Antibiotics, Vol. 9, Pages 317: Synthesis and Anti-Saprolegnia Activity of New 2’,4’-Dihydroxydihydrochalcone Derivatives Antibiotics doi: 10.3390/antibiotics9060317 Authors: Enrique Werner Iván Montenegro Bastian Said Patricio Godoy Ximena Besoain Nelson Caro Alejandro Madrid In the present study, seven 2’,4’-dihydroxydihydrochalcone derivatives (compounds 3–9) were synthesized and their capacity as anti-Saprolegnia agents were evaluated...
Wed Jun 10, 2020 03:00
Antibiotics, Vol. 9, Pages 316: A Prediction Tool for the Presence of Ceftriaxone-Resistant Uropathogens upon Hospital Admission Antibiotics doi: 10.3390/antibiotics9060316 Authors: Nancy Yanzhe Li Gang Quan Poh Gladys Chung Wei Teng Hui Hiong Chen Douglas Su Gin Chan Siew-Pang Chan Paul Anantharajah Tambyah Natasha Bagdasarian Jia En Wu Antimicrobial resistance among uropathogens is a particularly pressing problem in the Asia-Pacific region. The objectives of...
Wed Jun 10, 2020 03:00
Antibodies, Vol. 9, Pages 22: Principles of N-Linked Glycosylation Variations of IgG-Based Therapeutics: Pharmacokinetic and Functional Considerations Antibodies doi: 10.3390/antib9020022 Authors: Boune Hu Epstein Khawli The development of recombinant therapeutic proteins has been a major revolution in modern medicine. Therapeutic-based monoclonal antibodies (mAbs) are growing rapidly, providing a potential class of human pharmaceuticals that can improve the management of...
Wed Jun 10, 2020 03:00
Antioxidants, Vol. 9, Pages 512: Screening and Characterization of Antiglycoxidant Anthocyanins from Vaccinium myrtillus Fruit Using DPPH and Methylglyoxal Pre-Column HPLC Assays Antioxidants doi: 10.3390/antiox9060512 Authors: Fraisse Bred Felgines Senejoux Vaccinium myrtillus fruit (bilberry) is well known for its high richness in anthocyanins, which may be responsible for its preventive effects on several oxidative and carbonyl stress-related pathologies. However, limited...
Wed Jun 10, 2020 03:00
Antioxidants, Vol. 9, Pages 511: The Role of Cashew (Anacardium occidentale L.) Nuts on an Experimental Model of Painful Degenerative Joint Disease Antioxidants doi: 10.3390/antiox9060511 Authors: Fusco Siracusa Peritore Gugliandolo Genovese D’Amico Cordaro Crupi Mandalari Impellizzeri Cuzzocrea Di Paola Osteoarthritis is a progressive joint disease characterized by the activation of different molecular mediators, including proinflammatory...
Wed Jun 10, 2020 03:00
Antioxidants, Vol. 9, Pages 510: Seed Oil from Mediterranean Aromatic and Medicinal Plants of the Lamiaceae Family as a Source of Bioactive Components with Nutritional Antioxidants doi: 10.3390/antiox9060510 Authors: María Quílez Federico Ferreres Santiago López-Miranda Eva Salazar María J. Jordán The potential use as food ingredients of 12 commercial seed species belonging to the Lamiaceae family constitutes the main goal of this research. For that, the oil yield, the lipid...
Wed Jun 10, 2020 03:00
Antioxidants, Vol. 9, Pages 509: Assessment of the In Vivo Antioxidant Activity of an Anthocyanin-Rich Bilberry Extract Using the Caenorhabditis elegans Model Antioxidants doi: 10.3390/antiox9060509 Authors: Ana M. González-Paramás Virginia Brighenti Laura Bertoni Laura Marcelloni Begoña Ayuda-Durán Susana González-Manzano Federica Pellati Celestino Santos-Buelga Anthocyanins have been associated with several health benefits, although the responsible mechanisms are...
Wed Jun 10, 2020 03:00
Atmosphere, Vol. 11, Pages 615: Extraction of Quasi-Monochromatic Gravity Waves from an Airglow Imager Network Atmosphere doi: 10.3390/atmos11060615 Authors: Chang Lai Wei Li Jiyao Xu Xiao Liu Wei Yuan Jia Yue Qinzeng Li An algorithm has been developed to isolate the gravity waves (GWs) of different scales from airglow images. Based on the discrete wavelet transform, the images are decomposed and then reconstructed in a series of mutually orthogonal spaces, each of...
