Christoph DC Abstract Introduction: Fixed-dose pembrolizumab (200 mg abs., d1, q3w) for the treatment of malignant pleural mesothelioma...
Sun Jun 14, 2020 13:06
Related ArticlesNivolumab in Patients with Advanced Platinum-Resistant Urothelial Carcinoma: Efficacy, Safety, and Biomarker Analyses with Extended Follow-up from CheckMate 275. Clin Cancer Res. 2020 Jun 12;: Authors: Galsky M, Saci A, Szabo PM, Han GC, Grossfeld GD, Collette S, Siefker-Radtke AO, Necchi A, Sharma P Abstract PURPOSE: We report efficacy and safety with extended follow-up, and exploratory biomarker analyses from the phase II CheckMate...
Sun Jun 14, 2020 13:06
Related ArticlesEfficacy and Safety of 177Lu-labeled Prostate-specific Membrane Antigen Radionuclide Treatment in Patients with Diffuse Bone Marrow Involvement: A Multicenter Retrospective Study. Eur Urol. 2020 Jun 09;: Authors: Gafita A, Fendler WP, Hui W, Sandhu S, Weber M, Esfandiari R, Calais J, Rauscher I, Rathke H, Tauber R, Delpassand ES, Weber WA, Herrmann K, Czernin J, Eiber M, Hofman MS Abstract The 177Lu-labeled prostate-specific membrane...
Sun Jun 14, 2020 13:06
Related ArticlesSurvival impacts of different nodal characteristics and T-classification in N3 nasopharyngeal carcinoma patients. Oral Oncol. 2020 Jun 09;108:104820 Authors: Lin TY, Lan MY, Tsou HH, Ho CY, Twu CW, Liu YC, Lin PJ, Huang PI, Shiau CY, Lin JC Abstract OBJECTIVES: We investigated the survival impacts of various nodal characteristics and T-classification on nasopharyngeal carcinoma (NPC) patients with the 8th AJCC/UICC staging criteria N3....
Sat Jun 13, 2020 15:15
Related ArticlesDeep learning for automated exclusion of cardiac CT examinations negative for coronary artery calcium. Eur J Radiol. 2020 Jun 03;129:109114 Authors: van den Oever LB, Cornelissen L, Vonder M, Xia C, van Bolhuis JN, Vliegenthart R, Veldhuis RNJ, de Bock GH, Oudkerk M, van Ooijen PMA Abstract PURPOSE: Coronary artery calcium (CAC) score has shown to be an accurate predictor of future cardiovascular events. Early detection by CAC scoring...
Sat Jun 13, 2020 15:15
Related ArticlesArtificial Intelligence for Breast Cancer Detection in Mammography and Digital Breast Tomosynthesis: state of the art. Semin Cancer Biol. 2020 Jun 09;: Authors: Sechopoulos I, Teuwen J, Mann R Abstract Screening for breast cancer with mammography has been introduced in various countries over the last 30 years, initially using analog screen-film-based systems and, over the last 20 years, transitioning to the use of fully digital systems....
Sat Jun 13, 2020 15:15
Related ArticlesCorrigendum. Future Oncol. 2020 Jun 12;: Authors: PMID: 32530299 [PubMed - as supplied by publisher]
Sat Jun 13, 2020 15:15
Related ArticlesEfficacy and safety of afatinib for non-small-cell lung cancer: state-of-the-art and future perspectives. Expert Rev Anticancer Ther. 2020 Jun 12;:1-12 Authors: Sartori G, Belluomini L, Lombardo F, Avancini A, Trestini I, Vita E, Tregnago D, Menis J, Bria E, Milella M, Pilotto S Abstract INTRODUCTION: Afatinib is a second-generation epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor, acting as an irreversible and multitarget...
Sat Jun 13, 2020 15:15
Related ArticlesCord blood transplantation for acute leukemia. Expert Opin Biol Ther. 2020 Jun 12;: Authors: Algeri M, Gaspari S, Locatelli F Abstract INTRODUCTION: Umbilical cord blood transplantation (UCBT) is a suitable alternative for patients with acute leukemia (AL) in need of an allograft and who lack an HLA-matched donor. Single-institution and registry studies have shown that, in both children and adults with AL, the outcome of UCBT is comparable...
