Related ArticlesA new variant of posterior canal-benign paroxysmal positional vertigo-canalolithiasis. Auris Nasus Larynx. 2020 Jun 07;: Authors: Shigeno K, Kitaoka K Abstract OBJECTIVE: The characteristics of typical posterior canal-benign paroxysmal positional vertigo-canalolithiasis (P-BPPV-Can) are well known. We found 10 patients with a new variant of P-BPPV-Can: Reverse (Rev)-P-BPPV-Can. The characteristics and pathophysiology of Rev-P-BPPV-Can...
Fri Jun 12, 2020 13:08
Related ArticlesExpression of E-cadherin and β-catenin in Laryngeal and Hypopharyngeal Squamous Cell Carcinomas. Acta Otorrinolaringol Esp. 2020 Jun 07;: Authors: García-Cabo P, García-Pedrero JM, Villaronga MÁ, Hermida-Prado F, Granda-Díaz R, Allonca E, López F, Rodrigo JP Abstract INTRODUCTION AND OBJECTIVES: Dysfunction of the E-cadherin/catenin complex is directly related to carcinogenesis and metastases development. The aim of this paper is...
Fri Jun 12, 2020 13:08
Related ArticlesFNDC5/irisin improves the therapeutic efficacy of bone marrow-derived mesenchymal stem cells for myocardial infarction. Stem Cell Res Ther. 2020 Jun 10;11(1):228 Authors: Deng J, Zhang N, Wang Y, Yang C, Wang Y, Xin C, Zhao J, Jin Z, Cao F, Zhang Z Abstract BACKGROUND: The beneficial functions of bone marrow mesenchymal stem cells (BM-MSCs) decline with decreased cell survival, limiting their therapeutic efficacy for myocardial infarction...
Fri Jun 12, 2020 13:08
Related ArticlesPatients with cutaneous head and neck melanoma, particularly elderly with more advanced primary tumors, seem to benefit from initial CT staging before considering a sentinel lymph node biopsy. Acta Otolaryngol. 2020 Jun 10;:1-8 Authors: Hafström A, Nateghi-Gillberg B, Nilsson MA, Greiff L Abstract Background: The role of CT scanning at the time of diagnosis for patients with primary cutaneous head and neck melanoma (cHNM) clinically...
Fri Jun 12, 2020 13:08
Related ArticlesSafety and Efficacy of Non- and Minimally Irradiated Homologous Costal Cartilage in Primary and Revision Rhinoplasty. Facial Plast Surg Aesthet Med. 2020 Jun 09;: Authors: Rogal J, Glasgold A, Glasgold RA Abstract Importance: Despite favorable results with conventionally irradiated homologous costal cartilage, there have been no clinical studies to date evaluating the utility of non- or minimally irradiated homologous costal cartilage...
Fri Jun 12, 2020 13:08
Related ArticlesUsing Ultrasound to Evaluate Nasal Septal Cartilage. Facial Plast Surg Aesthet Med. 2020 Jun 10;: Authors: Eid I, Humphrey C, Jones J, Bhalla V, Kriet JD Abstract Importance: Having a noninvasive tool that quantifies the amount of remaining septal cartilage in the setting of prior septoplasty would be useful for surgical planning and patient counseling. Objective: The objective of this pilot study is to determine if endocavitary ultrasound...
Fri Jun 12, 2020 13:08
Comparison of Autophagy mRNA Expression between Chronic Otitis Media With and Without Cholesteatoma.
Related ArticlesComparison of Autophagy mRNA Expression between Chronic Otitis Media With and Without Cholesteatoma. J Audiol Otol. 2020 Jun 12;: Authors: Jung J, Jung SY, Kim MG, Kim YI, Kim SH, Yeo SG Abstract Background and Objectives: Autophagy is known to be associated with pathogen infection. However, the expression of autophagy-related proteins has not been studied in chronic otitis media without cholesteatoma (COM) or with cholesteatoma (CholeOM)....
Fri Jun 12, 2020 13:08
Related ArticlesEffect of Speech Degradation and Listening Effort in Reverberating and Noisy Environments Given N400 Responses. J Audiol Otol. 2020 Jun 12;: Authors: Kyong JS, Kwak C, Han W, Suh MW, Kim J Abstract Background and Objectives: In distracting listening conditions, individuals need to pay extra attention to selectively listen to the target sounds. To investigate the amount of listening effort required in reverberating and noisy backgrounds,...
Fri Jun 12, 2020 13:08
Related ArticlesDo smoking and human papilloma virus have a synergistic role in the development of head and neck cancer? A systematic review and meta-analysis. J BUON. 2020 Mar-Apr;25(2):1107-1115 Authors: Skoulakis A, Tsea M, Koltsidopoulos P, Lachanas V, Hajiioannou J, Petinaki E, Bizakis J, Skoulakis C Abstract PURPOSE: Head and neck squamous cell carcinoma (HNSCC), arising from the squamous epithelium, is the most common head and neck cancer...
