Πέμπτη 4 Ιουνίου 2020


Coronavirus Disease 2019 (COVID-19) Pandemic and Lacrimal Practice: Diagnostic and Therapeutic Nasal Endoscopy and Dacryoendoscopy
No abstract available
Ophthalmic Plastic & Reconstructive Surgery - Published Ahead-of-Print
Wed Jun 03, 2020 03:00
Conjunctival Lymphoma With Nasal Spread Through the Nasolacrimal Duct
Conjunctival mucosa-associated lymphoid tissue lymphoma classically presents as a subconjunctival mass, most often in the fornix. The presence of conjunctival mucosa-associated lymphoid tissue lymphoma with spread down the nasolacrimal duct has only been reported once previously. The authors present a case of a 35-year-old woman with a right conjunctival mass in the inferior fornix along with sinus congestion and fullness. A biopsy of the conjunctival mass and the nasal turbinate revealed a conjunctival...
Ophthalmic Plastic & Reconstructive Surgery - Published Ahead-of-Print
Wed Jun 03, 2020 03:00
Clinical characteristics of subglottic cancer: emphasis on therapeutic management strategies for stage II subglottic cancer.
Related ArticlesClinical characteristics of subglottic cancer: emphasis on therapeutic management strategies for stage II subglottic cancer. Acta Otolaryngol. 2020 Jun 03;:1-6 Authors: Komatsubara Y, Tachibana T, Orita Y, Makino T, Kuroda K, Naoi Y, Kataoka Y, Sato Y, Kariya S, Nishizaki K Abstract Background: Subglottic cancer (SGC) is extremely rare, as most laryngeal cancers are localized to the glottic region. Accordingly, the clinical characteristics...
Rare Cancers
Thu Jun 04, 2020 15:06
Penile cancer with visceral metastasis and p16/human papillomavirus positivity: An unusual case of long-term survival.
Related ArticlesPenile cancer with visceral metastasis and p16/human papillomavirus positivity: An unusual case of long-term survival. Urol Case Rep. 2020 Nov;33:101278 Authors: Mehra NS, Ho TP, Herrera Hernandez L, Quevedo JF, Costello BA, Pagliaro LC Abstract Squamous cell carcinoma (SCC) of the penis is a rare cancer in the industrialized countries, including the United States. Risk factors for these cancers include inflammatory conditions as well...
Rare Cancers
Thu Jun 04, 2020 13:57
Thyroid metastasis revealing a lung adenocarcinoma.
Related ArticlesThyroid metastasis revealing a lung adenocarcinoma. Respir Med Case Rep. 2020;30:101065 Authors: Ben Saad A, Mhamed SC, Migaou A, Njima M, Achour A, Fahem N, Rouatbi N, Joobeur S Abstract Thyroid metastasis revealing a primary lung cancer is an extremely rare condition. Only few cases have been reported in the literature. A multidisciplinary approach is essential for the diagnosis. The prognosis is generally poor. We report a case of...
Rare Cancers
Thu Jun 04, 2020 13:57
The dormant cancer cell life cycle.
Related ArticlesThe dormant cancer cell life cycle. Nat Rev Cancer. 2020 Jun 02;: Authors: Phan TG, Croucher PI Abstract The success of targeted therapies and immunotherapies has created optimism that cancers may be curable. However, not all patients respond, drug resistance is common and many patients relapse owing to dormant cancer cells. These rare and elusive cells can disseminate early and hide in specialized niches in distant organs before being...
Rare Cancers
Thu Jun 04, 2020 13:57
A Rare Case of Well-Differentiated Neuroendocrine Tumor Arising From a Jejunal Pancreatic Heterotopia.
Related ArticlesA Rare Case of Well-Differentiated Neuroendocrine Tumor Arising From a Jejunal Pancreatic Heterotopia. Int J Surg Pathol. 2020 Jun 02;:1066896920928126 Authors: Sappenfield RL, Byrnes K Abstract Pancreatic heterotopia is a well-described entity occurring at multiple abdominal sites, most commonly the stomach and small intestine. They can develop similar disease processes as the pancreas ranging from acute pancreatitis, cyst formation,...
