The CTC1-STN1-TEN1 (CST) complex is essential for telomere maintenance and resolution of stalled replication forks genome-wide. Here, we report the 3.0-angstrom cryo–electron microscopy structure of human CST bound to telomeric single-stranded DNA (ssDNA), which assembles as a decameric supercomplex. The atomic model of the 134-kilodalton CTC1 subunit, built almost entirely de novo, reveals the overall architecture of CST and the DNA-binding anchor site. The carboxyl-terminal domain of STN1 interacts...
Thu Jun 04, 2020 20:39
Harvesting heat from the environment into electricity has the potential to power Internet-of-things (IoT) sensors, freeing them from cables or batteries and thus making them especially useful for wearable devices. We demonstrate a giant positive thermopower of 17.0 millivolts per degree Kelvin in a flexible, quasi-solid-state, ionic thermoelectric material using synergistic thermodiffusion and thermogalvanic effects. The ionic thermoelectric material is a gelatin matrix modulated with ion providers...
Thu Jun 04, 2020 20:39
The toxicity and environmental persistence of anthropogenic per- and poly-fluoroalkyl substances (PFAS) are of global concern. To address legacy PFAS concerns in the United States, industry developed numerous replacement PFAS that commonly are treated as confidential information. To investigate the distribution of PFAS in New Jersey, soils collected from across the state were subjected to nontargeted mass-spectral analyses. Ten chloroperfluoropolyether carboxylates were tentatively identified, with...
Thu Jun 04, 2020 20:39
Spectral measurements of boundary-localized topological modes are commonly used to identify topological insulators. For high-order insulators, these modes appear at boundaries of higher codimension, such as the corners of a two-dimensional material. Unfortunately, this spectroscopic approach is only viable if the energies of the topological modes lie within the bulk bandgap, which is not required for many topological crystalline insulators. The key topological feature in these insulators is instead...
Thu Jun 04, 2020 20:39
Immunological memory specific to previously encountered antigens is a cardinal feature of adaptive lymphoid cells. However, it is unknown whether innate myeloid cells retain memory of prior antigenic stimulation and respond to it more vigorously on subsequent encounters. In this work, we show that murine monocytes and macrophages acquire memory specific to major histocompatibility complex I (MHC-I) antigens, and we identify A-type paired immunoglobulin-like receptors (PIR-As) as the MHC-I receptors...
Thu Jun 04, 2020 20:39
The lumicrine system is a postulated signaling system in which testis-derived (upstream) secreted factors enter the male reproductive tract to regulate epididymal (downstream) pathways required for sperm maturation. Until now, no lumicrine factors have been identified. We demonstrate that a testicular germ-cell–secreted epidermal growth factor–like protein, neural epidermal growth factor–like–like 2 (NELL2), specifically binds to an orphan receptor tyrosine kinase, c-ros oncogene 1 (ROS1), and mediates...
Thu Jun 04, 2020 20:39
Although microplastics are known to pervade the global seafloor, the processes that control their dispersal and concentration in the deep sea remain largely unknown. Here, we show that thermohaline-driven currents, which build extensive seafloor sediment accumulations, can control the distribution of microplastics and create hotspots with the highest concentrations reported for any seafloor setting (190 pieces per 50 grams). Previous studies propose that microplastics are transported to the seafloor...
Thu Jun 04, 2020 20:39
Rice et al. suggest that the CRISPR-associated transposase ShCAST system could lead to additional insertion products beyond simple integration of the donor. We clarify the outcomes of ShCAST-mediated insertions in Escherichia coli, which consist of both simple insertions and integration of the donor plasmid. This latter outcome can be avoided by use of a 5' nicked DNA donor.
Thu Jun 04, 2020 20:39
The miniaturization of semiconductor transistors has driven the growth in computer performance for more than 50 years. As miniaturization approaches its limits, bringing an end to Moore’s law, performance gains will need to come from software, algorithms, and hardware. We refer to these technologies as the "Top" of the computing stack to distinguish them from the traditional technologies at the "Bottom": semiconductor physics and silicon-fabrication technology. In the post-Moore era, the Top will...
Thu Jun 04, 2020 20:39
Publication date: Available online 4 June 2020Source: Radiotherapy and OncologyAuthor(s): Shinn-Jye Liang, Chun-Ru Chien
Thu Jun 04, 2020 21:01
Publication date: Available online 3 June 2020Source: Radiotherapy and OncologyAuthor(s): Romaana Mir, Sarah M Kelly, Ying Xiao, Alisha Moore, Catharine H Clark, Enrico Clementel, Coreen Corning, Martin Ebert, Peter Hoskin, Coen W Hurkmans, Satoshi Ishikura, Ingrid Kristensen, Stephen F Kry, Joerg Lehmann, Jeff M Michalski, Angelo F Monti, Mitsuhiro Nakamura, Kenton Thompson, Huiqi Yang, Eduardo Zubizarreta
Thu Jun 04, 2020 21:01
Healthy aging (HA) is a contemporary challenge for population health worldwide. Electronic health (e-Health) interventions have the potential to support empowerment and education of adults aged 50 and over.
Wed Jun 03, 2020 03:00
According to the UK’s Office for National Statistics, England and Wales reported a 2.9% increase in sexual aggression cases (3.4 million females and 631,000 males) between 2009 and 2019. In Scotland, sexual ag...
Wed Jun 03, 2020 03:00
Related Articles[Case report of contact allergy to filtering facepiece class 2 mask of a medical worker during Covid-19 pandemic]. Laryngorhinootologie. 2020 Jun 03;: Authors: Klimek L, Spielhaupter M, Alali A, Freudelsperger L, Cichy M, Huppertz T, Hagemann J PMID: 32492726 [PubMed - as supplied by publisher]
Thu Jun 04, 2020 20:47
Δεν υπάρχουν σχόλια:
Δημοσίευση σχολίου