Abstract This study aimed to evaluate the differences in the Raman spectra of nine clinical species of bacteria isolated from infections (three Gram-positive and six Gram-negative species), correlating the spectra with the chemical composition of each species and to develop a classification model through discriminant analysis to categorize each bacterial strain using the peaks with the most significant differences. Bacteria were cultured in Mueller Hinton agar and a sample of...
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To examine, if a shift in indications for radiotherapy is to be expected in the context of the COVID-19 pandemic, the database Pubmed was searched for multidisciplinary or surgical expert recommendations on th...
Wed Jun 03, 2020 03:00
Circulating tumor cells (CTCs) are an established prognostic marker in castration-resistant prostate cancer but have received little attention in localized high-risk disease. We studied the detection rate of C...
Mon Jun 01, 2020 03:00
Developments in the field of proton beam therapy (PBT) have recently crossed the tipping point wherein the modality is now more versatile than ever before, with possibilities and likely indications expanding r...
Mon Jun 01, 2020 03:00
Endoscopic resection is widely used as an effective treatment for superficial esophageal cancer. However, the risk of lymph node metastasis increases in cases of muscularis mucosae or deeper invasion, for whic...
Mon Jun 01, 2020 03:00
Summary CTLA‐4 and PD‐1 play a key role in tumor‐induced downregulation of lymphocytic immune responses. Immune checkpoint inhibitors have been shown to alter the immune response to various cancer types. Anti‐CTLA‐4 and anti‐PD‐1 antibodies affect the interaction between tumor, antigen‐presenting cells and T lymphocytes. Clinical studies of the anti‐CTLA‐4 antibody ipilimumab and the anti‐PD‐1 antibodies nivolumab and pembrolizumab have provided evidence of their positive effects on overall survival...
Wed Jun 03, 2020 22:42
A dual‐raster‐scanned photoacoustic microscope (DRS‐PAM) was reported, which integrates a two‐dimensional motorized translation stage for large field‐of‐view imaging and a two‐axis fast galvanometer scanner for real‐time imaging. The DRS‐PAM provides a flexible transition from wide‐field monitoring the vasculature of organs to real‐time imaging of local dynamics. Further details can be found in the article by Fei Yang, Zhiyang Wang, Wuyu Zhang, et al. (e202000022). Abstract A dual‐raster‐scanned...
Mon Jun 01, 2020 19:26
A type of compact and cost‐effective light‐sheet imaging device, termed sub‐voxel‐resolving light‐sheet add‐on module (SLAM), is developed to cooperate with conventional 2D epifluorescence microscope, allowing high‐contrast, resolution‐improved 3D imaging of various biological samples at high throughput. Further details can be found in the article by Fang Zhao, Yicong Yang, Yi Li, et al. (e201960243). Abstract A type of compact and cost‐effective light‐sheet imaging device, termed sub‐voxel‐resolving...
Mon Jun 01, 2020 19:26
A multi‐wavelength Spatial Frequency Domain Imaging (SFDI) utilizes structured illumination to provide absorption and reduced scattering coefficient maps of colorectal tissue. Combining SFDI with a Machine Learning algorithm ‐ AdaBoost, different types of colorectal tissues including normal, adenomatous polyp and cancer, can be differentiated with high accuracy. This new technique provides a potential method to assist in colorectal cancer screening. Further details can be found in the article by...
Mon Jun 01, 2020 19:26
Related Articlesβ-Naphthoflavone and Ethanol Reverse Mitochondrial Dysfunction in A Parkinsonian Model of Neurodegeneration. Int J Mol Sci. 2020 May 31;21(11): Authors: Fernandez-Abascal J, Chiaino E, Frosini M, Davey GP, Valoti M Abstract The 1-methyl-4-phenylpyridinium (MPP+) is a parkinsonian-inducing toxin that promotes neurodegeneration of dopaminergic cells by directly targeting complex I of mitochondria. Recently, it was reported that some Cytochrome...
Thu Jun 04, 2020 16:25
Related ArticlesBellwether Procedures for Monitoring Subnational Variation of All-cause Perioperative Mortality in Brazil. World J Surg. 2020 Jun 02;: Authors: Truche P, Roa L, Citron I, Caddell L, Neto J, Reis M, Moore E, Botelho F, Alonso N, Watters D Abstract BACKGROUND: All-cause perioperative mortality rate (POMR) is a commonly reported metric to assess surgical quality. Benchmarking POMR remains difficult due to differences in surgical volume and...
