Objectives/Hypothesis The supraclavicular artery island (SAI) flap may be a good option for selected head and neck reconstruction due to its reliability, ease of harvest, and favorable color match. The objective of this study was to examine the rates of complications for the SAI flap in head and neck oncologic reconstruction, with examination of risk factors and comparisons to alternative flaps often considered the gold‐standard soft‐tissue flaps for head and neck reconstruction: the pectoralis...
Wed Jun 03, 2020 21:46
Objectives Self‐ratings seem to be the most effortless strategy for assessment of patients' chemical senses. Notably, although flavor perception strongly relies on olfaction, the relationship between self‐reported flavor perception and orthonasal olfactory tests have hitherto not been considered. The aim of this study was to investigate the relationship between self‐perceived olfactory function (SO), taste (ST), and flavor perception (SF) and smell test results in patients with olfactory dysfunction...
Wed Jun 03, 2020 21:43
Publication date: Available online 4 June 2020Source: Journal of Cranio-Maxillofacial SurgeryAuthor(s): Omar Breik, Anand Kumar, James Birchall, Sean Mortimore, David Laugharne, Keith Jones
Thu Jun 04, 2020 13:47
Publication date: Available online 4 June 2020Source: Journal of Cranio-Maxillofacial SurgeryAuthor(s): Chang Ryul Yi, Tea Min Oh, Woo Shik Jeong, Jong-Woo Choi, Tae Suk Oh
Thu Jun 04, 2020 13:47
Publication date: Available online 3 June 2020Source: Journal of Cranio-Maxillofacial SurgeryAuthor(s): Florian Peters, Andreas Kroh, Ulf P. Neumann, Florian T. Ulmer, Stephan Chr. Möhlhenrich, Anna Bock, Frank Hölzle, Ali Modabber
Thu Jun 04, 2020 13:47
Related ArticlesThe nonsurgical management of early stage (T1/2 N0 M0) laryngeal cancer: A population analysis. Oral Surg Oral Med Oral Pathol Oral Radiol. 2020 May 30;: Authors: Lee KC, Chuang SK Abstract BACKGROUND: The purpose of this study was to evaluate the patterns of care and survival in the nonsurgical management of early-stage (T1/2 N0 M0) laryngeal cancer. STUDY DESIGN: This was a retrospective cohort study using data from the...
Thu Jun 04, 2020 13:43
Related ArticlesFacial dog bites treated at the Massachusetts General Hospital over a 20-year period. Oral Surg Oral Med Oral Pathol Oral Radiol. 2020 May 30;: Authors: Zhu N, Cruz Walma A, Troulis MJ, August M Abstract OBJECTIVE: The aim of this study was to identify risk factors associated with facial dog bites and discuss prevention strategies. STUDY DESIGN: This is a retrospective analysis of facial dog bites treated at the Massachusetts...
Thu Jun 04, 2020 13:43
Related ArticlesSpontaneous, Intrasphenoidal Rupture of Ecchordosis Physaliphora with Pneumocephalus Captured During Serial Imaging and Clinical Follow-up: Pathoanatomic Features and Management. World Neurosurg. 2020 May 31;: Authors: Derakhshani A, Livingston S, William C, Lieberman S, Young M, Pacione D, Dehkharghani S Abstract BACKGROUND: Ecchordosis physaliphora (EP) is a congenital, uniformly asymptomatic, hamartomatous lesion of the primitive notochord....
Thu Jun 04, 2020 17:34
Related ArticlesChemotherapy associated dural sinus thrombosis presenting as a cerebrospinal fluid leak. BMJ Case Rep. 2020 Jun 01;13(6): Authors: Bujoreanu I, Ferguson M, Saleh H Abstract Despite the well documented increased risk of thrombosis in patients with cancer and during chemotherapy, cerebral venous sinus thrombosis (CVT) remains a rare entity. We present a rare case of cerebrospinal fluid (CSF) rhinorrhoea secondary to a left transverse sinus...
Thu Jun 04, 2020 13:36
Related ArticlesImpression materials: does water affect the performance of alginates? Minerva Stomatol. 2020 Apr;69(2):106-111 Authors: Cervino G Abstract Alginic acid is a polysaccharide widely present in the cellular walls of brown algae. Alginate is widely used as a mold material in dentistry, in the production of prostheses and in the production of positives for small-scale casting. It is also used in the pharmaceutical, cosmetic and food industries...
