We appreciate the interest and comments by doctors Liang and Chien on our article “Advances in cancer imaging require renewed radiotherapy dose and target volume concepts”.[1] They bring up the debate about elective nodal irradiation (ENI) in lung cancer and argue that minimization of ENI is already practice in this disease. We agree with their remarks but the history of this approach in lung cancer is different from that in head and neck cancer.
Thu Jun 04, 2020 03:00
Trott and colleagues wrote an editorial [1] on our manuscript in which we argue that in the absence of supportive pre-clinical or clinical data for using radiation therapy for viral pneumonia, the risks of low dose thoracic radiotherapy make clinical trials testing radiation therapy as a treatment for COVID-19 pneumonia unacceptable [2]. Trott et al. concur with our interpretation of the available pre-clinical data testing low dose radiotherapy in animal models of viral pneumonia: “They really do...
Thu Jun 04, 2020 03:00
Several proposals had been suggested for the use of low dose radiation to treat COVID-19 patients [12]. This was quickly followed by suggestions for low dose total body irradiation [3]. We urge caution and careful examination of the evidence and logistics of low dose radiotherapy in COVID-19 patients.
Thu Jun 04, 2020 03:00
Future Oncology, Ahead of Print.
Thu Jun 04, 2020 15:19
Abstract Rationale Although both psilocybin and dextromethorphan (DXM) produce psychedelic-like subjective effects, rates of non-medical use of psilocybin are consistently greater than DXM. Objective New data are presented from a study of psilocybin and DXM relevant to understanding the features of psilocybin subjective effects that may account for its higher...
03:00
Abstract Background This study investigated whether patterns of impulsive decision-making (i) differ between individuals with DSM-5 substance use disorders (SUD) or non-substance-related addictive disorders (ND) and healthy controls, and (ii) predict the increase of SUD and ND severity after one year. Methods In a prospective-longitudinal community study,...
03:00
Abstract Rationale 3,4-Methylenedioxypyrovalerone (MDPV) is a synthetic cathinone abused for its cocaine-like psychostimulant effects in “bath salts” products. While there are currently no pharmacotherapies for MDPV abuse, rodent studies suggest immunotherapy may offer a feasible treatment option. Objectives These studies tested the capacity of active vaccination...
Thu Jun 04, 2020 03:00
Abstract Rationale Posttraumatic stress disorder (PTSD) is a chronic condition that has wide-ranging negative effects on an individual’s health and interpersonal relationships. Treatments with long-term benefits are needed to promote the safety and well-being of those suffering from PTSD. Objectives To examine long-term change in PTSD symptoms and additional...
Thu Jun 04, 2020 03:00
Abstract The aims of this study were to find a treatment for acute kidney injury in sepsis and study the role of miR-128-3p in this process. We generated a model of septic acute kidney injury through cecal ligation and puncture (CLP) induction and screened differentially expressed microRNAs through microarray. The mechanism used by miR-128-3p in inflammatory response to septic acute kidney injury was investigated using cell transfection...
03:00
Abstract Sepsis is a disease that is characterized by a severe systemic inflammatory response to microbial infection and lipopolysaccharide (LPS) and is a well-known inducer of sepsis, as well as endothelial cell hyperpermeability. In the present study, we confirm the elevation of CXC chemokine ligand 13 (CXCL13) in sepsis patients. We also show that LPS exposure increases the release of CXCL13, as well as the mRNA and protein expression...
Thu Jun 04, 2020 03:00
Abstract Objectives To evaluate the efficacy of a stepwise intraoperative activation (SIA) of irrigants during and after the instrumentation compared with that of a conventional activation (CA) performed only after the instrumentation to remove smear layer and debris using different activation devices. Materials and methods A total of 70 single-rooted teeth...
03:00
Abstract Objectives Evaluate whether there is an association between convergence insufficiency and temporomandibular disorder (TMD) and whether there is an association between pain and range of motion in different degrees of TMD. Methods We evaluated 138 individuals with TMD and 46 without TMD using the Research Diagnostic Criteria for temporomandibular disorders,...