Thu Jun 04, 2020 16:22
Related ArticlesExploring the Impact of COVID-19 on Progress Towards Achieving Global Surgery Goals. World J Surg. 2020 Jun 02;: Authors: Mazingi D, Navarro S, Bobel MC, Dube A, Mbanje C, Lavy C Abstract INTRODUCTION: In the 5 months since it began, the COVID-19 pandemic has placed extraordinary demands on health systems around the world including surgery. Competing health objectives and resource redeployment threaten to retard the scale-up of surgical...
Thu Jun 04, 2020 16:22
Related ArticlesHaemostatic Efficacy of Topical Agents During Liver Resection: A Network Meta-Analysis of Randomised Trials. World J Surg. 2020 Jun 02;: Authors: Wells CI, Ratnayake CBB, Mentor K, Sen G, Hammond JS, French JJ, Wilson CH, Manas D, White S, Pandanaboyana S Abstract BACKGROUND: Hepatic resection carries a high risk of parenchymal bleeding both intra- and post-operatively. Topical haemostatic agents are frequently used to control bleeding...
Thu Jun 04, 2020 16:22
Related ArticlesTextbook Outcomes in Liver Transplantation. World J Surg. 2020 Jun 02;: Authors: Moris D, Shaw BI, Gloria J, Kesseli SJ, Samoylova ML, Schmitz R, Manook M, McElroy LM, Patel Y, Berg CL, Knechtle SJ, Sudan DL, Barbas AS Abstract BACKGROUND: Textbook outcome (TO) is an emerging concept within multiple surgical domains, which represents a novel effort to define a standardized, composite quality benchmark based on multiple postoperative endpoints...
Thu Jun 04, 2020 16:22
Related ArticlesOperative Case Volume Minimums Necessary for Surgical Training Throughout Rural Africa. World J Surg. 2020 Jun 02;: Authors: Parker RK, Topazian HM, Parker AS, Mwachiro MM, Strain S, White RE, Thelander K, Riviello R Abstract BACKGROUND: Resident operative case volumes are an important aspect of surgical education, and minimums are required in Accreditation Council for Graduate Medical Education (ACGME) programs. Minimum operative case...
Thu Jun 04, 2020 16:22
Related ArticlesHow Can We Predict the Recovery from Pitch Lowering After Thyroidectomy? World J Surg. 2020 Jun 02;: Authors: Kim SY, Park JO, Bae JS, Lee SH, Hwang YS, Shim MR, Park YH, Sun DI Abstract BACKGROUND: Some of patients are suffered from pitch lowering of voice after thyroidectomy. We sought to identify factors predictive of a recovery from lowered pitch voice after thyroid surgery. METHODS: We retrospectively reviewed the records...
Thu Jun 04, 2020 16:22
Related ArticlesTransnasal endoscopic skull base surgery during COVID-19 pandemic: algorithm of management in an Italian reference COVID center. Acta Neurochir (Wien). 2020 Jun 03;: Authors: Mattogno PP, Rigante M, Lauretti L, Parrilla C, D'Alessandris QG, Paludetti G, Olivi A PMID: 32488323 [PubMed - as supplied by publisher]
Thu Jun 04, 2020 16:20
Related ArticlesChemotherapy associated dural sinus thrombosis presenting as a cerebrospinal fluid leak. BMJ Case Rep. 2020 Jun 01;13(6): Authors: Bujoreanu I, Ferguson M, Saleh H Abstract Despite the well documented increased risk of thrombosis in patients with cancer and during chemotherapy, cerebral venous sinus thrombosis (CVT) remains a rare entity. We present a rare case of cerebrospinal fluid (CSF) rhinorrhoea secondary to a left transverse sinus...
Thu Jun 04, 2020 16:20
Related ArticlesAnalysis of transgenic zebrafish expressing the Lenz-Majewski syndrome gene PTDSS1 in skeletal cell lineages. F1000Res. 2019;8:273 Authors: Seda M, Peskett E, Demetriou C, Bryant D, Moore GE, Stanier P, Jenkins D Abstract Background: Lenz-Majewski syndrome (LMS) is characterized by osteosclerosis and hyperostosis of skull, vertebrae and tubular bones as well as craniofacial, dental, cutaneous, and digit abnormalities. We previously...