Rare Cancers
Thu Jun 04, 2020 13:57
[Mediastinal T lymphoblastic lymphoma/leukemia: clinicopathological and prognostic analyses of 61 cases].
Related Articles[Mediastinal T lymphoblastic lymphoma/leukemia: clinicopathological and prognostic analyses of 61 cases]. Zhonghua Bing Li Xue Za Zhi. 2020 Jun 08;49(6):601-606 Authors: Gao XZ, Wei JG, Li SL, Han J, Wang GN, Li WC Abstract Objective: To investigate the clinicopathologic features and prognosis of mediastinal T lymphoblastic lymphoma/leukemia (T-LBL/ALL). Methods: Sixty-one patients with mediastinal T-LBL/ALL diagnosed at First Affiliated...
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Thu Jun 04, 2020 13:57
[Clinicopathological and molecular features of pulmonary enteric adenocarcinoma].
Related Articles[Clinicopathological and molecular features of pulmonary enteric adenocarcinoma]. Zhonghua Bing Li Xue Za Zhi. 2020 Jun 08;49(6):544-549 Authors: Gao G, Wang YZ, Zhang YP, Feng SE, Hou M, Xia QX Abstract Objective: To investigate the clinicopathological and molecular characteristics of pulmonary enteric adenocarcinoma (PEAC). Methods: The clinical and pathological data of 19 cases of PEAC in the Affiliated Cancer Hospital of Zhengzhou...
Rare Cancers
Thu Jun 04, 2020 13:57
Functional Characterization of POFUT1 Variants Associated with Colorectal Cancer.
Related ArticlesFunctional Characterization of POFUT1 Variants Associated with Colorectal Cancer. Cancers (Basel). 2020 May 31;12(6): Authors: Deschuyter M, Pennarubia F, Pinault E, Legardinier S, Maftah A Abstract BACKGROUND: Protein O-fucosyltransferase 1 (POFUT1) overexpression, which is observed in many cancers such as colorectal cancer (CRC), leads to a NOTCH signaling dysregulation associated with the tumoral process. In rare CRC cases, with no...
Rare Cancers
Thu Jun 04, 2020 13:57
Primary Peritoneal High-grade Serous Carcinoma Misinterpreted as Metastatic Breast Carcinoma: A Rare Encounter in Peritoneal Fluid Cytology.
Related ArticlesPrimary Peritoneal High-grade Serous Carcinoma Misinterpreted as Metastatic Breast Carcinoma: A Rare Encounter in Peritoneal Fluid Cytology. Anticancer Res. 2020 May;40(5):2933-2939 Authors: Park S, Cho EY, Oh YL, Park YH, Kim HS Abstract BACKGROUND/AIM: Peritoneal fluid (PF) cytology is critical for distinguishing high-grade serous carcinoma (HGSC) from metastatic disease in patients with breast carcinoma who present with peritoneal...
Rare Cancers
Thu Jun 04, 2020 13:57
Resection for Internal Jugular Vein Thrombosis and Cervical Lymph Nodes' Involvement from Gastric Cancer.
Related ArticlesResection for Internal Jugular Vein Thrombosis and Cervical Lymph Nodes' Involvement from Gastric Cancer. Anticancer Res. 2020 May;40(5):2889-2893 Authors: Illuminati G, Pasqua R, Nardi P, Fratini C, Minni A, Giordano C Abstract BACKGROUND/AIM: Thrombosis internal jugular vein (IJV) with cervical adenopathy, as first manifestation of gastric cancer is rare. We aimed to compare resection of the cervical mass followed by gastrectomy with...
Rare Cancers
Thu Jun 04, 2020 13:57
Inflammatory Liver Tumor Caused by Fasciola hepatica Mimicking Intrahepatic Cholangiocarcinoma.
