Omphalocele is a congenital malformation of the abdominal wall consisting of a protrusion of the abdominal contents at the base of the umbilical cord. It has a high association with genetic and structural defects; however, if the latter is ruled out, its prognosis improves significantly. Prenatal diagnosis has a key role in this condition as omphalocele can be diagnosed by ultrasound in the first trimester scan, enabling a coordinated approach strategy to achieve the best perinatal results. We present...
Wed Jun 10, 2020 16:05
Abstract Leber hereditary optic neuropathy and Dominant optic atrophy are associated with a selective loss of retinal ganglion cells (RGC). A subtype of RGC is responsible for light‐dependent physiological processes. The aim of our study was to evaluate both subjective and objective sleep parameters in 36 (18 males; mean age 33.8 ± 16.7) symptomatic/asymptomatic subjects with Leber hereditary optic neuropathy and dominant optic atrophy. The Pittsburgh Sleep Quality Index (PSQI), the Epworth Sleepiness...
Wed Jun 10, 2020 19:09
Abstract Background Temporomandibular joint osteoarthritis (TMJOA) is a progressive degenerative disease caused by imbalance between anabolic and catabolic stimuli. Objective The aim of this study was to evaluate histopathological changes, collagen degeneration, and the expression of eleven TMJOA biomarkers in articular discs. Methods Specimens were obtained from eight female patients submitted to discectomy. Discs were divided into anterior band (AB), intermediate zone (IZ), and...
Wed Jun 10, 2020 16:19
Journal of Neurotrauma, Ahead of Print.
Wed Jun 10, 2020 10:00
Journal of Neurotrauma, Ahead of Print.
Tue Jun 09, 2020 10:00
Soft Robotics, Ahead of Print.
Wed Jun 10, 2020 10:00
Thyroid, Ahead of Print.
Wed Jun 10, 2020 10:00
Thyroid, Ahead of Print.
Wed Jun 10, 2020 10:00
Thyroid, Ahead of Print.
Wed Jun 10, 2020 10:00
Thyroid, Ahead of Print.
Wed Jun 10, 2020 10:00
Alternative splicing is responsible for much of the transcriptomic and proteomic diversity observed in eukaryotes and involves combinatorial regulation by many cis-acting elements and trans-acting factors. SR and hnRNP splicing regulatory proteins often have opposing effects on splicing efficiency depending on where they bind the pre-mRNA relative to the splice site. Position-dependent splicing repression occurs at spliceosomal E-complex, suggesting that U1 snRNP binds but cannot facilitate higher...
Wed Jun 10, 2020 20:01
The majority of mouse and human genes are subject to alternative cleavage and polyadenylation (APA), which most often leads to the expression of two or more alternative length 3' untranslated region (3' UTR) mRNA isoforms. In neural tissues, there is enhanced expression of APA isoforms with longer 3' UTRs on a global scale, but the physiological relevance of these alternative 3' UTR isoforms is poorly understood. Calmodulin 1 (Calm1) is a key integrator of calcium signaling that generates short (Calm1-S)...
Wed Jun 10, 2020 19:23
Surgical Infections, Ahead of Print.
Wed Jun 10, 2020 10:00
Surgical Infections, Ahead of Print.
Wed Jun 10, 2020 10:00
Abstract The brain’s intrinsic activity plays a fundamental role in its function. In normal conditions this activity is responsive to behavioural context, changing as an individual switches between directed tasks and task‐free conditions. A key feature of such changes is the movement of the brain between corresponding critical and sub‐critical states, with these dynamics supporting efficient cognitive processing. Breakdowns in processing efficiency can occur, however, in brain disorders such as...
Wed Jun 10, 2020 16:15
For a meal presentation that looks as good as it tastes. (Amazon/)When you’re throwing together last night’s leftovers, it’s tempting to nestle a rice dish next to some lightly dressed greens and call it a trendy bowl. But unlike a bowl, which is generally served fresh at the table, your lunch will likely be jostled together on the route to work or school. Japanese bento boxes offer a sophisticated solution that ensures that spicy salad dressing will stay out of your main dish, and that pickle juice...
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It’s hot, but don’t sweat it. (Akshar Dave via Unsplash/)People who have ceiling fans in addition to air conditioners know that the power to circulate air throughout your space can help ensure comfort. But for many apartment dwellers, one person’s ceiling fan is another person’s nightmare when the vibrations from the fan downstairs cause an annoying hum in the apartment just above. In contrast, floor fans can be moved to the perfect spot, and can be positioned to efficiently direct air while you’re...
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A police body camera. (Lutsenko Oleksandr / Deposit Photos /)In the wake of George Floyd and Breonna Taylor’s deaths, the US is focusing on police reform. Among new measures on the table is an emphasis on the cameras that police officers wear on their bodies. In fact, a new proposal on Monday from Congressional Democrats makes supporting the tech a key point.The Justice in Policing Act of 2020 would make it compulsory for “federal uniformed police officers to wear body cameras.” It would also require...
