Τετάρτη 10 Ιουνίου 2020


First-in-human study of the PARP/tankyrase inhibitor E7449 in patients with advanced solid tumours and evaluation of a novel drug-response predictor
Cancer
01:25
Quantification of Avoidable Radiation Exposure in Interventional Fluoroscopy With Eye Tracking Technology
Objectives Reducing avoidable radiation exposure during medical procedures is a top priority. The purpose of this study was to quantify, for the first time, the percentage of avoidable radiation during fluoroscopically guided cardiovascular interventions using eye tracking technologies. Materials and Methods Mobile eye tracking glasses were used to measure precisely when the operators looked at a fluoroscopy screen during the interventions. A novel machine learning algorithm and image processing...
Investigative Radiology - Current Issue
04:13
The Performance of Chest CT in Evaluating the Clinical Severity of COVID-19 Pneumonia: Identifying Critical Cases Based on CT Characteristics
Objectives The aim of this study was to assess the clinical severity of COVID-19 pneumonia using qualitative and/or quantitative chest computed tomography (CT) indicators and identify the CT characteristics of critical cases. Materials and Methods Fifty-one patients with COVID-19 pneumonia including ordinary cases (group A, n = 12), severe cases (group B, n = 15), and critical cases (group C, n = 24) were retrospectively enrolled. The qualitative and quantitative indicators from chest CT...
Investigative Radiology - Current Issue
04:13
Novel Magnetic Resonance Late Gadolinium Enhancement With Fixed Short Inversion Time in Ischemic Myocardial Scars
Aims Late gadolinium enhancement (LGE) visualizes scar tissue after myocardial infarction. However, in clinically used LGE sequences, subendocardial infarcts can be missed due to low contrast between blood pool and subendocardium. The purpose of his study was to compare scar visibility in a novel 3-dimensional (3D) single breath-hold inversion recovery sequence with fixed, short inversion time (TI = 100 milliseconds) (short LGE) and standard 3D LGE imaging with individually adjusted TI (LGE). ...
Investigative Radiology - Current Issue
04:13
Subregion Radiomics Analysis to Display Necrosis After Hepatic Microwave Ablation—A Proof of Concept Study
Objectives The aim of this study was to improve the visualization of coagulation necrosis after computed tomography (CT)–guided microwave ablation (MWA) in routine postablational imaging. Materials and Methods Ten MWAs were performed in 8 pigs under CT guidance. After each ablation, we obtained contrast-enhanced CT scans in venous phase. Ablations were then resected as a whole, and histologic slices were obtained orthogonally through the ablation center. Subsequently, a vital stain was applied...
Investigative Radiology - Current Issue
04:13
Establishing Reference Intervals for Gadolinium Concentrations in Blood, Plasma, and Urine in Individuals Not Previously Exposed to Gadolinium-Based Contrast Agents
Objectives Over the recent years, there have been increasing concerns that exposure to gadolinium-based contrast agents (GBCAs) may be associated with retention of Gd within the skin, bones, and solid organs in patients with normal renal function, although the clinical implications of this deposition remain to be established. There are no published data available to guide the development of reference intervals for Gd concentrations in biological samples from healthy people. The aims of this study...
Investigative Radiology - Current Issue
04:13
Assessment of Low-Grade Focal Cartilage Lesions in the Knee With Sodium MRI at 7 T: Reproducibility and Short-Term, 6-Month Follow-up Data
Objectives Several articles have investigated potential of sodium (23Na) magnetic resonance imaging (MRI) for the in vivo evaluation of cartilage health, but so far no study tested its feasibility for the evaluation of focal cartilage lesions of grade 1 or 2 as defined by the International Cartilage Repair Society. The aims of this study were to evaluate the ability of 23Na-MRI to differentiate between early focal lesions and normal-appearing cartilage, to evaluate within-subject reproducibility...