Sat Jun 13, 2020 15:15
Related ArticlesSpectrum and Clinical Activity of PD-1/PD-L1 Inhibitors: Regulatory Approval and Under Development. Curr Oncol Rep. 2020 Jun 12;22(7):70 Authors: Oliveira LJC, Gongora ABL, Jardim DLF Abstract PURPOSE OF REVIEW: The aim of this review is to highlight the clinical development of PD-1 and PD-L1 inhibitors in cancer therapy. We focus on detailing the registration trials that have led to FDA-approved indications of anti-PD-1 and anti-PD-L1...
Sat Jun 13, 2020 13:49
Related ArticlesStereotactic Body Radiation Therapy for the Definitive Treatment of Early Stage Kidney Cancer: A Survival Comparison With Surgery, Tumor Ablation, and Observation. Adv Radiat Oncol. 2020 May-Jun;5(3):495-502 Authors: Grant SR, Lei X, Hess KR, Smith GL, Matin SF, Wood CG, Nguyen Q, Frank SJ, Anscher MS, Smith BD, Karam JA, Tang C Abstract Purpose: Partial nephrectomy is the preferred definitive treatment for early stage kidney cancer,...
Sat Jun 13, 2020 13:49
Related ArticlesVariations Between Dose-Ventilation and Dose-Perfusion Metrics in Radiation Therapy Planning for Lung Cancer. Adv Radiat Oncol. 2020 May-Jun;5(3):459-465 Authors: Nakajima Y, Kadoya N, Kimura T, Hioki K, Jingu K, Yamamoto T Abstract Purpose: Currently, several active clinical trials of functional lung avoidance radiation therapy using different imaging modalities for ventilation or perfusion are underway. Patients with lung cancer often...
Sat Jun 13, 2020 13:49
Related ArticlesThe Capital Investment Strategy for Radiation therapy in Ontario: A Framework to Ensure Access to Radiation Therapy. Adv Radiat Oncol. 2020 May-Jun;5(3):318-324 Authors: Glicksman RM, Wong A, Wang J, Favell L, Matheson G, Brundage M, Renaud J, Malkoske K, MacPhail J, Finnerty D, Foxcroft S, Gutierrez E, Warde P Abstract Purpose: Ontario Health (Cancer Care Ontario), formerly known as CCO, is the provincial governmental agency in Ontario,...
Sat Jun 13, 2020 13:49
Related ArticlesFertility preservation in boys: recent developments and new insights †. Hum Reprod Open. 2020;2020(3):hoaa016 Authors: Goossens E, Jahnukainen K, Mitchell RT, van Pelt A, Pennings G, Rives N, Poels J, Wyns C, Lane S, Rodriguez-Wallberg KA, Rives A, Valli-Pulaski H, Steimer S, Kliesch S, Braye A, Andres MM, Medrano J, Ramos L, Kristensen SG, Andersen CY, Bjarnason R, Orwig KE, Neuhaus N, Stukenborg JB Abstract BACKGROUND: Infertility is...
Sat Jun 13, 2020 13:49
Related ArticlesPrecision Stereotactic Radiotherapy for Spinal Tumors: Mechanism, Efficacy, and Issues. Front Oncol. 2020;10:826 Authors: Zhuang H, Zhuang H, Lang N, Liu J Abstract Stereotactic ablative radiotherapy (SABR/SBRT) is a revolutionary technique for tumor therapy. Its advantages are especially beneficial for the treatment spinal tumors. It has a wide range of indications in radiotherapy alone and in preoperative and postoperative treatments...
Sat Jun 13, 2020 13:49
Related ArticlesSuccessful Anti-CLL1 CAR T-Cell Therapy in Secondary Acute Myeloid Leukemia. Front Oncol. 2020;10:685 Authors: Zhang H, Gan WT, Hao WG, Wang PF, Li ZY, Chang LJ Abstract Secondary acute myeloid leukemia (sAML) is a high-risk AML evolving from heterogenous prior hematological disorders. Compared to de novo AML, sAML has even worse responses to current therapy and thus is associated with lower remission rates, inferior overall survival...