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Don't be square. (David von Diemar via Unsplash/)While the fundamentals of ice don’t change—combine two parts hydrogen and one part oxygen, then chill until solid—the way we shape that ice is limitless. Sometimes these shapes serve a function, such as large blocks or spheres that are slower to melt and don’t dilute our drinks. And in other cases, odd shapes add a touch of whimsy to our glasses. Anyone can enjoy a cool beverage on a warm day, but here’s a chance to do it with some style.Hexagonal...
Wed Jun 10, 2020 22:21
Not all of New Zealand's anti-COVID tactics can be applied here, but they can still teach us plenty. (Unsplash/)Follow all of PopSci’s COVID-19 coverage here, including news on federal policies, how to avoid spreading illness while participating in protests, and a state-by-state breakdown of confirmed cases.On June 8, New Zealand announced that its last person known to be infected with COVID-19 has recovered. This means that, at least for now, the island nation has eliminated the disease. The country...
Wed Jun 10, 2020 21:00
A cut above the rest. (Creatv Eight via Unsplash/)Sharp knives in a variety of types are a must-have for home chefs paring fresh garnishes and perfectly sliced vegetables. With pro-level knife ownership comes a responsibility to keep pointy objects carefully stored, both to protect the blade from dings that blunt its usefulness and to protect others from unexpected jabs. These four knife blocks provide options that keep you safer in style, so you have absolutely no excuses for cavalierly tossing...
Wed Jun 10, 2020 20:45
Prices for solar panels and installations have plummeted in recent years. (Pexels/)Jeremy Deaton writes for Nexus Media. You can follow him @deaton_jeremy. This story was published in partnership with Nexus Media, a syndicated newswire covering climate, energy, policy, art, and culture.Experts disagree about how fast the US can replace coal and gas-fired power plants with zero-carbon electricity. Some say we can shift to 100 percent clean power by 2050 with little friction and minimal cost. Others...
Wed Jun 10, 2020 18:18
A convenient and compostable way to caffeinate. (Farhan Khan via Unsplash/)Keurig machines are hard to beat in terms of convenience, but can you get truly exquisite coffee from a pod? Yes. Specialty coffee makers all over the globe have adopted the pod as an efficient vehicle for bringing their brews to your mugs. If making a french press or pour over in the morning slows you down, opt for a high quality first fix at the push of a button. If you have concerns about K-cups due to their carbon footprint,...
Wed Jun 10, 2020 17:31
Bring your cooking to the small screen. (Sander Dalhuisen via Unsplash/)You’ve spent your time during lockdown improving your cooking game, and now, having mastered your stove, oven, and mixer, it’s time to put together a video kit that can help you showcase your skill with a grill, your chopping chops, and your plating proficiency. This mid-tier kit can compete with much of what you’ll find on the better blogging sites and YouTube channels, but it still leaves room to grow with your production...
Wed Jun 10, 2020 16:07
Having sex with people outside your social distancing circle can be made safer by showering before and after, avoiding contact with other bodily fluids (including kissing), and wearing a mask during sex. (Pexels/)Social distancing in order to slow the spread of COVID-19 has radically changed the way we live. But that doesn’t stop people from needing each other, in every sense of the word. This has healthcare practitioners considering how to talk to patients about an entirely new kind of safe sex....
Wed Jun 10, 2020 15:00
Abstract Background Optic Pathway Gliomas (OPG) are the most common brain tumor in Neurofibromatosis 1 patients (NF1). They are found along the optic pathway and may involve the optic nerves, chiasm, retro-chiasmatic structures, and the optic radiations. NF1 associate OPG (NF1-OPG) have variable presentation, disease course and response to treatment. The optimal management is patient-specific and should be tailored by a multidisciplinary...
03:00
Abstract Neurofibromatosis type 1 (NF1) is one of the most prevalent rare diseases. Whilst penetrance is complete by adulthood, its expressivity is extremely variable with potential multi-systemic complications. Although NF1 is diagnosed clinically, molecular analysis has a part to play in the screening of atypical forms and in genetic counselling. The screening of complications is primarily based on a full annual clinical examination and an ophthalmological examination. Targeted...
Wed Jun 10, 2020 03:00
Purpose. Natural killer (NK) cells exert antibody-dependent cell cytotoxicity (ADCC). We infused expanded, activated autologous NK cells to potentiate trastuzumab-mediated ADCC in patients with HER2-positive malignancies. Patients and Methods. In a Phase I trial, patients with treatment-refractory HER2-positive solid tumors received trastuzumab, with or without bevacizumab, and autologous NK cells expanded by 10-day co-culture with K562-mb15-41BBL cells. Primary objectives included safety and recommended...
