Abstract Background Otolaryngologists are among the highest risk for COVID‐19 exposure. Methods This is a cross‐sectional, survey‐based, national study evaluating academic otolaryngologists. Burnout, anxiety, distress, and depression were assessed by the single‐item Mini‐Z Burnout Assessment, 7‐item Generalized Anxiety Disorder Scale, 15‐item Impact of Event Scale, and 2‐item Patient Health Questionnaire, respectively. Results A total of 349 physicians completed the survey. Of them,...
Thu Jun 04, 2020 17:32
Abstract Introduction Detecting volatile organic compounds in exhaled breath enables the diagnosis of cancer. We investigated whether a handheld version of an electronic nose is able to discriminate between patients with head and neck squamous cell cancer (HNSCC) and healthy controls. Methods Ninety‐one patients with HNSCC and 72 controls exhaled through an e‐nose. An artificial neural network based model was built to separate between HNSCC patients and healthy controls. Additionally, three...
Wed Jun 03, 2020 14:51
Abstract Background Differentiated thyroid cancer (DTC) reports a poorer health‐related quality of life (HRQoL) than a norm population. Patients' illness perceptions are modifiable and known associates of HRQoL in other cancers. The aim was to examine the relationship between illness perceptions and HRQoL among DTC survivors. Methods DTC survivors registered in the Netherlands Cancer Registry diagnosed between 1990 and 2008, received a survey on illness perceptions (Brief‐Illness Perception...
Wed Jun 03, 2020 11:44
Walk around the city-like campus of Texas Medical Center (TMC), and you might find it hard to picture the bootstrapped, garage-like digs that one associates with startup companies. But on the eastern edge of the sprawling complex in a former Nabisco cookie factory, TMC has set up the Innovation Institute for these types of ventures. During our recent visit to TMC, we had the opportunity to tour the Innovation Institute and learn how they’re supporting innovative and promising medtech and healthcare...
Thu Jun 04, 2020 20:23
Precise delivery of therapeutic drugs into diseased tissue remains a challenge in a variety of cases. Tumors can be hard to seed with chemo agents, particularly when the blood flow is not favorable for delivery. Now, researchers at the Max Planck Institute for Intelligent Systems in Germany have developed microscopic drug delivery devices that can travel against the flow of blood. The new microrobots were inspired by leukocytes (white blood cells) that are naturally able to roll along...
Thu Jun 04, 2020 18:43
Researchers at Texas A&M University have developed a microfluidic device that mimics the complex architecture of vasculature to better study blood clot treatments. The device includes channels with spirals, bends, and curves that are similar to those found in blood vessels, and which can influence blood clotting. Besides being biomimetic, the device is also faster and less expensive than existing blood clot testing technologies, and does not require a skilled technician to operate it. Blood...
Thu Jun 04, 2020 17:32
At the Swiss Federal Institute of Technology Lausanne (EPFL) researchers have developed special textile threads that can be used to detect slight variations in how a fabric is stretched, the pressures that are applied to it, and even the torque that twists it. The capability may end up being used in clothing and even bed sheets to continuously monitor people’s breathing and heart rates, body movement, and other parameters that may be useful in medicine and healthcare. “Imagine clothing or...
Thu Jun 04, 2020 16:06
This study reports the overall survival (OS) comparing regional to metropolitan hospitals in patients having resections for colorectal cancers. It uses validated administrative data linked to death data to report on OS over 10 years in the state of Victoria. Results are adjusted for potential confounders using a multivariable Cox regression analysis. Abstract Background This study aimed to use administrative data (AD) linked to the Victorian death index (VDI) to report on overall long‐term...
Thu Jun 04, 2020 12:40
Wed Jun 03, 2020 21:39
Wed Jun 03, 2020 21:05
Initial and repeat cholecystectomy over time. Number of first and second cholecystectomies annually. Rate of second cholecystectomy as a percentage of all cholecystectomies, demonstrating an increasing annual trend. Abstract Background Subtotal cholecystectomy is utilized in conditions of high risk to critical structures, like the common bile duct. However, the remnant gall bladder may become symptomatic and require a completion cholecystectomy for treatment. This second procedure can itself...
Wed Jun 03, 2020 20:29
Abstract Objectives To explore male human papillomavirus (HPV) contemporary genotyping epidemiology and correlations to peniscopy, cytology, and histopatology. Methods Medical records of patients who had been submitted to HPV infection screening with genotyping, peniscopy, cytology, and histopathology in a period of 2 years were reviewed. Frequency analysis and correlations between the diagnostic tools were established. Results Genotype of 1132 men resulted in 69.2% (784) positivity...
Thu Jun 04, 2020 12:22
Abstract Anaplastic large cell lymphoma (ALCL) is a non‐Hodgkin lymphoma of T‐cell or null‐cell lineage with variable cytomorphology. We report two rare ALCL cases with carcinomatous and sarcomatous patterns, respectively, in fine needle aspiration (FNA) cytology and histopathology. The first case was a 56‐year‐old man with enlarged left inguinal lymph node. FNA smears showed a malignant small round cell tumor with nuclear molding. In addition, there were large bi‐nucleated and multinucleated cells...