Thu Jun 04, 2020 13:31
Related ArticlesCorrelations between dental assistance/oral health and clinical intercurrences in an end-stage kidney disease patients: a historical cohort study. Minerva Stomatol. 2020 Apr;69(2):100-105 Authors: Assante SM, Morimoto S, Tedesco TK, Gimenez T, Ramalho KM Abstract BACKGROUND: The aim of this study was to correlate the self-report oral health, oral hygiene and dental assistance with clinic intercurrences with hospitalization in adults in...
Thu Jun 04, 2020 13:31
Related ArticlesSelf-perception and physician's awareness on early detection of tongue cancer: experience of the Oral Medicine Unit of Trieste. Minerva Stomatol. 2020 Apr;69(2):95-99 Authors: Gobbo M, Ottaviani G, Rupel K, Zoi V, Di Lenarda R, Biasotto M, Poropat A Abstract BACKGROUND: The objective of this retrospective study was to characterize the outpatient oral medicine referral pattern for tongue lesions with particular emphasis on cancer. ...
Thu Jun 04, 2020 13:31
Related ArticlesSimplified basic periodontal examination in adolescents before and after a tailored treatment dental program. Minerva Stomatol. 2020 Apr;69(2):72-78 Authors: Miceli M, Cosseddu G, Pasini M, Semeraro S, Lardani L, Giuca MR Abstract BACKGROUND: The aim of this study was to evaluate the effectiveness of a tailored treatment dental program in adolescents in combination with a professional oral hygiene. METHODS: Ninety-three adolescents...
Thu Jun 04, 2020 13:31
According to a report by the Congressional Budget Office, roughly 1% of prescription drugs dispensed under Medicare Part D and Medicaid accounted for about 30% of net drug spending in each program in 2015. The agency found that between 2010 and 2015, net spending on these so-called specialty drugs…
Thu Jun 04, 2020 03:00
To the Editor: Chronic kidney disease of unknown origin is a leading cause of death in adults living in dry, lowland farming regions of Sri Lanka, Nicaragua, El Salvador, and India. The Central Valley of California has a high annual incidence of end-stage renal disease (ESRD) of 545 cases per…
Thu Jun 04, 2020 03:00
Current efforts to fight the Covid-19 pandemic aim to slow viral spread and increase testing, protect health care workers from infection, and obtain ventilators and other equipment to prepare for a surge of critically ill patients. But additional actions are needed to rapidly increase health…
Thu Jun 04, 2020 03:00
In March 2020, as the coronavirus pandemic spread throughout the United States, Americans bought nearly 2 million guns — the second highest monthly total in the decades since such records have been kept. Previous spikes in U.S. firearm sales have followed widely publicized mass shootings and the…
Thu Jun 04, 2020 03:00
Drug prices are lower in Germany than in the United States, despite similarities between the two countries in terms of average household income, reliance on private in addition to public health insurance plans, and cultural preferences for negotiation over regulation. The experience of Germany and…
Thu Jun 04, 2020 03:00
Suicide attempts are often impulsive acts, driven by transient life crises. Most attempts are not fatal, and most people who attempt suicide do not go on to die in a future suicide. Whether a suicide attempt is fatal depends heavily on the lethality of the method used, and firearms are extremely…
Thu Jun 04, 2020 03:00
We understand that some people are citing our Perspective article (published on April 1 at NEJM.org) as support for discrediting widespread masking. In truth, the intent of our article was to push for more masking, not less. It is apparent that many people with SARS-CoV-2 infection are asymptomatic…
Wed Jun 03, 2020 03:00
In March 2020, when many U.S. states and localities issued their first emergency orders to address Covid-19, there was widespread acceptance of the government’s legal authority to respond quickly and aggressively to this unprecedented crisis. Today, that acceptance is fraying. As initial orders…
Wed Jun 03, 2020 03:00
Related ArticlesThe Role of Radiotherapy for Patients With Thyroid Cancer in the Modern Era. Anticancer Res. 2020 Jun;40(6):3379-3386 Authors: Samhouri L, Kriz J, Elsayad K, Channaoui M, Pascher A, Riemann B, Wiewrodt R, Haverkamp U, Scobioala S, Eich HT Abstract BACKGROUND/AIM: Thyroid cancer (TC) is a relatively rare malignancy. The mainstay treatment is surgery followed by radioactive iodine (RAI) and medical systemic treatments. The role of external...
Thu Jun 04, 2020 13:30
Related ArticlesPrognostic Implications of CD10 and CD15 Expression in Papillary Thyroid Carcinoma. Cancers (Basel). 2020 May 30;12(6): Authors: Oh EJ, Bychkov A, Cho H, Kim TM, Bae JS, Lim DJ, Jung CK Abstract Patients with papillary thyroid carcinoma (PTC) have excellent survival, but recurrence remains a major problem in the management of PTC. We aimed to determine the prognostic impact of the expression of CD10 and CD15 in patients with PTC....