Related ArticlesInflammatory Liver Tumor Caused by Fasciola hepatica Mimicking Intrahepatic Cholangiocarcinoma. Anticancer Res. 2020 May;40(5):2795-2800 Authors: Kaida T, Beppu T, Hayashi H, Imai K, Yamamura K, Okabe H, Matsumura K, Yoshii D, Komohara Y, Akahoshi S, Doi K, Yamashita YI, Baba H Abstract Human fascioliasis is a rare parasitic disease outside of countries in which it is endemic. The diagnosis of hepatic-phase fascioliasis by diagnostic...
Rare Cancers
Thu Jun 04, 2020 13:57
Blastic plasmacytoid dendritic cell neoplasm: diagnosis, manifestations, and treatment.
Related ArticlesBlastic plasmacytoid dendritic cell neoplasm: diagnosis, manifestations, and treatment. Curr Opin Hematol. 2020 Mar;27(2):103-107 Authors: Sweet K Abstract PURPOSE OF REVIEW: Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare and aggressive hematologic malignancy with historically poor outcomes. It typically manifests as asymptomatic skin lesions and cytopenias, which result from bone marrow involvement. Less commonly, it...
Rare Cancers
Thu Jun 04, 2020 13:57
Optimal therapeutic strategies for mixed phenotype acute leukemia.
Related ArticlesOptimal therapeutic strategies for mixed phenotype acute leukemia. Curr Opin Hematol. 2020 Mar;27(2):95-102 Authors: Wolach O, Stone RM Abstract PURPOSE OF REVIEW: Mixed phenotype acute leukemia (MPAL) encompasses a rare group of clinically, immunophenotypically, and genetically diverse leukemias. Diagnosing and treating these patients remains challenging. In recent years, systematic efforts have been made to better define the genetic...
Rare Cancers
Thu Jun 04, 2020 13:57
Myeloid sarcoma.
Related ArticlesMyeloid sarcoma. Curr Opin Hematol. 2020 Mar;27(2):88-94 Authors: Shahin OA, Ravandi F Abstract PURPOSE OF REVIEW: Myeloid sarcoma; also known as granulocytic sarcoma and chloroma, often occurs concomitantly with AML, and rarely without bone marrow involvement. In this article, we review the recent literature on myeloid sarcoma, focusing on treatment approach for this rare disease, and addressing the prognostic and therapeutic role of...
Rare Cancers
Thu Jun 04, 2020 13:57
Primary epithelioid rhabdomyosarcoma of the stomach: a case report and review of literature.
Related ArticlesPrimary epithelioid rhabdomyosarcoma of the stomach: a case report and review of literature. Diagn Pathol. 2019 Dec 23;14(1):137 Authors: Wang Y, Guo P, Zhang Z, Jiang R, Li Z Abstract BACKGROUND: Epithelioid rhabdomyosarcoma is a rare tumor that generally occurs in the bladder, the parotid gland, or the skin of the neck. We describe an unusual case of primary epithelioid rhabdomyosarcoma of the stomach and review the literature. ...
Rare Cancers
Thu Jun 04, 2020 13:57
"Slow and Steady" Infiltrates the Brain: An Autopsy Report of Lymphomatosis Cerebri.
Related Articles"Slow and Steady" Infiltrates the Brain: An Autopsy Report of Lymphomatosis Cerebri. Neurol India. 2019 Nov-Dec;67(6):1504-1508 Authors: Gupta K, Gupta V, Radotra BD, Tewari MK Abstract Primary central nervous system lymphomas (PCNSL) usually present as single or multiple lesions with mass effect involving the cerebral hemispheres or basal ganglia. An extremely rare pattern of involvement termed "Lymphomatosis cerebri" (LC) presents...
Rare Cancers
Thu Jun 04, 2020 13:57
Splenic cord capillary hemangioma with non-islet cell tumor hypoglycemia: a case report.
