IJMS, Vol. 21, Pages 4034: A Biological and Immunological Characterization of Schistosoma Japonicum Heat Shock Proteins 40 and 90α International Journal of Molecular Sciences doi: 10.3390/ijms21114034 Authors: Zhipeng Xu Minjun Ji Chen Li Xiaofeng Du Wei Hu Donald Peter McManus Hong You We characterized Schistosoma japonicum HSP40 (Sjp40) and HSP90α (Sjp90α) in this study. Western blot analysis revealed both are present in soluble egg antigens and...
Thu Jun 04, 2020 03:00
IJMS, Vol. 21, Pages 4030: Manipulation of Metabolic Pathways and Its Consequences for Anti-Tumor Immunity: A Clinical Perspective International Journal of Molecular Sciences doi: 10.3390/ijms21114030 Authors: Yang Wu Powell Lu In the relatively short history of anti-tumor treatment, numerous medications have been developed against a variety of targets. Intriguingly, although many anti-tumor strategies have failed in their clinical trials, metformin, an anti-diabetic medication,...
Thu Jun 04, 2020 03:00
IJMS, Vol. 21, Pages 4029: Repeated Freezing Procedures Preserve Structural and Functional Properties of Amniotic Membrane for Application in Ophthalmology International Journal of Molecular Sciences doi: 10.3390/ijms21114029 Authors: Olena Pogozhykh Nicola Hofmann Oleksandr Gryshkov Constantin von von Kaisenberg Marc Mueller Birgit Glasmacher Denys Pogozhykh Martin Börgel Rainer Blasczyk Constança Figueiredo For decades, the unique regenerative properties...
Thu Jun 04, 2020 03:00
IJMS, Vol. 21, Pages 4031: Tooth Formation: Are the Hardest Tissues of Human Body Hard to Regenerate? International Journal of Molecular Sciences doi: 10.3390/ijms21114031 Authors: Juliana Baranova Dominik Büchner Werner Götz Margit Schulze Edda Tobiasch With increasing life expectancy, demands for dental tissue and whole-tooth regeneration are becoming more significant. Despite great progress in medicine, including regenerative therapies, the complex structure of dental...
Thu Jun 04, 2020 03:00
IJMS, Vol. 21, Pages 4027: Heterologous Expression of Nitrate Assimilation Related-Protein DsNAR2.1/NRT3.1 Affects Uptake of Nitrate and Ammonium in Nitrogen-Starved Arabidopsis International Journal of Molecular Sciences doi: 10.3390/ijms21114027 Authors: Hongping Ma Junchao Zhao Shuang Feng Kun Qiao Shufang Gong Jingang Wang Aimin Zhou Nitrogen (N) is an essential macronutrient for plant growth. Plants absorb and utilize N mainly in the form of nitrate (NO3−)...
Thu Jun 04, 2020 03:00
IJMS, Vol. 21, Pages 4028: Regulation of Deubiquitinating Enzymes by Post-Translational Modifications International Journal of Molecular Sciences doi: 10.3390/ijms21114028 Authors: Tanuza Das Sang Chul Shin Eun Joo Song Eunice EunKyeong Kim Ubiquitination and deubiquitination play a critical role in all aspects of cellular processes, and the enzymes involved are tightly regulated by multiple factors including posttranslational modifications like most other proteins. Dysfunction...
Thu Jun 04, 2020 03:00
IJMS, Vol. 21, Pages 4026: Chronic Sulforaphane Administration Inhibits Resistance to the mTOR-Inhibitor Everolimus in Bladder Cancer Cells International Journal of Molecular Sciences doi: 10.3390/ijms21114026 Authors: Saira Justin Jochen Rutz Sebastian Maxeiner Felix K.-H. Chun Eva Juengel Roman A. Blaheta Progressive bladder cancer growth is associated with abnormal activation of the mammalian target of the rapamycin (mTOR) pathway, but treatment with an mTOR inhibitor...
Thu Jun 04, 2020 03:00
IJMS, Vol. 21, Pages 4024: The Effect of Sodium Bicarbonate, a Beneficial Adjuvant Molecule in Cystic Fibrosis, on Bronchial Epithelial Cells Expressing a Wild-Type or Mutant CFTR Channel International Journal of Molecular Sciences doi: 10.3390/ijms21114024 Authors: Ilona Gróf Alexandra Bocsik András Harazin Ana Raquel Santa-Maria Gaszton Vizsnyiczai Lilla Barna Lóránd Kiss Gabriella Fűr Zoltán Rakonczay, Jr. Rita Ambrus Piroska Szabó-Révész Fabien Gosselet...