Fri Jun 12, 2020 13:08
Related ArticlesDownregulation of miR-204 facilitates the progression of nasopharyngeal carcinoma by targeting CXCR4 through NF-κB signaling pathway. J BUON. 2020 Mar-Apr;25(2):1098-1104 Authors: Zong G, Han J, Yue Z, Liu Y, Cui Z, Shi L Abstract PURPOSE: Nasopharyngeal carcinoma (NPC) is a highly invasive and metastatic cancer. The alterations of miRNA deregulation and pathway have been reported to be implicated in NPC progression. Here, we aimed...
Fri Jun 12, 2020 13:08
Related Articlesmdm2 oncogene in laryngeal squamous cell carcinoma. J BUON. 2020 Mar-Apr;25(2):594-596 Authors: Mastronikolis N, Ragos V, Fotiades P, Papanikolaou V, Kyrodimos E, Chrysovergis A, Mastronikolis S, Tsiambas E Abstract Laryngeal squamous cell carcinoma (LSCC) demonstrates increasing rates worldwide due to viral-related (High Risk Human Papilloma Virus-HR HPV) persistent infection, cigarette and alcohol consumptions. Gross chromosomal...
Fri Jun 12, 2020 13:08
Related ArticlesSkin cancer development in a birthmark. CMAJ. 2019 09 30;191(39):E1082 Authors: Finstad AC, Kirchhof MG PMID: 31570547 [PubMed - indexed for MEDLINE]
Fri Jun 12, 2020 13:08
Related ArticlesLong noncoding RNA LINC-PINT regulates laryngeal carcinoma cell stemness and chemoresistance through miR-425-5p/PTCH1/SHH axis. J Cell Physiol. 2019 12;234(12):23111-23122 Authors: Yuan Z, Xiu C, Liu D, Zhou G, Yang H, Pei R, Ding C, Cui X, Sun J, Song K Abstract Functional, noncoding RNA of about 200 nucleotides in length are known as long noncoding RNA (lncRNA). Advances in -omics have revolutionized the information with respect to...
Fri Jun 12, 2020 13:08
Abstract Syndromic congenital ichthyoses (CI) are genetically determined disorders of cornification that are characterized by generalized scaling along with systemic symptoms. Data on congenital syndromic ichthyosis from developing countries are scarce. To assess the prevalence, phenotype‐genotype correlation, and management of syndromic CI patients presenting to our outpatient during the specified period Retrospective study of congenital syndromic ichthyosis patients attending a dermatology clinic...
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Abstract An atypical cellular blue nevus, a benign mass, may sometimes transform into a malignant melanoma. Here, we report a rare case of melanoma arising in a large congenital vulvar blue nevus. A 28‐year‐old Chinese woman presented to our hospital with a chief complaint of a vulvar mass that had persisted for eight years. The patient underwent extensive local excision, followed by reconstructive surgery of the female reproductive tract. The mass was diagnosed as being a vulvar malignant melanoma....
Fri Jun 12, 2020 19:10
ABSTRACT Topical antibiotic therapy is a central component of patient management for several skin conditions, including acne, hidradenitis suppurativa, rosacea, impetigo or other superinfected dermatitis, prevention of wound infections. Moreover, particular situations, such as skin diseases of bacterial origin in pregnancy and infants often warrant topical therapy. However, the occurrence of local delayed hypersensitivity reactions and the rising rate of antibiotic resistance are becoming great...
Fri Jun 12, 2020 19:10
Abstract Trichotillomania (TTM) is a condition in which affected individuals pull out their hair resulting in hair loss. This disorder affects roughly 0.5% to 2.0% of the population and can have significant psychological morbidity. Behavioral therapy has been used with success in the treatment of TTM, but not all patients are willing or able to comply with this treatment strategy. There is a need for effective pharmacological treatment options. Historically, pharmacotherapy for trichotillomania...
Fri Jun 12, 2020 19:09
Fri Jun 12, 2020 16:21
Abstract Intralesional immunotherapy by different antigens has shown promising efficacy and safety in the treatment of warts. However, the use of these antigens for the treatment of plane warts has been investigated in 2 studies only. To evaluate the efficacy and safety of three antigens; Measles Mumps, Rubella vaccine (MMR), Candida antigen, and purified protein derivative (PPD) in the treatment of multiple plane warts. The study included 120 patients who were randomly assigned to three groups,...
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Abstract We aim to evaluate the change in the diagnostic spectrum in dermatology outpatient applications compared to before COVID‐19. All patients were enrolled from the Department of Dermatology between February 12 and May 8, 2020, the duration of 4 weeks before COVID‐19 and eight weeks after were analyzed in 3 parts consisting of 4 weeks. Data obtained from the database such as age, gender, diagnoses were anonymized. Repeated applications with the same diagnosis in ten days after the first presentation...
Fri Jun 12, 2020 15:43
Abstract Psoriasis, a T‐cell mediated chronic dermatosis, has a complex etiopathogenesis. There has been extensive research into the aberrant immune response, which leads to the formation of clinical lesions, and the need for developing better and safer drugs has been unrelenting. The past two decades of research has opened up new areas of the immune pathway that can be targeted in order to control the disease. Therefore we have seen the emergence of biologics which either target T‐cell receptors...