Related ArticlesSplenic cord capillary hemangioma with non-islet cell tumor hypoglycemia: a case report. Diagn Pathol. 2019 Dec 16;14(1):135 Authors: Daimon T, Kosaka T, Horinaga M, Saito J, Ueyama Y, Matsuzaki S, Oya M Abstract BACKGROUND: Splenic cord capillary hemangioma is a rare benign vascular lesion classified as a splenic hamartoma. On the other hand, non-islet cell tumor hypoglycemia (NICTH) is one of the rare causes of spontaneous hypoglycemia...
Rare Cancers
Thu Jun 04, 2020 13:57
Case Report: Case report: A rare case of middle-ear Rhabdomyosarcoma in a 4-year-old boy.
Related ArticlesCase Report: Case report: A rare case of middle-ear Rhabdomyosarcoma in a 4-year-old boy. F1000Res. 2019;8:1734 Authors: Menzies-Wilson R, Wong G, Das P Abstract We present a rare case of a four-year-old boy with a botyroid embryonal rhabdomyosarcoma of the right middle ear. Rhabdomyosarcoma is a soft tissue malignancy which is thought to originate from embryonic mesenchymal cells of striated skeletal muscle.  It is a disease primarily...
Rare Cancers
Thu Jun 04, 2020 13:57
Nasal glomus tumor: A rare nasal tumor with diffuse and strongly positive synaptophysin expression.
Related ArticlesNasal glomus tumor: A rare nasal tumor with diffuse and strongly positive synaptophysin expression. Pathol Int. 2019 Nov;69(11):672-674 Authors: Meguro S, Kusama Y, Matsushima S, Yagi H, Kawasaki H, Kosugi I, Tsuchida T, Baba S, Enomoto Y, Hosokawa S, Iwashita T PMID: 31682049 [PubMed - indexed for MEDLINE]
Rare Cancers
Thu Jun 04, 2020 13:57
Pulmonary melanocytic nevus - A case report with a mutation analysis of common driver oncogenes.
Related ArticlesPulmonary melanocytic nevus - A case report with a mutation analysis of common driver oncogenes. Pathol Int. 2019 Nov;69(11):667-671 Authors: Tanaka M, Matsumura M, Okudela K, Mitsui H, Tateishi Y, Umeda S, Suzuki T, Koike C, Kataoka T, Kawano N, Kojima Y, Osawa H, Ohashi K Abstract Nevi are benign melanocytic tumors, and some nevi are considered to develop into malignant melanomas. Most nevi arise in the skin, but nevi occasionally...
Rare Cancers
Thu Jun 04, 2020 13:57
Multicentric Registry Study on Epidemiological and Biological Disease Profile as Well as Clinical Outcome in Patients with Low-Grade Gliomas: The LoG-Glio Project.
Related ArticlesMulticentric Registry Study on Epidemiological and Biological Disease Profile as Well as Clinical Outcome in Patients with Low-Grade Gliomas: The LoG-Glio Project. J Neurol Surg A Cent Eur Neurosurg. 2020 Jan;81(1):48-57 Authors: Pala A, Nadji-Ohl M, Faust K, Rückriegel S, Roder C, von der Brelie C, Forster MT, Löbel F, Schommer S, Löhr M, Renovanz M, Grübel N, Rothenbacher D, König R, Engelke J, Schmitz B, Wirtz CR, Ringel F, Senft C, Rohde V, Tatagiba...
Rare Cancers
Thu Jun 04, 2020 13:57
Cerebral arterial air emboli after stent insertion in esophageal cancer complicated with esophago-left atrial fistula: An autopsy case and review of the literature.
Related ArticlesCerebral arterial air emboli after stent insertion in esophageal cancer complicated with esophago-left atrial fistula: An autopsy case and review of the literature. Pathol Int. 2019 Nov;69(11):662-666 Authors: Park JK, Goto T, Nagano T, Yoshimura M, Yutani C Abstract Cerebral arterial air embolism is a rare and unexpected complication of advanced esophageal cancer. The entry of air to systemic circulation is an esophago-left atrial or...
Rare Cancers
Thu Jun 04, 2020 13:57
Neuroendocrine carcinoma of the colon: a rare case arising from a serrated polyp.