Thu Jun 04, 2020 16:20
Related ArticlesRepair of Temporal Bone Defects via the Middle Cranial Fossa Approach: Treatment of 2 Pathologies With 1 Operation. Neurosurgery. 2019 06 01;84(6):1290-1295 Authors: Eddelman DB, Munich S, Kochanski RB, Eggerstedt M, Kazan RP, Moftakhar R, Munoz L, Byrne RW, Wiet RM Abstract BACKGROUND: Temporal bone dehiscence (TBD) often results in leakage of cerebrospinal fluid (CSF) and/or encephalocele. TBD can also occur over the superior semicircular...
Thu Jun 04, 2020 16:20
Related ArticlesStatPearls Book. 2020 01 Authors: Abstract The nasopharynx represents the most superior portion of the pharynx, bounded superiorly by the skull base and inferiorly by the soft palate. The nasopharynx connects the nasal cavity to the oropharynx and contains the Eustachian tube openings and adenoids. Notable clinical situations include nasopharyngeal carcinoma and adenoidal hypertrophy. This review will discuss the anatomy of the nasopharynx, including the...
Thu Jun 04, 2020 16:20
Related ArticlesStatPearls Book. 2020 01 Authors: Abstract Skull fractures are common injuries observed in the setting of both blunt and penetrating trauma. The frontal sinuses are located within the frontal bone, superior and medial to the orbits. The frontal sinuses begin developing around 5 to 6 years old and become fully developed between the ages of 12 to 20. They are innervated by both the supraorbital and supratrochlear nerves, which are supplied by the ophthalmic...
Thu Jun 04, 2020 16:20
Related ArticlesTreat or Wait? Hepatobiliary Phase Hypointense Nodule without Arterial Phase Hyperenhancement. Radiology. 2020 Jun 02;:201726 Authors: Motosugi U PMID: 32491954 [PubMed - as supplied by publisher]
Thu Jun 04, 2020 16:18
Related ArticlesClover-Style Fasciocutaneous Perforator Flap for Reconstruction of Massive Sacral Pressure Sores. Ann Plast Surg. 2020 May 28;: Authors: Cheng J, Zhang Q, Feng S, Wu X, Huo W, Ma Y, Cai J, Liu M Abstract BACKGROUND: As a common complication of the long-term bedridden patients, pressure sore is a great challenge for surgeons. The purpose of this study was to explore the surgical method of using a clover-style fasciocutaneous perforator...
Thu Jun 04, 2020 16:18
Related ArticlesSaethre-Chotzen Syndrome: A Report of 7 Patients and Review of the Literature. Ann Plast Surg. 2020 Jun 01;: Authors: Abulezz TA, Allam KA, Wan DC, Lee JC, Kawamoto HK Abstract INTRODUCTION: Saethre-Chotzen syndrome is a genetic condition characterized by craniofacial and limb anomalies, with craniosynostosis (mainly coronal) being the most frequent craniofacial finding. Cranial and facial deformities can be extremely variable requiring...
Thu Jun 04, 2020 16:18
Related ArticlesMechanism of dysphagia after acute traumatic cervical spinal cord injury. J Neurotrauma. 2020 Jun 03;: Authors: Hayashi T, Fujiwara Y, Ariji Y, Sakai H, Kubota K, Kawano O, Masuda M, Morishita Y, Maeda T Abstract INTRODUCTION: Swallowing dysfunction, which may cause aspiration pneumonia, is one of the most important complications of treatment of traumatic cervical spinal cord injury (CSCI); however, the mechanism of dysphagia is not well...
Thu Jun 04, 2020 16:08
Related ArticlesStatPearls Book. 2020 01 Authors: Abstract The innervation of the larynx is intricate, detailed, and represents some of the more complex relationships in the anatomy of the head and neck. The vagus nerve is the large nerve that supplies the many branches of nerves that innervate the larynx. The superior laryngeal nerve, its external and internal branches, and the recurrent laryngeal nerve all have very distinct roles in motor and sensory innervation of...
Thu Jun 04, 2020 16:08
Related ArticlesVagus nerve stimulation (VNS)-induced layer-specific modulation of evoked responses in the sensory cortex of rats. Sci Rep. 2020 Jun 02;10(1):8932 Authors: Takahashi H, Shiramatsu TI, Hitsuyu R, Ibayashi K, Kawai K Abstract Neuromodulation achieved by vagus nerve stimulation (VNS) induces various neuropsychiatric effects whose underlying mechanisms of action remain poorly understood. Innervation of neuromodulators and a microcircuit structure...