Thu Jun 04, 2020 03:00
IJMS, Vol. 21, Pages 4018: The Emerging Role of Innate Immunity in Chronic Kidney Diseases International Journal of Molecular Sciences doi: 10.3390/ijms21114018 Authors: Philip Chiu-Tsun Tang Ying-Ying Zhang Max Kam-Kwan Chan Winson Wing-Yin Lam Jeff Yat-Fai Chung Wei Kang Ka-Fai To Hui-Yao Lan Patrick Ming-Kuen Tang Renal fibrosis is a common fate of chronic kidney diseases. Emerging studies suggest that unsolved inflammation will progressively transit into tissue...
Thu Jun 04, 2020 03:00
IJMS, Vol. 21, Pages 4017: Concordance between Thioacetamide-Induced Liver Injury in Rat and Human In Vitro Gene Expression Data International Journal of Molecular Sciences doi: 10.3390/ijms21114017 Authors: Patric Schyman Richard L. Printz Shanea K. Estes Tracy P. O’Brien Masakazu Shiota Anders Wallqvist The immense resources required and the ethical concerns for animal-based toxicological studies have driven the development of in vitro and in silico approaches. Recently,...
Thu Jun 04, 2020 03:00
IJMS, Vol. 21, Pages 4025: Bacterial Actin-Specific Endoproteases Grimelysin and Protealysin as Virulence Factors Contributing to the Invasive Activities of Serratia International Journal of Molecular Sciences doi: 10.3390/ijms21114025 Authors: Sofia Khaitlina Ekaterina Bozhokina Olga Tsaplina Tatiana Efremova The article reviews the discovery, properties and functional activities of new bacterial enzymes, proteases grimelysin (ECP 32) of Serratia grimesii and protealysin of...
Thu Jun 04, 2020 03:00
IJMS, Vol. 21, Pages 4022: Novel Comprehensive Bioinformatics Approaches to Determine the Molecular Genetic Susceptibility Profile of Moderate and Severe Asthma International Journal of Molecular Sciences doi: 10.3390/ijms21114022 Authors: Hatem Zayed Background: Asthma is a chronic inflammatory condition linked to hyperresponsiveness in the airways. There is currently no cure available for asthma, and therapy choices are limited. Asthma is the result of the interplay between genes and...
Thu Jun 04, 2020 03:00
IJMS, Vol. 21, Pages 4021: Cell-Clearing Systems Bridging Repeat Expansion Proteotoxicity and Neuromuscular Junction Alterations in ALS and SBMA International Journal of Molecular Sciences doi: 10.3390/ijms21114021 Authors: Fiona Limanaqi Carla Letizia Busceti Francesca Biagioni Federica Cantini Paola Lenzi Francesco Fornai The coordinated activities of autophagy and the ubiquitin proteasome system (UPS) are key to preventing the aggregation and toxicity of misfold-prone...
Thu Jun 04, 2020 03:00
IJMS, Vol. 21, Pages 4023: OsCpn60β1 is Essential for Chloroplast Development in Rice (Oryza sativa L.) International Journal of Molecular Sciences doi: 10.3390/ijms21114023 Authors: Qingfei Wu Cheng Zhang Yue Chen Kaiyue Zhou Yihua Zhan Dean Jiang The chaperonin 60 (Cpn60) protein is of great importance to plants due to its involvement in modulating the folding of numerous chloroplast protein polypeptides. In chloroplasts, Cpn60 is differentiated into two subunit types—Cpn60α...
Thu Jun 04, 2020 03:00
IJMS, Vol. 21, Pages 4019: Recent Advances in Electrospun Sustainable Composites for Biomedical, Environmental, Energy, and Packaging Applications International Journal of Molecular Sciences doi: 10.3390/ijms21114019 Authors: Hao Liu Christopher R. Gough Qianqian Deng Zhenggui Gu Fang Wang Xiao Hu Electrospinning has gained constant enthusiasm and wide interest as a novel sustainable material processing technique due to its ease of operation and wide adaptability for fabricating...
Thu Jun 04, 2020 03:00
IJMS, Vol. 21, Pages 4016: The Effect of TBB, as an Initiator, on the Biological Compatibility of PMMA/MMA Bone Cement International Journal of Molecular Sciences doi: 10.3390/ijms21114016 Authors: Kosuke Hamajima Ryotaro Ozawa Juri Saruta Makiko Saita Hiroaki Kitajima Samira Rahim Taleghani Dan Usami Donya Goharian Mitsunori Uno Ken Miyazawa Shigemi Goto Keiichi Tsukinoki Takahiro Ogawa Acrylic bone cement is widely used in orthopedic surgery for...