Thu Jun 04, 2020 03:00
Abstract Objectives Chronic rhinosinusitis (CRS) frequently stems from a dental origin, although odontogenic sinusitis (OS) remains underdiagnosed amongst different professionals. This study aimed to explore how often odontogenic causes are considered when diagnosing CRS. Materials and methods Patient records from 374 new CRS patients treated at a tertiary-level...
Thu Jun 04, 2020 03:00
Abstract Objectives The purpose of this pilot porcine cadaver study was to evaluate the feasible temperature thresholds, which affect osteocyte viability and bone matrix in a preclinical setup, assessing the potential of thermal necrosis for implant removal for further in vivo investigations. Materials and methods After implant bed preparation in the upper...
Thu Jun 04, 2020 03:00
Abstract Objectives Clinicians agree that children with isolated cleft lip have fewer cleft-associated problems than children with cleft lip and palate. Unfortunately, for isolated cleft lip children, the risk of cleft-associated problems is unknown and maybe underestimated. Often, these children do not get the required follow-up by a multidisciplinary team and thereby not the known benefits in supporting their development. This study...
Thu Jun 04, 2020 03:00
Soft Robotics, Volume 7, Issue 3, Page 309-320, June 2020.
Tue Jun 02, 2020 10:00
Soft Robotics, Volume 7, Issue 3, Page 321-331, June 2020.
Tue Jun 02, 2020 10:00
Soft Robotics, Volume 7, Issue 3, Page 267-282, June 2020.
Tue Jun 02, 2020 10:00
White Matter Abnormalities in Retired Professional Rugby League Players with a History of Concussion
Journal of Neurotrauma, Ahead of Print.
Wed Jun 03, 2020 10:00
Journal of Neurotrauma, Ahead of Print.
Wed Jun 03, 2020 10:00
Journal of Neurotrauma, Ahead of Print.
Wed Jun 03, 2020 10:00
Journal of Neurotrauma, Ahead of Print.
Wed Jun 03, 2020 10:00
Journal of Neurotrauma, Ahead of Print.
Wed Jun 03, 2020 10:00
Journal of Neurotrauma, Ahead of Print.
Wed Jun 03, 2020 10:00
Surgical Infections, Ahead of Print.
Tue Jun 02, 2020 10:00
Tissue Engineering Part A, Ahead of Print.
Wed Jun 03, 2020 10:00
Related ArticlesStatPearls Book. 2020 01 Authors: Abstract Simulation has become a mainstay in the education of not only healthcare professionals but many different professions the world over. As our global medical knowledge continues to expand, and our societal, technological advancements continue to broaden, the idea of learning on a live patient is becoming a less preferred method of teaching medical professionals.[1] Patient safety is a commonly cited reason simulation...
05:57
Background and Aims. Celiac disease (CD) is possibly the most common autoimmune disorder, which may lead to dietary problems in the Arab region. This paper is aimed at exploring the epidemiology of the celiac disease in Arab countries, including its prevalence, associated risk factors, and clinical patterns. Methods. An extensive search of the literature was conducted from electronic databases such as PubMed, Embase, and Google Scholar. In total, 134 research papers were retrieved. We extracted studies...
Thu Jun 04, 2020 19:05
Background. Animal tissues and tissue-derived biomaterials are widely used in the field of xenotransplantation and regenerative medicine. A potential immunogenic risk that affects the safety and effectiveness of xenografts is the presence of remnant α-Gal antigen (synthesized by GGTA1 or/and iGb3S). GGTA1 knockout mice have been developed as a suitable model for the analysis of anti-Gal antibody-mediated immunogenicity. However, we are yet to establish whether GGTA1/iGb3S double knockout (G/i DKO)...
Thu Jun 04, 2020 18:50
Background. The incidence of sepsis has been increasing in recent years. The molecular mechanism of different pathogenic sepsis remains elusive, and biomarkers of sepsis against different pathogens are still lacking. Methods. The microarray data of bacterial sepsis, fungal sepsis, and mock-treated samples were applied to perform differentially expressed gene (DEG) analysis to identify a bacterial sepsis-specific gene set and a fungal sepsis-specific gene set. Functional enrichment analysis was used...