Sat Jun 13, 2020 13:49
Related ArticlesRAS-targeted therapies: is the undruggable drugged? Nat Rev Drug Discov. 2020 Jun 11;: Authors: Moore AR, Rosenberg SC, McCormick F, Malek S Abstract RAS (KRAS, NRAS and HRAS) is the most frequently mutated gene family in cancers, and, consequently, investigators have sought an effective RAS inhibitor for more than three decades. Even 10 years ago, RAS inhibitors were so elusive that RAS was termed 'undruggable'. Now, with the success...
Sat Jun 13, 2020 13:49
Related ArticlesPD-1 inhibitors: Do they have a future in the treatment of glioblastoma? Clin Cancer Res. 2020 Jun 11;: Authors: Khasraw M, Reardon DA, Weller M, Sampson JH Abstract Glioblastoma (WHO grade IV glioma) is the most common malignant primary brain tumor in adults. Survival has remained largely static for decades, despite significant efforts to develop new effective therapies. Immunotherapy, and especially immune checkpoint inhibitors and...
Sat Jun 13, 2020 13:49
Related Articles[CAR-T immunotherapy in pediatric hemato-oncology… present and future]. An Pediatr (Barc). 2020 Jun 08;: Authors: Juan M, Rives S PMID: 32527709 [PubMed - as supplied by publisher]
Sat Jun 13, 2020 13:49
Related ArticlesAdjuvant endocrine treatment for estrogen receptor (ER)-positive/ HER2-negative breast cancer. Chin Clin Oncol. 2020 Jun 08;: Authors: Kubo M Abstract Approximately 70% of women with breast cancer worldwide receive a diagnosis of ER-positive/ HER2-negative disease. Recurrence-free survival of the node-negative population of these women is approximately 85%, and most are treated with endocrine chemotherapy. Endocrine treatment for ERpositive/HER2-negative...
Sat Jun 13, 2020 13:49
Related ArticlesCombined PARP Inhibition and Immune Checkpoint Therapy in Solid Tumors. Cancers (Basel). 2020 Jun 09;12(6): Authors: Peyraud F, Italiano A Abstract Genomic instability is a hallmark of cancer related to DNA damage response (DDR) deficiencies, offering vulnerabilities for targeted treatment. Poly (ADP-ribose) polymerase (PARP) inhibitors (PARPi) interfere with the efficient repair of DNA damage, particularly in tumors with existing defects...
Sat Jun 13, 2020 13:49
Related ArticlesUsing Magnetic Resonance Perfusion to Stratify Overall Survival in Treated High-Grade Gliomas. Can J Neurol Sci. 2019 09;46(5):533-539 Authors: Fong C, Parpia S, Yemen B, Tsai S, Greenspoon J Abstract BACKGROUND: MR perfusion imaging is a relatively new technique that may aid in identifying recurrent tumor (RT) in those with radically treated high-grade gliomas (HGG). We aim to assess the relationship between dynamic susceptibility contrast-enhanced...
Sat Jun 13, 2020 13:49
Related ArticlesBK virus infection in allogeneic hematopoietic cell transplantation: an update on pathogenesis, immune responses, diagnosis and treatments. J Infect. 2020 Jun 08;: Authors: Saade A, Styczynski J, Cesaro S, Infectious Disease Working party of EBMT Abstract In hematopoietic cell transplantation (HCT) patients, BK polyomavirus (BKPyV) infection results in significant morbidity mainly due to hemorrhagic cystitis (HC). Despite increased knowledge...