Thu Jun 04, 2020 13:30
Related ArticlesStatPearls Book. 2020 01 Authors: Abstract Radioactive iodine (iodine-131) therapy is indicated for the management of hyperfunctioning thyroid disease and thyroid cancer.[1][2] It is classified as radioactive nuclear medicine and was first synthesized in 1941, and the FDA approved it in 1971 for its therapeutic use. Its action causes permanent destruction to the thyroid tissue by emitting radiation of two sorts, gamma and beta rays.[3][4] Gamma radiation...
Thu Jun 04, 2020 17:26
Related ArticlesInosine 5'-diphosphate, a molecular decoy rescues Nucleoside diphosphate kinase from c-MYC G-Quadruplex unfolding. Biochim Biophys Acta Gen Subj. 2020 May 31;:129649 Authors: Sengupta P, Chatterjee S Abstract BACKGROUND: The transcription-inhibitory G-Quadruplex(Pu27-GQ) atc-MYCpromoter is challenging to target due to structural heterogeneity. Nucleoside diphosphate kinase (NM23-H2) specifically binds and unfolds Pu27-GQ to increasec-MYC...
Thu Jun 04, 2020 15:27
Related ArticlesSuppressed microRNA-195-5p expression in mycosis fungoides promotes tumor cell proliferation. Exp Dermatol. 2020 Jun 03;: Authors: Rittig AH, Johansen C, Celis P, Odum N, Litman T, Woetmann A, Lindahl LM, Iversen L Abstract BACKGROUND: Several cancers, including mycosis fungoides (MF), have reported dysregulation of miR-195-5p. miR-195-5p plays a role in cell cycle regulation in several malignant diseases. OBJECTIVES: This...
Thu Jun 04, 2020 15:27
Related ArticlesThe Power of Phytochemicals Combination in Cancer Chemoprevention. J Cancer. 2020;11(15):4521-4533 Authors: Rizeq B, Gupta I, Ilesanmi J, AlSafran M, Rahman MM, Ouhtit A Abstract Conventional therapies for cancer treatment have posed many challenges, including toxicity, multidrug resistance and economic expenses. In contrast, complementary alternative medicine (CAM), employing phytochemicals have recently received increased attention...
Thu Jun 04, 2020 13:29
Related ArticlesCytoplasm-localized SIRT1 downregulation attenuates apoptosis and cell cycle arrest in cisplatin-resistant lung cancer A549 cells. J Cancer. 2020;11(15):4495-4509 Authors: Yu H, Kim YM, Cho M Abstract Objective: We propose that sirtuin (SIRT) may induce a pro-apoptotic effect by deacetylating transcription factors in A549 cells: depletion of sirtuin-1 (SIRT1) induced cell cycle arrest in cisplatin-resistant A549 (A549/CADD) cells....
Thu Jun 04, 2020 13:29
Related ArticlesTrisenox Disrupts MDM2-DAXX-HAUSP Complex and Induces Apoptosis in a Mouse Model of Acute Leukemia. J Cancer. 2020;11(15):4373-4383 Authors: Kumar S, Tchounwou PB Abstract Trisenox (TX) is successfully used for both de novo and relapsed acute promyelocytic leukemia (APL) treatment. Although TX toxicity to APL cells is mediated by oxidative stress, DNA damage, cell cycle arrest, and apoptosis, its mode of action in the transgenic mice...
Thu Jun 04, 2020 13:29
Related ArticlesGarcinol Alone and in Combination With Cisplatin Affect Cellular Behavior and PI3K/AKT Protein Phosphorylation in Human Ovarian Cancer Cells. Dose Response. 2020 Apr-Jun;18(2):1559325820926732 Authors: Zhang J, Fang H, Zhang J, Guan W, Xu G Abstract Garcinol is a plant-derived compound that has some physiological benefits to human cells. However, the effect of garcinol on ovarian cancer (OC) cell proliferation and apoptosis is unknown....
Thu Jun 04, 2020 13:29
Related ArticlesAscofuranone suppresses invasion and F-actin cytoskeleton organization in cancer cells by inhibiting the mTOR complex 1 signaling pathway. Cell Oncol (Dordr). 2020 Jun 02;: Authors: Jeong YJ, Hwang SK, Magae J, Chang YC Abstract PURPOSE: Ascofuranone is an antiviral antibiotic that is known to exert multiple anti-tumor effects, including cell cycle arrest, inhibition of mitochondrial respiration, and inhibition of angiogenesis. In...