Wed Jun 10, 2020 16:36
Purpose: The choice of therapy for breast cancer patients is often based on clinicopathological parameters, hormone receptor status, and HER2 amplification. To improve individual prognostication and tailored treatment decisions, we combined clinicopathological prognostic data with genome instabilty profiles established by quantitative measurements of the DNA content. Experimental Design: We retrospectively assessed clinical data of 4,003 breast cancer patients with a minimum postoperative follow-up...
Wed Jun 10, 2020 16:36
Purpose: Various biomarkers have been proposed for sunitinib therapy in GIST. However, the lack of 'real-life' comparative studies hampers the selection of the most appropriate one. We therefore set up a pharmacometric simulation framework to compare each proposed biomarker. Experimental Design: Models describing relations between sunitinib exposure, adverse events (HFS, fatigue, hypertension and neutropenia), sVEGFR-3 and overall survival were connected to evaluate the differences in survival and...
Wed Jun 10, 2020 16:36
Analyst, 2020, Accepted ManuscriptDOI: 10.1039/D0AN00648C, PaperLujie Yang, Quanqing Zhang, Yuanyu Huang, Ling Lin, Hartmut Schlüter, Ke Wang, Cuiping Zhang, Pengyuan Yang, Hongxiu YuGlycosylation is an important mechanism of secondary protein processing. Large-scale profiling of glycopeptides released by proteolytic digestion of glycoproteins from biologic samples with complex compositions is limited due to their...The content of this RSS Feed (c) The Royal Society of Chemistry
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Analyst, 2020, Advance ArticleDOI: 10.1039/D0AN00564A, PaperSuchanat Boonkaew, Prinjaporn Teengam, Sakda Jampasa, Sirirat Rengpipat, Weena Siangproh, Orawon ChailapakulA label-free electrochemical immunosensor for detecting ferritin using a paper-based analytical device (ePAD) was created.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry
Wed Jun 10, 2020 02:00
Analyst, 2020, Accepted ManuscriptDOI: 10.1039/D0AN00645A, Critical ReviewShaoqing Dong, Lijuan Zhang, Yanjun Lin, Caifeng Ding, Chao LuHClO/ClO− is the most effective antibacterial active oxygen in neutrophils. However, its excessive existence often leads to the destruction of human physiological mechanisms. In recent years, the developed luminescence probes...The content of this RSS Feed (c) The Royal Society of Chemistry
Wed Jun 10, 2020 02:00
Analyst, 2020, Accepted ManuscriptDOI: 10.1039/D0AN00617C, PaperZhengbo Chen, Bin Liu, Ying Chen, Mingqian Zhang, Xia ZuoHere we report a simple but effective nose/tongue-mimic sensor array based on HAuCl4/3,3',5,5'-tetramethylbenzidine (TMB) for colorimetric discrimination and determination of antioxidants. Two concentrations of HAuCl4 were employed as receptor units...The content of this RSS Feed (c) The Royal Society of Chemistry
Wed Jun 10, 2020 02:00
Analyst, 2020, Accepted ManuscriptDOI: 10.1039/D0AN00205D, PaperZhiqi Ge, Mingyu Ma, Gang Chang, Meijun Chen, Hanping He, Xiuhua Zhang, Shengfu WangA new way to detect GAA trinucleotide repeats (TNR) based on solution-gated graphene transistor (SGGT) with high performance was developed. Friedreich's ataxia (FRDA) is a neurodegenerative disease where the first...The content of this RSS Feed (c) The Royal Society of Chemistry
Wed Jun 10, 2020 02:00
Purpose of review The purpose of this review is to provide an update on current practice and trends in fat graft surgery. The present review covers postoperative fat graft survival and phases, recipient bed and fat tissue enrichment issues, the spectrum of clinical applications in the cleft-craniofacial field, surgical techniques, and predictive factors for different outcomes. Recent findings Current investigations have led to a better understanding of fat graft survival and postoperative...
Mon Jun 08, 2020 03:00
Purpose of review Ballistic trauma represents a small proportion of injuries to the craniomaxillofacial (CMF) region, even in societies where the availability of firearms is more prevalent. The aim of this article is to review current opinion in the assessment and management of ballistic injuries sequentially from primary survey to definitive reconstruction. Recent findings For mandibular fractures because of ballistic trauma, load-bearing fixation remains the mainstay in the treatment. The...
Mon Jun 08, 2020 03:00
Purpose of review Cleft lip with or without palate is one of the most common pediatric birth anomalies. Patients with cleft palate often have speech difficulties from underlying anatomical defects that can persist after surgery. This significantly impacts child development. There is a lack of evidence exploring, which surgical techniques optimize speech outcomes. The purpose of this update is to report on recent literature investigating how to optimize speech outcomes for cleft palate. Recent...
Mon Jun 08, 2020 03:00
British Journal of Cancer, Published online: 11 June 2020; doi:10.1038/s41416-020-0916-5First-in-human study of the PARP/tankyrase inhibitor E7449 in patients with advanced solid tumours and evaluation of a novel drug-response predictor
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