Related ArticlesNeuroendocrine carcinoma of the colon: a rare case arising from a serrated polyp. Gastrointest Endosc. 2019 12;90(6):984-985 Authors: Hatamori H, Saito S, Ide D, Chino A, Kawachi H PMID: 31301287 [PubMed - indexed for MEDLINE]
Rare Cancers
Thu Jun 04, 2020 13:57
Checkpoint Inhibitor-Associated Autoimmune Diabetes Is Distinct From Type 1 Diabetes.
Related ArticlesCheckpoint Inhibitor-Associated Autoimmune Diabetes Is Distinct From Type 1 Diabetes. J Clin Endocrinol Metab. 2019 11 01;104(11):5499-5506 Authors: Tsang VHM, McGrath RT, Clifton-Bligh RJ, Scolyer RA, Jakrot V, Guminski AD, Long GV, Menzies AM Abstract CONTEXT: Checkpoint inhibitor-associated autoimmune diabetes mellitus (CIADM) is a rare illness, and little is known about its incidence, clinical features, or pathogenesis. ...
Rare Cancers
Thu Jun 04, 2020 13:57
Liquid biopsy in the era of immuno-oncology: is it ready for prime-time use for cancer patients?
Related ArticlesLiquid biopsy in the era of immuno-oncology: is it ready for prime-time use for cancer patients? Ann Oncol. 2019 09 01;30(9):1448-1459 Authors: Hofman P, Heeke S, Alix-Panabières C, Pantel K Abstract The emergence of immunotherapy in oncology requires the discovery, validation and subsequent adoption of robust, sensitive and specific predictive and prognostic biomarkers for daily practice. Until now, anti-PD-L1 immunohistochemistry (IHC)...
Rare Cancers
Thu Jun 04, 2020 13:57
N-Methyl-D-Aspartate Receptor Encephalitis with Psychiatric Symptoms and an Ovarian Teratoma Detected by MRI in a 17-Year-Old Girl.
Related ArticlesN-Methyl-D-Aspartate Receptor Encephalitis with Psychiatric Symptoms and an Ovarian Teratoma Detected by MRI in a 17-Year-Old Girl. Neuropediatrics. 2019 08;50(4):253-256 Authors: Barth A, Nassenstein I, Tröbs RB, Tannapfel A, Dercks H, Rostásy K, Wegener-Panzer A Abstract N-methyl-D-aspartate receptor (NMDAR) encephalitis is a rare antibody-mediated autoimmune encephalitis often associated with an ovarian teratoma in adolescent females....
Rare Cancers
Thu Jun 04, 2020 13:57
Acquired N-Linked Glycosylation Motifs in B-Cell Receptors of Primary Cutaneous B-Cell Lymphoma and the Normal B-Cell Repertoire.
Related ArticlesAcquired N-Linked Glycosylation Motifs in B-Cell Receptors of Primary Cutaneous B-Cell Lymphoma and the Normal B-Cell Repertoire. J Invest Dermatol. 2019 10;139(10):2195-2203 Authors: Koning MT, Quinten E, Zoutman WH, Kiełbasa SM, Mei H, van Bergen CAM, Jansen P, Vergroesen RD, Willemze R, Vermeer MH, Tensen CP, Veelken H Abstract Primary cutaneous follicle center lymphoma (PCFCL) is a rare mature B-cell lymphoma with an unknown etiology....
Rare Cancers
Thu Jun 04, 2020 13:57
Alternative splicing and ACMG-AMP-2015-based classification of PALB2 genetic variants: an ENIGMA report.
Related ArticlesAlternative splicing and ACMG-AMP-2015-based classification of PALB2 genetic variants: an ENIGMA report. J Med Genet. 2019 07;56(7):453-460 Authors: Lopez-Perolio I, Leman R, Behar R, Lattimore V, Pearson JF, Castéra L, Martins A, Vaur D, Goardon N, Davy G, Garre P, García-Barberán V, Llovet P, Pérez-Segura P, Díaz-Rubio E, Caldés T, Hruska KS, Hsuan V, Wu S, Pesaran T, Karam R, Vallon-Christersson J, Borg A, kConFab Investigators, Valenzuela-Palomo...