Fri Jun 12, 2020 15:20
This study determined the incidence of unsuspected choledocholithiasis in a population deemed to be low risk undergoing laparoscopic cholecystectomy with routine intra‐operative cholangiography. In addition to this, the management of these patients was reported along with predictive factors for an abnormal intra‐operative cholangiogram were determined. Risk factors independently associated with unsuspected choledocholithiasis included patients over the age of 55 years of age (odds ratio 2.93, P ...
Sat Jun 13, 2020 16:09
A retrospective review of 122 consecutive ATTUNE total knee arthroplasty (TKA) procedures were followed up and investigated for periprosthetic radiolucency (PPRL). PPRL was noted in 29 TKAs (23.8%), of which eight were symptomatic (6.6% of all TKAs/27.6% of TKA with PPRL). A high incidence of early PPRL of unknown clinical significance is seen in patients undergoing primary TKA using the ATTUNE system, mainly involving the tibial component Abstract Background Recently introduced total knee...
Sat Jun 13, 2020 16:03
We describe a practical approach to the management of complex anal fistula in an immunocompromised patient. We define our treatment motifs: to close the internal opening, maintain external drainage until internal opening and tract healed; minimize sphincter damage. We hope other authors can build on this case technique to improve fistula surgery outcomes.
Sat Jun 13, 2020 14:29
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Fri Jun 12, 2020 21:03
Abstract Background We report on the feasibility of a novel robotic‐assisted extended “Sistrunk” approach (RESA) to the larynx, hypopharynx, and lateral neck lymphatics. Methods Studies were performed using the da Vinci Xi and SP system on three cadavers comprising of three supraglottic laryngectomies, one partial hypopharyngectomy, and four lateral level II to IV neck dissections. Results In all resections at first a central common working space overlying the hyoid bone was created....
Sat Jun 13, 2020 11:42
Abstract The coronavirus disease 2019 (COVID‐19) pandemic has become a major public health crisis. The diagnostic and containment efforts for the disease have presented significant challenges for the global health‐care community. In this brief report, we provide perspective on the potential use of salivary specimens for detection and serial monitoring of severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2), based on current literature. Oral health‐care providers are at an elevated risk of...
Sat Jun 13, 2020 11:25
Abstract Objective To survey a large cohort of thyroid cancer survivors from ThyCa on information needs and expectations of their treatment to better understand the pretreatment counseling, information, and support needs of this population. Methods Anonymous survey of thyroid cancer survivors. Results One thousand one hundred twenty‐four patients with thyroid cancer participated in the survey. Three hundred sixty‐two (37.44%) reported not having had a full understanding of their treatment...
Fri Jun 12, 2020 14:20
Abstract Background No reports describe falsepositive reverse transcriptase polymerase chain reaction (RT‐PCR) for novel coronavirus in preoperative screening. Methods Preoperative patients had one or two nasopharyngeal swabs, depending on low or high risk of viral transmission. Positive tests were repeated. Results Forty‐three of 52 patients required two or more preoperative tests. Four (9.3%) had discrepant results (positive/negative). One of these left the coronavirus disease (COVID)...
Fri Jun 12, 2020 14:09
Sat Jun 13, 2020 20:14
Objectives Supraglottic stenosis is a rare type of laryngeal stenosis that is caused by congenital laryngotracheal anomalies, iatrogenic instrumentation injuries, autoimmune disorders, infection, irradiation, chemical or thermal burns, and external blunt or penetrating trauma. The author presents his experience on nine patients using this new endoscopic surgical technique for treatment of supraglottic stenosis. Study Design Individual retrospective cohort study, tertiary referral center, university...
Sat Jun 13, 2020 17:48
Sat Jun 13, 2020 17:44
Objectives/Hypothesis To examine the correlation between transoral and awake endoscopic examination and investigate their respective ability to predict outcomes of hypoglossal nerve stimulation (HGNS). Study Design Retrospective cohort study at a US medical center. Methods Subjects were adults with apnea‐hypopnea index (AHI) >15 events/hr who underwent HGNS according to standard indications. Eligible subjects had diagnostic preoperative sleep studies, full‐night efficacy postoperative...
Sat Jun 13, 2020 17:34
Objective To evaluate factors associated with overall survival (OS) of patients with non‐rhabdomyosarcoma soft tissue sarcomas of the head and neck. Study Design Retrospective cohort study. Methods The National Cancer Database was queried for cases of non‐rhabdomyosarcoma soft tissue sarcomas of the head and neck between 2004 and 2014. Cases were categorized according to the World Health Organization classification of soft tissue tumors. A multivariable Cox proportional hazards model...
Fri Jun 12, 2020 21:24
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Sat Jun 13, 2020 13:25
Key points The comprehensive visualization and quantification of in vivo fetal hepatic hemodynamics, particularly the shunting of ductus venosus blood, has been elusive and is not yet fully understood. We introduce the combination of chronically instrumented fetal sheep and 4D flow MRI of the whole fetal liver, which allows retrospective blood flow measurement in all visible vessels as well as qualitative assessment. The applicability and usefulness of this technique is exhibited in normally...
Sat Jun 13, 2020 13:24
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Abstract Cortical networks are complex systems of a great many interconnected neurons that operate from collective dynamical states. To understand how cortical neural networks function, it is important to identify their common dynamical operating states from the probabilistic viewpoint. Probabilistic characteristics of these operating states often underlie network functions. Here, using multi‐electrode data from three separate experiments, we identify and characterize a cortical operating state...