Wed Jun 10, 2020 03:00
Atmosphere, Vol. 11, Pages 614: Characterizing Greenhouse Gas Emissions and Global Warming Potential of Wheat-Maize Cropping Systems in Response to Organic Amendments in Eutric Regosols, China Atmosphere doi: 10.3390/atmos11060614 Authors: Hamidou Bah Xiao Ren Yanqiang Wang Jialiang Tang Bo Zhu Characterizing greenhouse gas (GHG) emissions and global warming potential (GWP) has become a key step in the estimation of atmospheric GHG concentrations and their potential mitigation...
Wed Jun 10, 2020 03:00
Atmosphere, Vol. 11, Pages 613: Damage Analysis of Three Long-Track Tornadoes Using High-Resolution Satellite Imagery Atmosphere doi: 10.3390/atmos11060613 Authors: Daniel Burow Hannah V. Herrero Kelsey N. Ellis Remote sensing of tornado damage can provide valuable observations for post-event surveys and reconstructions. The tornadoes of 3 March 2019 in the southeastern United States are an ideal opportunity to relate high-resolution satellite imagery of damage with estimated wind...
Wed Jun 10, 2020 03:00
Behavioral Sciences, Vol. 10, Pages 99: Loss of Close Relationships and Loss of Religious Belonging as Cumulative Ostracism: From Social Death to Social Resurrection Behavioral Sciences doi: 10.3390/bs10060099 Authors: Adriano Zamperini Marialuisa Menegatto Miriam Mostacchi Simone Barbagallo Ines Testoni Background: Ostracism is a negative experience that has been studied primarily in laboratory settings. This study extends current research by investigating ostracism in daily...
Wed Jun 10, 2020 03:00
Behavioral Sciences, Vol. 10, Pages 98: Time is on My Side—or Is It? Assessing How Perceived Control of Time and Procrastination Influence Emotional Exhaustion on the Job Behavioral Sciences doi: 10.3390/bs10060098 Authors: Catherine A. Roster Joseph R. Ferrari The job demands–control model (JDC) postulates that an increased control over work resources mitigates or “buffers” the positive association between job stressors and strainers. However, the inconclusive...
Wed Jun 10, 2020 03:00
Biomolecules, Vol. 10, Pages 892: Cigarette Smoking during Pregnancy: Effects on Antioxidant Enzymes, Metallothionein and Trace Elements in Mother-Newborn Pairs Biomolecules doi: 10.3390/biom10060892 Authors: Pizent Lazarus Kovačić Tariba Lovaković Brčić Karačonji Živković Semren Sekovanić Orct Branović-Čakanić Brajenović Jurič Miškulin Škrgatić Stasenko Mioč Jurasović Piasek The effect of maternal smoking as a source of...
Wed Jun 10, 2020 03:00
Biomolecules, Vol. 10, Pages 888: Bakkenolides and Caffeoylquinic Acids from the Aerial Portion of Petasites japonicus and Their Bacterial Neuraminidase Inhibition Ability Biomolecules doi: 10.3390/biom10060888 Authors: Hyun Sim Woo Kyung-Chul Shin Jeong Yoon Kim Yeong-Su Kim Young Jun Ban Yu Jin Oh Hae Jin Cho Deok-Kun Oh Dae Wook Kim Petasites japonicus have been used since a long time in folk medicine to treat diseases including plague, pestilential fever,...
Wed Jun 10, 2020 03:00
Biomolecules, Vol. 10, Pages 890: Effect of Musts Oxygenation at Various Stages of Cider Production on Oenological Parameters, Antioxidant Activity, and Profile of Volatile Cider Compounds Biomolecules doi: 10.3390/biom10060890 Authors: Tomasz Tarko Aleksandra Duda-Chodak Paweł Sroka Magdalena Januszek The micro-oxygenation of musts may affect the quality of a finished alcoholic beverage. The aim of this study was to determine the effect of micro-oxygenation at various stages...
Wed Jun 10, 2020 03:00
Biomolecules, Vol. 10, Pages 889: Quantification of One Prenylated Flavanone from Eysenhardtia platycarpa and Four Derivatives in Ex Vivo Human Skin Permeation Samples Applying a Validated HPLC Method Biomolecules doi: 10.3390/biom10060889 Authors: Paola Bustos-Salgado Berenice Andrade-Carrera María Luisa Garduño-Ramírez Helen Alvarado Ana Calpena-Campmany Prenylated flavanones are polyphenols that have diverse biological properties. The present paper focuses on a HPLC method...