Investigative Radiology - Current Issue
04:13
Steady-State Multifrequency Magnetic Resonance Elastography of the Thoracic and Abdominal Human Aorta—Validation and Reference Values
Objectives The aim of this study was to investigate the potential of stroboscopic-wavefield-sampling-based multifrequency magnetic resonance elastography (sMRE) for quantifying the stiffness of the human thoracic and abdominal aorta in vivo. Materials and Methods The sMRE of the thoracic and abdominal aorta was performed at 1.5 T field strength in 20 healthy volunteers aged 27 to 77 years (3 women; median age, 33 years; interquartile range [IQR], 16 years). Compound maps of shear wave speed...
Investigative Radiology - Current Issue
04:13
Computer-Aided Diagnosis in Multiparametric Magnetic Resonance Imaging Screening of Women With Extremely Dense Breasts to Reduce False-Positive Diagnoses
Objectives To reduce the number of false-positive diagnoses in the screening of women with extremely dense breasts using magnetic resonance imaging (MRI), we aimed to predict which BI-RADS 3 and BI-RADS 4 lesions are benign. For this purpose, we use computer-aided diagnosis (CAD) based on multiparametric assessment. Materials and Methods Consecutive data were used from the first screening round of the DENSE (Dense Tissue and Early Breast Neoplasm Screening) trial. In this trial, asymptomatic...
Investigative Radiology - Current Issue
04:13
In Vivo Aortic Magnetic Resonance Elastography in Abdominal Aortic Aneurysm: A Validation in an Animal Model
Objectives Using maximum diameter of an abdominal aortic aneurysm (AAA) alone for management can lead to delayed interventions or unnecessary urgent repairs. Abdominal aortic aneurysm stiffness plays an important role in its expansion and rupture. In vivo aortic magnetic resonance elastography (MRE) was developed to spatially measure AAA stiffness in previous pilot studies and has not been thoroughly validated and evaluated for its potential clinical value. This study aims to evaluate noninvasive...
Investigative Radiology - Current Issue
04:13
Perplexing perspectives of ICAD
M. V. P. SrivastavaAnnals of Indian Academy of Neurology 2020 23(3):245-245
Annals of Indian Academy of Neurology : 2015 - 18(2)
Wed Jun 10, 2020 00:00
Intracranial atherosclerosis disease: A preventable epidemic
Majaz MoonisAnnals of Indian Academy of Neurology 2020 23(3):246-247
Annals of Indian Academy of Neurology : 2015 - 18(2)
Wed Jun 10, 2020 00:00
Early onset dementia in ataxia associated with ocular apraxia type 1 (AOA1)
Anastasiou I Aikaterini, Georgios I Papagiannis, Kontoangelos A Konstantinos, Konstantina G YiannopoulouAnnals of Indian Academy of Neurology 2020 23(3):391-392
Annals of Indian Academy of Neurology : 2015 - 18(2)
Wed Jun 10, 2020 00:00
Vitamin responsive movement disorders in children
Sujith OvallathAnnals of Indian Academy of Neurology 2020 23(3):248-248
Annals of Indian Academy of Neurology : 2015 - 18(2)
Wed Jun 10, 2020 00:00
Ipsilesional torsional nystagmus in midbrain infarction: A rare entity of localizing value
Divyani Garg, Ankit Gupta, Rajinder K DhamijaAnnals of Indian Academy of Neurology 2020 23(3):378-379
Annals of Indian Academy of Neurology : 2015 - 18(2)
Wed Jun 10, 2020 00:00
Border zones of evidence: How non-evidence based factors influence evidence generation and clinical practice in stroke medicine
PR Srijithesh, Shakir HusainAnnals of Indian Academy of Neurology 2020 23(3):249-252 The interpretation of the results of clinical trials should be done by examining the finer prints of extraneous factors such as stopping rules, interim analysis, intricacies of patient selection, and the rationale of decisions that lead to non-prespecified termination. This can be done only by critical education in the art and science of interpretation of evidence emerging from clinical trials. The pioneering pivotal...