Sat Jun 13, 2020 12:01
Abstract Post‐stroke fatigue (PSF) is prevalent among stroke patients, but its mechanisms are poorly understood. Many patients with PSF experience cognitive difficulties, but studies aiming to identify cognitive correlates of PSF have been largely inconclusive. With the aim of characterizing the relationship between subjective fatigue and attentional function, we collected behavioral data using the attention network test (ANT) and self‐reported fatigue scores using the fatigue severity scale (FSS)...
Fri Jun 12, 2020 18:40
Abstract Integrins are extracellular matrix receptors that mediate biochemical and mechanical bi‐directional signals between the extracellular and intracellular environment of a cell thanks to allosteric conformational changes. In the brain, they are found in both neurons and glial cells, where they play essential roles in several aspects of brain development and function, such as cell migration, axon guidance, synaptogenesis, synaptic plasticity and neuro‐inflammation. Although there are many successful...
Fri Jun 12, 2020 13:11
In March 2020, we treated a cohort of 26 critically ill hospitalized SARS‐CoV‐2 infected patients who received EEGs to assess unexplained altered mental status, loss of consciousness, or poor arousal and responsiveness. Of the 26 patients studied, 5 patients had EEGs that showed Periodic Discharges (PD) consisting of high amplitude frontal monomorphic delta waves with absence of epileptic activity. These findings may suggest CNS injury potentially related to COVID‐19 in these patients. This article...
Sat Jun 13, 2020 14:29
Abstract Stress refers to situations in which one feels that the demands imposed on them exceed the limitations of their ability to adapt. This causes a series of adverse consequences among which is compromised health (Lazarus and Folkman, 1984). On 11th March 2020, the World Health Organization declared the pandemic status of COVID‐19 diseases, leading to the European Union states imposing the lockdown, Croatia being one among them. Infection prevention became the nation's most important goal,...
Sat Jun 13, 2020 22:54
Abstract Objectives The aim of this Systematic Review is to estimate the osteoradionecrosis rate in patients with head and neck cancer due to teeth extraction performed before radiotherapy and to identify possible risk factors. Material and Methods PRISMA protocol was used to evaluate and present the results. PubMed, Scopus, and Web of Science were used as search engines: English full‐length papers of clinical studies, in peer‐reviewed journals, were investigated. Cumulative meta‐analysis...
Fri Jun 12, 2020 13:30
Abstract Objectives The aim of this study was to examine temporal summation (TS) and conditioned pain modulation (CPM) in patients with burning mouth syndrome (BMS) and healthy controls using intra‐epidermal electrical stimulation (IES). Materials and Methods Twenty‐six female BMS patients and 27 healthy female controls participated in this study. A single stimulus with electrical stimulation followed by a train of 10 successive stimuli was administered to the right chin of participants...
Fri Jun 12, 2020 13:28
Abstract Objective We aimed to investigate Notch pathway dysregulation in solid adenoid cystic carcinoma (AdCC) and to define the association of Notch activation with cell differentiation and prognosis in AdCCs. Materials and methods Notch1 mutations were detected from 125 AdCCs (62 cribriform‐tubular; 63 solid). RNA‐seq was performed in 16 AdCCs (6 Notch‐mutant; 10 wildtype). Notch activation indicator NICD and myoepithelial marker p63 were detected using immunohistochemistry and double‐labelling...
Fri Jun 12, 2020 13:27
Abstract Objective To investigate an association between odontogenic infections (OI) and maxillary sinuses pathologic disorder (MSPD). The distance between the sinus floor and the root apex of upper posterior teeth was also assessed. Methods Out of 4402 cone beam computed tomography scans, 230 were selected, and 431 teeth were evaluated regarding the presence of OI: bone loss with furcation involvement, periapical and endodontic‐periodontal lesions. The maxillary sinuses were assessed regarding...
Fri Jun 12, 2020 13:24
Abstract Objective The objective of this research was to evaluate the effects of bromelain (derived from Ananas comosus ) upon periodontitis in rats. Materials and Methods Twenty‐four rats were separated into groups: Control, Periodontitis and Bromelain treatment. Bromelain was administered daily by intraperitoneal injection for 20 days. Periodontitis was induced by ligature around the first molars. Oral parameters and blood biomarkers were measured. The histopathological evaluation of...
Fri Jun 12, 2020 13:16
Abstract Objectives The frequency of oral squamous cell carcinoma in young adults has increased in the last decades and there are conflicting results in literature about its prognosis in young subjects. The aim of this study was to analyze the clinical and pathological features of oral squamous cell carcinoma in a cohort of young adults in order to investigate the presence of new independent prognostic markers. Materials and Methods Only HPV‐negative young patients (under 40‐year‐old) affected...
Fri Jun 12, 2020 13:15
Abstract Objective Hyposalivation related xerostomia is an irreversible, untreatable and frequent condition after radiotherapy for head and neck cancer. Stem cell therapy is an attractive option of treatment, but demands knowledge of stem cells functioning. Therefore, we aimed to develop a murine parotid gland organoid model to explore radiation response of stem cells in vitro . Material and Methods Single cells derived from murine parotid gland organoids were passaged in Matrigel with...