Fri Jun 12, 2020 14:38
Related ArticlesHepatocellular Carcinoma (HCC) in the COVID-19 era: Primetime for Stereotactic Body Radiotherapy and a lesson for the future? Oncologist. 2020 Jun 11;: Authors: Scorsetti M, Goodman KA, Seong J, Loi M, Huguet F, Dawson LA PMID: 32525607 [PubMed - as supplied by publisher]
Fri Jun 12, 2020 14:38
Related ArticlesStereotactic ablative body radiation therapy (SABR) in NSW. Phys Eng Sci Med. 2020 Jun;43(2):641-650 Authors: Claridge Mackonis ER, Hardcastle N, Haworth A Abstract A survey was conducted to establish the current utilisation of stereotactic ablative radiation therapy (SABR) services in NSW. The objective of the survey was to generate baseline data to inform requirements for a networked approach to the implementation of new radiation therapy...
Fri Jun 12, 2020 13:12
Related ArticlesPhysical Inactivity and Pancreatic Cancer Mortality. J Gastrointest Cancer. 2020 Jun 10;: Authors: Pratapwar M, Stenzel AE, Joseph JM, Fountzilas C, Etter JL, Mongiovi JM, Cannioto R, Moysich KB Abstract OBJECTIVE: To determine the association between pre-diagnostic recreational physical inactivity (RPI) and pancreatic cancer (PC) mortality. METHODS: This analysis included 107 patients seen at Roswell Park Comprehensive Cancer...
Fri Jun 12, 2020 13:12
Related ArticlesMicrobiota Manipulation by Probiotics Administration as Emerging Tool in Cancer Prevention and Therapy. Front Oncol. 2020;10:679 Authors: Panebianco C, Latiano T, Pazienza V Abstract A growing body of literature indicates that microbiota plays a significant role in the development and curability of cancer, essentially due to the microbial ability to modulate immune and inflammatory responses to cancer and therapeutic treatments. Probiotics...
Fri Jun 12, 2020 13:12
Related ArticlesThe role of EGFR mutations in predicting recurrence in early and locally advanced lung adenocarcinoma following definitive therapy. Oncotarget. 2020 May 26;11(21):1953-1960 Authors: Galvez C, Jacob S, Finkelman BS, Zhao J, Tegtmeyer K, Chae YK, Mohindra N, Salgia R, Jovanovic B, Behdad A, Villaflor V Abstract INTRODUCTION: Roughly one third of new non-small cell lung cancer (NSCLC) is diagnosed at early stages. While lobectomy can improve...
Fri Jun 12, 2020 13:12
Related ArticlesWeighted Gene Coexpression Network Analysis Reveals the Dynamic Transcriptome Regulation and Prognostic Biomarkers of Hepatocellular Carcinoma. Evol Bioinform Online. 2020;16:1176934320920562 Authors: Qu S, Shi Q, Xu J, Yi W, Fan H Abstract This study was aimed at revealing the dynamic regulation of mRNAs, long noncoding RNAs (lncRNAs), and microRNAs (miRNAs) in hepatocellular carcinoma (HCC) and to identify HCC biomarkers capable of...
Fri Jun 12, 2020 13:12
Related ArticlesSalivary Cortisol Levels and Burning Symptoms in Patients with Burning Mouth Syndrome before and after Low Level Laser Therapy: a Double Blind Controlled Randomized Clinical Trial. Acta Stomatol Croat. 2020 Mar;54(1):44-50 Authors: Škrinjar I, Lončar Brzak B, Vidranski V, Vučićević Boras V, Rogulj AA, Pavelić B Abstract Objectives: Burning mouth syndrome (BMS) is a disorder which is described as burning sensation of the oral mucosa without...
Fri Jun 12, 2020 13:12
Related ArticlesPrediction of prostate cancer aggressiveness using 18F-Fluciclovine (FACBC) PET and multisequence multiparametric MRI. Sci Rep. 2020 Jun 10;10(1):9407 Authors: Movahedi P, Merisaari H, Perez IM, Taimen P, Kemppainen J, Kuisma A, Eskola O, Teuho J, Saunavaara J, Pesola M, Kähkönen E, Ettala O, Liimatainen T, Pahikkala T, Boström P, Aronen H, Minn H, Jambor I Abstract The aim of this prospective single-institution clinical trial (NCT02002455)...