Wed Jun 10, 2020 03:00
Biomolecules, Vol. 10, Pages 891: A Lipidomic Perspective of the Action of Group IIA Secreted Phospholipase A2 on Human Monocytes: Lipid Droplet Biogenesis and Activation of Cytosolic Phospholipase A2α Biomolecules doi: 10.3390/biom10060891 Authors: Juan P. Rodríguez Elbio Leiguez Carlos Guijas Bruno Lomonte José M. Gutiérrez Catarina Teixeira María A. Balboa Jesús Balsinde Phospholipase A2s constitute a wide group of lipid-modifying enzymes which display a variety...
Wed Jun 10, 2020 03:00
Biomolecules, Vol. 10, Pages 887: Jaw Periosteal Cells Seeded in Beta-Tricalcium Phosphate Inhibit Dendritic Cell Maturation Biomolecules doi: 10.3390/biom10060887 Authors: Jingtao Dai Felix Umrath Siegmar Reinert Dorothea Alexander Mesenchymal stem cells (MSCs) have gained attraction not only in the field of regenerative medicine but also in the field of autoimmune disease therapies or organ transplantation due to their immunoregulatory and/or immunosuppressive features. Dendritic...
Wed Jun 10, 2020 03:00
Biosensors, Vol. 10, Pages 63: Low-Fouling Substrates for Plasmonic Sensing of Circulating Biomarkers in Biological Fluids Biosensors doi: 10.3390/bios10060063 Authors: Elba Mauriz The monitoring of biomarkers in body fluids provides valuable prognostic information regarding disease onset and progression. Most biosensing approaches use noninvasive screening tools and are conducted in order to improve early clinical diagnosis. However, biofouling of the sensing surface may disturb the...
Wed Jun 10, 2020 03:00
Brain Sciences, Vol. 10, Pages 363: Fully Endoscopic Transforaminal Lumbar Discectomy for Upward Migration of Upper Lumbar Disc Herniation: Clinical and Radiological Outcomes and Technical Considerations Brain Sciences doi: 10.3390/brainsci10060363 Authors: Dong Hwa Heo Dong Keun Lee Dong Chan Lee Hyeun Sung Kim Choon Keun Park Microdiscectomy for the upward migration of upper lumbar herniated discs has a high risk of isthmus and facet injury. Fully endoscopic transforaminal...
Wed Jun 10, 2020 03:00
Brain Sciences, Vol. 10, Pages 361: Blood-Based Biomarkers Predictive of Metformin Target Engagement in Fragile X Syndrome Brain Sciences doi: 10.3390/brainsci10060361 Authors: Mittal Jasoliya Heather Bowling Ignacio Cortina Petrasic Blythe Durbin-Johnson Eric Klann Aditi Bhattacharya Randi Hagerman Flora Tassone Recent advances in neurobiology have provided several molecular entrees for targeted treatments for Fragile X syndrome (FXS). However, the efficacy of these...
Wed Jun 10, 2020 03:00
Brain Sciences, Vol. 10, Pages 362: Characterizing Olfactory Function in Children with Autism Spectrum Disorder and Children with Sensory Processing Dysfunction Brain Sciences doi: 10.3390/brainsci10060362 Authors: Julia R. Sweigert Tanya St. John Kristin Kawena Begay Greg E. Davis Jeffrey Munson Eric Shankland Annette Estes Stephen R. Dager Natalia M. Kleinhans Abnormalities in olfactory function have been identified in a number of neurological and psychiatric...
Wed Jun 10, 2020 03:00
Cancers, Vol. 12, Pages 1523: New Anti-Cancer Strategy to Suppress Colorectal Cancer Growth Through Inhibition of ATG4B and Lysosome Function Cancers doi: 10.3390/cancers12061523 Authors: Yuanyuan Fu Qianqian Gu Li Luo Jiecheng Xu Yuping Luo Fan Xia Fanghai Han Liang Hong Xiao-Ming Yin Zhiying Huang Min Li Autophagy inhibition has been proposed to be a potential therapeutic strategy for cancer, however, few autophagy inhibitors have been developed. Recent...
Wed Jun 10, 2020 03:00
Cancers, Vol. 12, Pages 1529: Pathophysiology of Bone Loss in Patients with Prostate Cancer Receiving Androgen-Deprivation Therapy and Lifestyle Modifications for the Management of Bone Health: A Comprehensive Review Cancers doi: 10.3390/cancers12061529 Authors: Tae Jin Kim Kyo Chul Koo Androgen-deprivation therapy (ADT) is a systemic therapy administered for the management of advanced prostate cancer (PCa). Although ADT may improve survival, long-term use reduces bone mass density...