Thu Jun 04, 2020 13:29
Related ArticlesCell Cycle Dysregulation Is Associated With 5-Fluorouracil Resistance in Gastric Cancer Cells. Anticancer Res. 2020 Jun;40(6):3247-3254 Authors: Kim DS, Min K, Lee SK Abstract BACKGROUND/AIM: 5-Fluorouracil (5-FU) is an anticancer drug commonly used to treat gastric cancer; however, continuous 5-FU chemotherapy causes drug resistance. MATERIALS AND METHODS: We established five sublines of 5-FU-resistant AGS gastric cancer...
Thu Jun 04, 2020 13:29
Related ArticlesNCAPH Is Required for Proliferation, Migration and Invasion of Non-small-cell Lung Cancer Cells. Anticancer Res. 2020 Jun;40(6):3239-3246 Authors: Kim B, Kim SW, Lim JY, Park SJ Abstract BACKGROUND/AIM: Non-structural maintenance of chromosomes condensin I complex subunit H (NCAPH) is implicated in correct chromosome condensation and segregation during mitosis. However, the functional role of NCAPH in the pathogenesis of non-small-cell...
Thu Jun 04, 2020 13:29
Related ArticlesTannic Acid Inhibits Non-small Cell Lung Cancer (NSCLC) Stemness by Inducing G0/G1 Cell Cycle Arrest and Intrinsic Apoptosis. Anticancer Res. 2020 Jun;40(6):3209-3220 Authors: Sp N, Kang DY, Kim DH, Yoo JS, Jo ES, Rugamba A, Jang KJ, Yang YM Abstract BACKGROUND/AIM: Non-small cell lung cancer (NSCLC) is one among the most common cancers worldwide. Recently, dietary phytochemicals have been reported as an attractive approach to improve...
Thu Jun 04, 2020 13:29
Related ArticlesUrine cell cycle arrest biomarkers distinguish poorly between transient and persistent AKI in early septic shock: a prospective, multicenter study. Crit Care. 2020 Jun 01;24(1):280 Authors: Titeca-Beauport D, Daubin D, Van Vong L, Belliard G, Bruel C, Alaya S, Chaoui K, Andrieu M, Rouquette-Vincenti I, Godde F, Pascal M, Diouf M, Vinsonneau C, Klouche K, Maizel J Abstract BACKGROUND: The urine biomarkers tissue inhibitor of metalloproteinases-2...
Thu Jun 04, 2020 13:29
Related ArticlesBioactive C17 and C18 Acetylenic Oxylipins from Terrestrial Plants as Potential Lead Compounds for Anticancer Drug Development. Molecules. 2020 May 31;25(11): Authors: Christensen LP Abstract Bioactive C17 and C18 acetylenic oxylipins have shown to contribute to the cytotoxic, anti-inflammatory, and potential anticancer properties of terrestrial plants. These acetylenic oxylipins are widely distributed in plants belonging to the families...
Thu Jun 04, 2020 13:29
Related ArticlesThe Cytotoxicity and Genotoxicity of Three Dental Universal Adhesives-An In Vitro Study. Int J Mol Sci. 2020 May 31;21(11): Authors: Wawrzynkiewicz A, Rozpedek-Kaminska W, Galita G, Lukomska-Szymanska M, Lapinska B, Sokolowski J, Majsterek I Abstract Dental universal adhesives are considered an useful tool in modern dentistry as they can be used in different etching techniques, allow for simplified protocol and provide sufficient...
Thu Jun 04, 2020 13:29
Related Articles1-Hydroxyanthraquinones Containing Aryl Substituents as Potent and Selective Anticancer Agents. Molecules. 2020 May 29;25(11): Authors: Sirazhetdinova NS, Savelyev VA, Frolova TS, Baev DS, Klimenko LS, Chernikov IV, Oleshko OS, Sarojan TA, Pokrovskii AG, Shults EE Abstract A series of 1,2-, 1,4-disubstituted or 1,2,4-trisubstituted anthraquinone-based compounds was designed, synthesized, characterized and biologically evaluated for...
Thu Jun 04, 2020 13:29
Related ArticlesLong noncoding RNA LCAT1 functions as a ceRNA to regulate RAC1 function by sponging miR-4715-5p in lung cancer. Mol Cancer. 2019 11 29;18(1):171 Authors: Yang J, Qiu Q, Qian X, Yi J, Jiao Y, Yu M, Li X, Li J, Mi C, Zhang J, Lu B, Chen E, Liu P, Lu Y Abstract INTRODUCTION: Long noncoding RNAs (lncRNAs) are emerging as key players in the development and progression of cancer. However, the biological role and clinical significance of most...
Thu Jun 04, 2020 13:29
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