Rare Cancers
Thu Jun 04, 2020 13:57
Targeted next-generation sequencing detects rare genetic events in pheochromocytoma and paraganglioma.
Related ArticlesTargeted next-generation sequencing detects rare genetic events in pheochromocytoma and paraganglioma. J Med Genet. 2019 08;56(8):513-520 Authors: Ben Aim L, Pigny P, Castro-Vega LJ, Buffet A, Amar L, Bertherat J, Drui D, Guilhem I, Baudin E, Lussey-Lepoutre C, Corsini C, Chabrier G, Briet C, Faivre L, Cardot-Bauters C, Favier J, Gimenez-Roqueplo AP, Burnichon N Abstract BACKGROUND: Knowing the genetic status of patients affected by...
Rare Cancers
Thu Jun 04, 2020 13:57
Adrenocortical cancer cell line mutational profile reveals aggressive genetic background.
Related ArticlesAdrenocortical cancer cell line mutational profile reveals aggressive genetic background. J Mol Endocrinol. 2019 05;62(4):179-186 Authors: Nicolson NG, Korah R, Carling T Abstract Adrenocortical carcinomas are rare tumors with poor prognosis and limited treatment options. Although widely used as in vitro models to test novel therapeutic strategies, the adrenocortical carcinoma-derived cell lines NCI-H295R and SW-13 have only partially...
Rare Cancers
Thu Jun 04, 2020 13:57
Update on genetic predisposition to colorectal cancer and polyposis.
Related ArticlesUpdate on genetic predisposition to colorectal cancer and polyposis. Mol Aspects Med. 2019 10;69:10-26 Authors: Valle L, de Voer RM, Goldberg Y, Sjursen W, Försti A, Ruiz-Ponte C, Caldés T, Garré P, Olsen MF, Nordling M, Castellvi-Bel S, Hemminki K Abstract The present article summarizes recent developments in the characterization of genetic predisposition to colorectal cancer (CRC). The main themes covered include new hereditary CRC...
Rare Cancers
Thu Jun 04, 2020 13:57
Clinicopathological Profile of Myelomatous Pleural Effusion: Single-center Real-world Experience and Review of Literature.
Related ArticlesClinicopathological Profile of Myelomatous Pleural Effusion: Single-center Real-world Experience and Review of Literature. Clin Lymphoma Myeloma Leuk. 2019 03;19(3):183-189.e1 Authors: Yanamandra U, Deo P, Sahu KK, Nampoothiri RV, Gupta N, Prabhakaran A, Dhibhar DP, Khadwal A, Prakash G, Sachdeva MUS, Lad D, Varma N, Varma S, Malhotra P Abstract BACKGROUND: Multiple myeloma (MM) is a hematologic malignancy of plasma cell origin. MM primarily...
Rare Cancers
Thu Jun 04, 2020 13:57
Outcome of Childhood Acute Megakaryoblastic Leukemia: Children's Cancer Hospital Egypt 57357 Experience.
Related ArticlesOutcome of Childhood Acute Megakaryoblastic Leukemia: Children's Cancer Hospital Egypt 57357 Experience. Clin Lymphoma Myeloma Leuk. 2019 03;19(3):e142-e152 Authors: Maarouf N, Mahmoud S, Khedr R, Lehmann L, Shaaban K, Ibrahim S, Fahmy S, Hassanain O, Nader N, Elhaddad A Abstract INTRODUCTION: Acute megakaryoblastic leukemia is a rare subtype of pediatric acute myeloid leukemia (AML) with poor outcomes in patients with non-Down syndrome....
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Thu Jun 04, 2020 13:57
Targeted Resequencing of the Coding Sequence of 38 Genes Near Breast Cancer GWAS Loci in a Large Case-Control Study.