Wed Jun 03, 2020 17:41
Abstract Background The prognosis of patients with biliary atresia (BA) after Kasai portoenterostomy (KPE) varies, and precisely predicting the outcomes of KPE before surgery is still challenging. Methods A total of 158 patients who underwent KPE in our hospital were included in this study. The patients in the training cohort were recruited from January 2012 to October 2017 (n = 118), and then, those in the validation cohort were recruited from November 2017 to April 2019 (n ...
Thu Jun 04, 2020 15:47
Thu Jun 04, 2020 19:18
Abstract Introduction Limited data establish the efficacy and safety of SBRT in the abdominopelvic (AP) space, where SBRT delivery is challenging due to the proximity of radiosensitive luminal gastrointestinal (GI) organs. The aim of this study was to assess clinical outcomes in patients with AP OM treated with SBRT. Methods Eligible patients were those with OM (defined as metastases in ≤3 total sites) in the AP space (excluding liver) treated with SBRT. Descriptive statistics and Kaplan–Meier...
Thu Jun 04, 2020 18:41
Publication date: Available online 4 June 2020Source: Clinical TherapeuticsAuthor(s): Jill L. Maron
Thu Jun 04, 2020 20:14
Publication date: Available online 3 June 2020Source: Clinical TherapeuticsAuthor(s): Stephen R. Southworth, Jill A. Sellers
Thu Jun 04, 2020 20:14
Abstract Medical imaging capable of generating imaging biomarkers, specifically radiology and nuclear medicine image acquisition and analysis processes, differs from frequently used comparators like blood or urine biomarkers. This difference arises from the sample acquisition methodology. While different analysis methodologies and equipment provide slightly different results in any analytical domain, unlike blood or urine analysis where the samples are obtained by simple extraction...
Thu Jun 04, 2020 03:00
Publication date: Available online 4 June 2020Source: European Journal of CancerAuthor(s): Valentina Biagioli, Silvia Belloni, Beatrice Albanesi, Alessio Piredda, Rosario Caruso
Thu Jun 04, 2020 19:57
Publication date: Available online 4 June 2020Source: European Journal of CancerAuthor(s): Serena Di Cosimo, Andrea Malfettone, José Manuel Pérez-García, Antonio Llombart-Cussac, Rosalba Miceli, Giuseppe Curigliano, Javier Cortés
Thu Jun 04, 2020 19:57
Publication date: Available online 4 June 2020Source: European Journal of CancerAuthor(s): Olivier Huillard, Francois Goldwasser
Thu Jun 04, 2020 19:57
Thu Jun 04, 2020 12:58
There is an unmet need to identify biomarkers sensitive to change in rare, slowly progressive neuromuscular diseases. Quantitative MRI of muscle may offer this opportunity, is non‐invasive and can be carried out almost independent of patient‐cooperation and disease severity. Muscle fat content correlates with muscle function in neuromuscular diseases, and changes in fat content precede changes in function, which suggests that muscle MRI is a strong biomarker candidate to predict prognosis and treatment...
Thu Jun 04, 2020 11:50
We screened 662 subjects comprising 462 essential tremor, ET (285 sporadic, 125 with family history and 52 probands from well‐characterized ET pedigrees and 200 controls and identified pathogenic NOTCH2NLC GGC repeat expansions in four sporadic ET patients. Two patients were followed up for over a decade: one with 90 repeats remained an ET phenotype that did not evolve after forty years, while another patient with 107 repeats developed motor symptoms and cognitive impairment after 8 to 10舁years....
Thu Jun 04, 2020 11:09
Wed Jun 03, 2020 20:15
Epicardial adipose tissue (EAT) has the unique property to release mediators that nourish the heart in healthy conditions, an effect that becomes detrimental when volume expands and proinflammatory cytokines start to be produced. Proprotein convertase subtilisin/kexin type 9 (PCSK9), a proinflammatory mediator involved in atherosclerosis, is also produced by visceral fat. Due to the correlation of inflammation with PCSK9 and EAT enlargement, we evaluated whether PCSK9 was expressed in EAT and associated...
Thu Jun 04, 2020 15:50
Thu Jun 04, 2020 19:10
Thu Jun 04, 2020 18:34
The Journal of Antibiotics, Published online: 04 June 2020; doi:10.1038/s41429-020-0321-6Role of symbiosis in the discovery of novel antibiotics
Thu Jun 04, 2020 03:00
The Journal of Antibiotics, Published online: 04 June 2020; doi:10.1038/s41429-020-0329-yGeneration of incednine derivatives by mutasynthesis
Thu Jun 04, 2020 03:00
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus responsible for Coronavirus disease 2019 (COVID-19) has a predilection for infecting the mucosa of the upper and lower airways. Otolaryng...
Wed Jun 03, 2020 03:00
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