Fri Jun 12, 2020 13:10
Abstract Objective To investigate the roles of integrin‐linked kinase (ILK) in mediating the cell migration, proliferation, and apoptosis of human periodontal ligament cells (hPDLCs) in response to cyclic tensile stress. Methods Primary hPDLCs were obtained through the enzyme digestion and tissue culture method. Short hairpin ILK‐expressing hPDLCs were constructed using a recombinant lentiviral vector that specifically targeted ILK gene expression. The silencing of the ILK gene was identified...
Fri Jun 12, 2020 12:54
Journal of Investigative Medicine High Impact Case Reports, Volume 8, Issue , January-December 2020. Tumor lysis syndrome (TLS) is a severe metabolic complication that usually occurs in patients with aggressive tumors who undergo treatment with chemotherapy. Traditionally, it was mainly associated with hematologic malignancies. However, over the past 4 decades, there have been increasing reports of TLS in solid tumors. We report a case of TLS in a patient with gastric cancer, as a complication of...
Sat Jun 13, 2020 10:43
Journal of Investigative Medicine High Impact Case Reports, Volume 8, Issue , January-December 2020. Coronavirus disease 2019, also called COVID-19, is a global pandemic resulting in significant morbidity and mortality worldwide. In the United States, influenza infection occurs mainly during winter and several factors influence the burden of the disease, including circulating virus characteristics, vaccine effectiveness that season, and the duration of the season. We present a case series of 3 patients...
Thu Jun 11, 2020 09:37
Journal of Investigative Medicine High Impact Case Reports, Volume 8, Issue , January-December 2020. In isolated partial anomalous pulmonary venous connections (PAPVCs), an abnormal vein connects venous blood from the pulmonary circulation to the systemic circulation, resulting in an extracardiac shunt. A single aberrant pulmonary vein (PV) is usually hemodynamically insignificant, and affected patients are generally asymptomatic. We describe a young Caribbean-Black woman with an isolated, singular...
Thu Jun 11, 2020 05:11
Journal of Investigative Medicine High Impact Case Reports, Volume 8, Issue , January-December 2020. Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is a rapidly spreading disease causing increased morbidity and mortality across the globe. There is limited available knowledge regarding the natural history of the SARS-CoV-2 infection. Other factors that are also making this infection spread like a pandemic include global travelers, lack...
Thu Jun 11, 2020 05:10
Journal of Investigative Medicine High Impact Case Reports, Volume 8, Issue , January-December 2020. Pancreatic ductal adenocarcinoma, an extremely aggressive cancer, has high metastatic potential. Cutaneous metastasis is very uncommon, representing only <10% of all cases, presenting mostly around the umbilical region. Non-umbilical metastasis is even rarer, and the significance remains unknown. In this article, we describe a case of a 76-year-old gentleman who initially presented with an asymptomatic...
Thu Jun 11, 2020 05:09
Journal of Investigative Medicine High Impact Case Reports, Volume 8, Issue , January-December 2020. Guillain-Barré syndrome (GBS) is an acute inflammatory demyelinating polyneuropathy affecting both motor and sensory peripheral nerves. Typically presenting after a gastrointestinal or a respiratory tract infection, it manifests as ascending paralysis with concomitant areflexia in patients. Cytoalbuminologic dissociation is a supportive finding on cerebrospinal fluid (CSF) analysis. Due to variability...
Thu Jun 11, 2020 05:08
Abstract Different evolutionary interests between males and females can lead to the evolution of sexual dimorphism. However, intersex genetic correlations due to the shared genome can constrain the evolution of sexual dimorphism, resulting in intra‐locus sexual conflict. One of the mechanisms resolving this conflict is sex‐linkage, which allows males and females to carry different alleles on sex chromosomes. Another is a regulatory mutation causing sex‐biased gene expression, which is often mediated...
Sat Jun 13, 2020 14:29
Abstract In mid 1950s, Dr Jerome Conn described a patient with hypertension, and renal potassium wasting associated with adrenocortical adenoma and increased urinary excretion of a sodium‐retaining hormone, initially termed electrocortin, which was subsequently shown to be aldosterone. This was the first full report of primary hyperaldosteronism associated with an aldosterone‐producing adenoma (APA). It subsequently became apparent that similar abnormalities can occur in the absence of an adrenocortical...
Sat Jun 13, 2020 22:48
Abstract Coronavirus disease 2019 (COVID‐19) is associated with both severe systemic inflammation and a prothrombotic state, as reflected by significant increases in fibrinogen and D‐dimers levels that have been associated with poor prognosis and high rates of severe pulmonary embolism. A recent report suggested a role for antiphospholipid antibodies (aPLA) in the thrombotic manifestations associated with severe COVID‐19. As we also recently noticed unexplained lengthening of activated partial thromboplastin...