Wed Jun 10, 2020 03:00
Cancers, Vol. 12, Pages 1528: Prevalence and Type Distribution of High-Risk Human Papillomavirus (HPV) in Breast Cancer: A Qatar Based Study Cancers doi: 10.3390/cancers12061528 Authors: Gulab Sher Nadia Aziz Salman Michal Kulinski Rayyan Abdulaziz Fadel Vinod Kumar Gupta Ambika Anand Salahddin Gehani Sheraz Abayazeed Omer Al-Yahri Fakhar Shahid Salman Alshaibani Sara Hassan M. Zafar Chawdhery Giles Davies Said Dermime Shahab Uddin G. Hossein...
Wed Jun 10, 2020 03:00
Cancers, Vol. 12, Pages 1527: Copy Number Alterations of Depressed Colorectal Neoplasm Predict the Survival and Response to Oxaliplatin in Proximal Colon Cancer Cancers doi: 10.3390/cancers12061527 Authors: Li-Chun Chang Han-Mo Chiu Bing-Ching Ho Min-Hsuan Chen Yin-Chen Hsu Wei-Tzu Chiu Kang-Yi Su Chia-Tung Shun Jin-Tung Liang Sung-Liang Yu Ming-Shiang Wu Depressed colorectal neoplasm exhibits high malignant potential and shows rapid invasiveness. We investigated...
Wed Jun 10, 2020 03:00
Cancers, Vol. 12, Pages 1525: TP53-Deficient Angiosarcoma Expression Profiling in Rat Model Cancers doi: 10.3390/cancers12061525 Authors: Urszula Smyczyńska Damian Strzemecki Anna M. Czarnecka Wojciech Fendler Michał Fiedorowicz Marlena Wełniak-Kamińska Magdalena Guzowska Kamil Synoradzki Łukasz Cheda Zbigniew Rogulski Paweł Grieb Sarcomas are a heterogeneous group of malignant tumors, that develop from mesenchymal cells. Sarcomas are tumors associated with...
Wed Jun 10, 2020 03:00
Cancers, Vol. 12, Pages 1524: Update on GNA Alterations in Cancer: Implications for Uveal Melanoma Treatment Cancers doi: 10.3390/cancers12061524 Authors: Lionel Larribère Jochen Utikal Tumorigenesis is correlated with abnormal expression and activity of G protein-coupled receptors (GPCRs) and associated G proteins. Oncogenic mutations in both GPCRs and G proteins (GNAS, GNAQ or GNA11) encoding genes have been identified in a significant number of tumors. Interestingly, uveal melanoma...
Wed Jun 10, 2020 03:00
Cancers, Vol. 12, Pages 1526: Beneficial Molecular Adaptations In BRCA-Mutation Carriers By Combined HIT/HIRT Intervention: Results From A Pilot Study Cancers doi: 10.3390/cancers12061526 Authors: Bizjak Schulz Schumann Otto Kirsten Ebner Leinert Huober Janni Steinacker : Based on growing evidence that breast cancer (BRCA) also plays a pivotal role in the regulation of skeletal muscle metabolism and the response to anti-oxidative stress, we examined...
Wed Jun 10, 2020 03:00
Cancers, Vol. 12, Pages 1521: Compressive Stimulation Enhances Ovarian Cancer Proliferation, Invasion, Chemoresistance, and Mechanotransduction via CDC42 in a 3D Bioreactor Cancers doi: 10.3390/cancers12061521 Authors: Caymen M. Novak Eric N. Horst Emily Lin Geeta Mehta This report investigates the role of compressive stress on ovarian cancer in a 3D custom built bioreactor. Cells within the ovarian tumor microenvironment experience a range of compressive stimuli that contribute...
Wed Jun 10, 2020 03:00
Cancers, Vol. 12, Pages 1530: Extracellular Vesicles in Diagnosis and Treatment of Pancreatic Cancer: Current State and Future Perspectives Cancers doi: 10.3390/cancers12061530 Authors: J. Spencer Lane Daniel Von Hoff Derek Cridebring Ajay Goel Pancreatic cancer remains one of the deadliest diagnoses a patient can receive. One of the reasons for this lethality is that this malignancy is often detected very late due to a lack of symptoms during the early stages. In addition to...
Wed Jun 10, 2020 03:00
Cancers, Vol. 12, Pages 1519: Pazopanib and Trametinib as a Synergistic Strategy against Osteosarcoma: Preclinical Activity and Molecular Insights Cancers doi: 10.3390/cancers12061519 Authors: Giulia Chiabotto Giovanni Grignani Maja Todorovic Valentina Martin Maria Laura Centomo Elisa Prola Giorgia Giordano Alessandra Merlini Umberto Miglio Enrico Berrino Lucia Napione Claudio Isella Federica Capozzi Marco Basiricò Cristina Marsero Ilaria Gerardi...