Related ArticlesTargeted Resequencing of the Coding Sequence of 38 Genes Near Breast Cancer GWAS Loci in a Large Case-Control Study. Cancer Epidemiol Biomarkers Prev. 2019 04;28(4):822-825 Authors: Decker B, Allen J, Luccarini C, Pooley KA, Shah M, Bolla MK, Wang Q, Ahmed S, Baynes C, Conroy DM, Brown J, Luben R, Ostrander EA, Pharoah PDP, Dunning AM, Easton DF Abstract BACKGROUND: Genes regulated by breast cancer risk alleles identified through genome-wide...
Rare Cancers
Thu Jun 04, 2020 13:57
Nasoethmoidal Intestinal-Type Adenocarcinoma Treated with Cetuximab: Role of Liquid Biopsy and BEAMing in Predicting Response to Anti-Epidermal Growth Factor Receptor Therapy.
Related ArticlesNasoethmoidal Intestinal-Type Adenocarcinoma Treated with Cetuximab: Role of Liquid Biopsy and BEAMing in Predicting Response to Anti-Epidermal Growth Factor Receptor Therapy. Oncologist. 2019 03;24(3):293-300 Authors: Cabezas-Camarero S, de la Orden García V, García-Barberán V, Mediero-Valeros B, Subhi-Issa AI, Llovet García P, Bando-Polaino I, Merino Menéndez S, Pérez-Segura P, Díaz-Rubio E Abstract Sinonasal intestinal-type adenocarcinomas...
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Thu Jun 04, 2020 13:57
Cachexia does not induce loss of myonuclei or muscle fibres during xenografted prostate cancer in mice.
Related ArticlesCachexia does not induce loss of myonuclei or muscle fibres during xenografted prostate cancer in mice. Acta Physiol (Oxf). 2019 03;225(3):e13204 Authors: Winje IM, Sheng X, Hansson KA, Solbrå A, Tennøe S, Saatcioglu F, Bruusgaard JC, Gundersen K Abstract AIM: Cachexia is a severe wasting disorder involving loss of body- and muscle mass reducing survival and quality of life in cancer patients. We aim at determining if cachexia is a mere...
Rare Cancers
Thu Jun 04, 2020 13:57
The Mi-2 nucleosome remodeler and the Rpd3 histone deacetylase are involved in piRNA-guided heterochromatin formation
Nature Communications, Published online: 04 June 2020; doi:10.1038/s41467-020-16635-5In S. pombe, small non-coding RNA mediates heterochromatin formation by recruiting the nucleosome remodeling and histone deacetylase complex. Here, the authors show that fly nucleosome remodeler Mi-2 and histone deacetylase Rpd3 are involved in piRNA-dependent transcriptional silencing of transposable elements.
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Thu Jun 04, 2020 03:00

Structural and functional evidence of bacterial antiphage protection by Thoeris defense system via NAD<sup>+</sup> degradation
Nature Communications, Published online: 04 June 2020; doi:10.1038/s41467-020-16703-wThe Thoeris defense system is a recently discovered bacterial defense system that protects bacteria against phage infection and consists of the two genes thsA and thsB. Here, the authors present the crystal structures of Bacillus cereus ThsA and ThsB and show that ThsA is a NAD+ cleaving enzyme.
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Thu Jun 04, 2020 03:00
Extent of N-terminus exposure of monomeric alpha-synuclein determines its aggregation propensity
Nature Communications, Published online: 04 June 2020; doi:10.1038/s41467-020-16564-3In Parkinson’s disease (PD) the monomeric protein alpha-synuclein (aSyn) misfolds and aggregates into insoluble fibrils. Here the authors use NMR measurements and hydrogen–deuterium exchange mass spectrometry and find that the more solvent exposed the N-terminus of aSyn is, the more aggregation prone its conformation becomes, and further show how PD mutations and post translational modifications influence the extent...