Fri Jun 12, 2020 13:12
Related ArticlesFive-year survival decreases over time in patients with BRCA-mutated ovarian cancer: a systemic review and meta-analysis. Int J Gynecol Cancer. 2020 Jun 09;: Authors: Nahshon C, Barnett-Griness O, Segev Y, Schmidt M, Ostrovsky L, Lavie O Abstract INTRODUCTION: Short-term survival rates of patients with BRCA-mutated ovarian cancer have been previously shown to be longer than those of non-carriers. We aimed to study the long-term survival...
Fri Jun 12, 2020 13:12
Related ArticlesGrief symptoms and primary care use: a prospective study of family caregivers. BJGP Open. 2020 Jun 10;: Authors: Nielsen MK, Christensen K, Neergaard MA, Bidstrup PE, Guldin MB Abstract BACKGROUND: Family caregivers to patients who are severely ill have high use of primary health care and psychotropic medication. However, it remains sparsely investigated whether healthcare services target the most vulnerable caregivers. AIM:...
Fri Jun 12, 2020 13:12
Related ArticlesNeoadjuvant Immunotherapy for Non-Small Cell Lung Cancer - Current Concepts and Future Approaches. J Thorac Oncol. 2020 Jun 06;: Authors: Uprety D, Mandrekar SJ, Wigle D, Roden AC, Adjei AA Abstract Lung cancer is the leading cause of cancer-related deaths worldwide. Patients with resectable non-small cell lung cancer (NSCLC) are often treated with surgery and adjuvant chemotherapy. However, these patients continue to have a high risk...
Fri Jun 12, 2020 13:12
Related ArticlesIncidence and risk factors for hepatic sinusoidal obstruction syndrome after allogeneic hematopoietic stem cell transplantation: A retrospective multicenter study of Turkish hematology research and education group (ThREG). Transfus Apher Sci. 2020 May 26;:102827 Authors: Soyer N, Gunduz M, Tekgunduz E, Deveci B, Ozdogu H, Sahin HH, Turak EE, Okay M, Kuku I, Hindilerden IY, Topcuoglu P, Altuntas F, Karadogan I, Pehlivan M, Unal A, Goker H, Erkurt MA, Besısık...
Fri Jun 12, 2020 13:12
Related ArticlesA single-arm clinical trial investigating the effectiveness of a non-hormonal, hyaluronic acid-based vaginal moisturizer in endometrial cancer survivors. Gynecol Oncol. 2020 Jun 08;: Authors: Carter J, Goldfarb S, Baser RE, Goldfrank DJ, Seidel B, Milli L, Saban S, Stabile C, Canty J, Gardner GJ, Jewell EL, Sonoda Y, Kollmeier MA, Alektiar KM Abstract OBJECTIVE: To assess the efficacy of non-hormonal, hyaluronic acid (HLA)-based vaginal...
Fri Jun 12, 2020 13:12
Related ArticlesA moonshot approach toward the management of cancer patients in the COVID-19 time: what have we learned and what could the Italian network of cancer centers (Alliance Against Cancer, ACC) do after the pandemic wave? J Exp Clin Cancer Res. 2020 Jun 11;39(1):109 Authors: Silvestris N, Apolone G, Botti G, Ciliberto G, Costantini M, De Paoli P, Franceschi S, Opocher G, Paradiso A, Pronzato P, Sgambato A, De Maria R Abstract If we focus our...
Fri Jun 12, 2020 13:12
Related ArticlesA Predictive Model Using N-Glycan Biosignatures for Clinical Diagnosis of Early Hepatocellular Carcinoma Related to Hepatitis B Virus. OMICS. 2020 Jun 09;: Authors: Cong M, Ou X, Huang J, Long J, Li T, Liu X, Wang Y, Wu X, Zhou J, Sun Y, Shang Q, Chen G, Ma H, Xie W, Piao H, Yang Y, Gao Z, Xu X, Tan Z, Chen C, Zeng N, Wu S, Kong Y, Liu T, Wang P, You H, Jia J, Zhuang H Abstract Early diagnosis of hepatic cancer is a major public health...