Wed Jun 10, 2020 03:00
Cancers, Vol. 12, Pages 1513: A Guide for Oncologic Patient Management during Covid-19 Pandemic: The Initial Experience of an Italian Oncologic Hub with Exemplificative Focus on Uro-Oncologic Patients Cancers doi: 10.3390/cancers12061513 Authors: Francesco A. Mistretta Stefano Luzzago Luigi Orlando Molendini Matteo Ferro Enza Dossena Fabrizio Mastrilli Gennaro Musi Ottavio de Cobelli The recent exponential increase in the number of COVID-19 patients in Italy led...
Wed Jun 10, 2020 03:00
Cancers, Vol. 12, Pages 1520: National Policies to Prevent and Manage Cervical Cancer in East African Countries: A Policy Mapping Analysis Cancers doi: 10.3390/cancers12061520 Authors: Diana Wangeshi Njuguna Nour Mahrouseh Dede Onisoyonivosekume Orsolya Varga Policy mapping is used to provide evidence on effective interventions and highlight the necessary refinements of health policies. The goal of this work is to carry out legal mapping to identify and assess health policies...
Wed Jun 10, 2020 03:00
Cancers, Vol. 12, Pages 1517: The Clinicopathological Features and Genetic Alterations in Epstein–Barr Virus-Associated Gastric Cancer Patients after Curative Surgery Cancers doi: 10.3390/cancers12061517 Authors: Wen-Liang Fang Ming-Huang Chen Kuo-Hung Huang Chien-Hsing Lin Yee Chao Su-Shun Lo Anna Fen-Yau Li Chew-Wun Wu Yi-Ming Shyr Background: Epstein–Barr virus (EBV)-associated gastric cancer (GC) is one of four major gastric cancer types and is traditionally...
Wed Jun 10, 2020 03:00
Cancers, Vol. 12, Pages 1518: DUBs Activating the Hedgehog Signaling Pathway: A Promising Therapeutic Target in Cancer Cancers doi: 10.3390/cancers12061518 Authors: Francesca Bufalieri Ludovica Lospinoso Severini Miriam Caimano Paola Infante Lucia Di Marcotullio The Hedgehog (HH) pathway governs cell proliferation and patterning during embryonic development and is involved in regeneration, homeostasis and stem cell maintenance in adult tissues. The activity of this signaling...
Wed Jun 10, 2020 03:00
Cancers, Vol. 12, Pages 1522: Hypoxanthine Phosphoribosyl Transferase 1 Is Upregulated, Predicts Clinical Outcome and Controls Gene Expression in Breast Cancer Cancers doi: 10.3390/cancers12061522 Authors: Melina J. Sedano Enrique I. Ramos Ramesh Choudhari Alana L. Harrison Ramadevi Subramani Rajkumar Lakshmanaswamy Mina Zilaie Shrikanth S. Gadad Hypoxanthine phosphoribosyl transferase 1 (HPRT1) is traditionally believed to be a housekeeping gene; however, recent...
Wed Jun 10, 2020 03:00
Cancers, Vol. 12, Pages 1516: Dual Targeting of BRAF and mTOR Signaling in Melanoma Cells with Pyridinyl Imidazole Compounds Cancers doi: 10.3390/cancers12061516 Authors: Veronika Palušová Tereza Renzová Amandine Verlande Tereza Vaclová Michaela Medková Linda Cetlová Miroslava Sedláčková Hana Hříbková Iva Slaninová Miriama Krutá Vladimír Rotrekl Hana Uhlířová Aneta Křížová Radim Chmelík Pavel Veselý Michaela Krafčíková Lukáš Trantírek Kay...
Wed Jun 10, 2020 03:00
Cancers, Vol. 12, Pages 1514: The Role of Alternative RNA Splicing in the Regulation of hTERT, Telomerase, and Telomeres: Implications for Cancer Therapeutics Cancers doi: 10.3390/cancers12061514 Authors: Aaron L. Slusher Jeongjin JJ Kim Andrew T. Ludlow Alternative RNA splicing impacts the majority (>90%) of eukaryotic multi-exon genes, expanding the coding capacity and regulating the abundance of gene isoforms. Telomerase (hTERT) is a key example of a gene that is alternatively...
Wed Jun 10, 2020 03:00
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