Annals of Indian Academy of Neurology : 2015 - 18(2)
Wed Jun 10, 2020 00:00
Acute onset vision loss as a presenting manifestation of carcinoma lung
Divya M Radhakrishnan, Yeswanth Gogisetti, Niraj Kumar, Augustine Jose, Ritu ShreeAnnals of Indian Academy of Neurology 2020 23(3):407-409
Annals of Indian Academy of Neurology : 2015 - 18(2)
Wed Jun 10, 2020 00:00
A need for tailored approach for patients with symptomatic intracranial atherosclerotic stenosis
Mahesh P Kate, Ashfaq ShuaibAnnals of Indian Academy of Neurology 2020 23(3):253-254
Annals of Indian Academy of Neurology : 2015 - 18(2)
Wed Jun 10, 2020 00:00
A case of genetically confirmed chorea-acanthocytosis: Brain [18F]FDG-PET and [18F]FP-CIT-PET findings
Jong-Mok Lee, Chae Moon Hong, Ho-Sung RyuAnnals of Indian Academy of Neurology 2020 23(3):369-371
Annals of Indian Academy of Neurology : 2015 - 18(2)
Wed Jun 10, 2020 00:00
Sural radial amplitude ratio: A study in healthy Indian subjects
Khushnuma Mansukhani, Mayura Dhonde, Aarthika Sreenivasan, Alika Sharma, Lajita Balakrishnan, Priyanka ChavanAnnals of Indian Academy of Neurology 2020 23(3):255-260 Context: The amplitude ratio of sural radial sensory nerve action potential is used as a sensitive measure for the diagnosis of an early distal axonal peripheral neuropathy. There is no age-stratified reference data available. Aim: To establish age-stratified sural radial amplitude ratio (SRAR) reference data in healthy Indian subjects....
Annals of Indian Academy of Neurology : 2015 - 18(2)
Wed Jun 10, 2020 00:00
Hereditary spastic paraplegia with mental impairment, thin corpus callosum and amyotrophy: A road map to SPG11 contributors
Divya Goel, CM Sharma, BL KumawatAnnals of Indian Academy of Neurology 2020 23(3):384-386
Annals of Indian Academy of Neurology : 2015 - 18(2)
Wed Jun 10, 2020 00:00
Intracerebral hemorrhage and SARS-CoV-2: Association or causation
Ayush Agarwal, Venugopalan Y Vishnu, Deepti Vibha, Rohit Bhatia, Anu Gupta, Animesh Das, M V. Padma SrivastavaAnnals of Indian Academy of Neurology 2020 23(3):261-264 Background: Recent respiratory infection including SARS-CoV-2 is an independent risk factor for acute cerebrovascular disease. Purpose: There have been reports linking haemorrhagic strokes to SARS-CoV-2 infection during this pandemic, which lead us to evaluate if SARS-CoV-2 infection could be associated with increased risk of intracerebral...
Annals of Indian Academy of Neurology : 2015 - 18(2)
Wed Jun 10, 2020 00:00
Dysarthria, ataxia, and dystonia associated with COX20 (FAM36A) gene mutation: A case report of a Turkish child
Duygu G Ozcanyuz, Faruk Incecik, Ozlem M Herguner, Neslihan O Mungan, Sevcan T BozdoganAnnals of Indian Academy of Neurology 2020 23(3):399-401
Annals of Indian Academy of Neurology : 2015 - 18(2)
Wed Jun 10, 2020 00:00
Comparison of risk factors, treatment, and outcome in patients with symptomatic intracranial atherosclerotic disease in India and the United States
Udit Saraf, Shyam Prabhakaran, K Arun, Ahmed Babiker, Adithyan Rajendran, Chandrasekharan Kesavadas, PN SylajaAnnals of Indian Academy of Neurology 2020 23(3):265-269 Background and Aims: Intracranial atherosclerotic disease (ICAD) is common in the Asian population, but less studied in South Asians compared to East Asians. We compared risk factors, treatments, and outcomes among consecutive patients with symptomatic ICAD from India with a mixed-ethnic cohort from Chicago, Illinois. Methods: Consecutive...