Fri Jun 12, 2020 13:12
Related ArticlesMesoporous Silica Nanoparticles for Co-Delivery of Drugs and Nucleic Acids in Oncology: A Review. Pharmaceutics. 2020 Jun 08;12(6): Authors: Paris JL, Vallet-Regí M Abstract Mesoporous silica nanoparticles have attracted much attention in recent years as drug and gene delivery systems for biomedical applications. Among their most beneficial features for biomedicine, we can highlight their biocompatibility and their outstanding textural...
Fri Jun 12, 2020 13:12
Related ArticlesEpigenetic Landscape in Pancreatic Ductal Adenocarcinoma: On the Way to Overcoming Drug Resistance? Int J Mol Sci. 2020 Jun 08;21(11): Authors: Ciernikova S, Earl J, García Bermejo ML, Stevurkova V, Carrato A, Smolkova B Abstract Pancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive solid malignancies due to the rapid rate of metastasis and high resistance to currently applied cancer therapies. The complex mechanism underlying...
Fri Jun 12, 2020 13:12
Related ArticlesRecent developments in drug hypersensitivity in children. Expert Rev Clin Immunol. 2019 07;15(7):723-733 Authors: Kulhas Celik I, Dibek Misirlioglu E, Kocabas CN Abstract Introduction: Drug allergy is an important public health problem that causes 0.4-10.3% of hospital admissions in children. The epidemiology, clinical spectrum, diagnosis, and management of drug hypersensitivity reactions (DHRs) differ in pediatric and adult patients....
Fri Jun 12, 2020 13:12
Related ArticlesIn vitro effects of boric acid on human liver hepatoma cell line (HepG2) at the half-maximal inhibitory concentration. J Trace Elem Med Biol. 2020 May 30;62:126573 Authors: Tombuloglu A, Copoglu H, Aydin-Son Y, Guray NT Abstract BACKGROUND: Boron is a prominent part of the human diet and one of the essential trace elements for humans. Dietary boron is mostly transformed into boric acid within the body and has been associated with...
Sun Jun 14, 2020 14:58
Related ArticlesEffect of epiberberine from Coptis chinensis Franch on inhibition of tumor growth in MKN-45 xenograft mice. Phytomedicine. 2020 May 17;76:153216 Authors: Yu M, Ren L, Liang F, Zhang Y, Jiang L, Ma W, Li C, Li X, Ye X Abstract BACKGROUND AND PURPOSE: Gastric cancer is one of the major malignancies worldwide. Epiberberine (EPI) is a major alkaloid from Coptis chinensis Franch and the antitumor property of EPI remains poorly understood....
Sun Jun 14, 2020 14:58
Related ArticlesExploration of certain 1,3-oxazole- and 1,3-thiazole-based hydroxamic acids as histone deacetylase inhibitors and antitumor agents. Bioorg Chem. 2020 Jun 01;101:103988 Authors: Anh DT, Hai PT, Huong LT, Park EJ, Jun HW, Kang JS, Kwon JH, Dung DTM, Anh VT, Hue VTM, Han SB, Nam NH Abstract Several novel series of hydroxamic acids bearing 2-benzamidooxazole/thiazole (5a-g, 6a-g) or 2-phenylsulfonamidothiazole (8a-c) were designed and...
Sun Jun 14, 2020 14:58
Related ArticlesEnhanced expression of lncRNA ZXF1 promotes cisplatin resistance in lung cancer cell via MAPK axis. Exp Mol Pathol. 2020 Jun 10;:104484 Authors: Yu T, Bai W, Su Y, Wang Y, Wang M, Ling C Abstract Long non-coding RNA (lncRNA) ZXF1 has recently been associated with the poor prognosis of lung cancer by promoting metastasis. However, little is known regarding the role of ZXF1 in lung cancer treatment and the underlying mechanism. Here,...