Thu Jun 04, 2020 16:04
Related ArticlesTemporary Visual Deprivation Causes Decorrelation of Spatiotemporal Population Responses in Adult Mouse Auditory Cortex. eNeuro. 2019 Nov/Dec;6(6): Authors: Solarana K, Liu J, Bowen Z, Lee HK, Kanold PO Abstract Although within-modality sensory plasticity is limited to early developmental periods, cross-modal plasticity can occur even in adults. In vivo electrophysiological studies have shown that transient visual deprivation (dark...
Thu Jun 04, 2020 16:04
Related ArticlesCathodic-leading pulses are more effective than anodic-leading pulses in intracortical microstimulation of the auditory cortex. J Neural Eng. 2019 06;16(3):036002 Authors: Voigt MB, Kral A Abstract OBJECTIVE: Intracortical microstimulation (ICMS) is widely used in neuroscientific research. Earlier work from our lab showed the possibility to combine ICMS with neuronal recordings on the same shank of multi-electrode arrays and consequently...
Thu Jun 04, 2020 16:04
Related ArticlesCRISPRpred(SEQ): a sequence-based method for sgRNA on target activity prediction using traditional machine learning. BMC Bioinformatics. 2020 Jun 01;21(1):223 Authors: Muhammad Rafid AH, Toufikuzzaman M, Rahman MS, Rahman MS Abstract BACKGROUND: The latest works on CRISPR genome editing tools mainly employs deep learning techniques. However, deep learning models lack explainability and they are harder to reproduce. We were motivated to...
Thu Jun 04, 2020 15:52
We present a unique case study report of a male individual with a history of mild nonischaemic cardiomyopathy, with no ventricular ectopy, that at the age of 76 years sustained multiple concussions (i.e., mild traumatic brain injury) within a week of each other. Concussion symptoms included cognitive difficulties, “not feeling well,” lethargy, fatigue, and signs of depression. He was later medically diagnosed with postconcussion syndrome. The patient, WJT, was referred for cardiac and neurological...
Thu Jun 04, 2020 13:20
Related ArticlesDepletion interactions modulate the binding between disordered proteins in crowded environments. Proc Natl Acad Sci U S A. 2020 Jun 02;: Authors: Zosel F, Soranno A, Buholzer KJ, Nettels D, Schuler B Abstract Intrinsically disordered proteins (IDPs) abound in cellular regulation. Their interactions are often transitory and highly sensitive to salt concentration and posttranslational modifications. However, little is known about the effect...
Thu Jun 04, 2020 15:45
Related ArticlesWhy are momilactones always associated with biosynthetic gene clusters in plants? Proc Natl Acad Sci U S A. 2020 Jun 02;: Authors: Zhang J, Peters RJ PMID: 32487731 [PubMed - as supplied by publisher]
Thu Jun 04, 2020 15:45
Related ArticlesP-hacking in clinical trials and how incentives shape the distribution of results across phases. Proc Natl Acad Sci U S A. 2020 Jun 02;: Authors: Adda J, Decker C, Ottaviani M Abstract Clinical research should conform to high standards of ethical and scientific integrity, given that human lives are at stake. However, economic incentives can generate conflicts of interest for investigators, who may be inclined to withhold unfavorable results...
Thu Jun 04, 2020 15:45
Related ArticlesCommon homozygosity for predicted loss-of-function variants reveals both redundant and advantageous effects of dispensable human genes. Proc Natl Acad Sci U S A. 2020 Jun 02;: Authors: Rausell A, Luo Y, Lopez M, Seeleuthner Y, Rapaport F, Favier A, Stenson PD, Cooper DN, Patin E, Casanova JL, Quintana-Murci L, Abel L Abstract Humans homozygous or hemizygous for variants predicted to cause a loss of function (LoF) of the corresponding...
Thu Jun 04, 2020 15:45
Related ArticlesPore-scale investigation of the use of reactive nanoparticles for in situ remediation of contaminated groundwater source. Proc Natl Acad Sci U S A. 2020 Jun 02;: Authors: Pak T, Luz LFL, Tosco T, Costa GSR, Rosa PRR, Archilha NL Abstract Nanoscale zero-valent iron (nZVI) particles have excellent capacity for in situ remediation of groundwater resources contaminated by a range of organic and inorganic contaminants. Chlorinated solvents...
Thu Jun 04, 2020 15:45
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