Fri Jun 12, 2020 22:48
Abstract Alcohol has been produced by humans for nearly ten millennia, but gold‐standard evidence by which to judge the health effects of limited alcohol consumption remains elusive, introducing serious difficulty in considering the safety of alcohol consumption. To do so, physicians and policymakers must consider the population, dose, and context of alcohol consumption and the endpoint, preferably a holistic composite, of interest. The limitations of new research trends, such as mega‐cohorts,...
Fri Jun 12, 2020 10:27
The human microbiome comprises a diverse set of microorganisms, which play a mostly cooperative role in processes such as metabolism and host defense. Next‐generation genomic sequencing of bacterial nucleic acids now can contribute a much broader understanding of the diverse organisms composing the microbiome. Emerging evidence has suggested several roles of the microbiome in pediatric hematology/oncology, including susceptibility to infectious diseases, immune response to neoplasia, and contributions...
Sat Jun 13, 2020 18:19
Background Preclinical studies have implicated excess release of catecholamines and prostaglandins in the mediation of prometastatic processes during surgical treatment of cancer. In this study, we tested the combined perioperative blockade of these pathways in patients with colorectal cancer (CRC). Methods In a randomized, double‐blind, placebo‐controlled biomarker trial involving 34 patients, the β‐blocker propranolol and the COX2‐inhibitor etodolac were administered for 20 perioperative...
Sat Jun 13, 2020 18:15
Sat Jun 13, 2020 18:13
Background Insulin resistance is associated with higher all‐cause and cancer‐specific mortality in postmenopausal women. However, to the authors' knowledge, information regarding insulin resistance and breast cancer mortality risk is limited. Therefore, the authors examined associations between insulin resistance and breast cancer incidence and mortality in a subsample of Women's Health Initiative participants. Methods A total of 22,837 postmenopausal women with fasting baseline glucose and...
Fri Jun 12, 2020 18:16
Background The World Health Organization (WHO) advocates for early integration of palliative care for all children with life‐threatening illness. Provider awareness and misperceptions, however, can impede this imperative. In the Eurasian region, little is known about physician knowledge and perspectives on palliative care. Methods The Assessing Doctors' Attitudes on Palliative Treatment survey was developed as an evidence‐based and culturally relevant assessment of physician perceptions on...
Fri Jun 12, 2020 18:14
Abstract Background The rate of premature greying, referred to as canities, varies among populations and effective treatments are lacking.However, few studies at the molecular level have been reported. Objectives Comparing lipid profiles of individuals with premature canities and healthy volunteers to explore the mechanism of premature canities. Methods Ultra performance liquid chromatography/quadrupole time‐of‐flight mass spectrometry(UPLC‐QTOF‐MS) was used to detect lipids in the...
Sat Jun 13, 2020 11:10
Abstract Alopecia areata has basically been understood as a type 1 inflammatory disease. Activated NKG2D+CD8+ cells produce the Th1 cytokine interferon‐γ, which leads to the disruption of immune tolerance of hair follicles and the exposure of self‐antigens. This results in dense inflammatory cell infiltration and apoptosis around hair follicles, inducing hair loss. A well‐known complication of alopecia areata is atopic dermatitis, a typical type 2 inflammatory disease. Hair scientists have shied...
Sat Jun 13, 2020 11:09
Abstract Severe acute respiratory syndrome (SARS CoV‐2/COVID‐19) is a highly contagious and deadly disease caused by a virus belonging to the coronaviridae family. Researchers working in histopathology laboratories, dealing with morbid samples, are particularly vulnerable to infection unless they have very strong immunity. Hence, a proper precautionary protocol is required for the safety of the laboratory staff. The current review highlights the biological and physical agents that can be used to...
Sat Jun 13, 2020 11:41
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Fri Jun 12, 2020 18:39
Cu 2 O is a typical photoelectrocatalyst for sustainable hydrogen production, while the fast charge recombination hinders its further development. Herein, Ni 2+ cations have been doped into Cu 2 O lattice (named as Ni‐Cu 2 O) via a simple hydrothermal method and act as electron traps. Theoretical results predict that the Ni dopants produce an acceptor impurity level and lower the energy barrier of hydrogen evolution. Photoelectrochemical (PEC) measurements demonstrate that Ni‐Cu 2 O exhibits...
Sat Jun 13, 2020 22:49
The single‐domain GH11 glycosidase from Bacillus circulans (BCX) is involved in the degradation of hemicellulose, one of the most abundant renewable biomaterials in nature. We demonstrate that BCX in solution undergoes minimal structural changes during turnover. NMR spectroscopy results show that the rigid protein matrix provides a frame for fast substrate binding in multiple conformations, accompanied by slow conversion, attributed to an enzyme induced substrate distortion. A model is proposed...
Sat Jun 13, 2020 18:23
Synthetic nanomotors are appealing delivery vehicles for the dynamic transport of functional cargo. Although there are literature examples of such systems, their effective translation toward biological applications is limited due to the use of non‐degradable components. Furthermore, the limitation of size has been an impediment to application due to the importance of achieving nanoscale (ca. 100 nm) dimensions, as opposed to microscale examples that are far more prevalent in the literature. Here,...