Annals of Indian Academy of Neurology : 2015 - 18(2)
Wed Jun 10, 2020 00:00
Ataxia as forme fruste of opsoclonus myoclonus ataxia syndrome
Sumeet R Dhawan, Indar Kumar Sharawat, Renu Suthar, Deepak Bansal, Prema Menon, Bishan D Radotra, Anmol BhatiaAnnals of Indian Academy of Neurology 2020 23(3):415-417
Annals of Indian Academy of Neurology : 2015 - 18(2)
Wed Jun 10, 2020 00:00
Prevalence of non-motor symptoms in Parkinson's disease and its impact on quality of life in tertiary care center in India
Madhavi Karri, Balakrishnan Ramasamy, Ramadoss KalidossAnnals of Indian Academy of Neurology 2020 23(3):270-274 Context: Parkinson's disease (PD) is a neurodegenerative disease characterized by traditional motor features. Non-motor symptoms (NMS) are also seen in PD, which inevitably emerge through the disease progression and are often under-recognized and untargeted. Aims: We studied the prevalence of NMS in PD and their impact on health-related quality of life (HRQoL). Materials and Methods:...
Annals of Indian Academy of Neurology : 2015 - 18(2)
Wed Jun 10, 2020 00:00
Opsoclonus in scrub typhus
Divyani Garg, Rajinder K DhamijaAnnals of Indian Academy of Neurology 2020 23(3):367-367
Annals of Indian Academy of Neurology : 2015 - 18(2)
Wed Jun 10, 2020 00:00
Relation between the novel marker monocyte to high-density lipoprotein cholesterol ratio and severity in multiple sclerosis
Ersin Kasim Ulusoy, Ömer Faruk Bolattürk, Mehmet Fatih GölAnnals of Indian Academy of Neurology 2020 23(3):275-279 Introduction: This study aimed to establish whether there is a relationship between the Monocyte to High-Density Lipoprotein Cholesterol (HDL-C) ratio (MHR) and severity of disease, and whether it can be used as a new marker for predicting disability in Multiple Sclerosis (MS), a chronic disease, which is usually contracted in early adolescence. Methods: 184 patient subjects who had...
Annals of Indian Academy of Neurology : 2015 - 18(2)
Wed Jun 10, 2020 00:00
SACS mutation-positive autosomal recessive spastic ataxia of charlevoix saguenay (ARSACS) from Kerala
S Sheetal, S Amith Kumar, P ByjuAnnals of Indian Academy of Neurology 2020 23(3):374-376
Annals of Indian Academy of Neurology : 2015 - 18(2)
Wed Jun 10, 2020 00:00
Deep white matter lesions with persistent diffusion restriction on MRI as a diagnostic clue: Neuroimaging of a turkish family with hereditary diffuse leukoencephalopathy with spheroids and literature review
Halil Onder, Kader Karli Oguz, Figen Soylemezoglu, Kubilay VarliAnnals of Indian Academy of Neurology 2020 23(3):280-288 Background: Hereditary diffuse leukoencephalopathy with spheroids (HDLS), first described in 1984 is a rare disorder. Generally, it presents at adulthood with dementia, motor impairment, extrapyramidal abnormalities, and epilepsy. Definitive diagnosis is made by brain biopsy. Neuroimaging studies have revealed confluent white matter lesions predominantly in the frontal lobes,...
Annals of Indian Academy of Neurology : 2015 - 18(2)
Wed Jun 10, 2020 00:00
A syndrome of progressive ataxia and palatal tremor (PAPT) in a patient with hypertrophic olivary degeneration
Ismail Ibrahim Ismail, John K John, Jasem Y Al-HashelAnnals of Indian Academy of Neurology 2020 23(3):381-383
Annals of Indian Academy of Neurology : 2015 - 18(2)
Wed Jun 10, 2020 00:00
Parkinsonian and cerebellar phenotypes of probable MSA: An insight in to prognostic factors based on autonomic functions
Malligurki Raghurama Rukmani, Ravi Yadav, Binukumar Bhaskarapillai, Pramod Kumar Pal, Talakad N SathyaprabhaAnnals of Indian Academy of Neurology 2020 23(3):289-295 Background: Multiple system atrophy is an adult-onset, sporadic, neurodegenerative disorder with parkinsonian (MSA-P) and cerebellar (MSA-C) subtypes. Objective: We aimed to elucidate differences in prognostic factors between MSA subtypes. Methods: The study population comprised 45 probable MSA patients (MSA-P = 22; MSA-C = 23) and...