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Thu Jun 04, 2020 03:00
Pericyte FAK negatively regulates Gas6/Axl signalling to suppress tumour angiogenesis and tumour growth
Nature Communications, Published online: 04 June 2020; doi:10.1038/s41467-020-16618-6Focal adhesion kinase (FAK) is required for tumour angiogenesis and growth. Here, the authors show that deletion of pericyte FAK upregulates Gas6-Axl mediated Cyr61 production, which increases endothelial cell proliferation and angiogenesis, while elevating tissue factor production to enhance tumour cell proliferation.
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Thu Jun 04, 2020 03:00
Highly efficient phosphor-glass composites by pressureless sintering
Nature Communications, Published online: 04 June 2020; doi:10.1038/s41467-020-16649-zPhosphor-glass/ceramic composites are attractive for high-power white light-emitting diodes, but interfacial reaction leads to loss of quantum efficiency. Here the authors report a reduction sintering method for embedment of phosphors into silica glass with limited interfacial reaction.
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Thu Jun 04, 2020 03:00
Precise capture and dynamic relocation of nanoparticulate biomolecules through dielectrophoretic enhancement by vertical nanogap architectures
Nature Communications, Published online: 04 June 2020; doi:10.1038/s41467-020-16630-wLabel-free trapping of nanoparticles via dielectophoretic forces is traditionally done with electrodes in a horizontal gap layout. Here, the authors present a vertical nanogap architecture, which allows for precise capture and spatiotemporal manipulation of nanoparticles and molecular assemblies.
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Thu Jun 04, 2020 03:00
REV7 is required for processing AID initiated DNA lesions in activated B cells
Nature Communications, Published online: 04 June 2020; doi:10.1038/s41467-020-16632-8REV7 has emerged as a critical regulator of DNA double-strand breaks repair. Here, the authors show that REV7 is crucial for both antibody class switch recombination and somatic hypermutation in activated B cells, in addition to their survival upon AID-deamination.
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Thu Jun 04, 2020 03:00
Reversible single crystal-to-single crystal double [2+2] cycloaddition induces multifunctional photo-mechano-electrochemical properties in framework materials
Nature Communications, Published online: 04 June 2020; doi:10.1038/s41467-020-15510-7Porous coordination frameworks that undergo reversible structural transformations are promising for sensing, switching and separations. Here, the authors report an electroactive framework that exhibits a reversible single crystal-to-single crystal double [2+2] photocyclisation, leading to property changes.
Nature Communications - current - nature.com science feeds
Thu Jun 04, 2020 03:00
The Mi-2 nucleosome remodeler and the Rpd3 histone deacetylase are involved in piRNA-guided heterochromatin formation
Nature Communications - current - nature.com science feeds
Thu Jun 04, 2020 03:00
Structural and functional evidence of bacterial antiphage protection by Thoeris defense system via NAD<sup>+</sup> degradation
Nature Communications - current - nature.com science feeds
Thu Jun 04, 2020 03:00
Extent of N-terminus exposure of monomeric alpha-synuclein determines its aggregation propensity
Nature Communications - current - nature.com science feeds
Thu Jun 04, 2020 03:00
Pericyte FAK negatively regulates Gas6/Axl signalling to suppress tumour angiogenesis and tumour growth
Nature Communications - current - nature.com science feeds
Thu Jun 04, 2020 03:00
Highly efficient phosphor-glass composites by pressureless sintering
Nature Communications - current - nature.com science feeds
Thu Jun 04, 2020 03:00
Precise capture and dynamic relocation of nanoparticulate biomolecules through dielectrophoretic enhancement by vertical nanogap architectures
Nature Communications - current - nature.com science feeds
Thu Jun 04, 2020 03:00
REV7 is required for processing AID initiated DNA lesions in activated B cells
Nature Communications - current - nature.com science feeds
Thu Jun 04, 2020 03:00
Reversible single crystal-to-single crystal double [2+2] cycloaddition induces multifunctional photo-mechano-electrochemical properties in framework materials
Nature Communications - current - nature.com science feeds
Thu Jun 04, 2020 03:00

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