Sat Jun 13, 2020 13:19
The recently discovered strongly anti‐Gram‐positive lipolanthines represent a new group of lipidated, ribosomally synthesized and posttranslationally modified peptides (RiPPs). They are bicyclic octapeptides with a central quaternary carbon atom (avionin), which is installed through the cooperative action of the class‐III lanthipeptide synthetase MicKC and the cysteine decarboxylase MicD. Genome mining efforts indicate a widespread distribution and unprecedented biosynthetic diversity of lipolanthine...
Fri Jun 12, 2020 22:00
Spin dependent conduction and polarization in chiral polymers were studied, when the polymers are organized as self‐assembled monolayers and the conduction is along the polymer backbone, namely along its longer axis. Large spin polarization and magnetoresistance effects were observed, which showed a clear dependence on the secondary structure of the polymer. The results indicate that the spin polarization process does not include spin flipping and hence it results from backscattering probabilities...
Sat Jun 13, 2020 11:20
Herein, we report a highly efficient and practical method for pyridine‐derived heterobiaryls synthesis by resorting to palladium‐catalyzed electrophilic functionalization of easily available pyridine‐derived quaternary phosphonium salts. The nice generality of the present reaction protocol is further extrapolated beyond arylation regime by enabling facile incorporation of diverse carbon‐based fragments, including alkenyl, alkynyl and also allyl, onto pyridine core. Notably, the silver salt additive...
Fri Jun 12, 2020 21:18
Rationally designing DNA crystal lattices to scaffold molecular species and solve their structure with X‐ray crystallography is the foundational goal of structural DNA nanotechnology. DNA is an ideal molecule for the construction of 3D crystals with tunable properties due to its high programmability based on canonical Watson‐Crick base pairing, with crystal assembly in all three dimensions facilitated by immobile Holliday junctions and sticky end cohesion. Despite the promise of these systems, only...
Fri Jun 12, 2020 20:48
Inducing necroptosis in cancer cells is an effective approach to circumvent drug‐resistance. Metal‐based triggers have, however, rarely been reported. Ruthenium(II) complexes containing 1,1‐(pyrazin‐2‐yl)pyreno[4,5‐e][1,2,4]triazine were developed with a series of different ancillary ligands ( Ru1 ‐ 7 ). The combination of the main ligand with bipyridyl and phenylpyridyl ligands endows Ru7 with superior nucleus‐targeting properties. As a rare dual catalytic inhibitor, Ru7 effectively inhibits...
Fri Jun 12, 2020 19:20
Electroreduction of CO2 to liquid fuels such as ethanol and n‐propanol, powered by renewable electricity, offers a promising strategy for controlling the global carbon balance and addressing the need for the storage of intermittent renewable energy. In this work, we discovered that the composite composed of nitrogen‐doped graphene quantum dots (NGQ) on CuO‐derived Cu nanorods (NGQ/Cu‐nr) was outstanding electrocatalyst for CO2 reduction to ethanol and n‐propanol. The Faradaic efficiency (FE) of...
Fri Jun 12, 2020 17:50
Controlling the size and surface functionalization of nanoparticles (NPs) can lead to improved properties and applicability. In the present work, we demonstrate the efficiency of the metal‐carbene template approach (MCTA) to synthesize highly robust and soluble three‐dimensional polyimidazolium cages (PICs) of different sizes, each bearing numerous imidazolium groups, and use these as templates to synthesize and stabilize catalytically active, cavity‐hosted, dispersed poly‐NHC‐anchored gold NPs....
Fri Jun 12, 2020 17:49
In the last years, chalcogen bonding, the noncovalent interaction involving chalcogen centers, has emerged as interesting alternative to the ubiquitous hydrogen bonding in many research areas. Here, we could show by means of high‐level quantum chemical calculations, that the carbonyl‐‐‐tellurazole chalcogen bond is at least as strong as conventional hydrogen bonds. Using the carbonyl‐‐‐tellurazole binding motif, we were able to design complex supramolecular networks in solid phase starting from tellurazole‐substituted...
Fri Jun 12, 2020 16:50
The design and synthesis of organic materials with narrowband emission feature in longer wavelength region beyond 510 nm remain a great challenge. For constructing narrowband green emitters, we propose a unique molecular design strategy based on frontier molecular orbital engineering ( FMOE ), which can ingeniously integrate the advantages of twisted donor–acceptor (D–A) structure and multiple resonance (MR) delayed fluorescence skeleton. By attaching an auxiliary donor to a MR skeleton, a novel...
Fri Jun 12, 2020 16:49
Sodium metal is a promising anode, but the uneven Na deposition with a dendrite growth seriously impedes its application. Herein, a fibrous hydroxylated MXene/carbon nanotubes (h‐Ti 3 C 2 /CNTs) composite is designed as a scaffold for dendrite‐free Na metal electrode. This composite displays fast Na + /electron transport kinetics, satisfied thermal conductivity and mechanical property. The h‐Ti 3 C 2 contains abundant sodiophilic functional groups, which play a significant role in inducing...
Fri Jun 12, 2020 16:20
Herein, the synthesis and characterization of a hypervalent iodine‐based reagent that enables a direct and selective nitrooxylation of enolizable C‐H bonds to access a broad array of organic nitrate esters is reported. This compound is bench stable, easy‐to‐handle, and delivers the nitrooxy (‐ONO2) group under mild reaction conditions. Activation of the reagent by Brønsted and Lewis acids was demonstrated in the synthesis of nitrooxylated β‐keto esters, 1,3 diketones and malonates, while its activity...