Annals of Indian Academy of Neurology : 2015 - 18(2)
Wed Jun 10, 2020 00:00
Sphenoid sinusitis as a possible cause of trismus
Jong-Mok Lee, Myong H Hahm, Ho-Sung Ryu, Yang-Ha HwangAnnals of Indian Academy of Neurology 2020 23(3):387-389
Annals of Indian Academy of Neurology : 2015 - 18(2)
Wed Jun 10, 2020 00:00
Normative data for cortical evoked response audiometry of a heterogeneous Indian population and its comparison with behavioral audiometry
Priyanka Misale, Anjali Lepcha, Philip Thomas, Swapna Sebastian, Tunny SebastianAnnals of Indian Academy of Neurology 2020 23(3):296-302 Objective: The objective of the study is to establish normative values of cortical evoked response audiometry (CERA) in a heterogeneous Indian population and correlate CERA threshold with pure tone audiometric (PTA) threshold values. Materials and Methods: A prospective study was carried out on 31 volunteers (n = 62) who had no otological or neurological complaints....
Annals of Indian Academy of Neurology : 2015 - 18(2)
Wed Jun 10, 2020 00:00
Autosomal recessive spastic ataxia of charlevoix-saguenay (ARSACS): Case report of a novel nonsense mutation in the SACS gene
Ayush Agarwal, Divyani Garg, Akash Kharat, Abdul QaviAnnals of Indian Academy of Neurology 2020 23(3):395-397
Annals of Indian Academy of Neurology : 2015 - 18(2)
Wed Jun 10, 2020 00:00
Clinical profile and outcome of brain abscess in children from a tertiary care hospital in Eastern Uttar Pradesh
Rajniti Prasad, John Biswas, Kulwant Singh, Om P Mishra, Ankur SinghAnnals of Indian Academy of Neurology 2020 23(3):303-307 Background and Aims: Brain abscess is a serious and dreadful disease presenting at tertiary centre. The objective of this study was to look into the clinical profile, predisposing conditions, microbiology and outcome of children suffering from brain abscess. Methods: 30 children up to 18 years with clinical and imaging evidence of brain abscess were taken for study. Patients...
Annals of Indian Academy of Neurology : 2015 - 18(2)
Wed Jun 10, 2020 00:00
Age-stratified normative cognitive scores in urban and rural populations: A community-based study
Uma Sundar, Ameeta Mukhopadhyay, Nilesh Shah, Balkrishna AdsulAnnals of Indian Academy of Neurology 2020 23(3):403-405
Annals of Indian Academy of Neurology : 2015 - 18(2)
Wed Jun 10, 2020 00:00
The effect of dual tasking and deep brain stimulation frequency parameters on gait in advanced Parkinson's disease
Swetha Tandra, Rukmini M Kandadai, Ravi P Peddisetty, KJ Babu, T Surya Prabha, SA Jabeen, AK Meena, Rupam BorgohainAnnals of Indian Academy of Neurology 2020 23(3):308-312 Objective: To study the effect of dual tasking and deep brain stimulation frequency parameters on gait in advanced Parkinson's disease Materials and Methods: This is an open label interventional study evaluating 40 post STN-DBS patients with gait disturbances. All patients were diagnosed as PD by a movement disorder specialist...
Annals of Indian Academy of Neurology : 2015 - 18(2)
Wed Jun 10, 2020 00:00
Subacute sclerosing panencephalits mimicking anti-NMDA receptor encephalitis
Shilpa Devamare, Kavish Ihtisham, Himani Bhasin, Vikram Bhasker, Suvasini Sharma, Manjari TripathiAnnals of Indian Academy of Neurology 2020 23(3):411-413
Annals of Indian Academy of Neurology : 2015 - 18(2)
Wed Jun 10, 2020 00:00

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