Thu Jun 04, 2020 18:50
Leptin acts as an adipocytokine functions via the leptin receptor, which stimulates growth, migration, and invasion of cancer cells. This study is aimed at identifying leptin as a prognostic factor in colorectal cancer (CRC). The differentially expressed genes with prognostic value in CRC tissues either with or without liver metastasis were assessed based on The Cancer Genomic Atlas (TCGA). Leptin was considered a candidate gene for further analysis. Its expression features of 206 CRC patients without...
Thu Jun 04, 2020 18:50
The brain is the most important and complex organ in most living creatures which serves as the center of the nervous system. The function of human brain includes controlling of the motion of the body and different organs and maintaining basic homeostasis. The disorders of the brain caused by a variety of reasons often severely impact the patients’ normal life or lead to death in extreme cases. Monocyte is an important immune cell which is often recruited to the brain in a number of brain disorders....
Thu Jun 04, 2020 18:20
As an oncogenic virus, HPV16 can lead to the dysfunction of cervical epithelial cells and contribute to the progression of cervical cancer. Components from the cervical-vaginal fluid (CVF) could be used as the basis for cervical cancer screening. Exosomes are widely present in various body fluids and participate in intercellular communication via its cargos of proteins, mRNAs, and miRNAs. This study was conducted to explore the changes of miRNAs in exosomes isolated form the cervical-vaginal fluid...
Thu Jun 04, 2020 08:05
BACKGROUND AND PURPOSE:Cephaloceles are relatively rare conditions caused by a congenital and/or acquired skull defect. The incidence of associated venous brain anomalies with regard to cephaloceles remains to be fully elucidated. Accordingly, we sought to assess the prevalence of sigmoid sinus dehiscence and diverticula in patients with spontaneous skull base cephaloceles.MATERIALS AND METHODS:Our institutional data base was retrospectively queried from 2005 to 2018. Patients in whom spontaneous...
Thu Jun 04, 2020 18:18
SUMMARY:Approximately 15% of patients undergoing endovascular thrombectomy for anterior circulation acute ischemic stroke have a tandem lesion, defined as a severe stenosis or occlusion of the cervical internal carotid artery ipsilateral to its intracranial occlusion. Patients with tandem lesions have worse outcomes than patients with isolated intracranial occlusions, but the optimal management of their carotid lesions during endovascular thrombectomy remains controversial. The main options commonly...
Thu Jun 04, 2020 18:07
BACKGROUND AND PURPOSE:Focal cortical dysplasias are the most common resected epileptogenic lesions in children and the third most common lesion in adults, but they are often subtle and frequently overlooked on MR imaging. The purpose of this study was to evaluate whether MP2RAGE-based morphometric MR imaging analysis is superior to MPRAGE-based analysis in the detection of focal cortical dysplasia.MATERIALS AND METHODS:MPRAGE and MP2RAGE datasets were acquired in a consecutive series of 640 patients...
Thu Jun 04, 2020 18:01
BACKGROUND AND PURPOSE:Whiplash-associated disorders frequently develop following motor vehicle collisions and often involve a range of cognitive and affective symptoms, though the neural correlates of the disorder are largely unknown. In this study, a sample of participants with chronic whiplash injuries were scanned by using resting-state fMRI to assess brain network changes associated with long-term outcome metrics.MATERIALS AND METHODS:Resting-state fMRI was collected for 23 participants and...
Thu Jun 04, 2020 17:52
BACKGROUND AND PURPOSE:Cortical amyloid quantification on PET by using the standardized uptake value ratio is valuable for research studies and clinical trials in Alzheimer disease. However, it is resource intensive, requiring co-registered MR imaging data and specialized segmentation software. We investigated the use of deep learning to automatically quantify standardized uptake value ratio and used this for classification.MATERIALS AND METHODS:Using the Alzheimer’s Disease Neuroimaging Initiative...
Thu Jun 04, 2020 17:31
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