Fri Jun 12, 2020 13:49
Light‐activated gold catalysis facilitates selective arylation of aryl germanes (which are inert under Pd0/PdII catalysis) in the presence of valuable functionalities such as C−BPin, C−SiMe3, C−I, C−Br, and C−Cl, which in turn offer versatile opportunities for diversification. Abstract Selective C –C couplings are powerful strategies for the rapid and programmable construction of bi‐ or multiaryls. To this end, the next frontier of synthetic modularity will likely arise from harnessing...
Fri Jun 12, 2020 12:34
One for the books : An amine‐bearing DNA‐encoded chemical library (DEL) can be converted into a DNA‐encoded dynamic library (DEDL) and subjected to selection against biological targets for inhibitor discovery. Full ligand structures can be obtained without the need for fragment linking. Abstract Dynamic combinatorial libraries (DCLs) is a powerful tool for ligand discovery in biomedical research; however, the application of DCLs has been hampered by their low diversity. Recently, the concept...
Fri Jun 12, 2020 12:33
All‐polymer solar cells (all‐PSCs) are composed of polymer donors and acceptors, which hold potentially superior morphological stability and mechanical flexibility. In this work, a new random ternary copolymerization strategy was adopted to synthesize new polymer acceptors with high performance. The all‐PSCs based on the new polymer acceptor shows high power conversion efficiency of over 12.5 % and high photostability capable of withstanding long‐term illumination stress. Abstract Demonstrated...
Fri Jun 12, 2020 12:31
A novel alkynyl phosphane gold(I) complex (trimethylphosphane)(3‐(1,3‐dimethylxanthine‐7‐yl)prop‐1‐yn‐1yl)gold(I) 1 displayed mutiple biological acitivites including selective proliferation inhibitory, anti‐metastatic and anti‐angiogenic effects. The complex also induced effects related to aneuploidy in HCT‐116 colon carcinoma cells, which might be mainly ascribed to the dysfunction of mitochondrial bioenergetics and downregulation of glycosis. Induction of aneuploidy beyond a critical level can...
Fri Jun 12, 2020 11:19
<p><p><p><p>Light‐induced transitions between the <em>trans</em> and <em>cis</em> isomer of TATA‐based azobenzene derivatives on Au(111) surfaces were observed directly by scanning tunneling microscopy, allowing atomic‐scale studies of the photoisomerization kinetics. Although the azobenzene units in these adlayers are free‐standing and spaced at uniform distances of 1.26 nm, their photoswitching depends on the isomeric state of the surrounding molecules...
Thu Jun 11, 2020 22:00
View to a kill : Emissive metallacycle‐crosslinked supramolecular networks with hexagonal metallacycles as their crosslinks were developed. These networks were employed for bacterial imaging and killing based on the properties of the introduced metallacycles. Abstract The chemical structures and topologies of the crosslinks in supramolecular networks play a crucial role in their properties and functions. Herein, the preparation of a type of poly(N‐isopropylacrylamide) (PNIPAAM)‐based supramolecular...
Thu Jun 11, 2020 21:40
Catalytic strategies for the α‐C−H functionalisation of primary amines are a major challenge in organic synthesis. A photocatalytic protocol for the α‐C−H alkylation of unprotected primary amines that is amenable to the direct synthesis of α‐tertiary primary amines is reported. This process is readily scalable in continuous flow to provide access to decagram quantities of valuable γ‐lactams and azaspirocycles, for application in drug discovery. Abstract A practical, catalytic entry to α,α,α‐trisubstituted...
Thu Jun 11, 2020 21:40
The electrooxidative C−H olefination of alkenes was achieved by rhodium catalysis. The olefinations of challenging electron‐poor benzamides were accomplished under electrochemical conditions in a fully dehydrogenative fashion with H2 as the only byproduct, thus avoiding stoichiometric chemical oxidants, . Abstract Metal‐catalyzed chelation‐assisted C−H olefinations have emerged as powerful tools for the construction of functionalized alkenes. Herein, we describe the rhoda‐electrocatalyzed...
Thu Jun 11, 2020 21:39
Selective monofunctionalization of substrates with distant, yet equally‐reactive functional groups is difficult to achieve, as it requires the second functional group to selectively modulate its reactivity once the first functional group has reacted. We now show that mechanically‐interlocked catalytic rings can effectively regulate the reactivity of stoppering groups in rotaxanes over a distance of ~2 nm. Our mechanism of communication is enabled by a unique interlocked design, which effectively...
Thu Jun 11, 2020 17:43
Flapping fluorophores (FLAP) with a flexible 8π ring are rapidly gaining attention as a versatile photofunctional system. Here we report a highly photostable “flapping peryleneimide” with an unprecedented fluorogenic mechanism based on a bent‐to‐planar conformational change in the S 1 excited state. The S 1 planarization induces an electronic configurational switch, almost quenching an inherent fluorescence (FL) of peryleneimide moieties. However, the FL quantum yield is remarkably improved with...
Thu Jun 11, 2020 17:17
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