Thu Jun 04, 2020 03:00
IJMS, Vol. 21, Pages 4020: Non-Coding RNA: Role in Gestational Diabetes Pathophysiology and Complications International Journal of Molecular Sciences doi: 10.3390/ijms21114020 Authors: Tiziana Filardi Giuseppina Catanzaro Stefania Mardente Alessandra Zicari Carmela Santangelo Andrea Lenzi Susanna Morano Elisabetta Ferretti Gestational Diabetes Mellitus (GDM) is defined as glucose intolerance that develops in the second or third trimester of pregnancy. GDM can lead...
Thu Jun 04, 2020 03:00
IJMS, Vol. 21, Pages 4014: Ionising Radiation Induces Promoter DNA Hypomethylation and Perturbs Transcriptional Activity of Genes Involved in Morphogenesis during Gastrulation in Zebrafish International Journal of Molecular Sciences doi: 10.3390/ijms21114014 Authors: Sophia Murat El Houdigui Christelle Adam-Guillermin Olivier Armant Embryonic development is particularly vulnerable to stress and DNA damage, as mutations can accumulate through cell proliferation in a wide number...
Thu Jun 04, 2020 03:00
IJMS, Vol. 21, Pages 4015: Anti-Citrullinated Protein Antibodies in Patients with Rheumatoid Arthritis: Biological Effects and Mechanisms of Immunopathogenesis International Journal of Molecular Sciences doi: 10.3390/ijms21114015 Authors: Chao-Yi Wu Huang-Yu Yang Jenn-Haung Lai Individuals with high anti-citrullinated protein antibody (ACPA) titers have an increased risk of developing rheumatoid arthritis (RA). Although our knowledge of the generation and production of ACPAs has...
Thu Jun 04, 2020 03:00
IJMS, Vol. 21, Pages 4013: Haemophilus influenzae HP1 Bacteriophage Encodes a Lytic Cassette with a Pinholin and a Signal-Arrest-Release Endolysin International Journal of Molecular Sciences doi: 10.3390/ijms21114013 Authors: Monika Adamczyk-Popławska Zuzanna Tracz-Gaszewska Przemysław Lasota Agnieszka Kwiatek Andrzej Piekarowicz HP1 is a temperate bacteriophage, belonging to the Myoviridae family and infecting Haemophilus influenzae Rd. By in silico analysis and molecular...
Thu Jun 04, 2020 03:00
IJMS, Vol. 21, Pages 4012: Gastric Cancer: Epidemiology, Risk Factors, Classification, Genomic Characteristics and Treatment Strategies International Journal of Molecular Sciences doi: 10.3390/ijms21114012 Authors: Julita Machlowska Jacek Baj Monika Sitarz Ryszard Maciejewski Robert Sitarz Gastric cancer (GC) is one of the most common malignancies worldwide and it is the fourth leading cause of cancer-related death. GC is a multifactorial disease, where both environmental...
Thu Jun 04, 2020 03:00
JCM, Vol. 9, Pages 1745: Prognostic Value of Early Intermittent Electroencephalography in Patients after Extracorporeal Cardiopulmonary Resuscitation Journal of Clinical Medicine doi: 10.3390/jcm9061745 Authors: Yong Oh Kim Ryoung-Eun Ko Chi Ryang Chung Jeong Hoon Yang Taek Kyu Park Yang Hyun Cho Kiick Sung Gee Young Suh Jeong-Am Ryu The aim of this study was to investigate whether early intermittent electroencephalography (EEG) could be used to predict neurological...
Thu Jun 04, 2020 03:00
JCM, Vol. 9, Pages 1743: The Influence of Various Smoking Categories on The Risk of Gestational Hypertension and Pre-Eclampsia Journal of Clinical Medicine doi: 10.3390/jcm9061743 Authors: Małgorzata Lewandowska Barbara Więckowska The relationship between smoking and the risk of pregnancy-induced hypertension (PIH) is not clearly established. Therefore, we conducted an analysis of cigarette smoking in a Polish cohort of women, recruited in the first trimester of a single pregnancy...
Thu Jun 04, 2020 03:00
JCM, Vol. 9, Pages 1742: Pre-Operative Combination of Normal BMI with Elevated YKL-40 and Leptin but Lower Adiponectin Level Is Linked to a Higher Risk of Breast Cancer Relapse: A Report of Four-Year Follow-Up Study Journal of Clinical Medicine doi: 10.3390/jcm9061742 Authors: Kornel Bielawski Piotr Rhone Marek Bulsa Barbara Ruszkowska-Ciastek Adipokines are powerful agents involved in the development of obesity-dependent cancers. This prospective study aimed to investigate...