Sun Jun 14, 2020 14:58
Related ArticlesInhibiting autophagy potentiates the antitumor efficacy of Euphorbia royleana for canine mammary gland tumors. BMC Vet Res. 2020 Jun 12;16(1):193 Authors: Huang YY, Chen CH, Hsu CH, Kuo TY, Liu CC, Liao AT, Lin CS Abstract BACKGROUND: Canine mammary gland tumors (cMGTs) are the most common neoplasms in intact female canines and viewed as a suitable model for studying human breast cancers. Euphorbia royleana has been reported to have...
Sun Jun 14, 2020 13:03
Related ArticlesCombined inhibition of ACK1 and AKT shows potential toward targeted therapy against KRAS-mutant non-small-cell lung cancer. Bosn J Basic Med Sci. 2020 Jun 01;: Authors: Yu X, Liu J, Qiu H, Hao H, Zhu J, Peng S Abstract Non-small-cell lung cancer (NSCLC) with KRAS (Kirsten RAt Sarcoma 2 viral oncogene homolog) mutation has become a clinical challenge in cancer treatment as KRAS-mutant tumors are often resistant to conventional anti-tumor...
Sat Jun 13, 2020 14:23
Cathepsin A regulates pluripotency, proliferation and differentiation in mouse embryonic stem cells.
Related ArticlesCathepsin A regulates pluripotency, proliferation and differentiation in mouse embryonic stem cells. Cell Biochem Funct. 2020 Jun 11;: Authors: Park S, Huang H, Kwon W, Kim HY, Park JK, Han JE, Cho GJ, Han SH, Sung Y, Ryoo ZY, Kim MO, Choi SK Abstract Mouse embryonic stem cells (mESCs) are pluripotent cells that possess the ability to self-renew and differentiate into three germ layers. Owing to these characteristics, mESCs act as...
Sat Jun 13, 2020 13:23
Related ArticlesIGFBP6 regulates vascular smooth muscle cell proliferation and morphology via cyclin E-CDK2. J Cell Physiol. 2020 Jun 11;: Authors: Wang Z, Qi Y, Wang R, Wu W, Li Z, Wang M, Liu R, Zhang C, Li W, Wang S Abstract Despite the high prevalence of varicose veins, the underlying pathogenesis of this disease remains unclear. The present study aims to explore the role of insulin-like growth factor binding protein 6 (IGFBP6) in vascular smooth...
Sat Jun 13, 2020 13:23
Related ArticlesOncogenic Gata1 causes stage-specific megakaryocyte differentiation delay. Haematologica. 2020 Jun 11;: Authors: Juban G, Sakakini N, Chagraoui H, Cruz Hernandez D, Cheng Q, Soady K, Stoilova B, Garnett C, Waithe D, Otto G, Doondeea J, Usukhbayar B, Karkoulia E, Alexiou M, Strouboulis J, Morrissey E, Roberts I, Porcher C, Vyas P Abstract The megakaryocyte/erythroid Transient Myeloproliferative Disorder (TMD) in newborns with Down...
Sat Jun 13, 2020 13:23
Related ArticlesRNA exosome mutations in pontocerebellar hypoplasia alter ribosome biogenesis and p53 levels. Life Sci Alliance. 2020 Aug;3(8): Authors: Müller JS, Burns DT, Griffin H, Wells GR, Zendah RA, Munro B, Schneider C, Horvath R Abstract The RNA exosome is a ubiquitously expressed complex of nine core proteins (EXOSC1-9) and associated nucleases responsible for RNA processing and degradation. Mutations in EXOSC3, EXOSC8, EXOSC9, and the...
Sat Jun 13, 2020 13:23
Related ArticlesMiR-486-5p enhances cisplatin sensitivity of human muscle-invasive bladder cancer cells by induction of apoptosis and down-regulation of metastatic genes. Urol Oncol. 2020 Jun 08;: Authors: Salimian J, Baradaran B, Azimzadeh Jamalkandi S, Moridikia A, Ahmadi A Abstract OBJECTIVES: Cisplatin is one of the common chemotherapy drugs for bladder cancer, and resistance to this drug is one of the major obstacles to effective chemotherapy....
Sat Jun 13, 2020 13:23
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