Thu Jun 04, 2020 03:00
JCM, Vol. 9, Pages 1744: Gender Differences in the Levels of Periodontal Destruction, Behavioral Risk Factors and Systemic Oxidative Stress in Ischemic Stroke Patients: A Cohort Pilot Study Journal of Clinical Medicine doi: 10.3390/jcm9061744 Authors: Ioana Stănescu Adriana Elena Bulboacă Iulia Cristina Micu Sorana D. Bolboacă Dana Gabriela Feștilă Angelo C. Bulboacă Gyorgy Bodizs Gabriela Dogaru Paul Mihai Boarescu Aurel Popa-Wagner Alexandra Roman Background:...
Thu Jun 04, 2020 03:00
JCM, Vol. 9, Pages 1741: Implications of Hereditary Origin on the Immune Phenotype of Mismatch Repair-Deficient Cancers: Systematic Literature Review Journal of Clinical Medicine doi: 10.3390/jcm9061741 Authors: Lena Bohaumilitzky Magnus von Knebel Doeberitz Matthias Kloor Aysel Ahadova Microsatellite instability (MSI) represents one of the major types of genomic instability in human cancers and is most common in colorectal cancer (CRC) and endometrial cancer (EC). MSI develops...
Thu Jun 04, 2020 03:00
JCM, Vol. 9, Pages 1739: Long-Term Changes in Sleep Disordered Breathing in Renal Transplant Patients: Relevance of the BMI Journal of Clinical Medicine doi: 10.3390/jcm9061739 Authors: Francesca Mallamaci Rocco Tripepi Graziella D’Arrigo Gaetana Porto Maria Carmela Versace Carmela Marino Maria Cristina Sanguedolce Giovanni Tripepi Carmine Zoccali Sleep disordered breathing (SDB), as defined by the Apnea Hypopnea Index (AHI), is a highly prevalent disturbance...
Thu Jun 04, 2020 03:00
JCM, Vol. 9, Pages 1737: Erythropoietin, Fibroblast Growth Factor 23, and Death After Kidney Transplantation Journal of Clinical Medicine doi: 10.3390/jcm9061737 Authors: Michele F. Eisenga Maarten A. De Jong David E. Leaf Ilja M. Nolte Martin H. De Borst Stephan J.L. Bakker Carlo A.J.M. Gaillard Elevated levels of erythropoietin (EPO) are associated with an increased risk of death in renal transplant recipients (RTRs), but the underlying mechanisms remain unclear....
Thu Jun 04, 2020 03:00
JCM, Vol. 9, Pages 1738: Circulating Tumor DNA as a Preoperative Marker of Recurrence in Patients with Peritoneal Metastases of Colorectal Cancer: A Clinical Feasibility Study Journal of Clinical Medicine doi: 10.3390/jcm9061738 Authors: Jamie J. Beagan Nina R. Sluiter Sander Bach Paul P. Eijk Stijn L. Vlek Daniëlle A. M. Heideman Miranda Kusters D. Michiel Pegtel Geert Kazemier Nicole C. T. van Grieken Bauke Ylstra Jurriaan B. Tuynman Cytoreductive Surgery...
Thu Jun 04, 2020 03:00
JCM, Vol. 9, Pages 1740: Outcome in Patients with Partial and Full-Thickness Cheek Defects following Free Flap Reconstruction—A Multicentric Analysis of 47 Cases Journal of Clinical Medicine doi: 10.3390/jcm9061740 Authors: Stefan Janik Rachelle Eljazzar Muhammad Faisal Stefan Grasl Erich Vyskocil Brett A. Miles Markus Brunner Rudolf Seemann Boban M. Erovic The objective of this study was to evaluate whether the extent of tumor resection and free flap reconstruction...
Thu Jun 04, 2020 03:00
JCM, Vol. 9, Pages 1735: Middle Cerebral Artery Doppler Velocimetry for the Diagnosis of Twin Anemia Polycythemia Sequence: A Systematic Review Journal of Clinical Medicine doi: 10.3390/jcm9061735 Authors: Clifton O. Brock Eric P. Bergh Kenneth J. Moise Anthony Johnson Edgar Hernandez-Andrade Dejian Lai Ramesha Papanna Twin anemia polycythemia sequence (TAPS) is a rare complication of monochorionic diamniotic (MCDA) twins. Middle cerebral artery peak systolic velocity...
Thu Jun 04, 2020 03:00
JCM, Vol. 9, Pages 1734: A Morphometric Analysis of Platelet Dense Granules of Patients with Unexplained Bleeding: A New Entity of Delta-Microgranular Storage Pool Deficiency Journal of Clinical Medicine doi: 10.3390/jcm9061734 Authors: William T. Gunning Meera Raghavan Edward P. Calomeni James N. Turner Bodri Roysam Shantala Roysam Mary R. Smith Peter A. Kouides Neil A. Lachant One thousand and eighty patients, having prolonged bleeding times, frequent epistaxis,...
Thu Jun 04, 2020 03:00
JCM, Vol. 9, Pages 1736: Body-Related Attentional Bias among Men with High and Low Muscularity Dissatisfaction Journal of Clinical Medicine doi: 10.3390/jcm9061736 Authors: Bruno Porras-Garcia Erik Exposito-Sanz Marta Ferrer-Garcia Oscar Castillero-Mimenza José Gutiérrez-Maldonado Previous studies have found gender differences in body-related attentional bias (AB), with women showing AB towards weight-related body parts. However, few studies have assessed the relationship...
Thu Jun 04, 2020 03:00
JFMK, Vol. 5, Pages 36: Craniomandibular Disorders in Pregnant Women: An Epidemiological Survey Journal of Functional Morphology and Kinesiology doi: 10.3390/jfmk5020036 Authors: Grazia Fichera Alessandro Polizzi Simone Scapellato Giuseppe Palazzo Francesco Indelicato Temporomandibular joint (TMJ) disorder has been reported to be 1.5 to two times more common in women than men. Such a gender-based difference could be attributed to behavioral, hormonal, anatomical, and psychological...
Thu Jun 04, 2020 03:00
JoF, Vol. 6, Pages 78: Saccharomyces boulardii: What Makes It Tick as Successful Probiotic? Journal of Fungi doi: 10.3390/jof6020078 Authors: Pedro Pais Vanda Almeida Melike Yılmaz Miguel C. Teixeira Saccharomyces boulardii is a probiotic yeast often used for the treatment of GI tract disorders such as diarrhea symptoms. It is genetically close to the model yeast Saccharomyces cerevisiae and its classification as a distinct species or a S. cerevisiae variant has long been discussed....
Thu Jun 04, 2020 03:00
J. Imaging, Vol. 6, Pages 42: Origins of Hyperbolicity in Color Perception Journal of Imaging doi: 10.3390/jimaging6060042 Authors: Nicoletta Prencipe Valérie Garcin Edoardo Provenzi In 1962, H. Yilmaz published a very original paper in which he showed the striking analogy between Lorentz transformations and the effect of illuminant changes on color perception. As a consequence, he argued that a perceived color space endowed with the Minkowski metric is a good approximation to...
Thu Jun 04, 2020 03:00
Medicina, Vol. 56, Pages 277: Acute Disseminated Encephalomyelitis with Seizures and Myocarditis: A Fatal Triad Medicina doi: 10.3390/medicina56060277 Authors: Lademann Bertsche Petzold Zack Büttner Däbritz Hauenstein Bahn Spang Reuter Warnke Ehler Autoimmune pathology of acute disseminated encephalomyelitis (ADEM) is generally restricted to the brain. Our objective is to expand the phenotype of ADEM. A four-year-old girl was admitted to the...
Thu Jun 04, 2020 03:00
Medicina, Vol. 56, Pages 276: Combination of a Self-Regulation Module and Mobile Application to Enhance Treatment Outcome for Patients with Acne Medicina doi: 10.3390/medicina56060276 Authors: Liu Lu Shieh Sun Background and Objectives: Acne, an inflammatory disorder of the pilosebaceous unit associated with both physiological and psychological morbidities, should be considered a chronic disease. The application of self-regulation theory and therapeutic patient education...
Thu Jun 04, 2020 03:00
Medicina, Vol. 56, Pages 275: A Six-Year Analysis of Biological Therapy for Severe Psoriasis in a Lithuanian Reference Centre of Dermatovenereology Medicina doi: 10.3390/medicina56060275 Authors: Raudonis Gliebute Grigaityte Lukosiunaite Karmaziene Grigaitiene Background and Objectives: Biological therapy is widely used for the treatment of severe psoriasis. The objective of this study was to evaluate the efficacy and safety of biological therapy for patients with...
Thu Jun 04, 2020 03:00
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