Related ArticlesImpact of Alcohol Consumption on Snoring and Sleep Apnea: A Systematic Review and Meta-analysis. Otolaryngol Head Neck Surg. 2020 Jun 09;:194599820931087 Authors: Burgos-Sanchez C, Jones NN, Avillion M, Gibson SJ, Patel JA, Neighbors J, Zaghi S, Camacho M Abstract OBJECTIVE: To systematically review the international literature for studies evaluating the effect of alcohol consumption on the occurrence and severity of snoring and obstructive...
Wed Jun 10, 2020 13:12
Related ArticlesLong-Term Changes in Sleep Disordered Breathing in Renal Transplant Patients: Relevance of the BMI. J Clin Med. 2020 Jun 04;9(6): Authors: Mallamaci F, Tripepi R, D'Arrigo G, Porto G, Versace MC, Marino C, Sanguedolce MC, Tripepi G, Zoccali C Abstract Sleep disordered breathing (SDB), as defined by the Apnea Hypopnea Index (AHI), is a highly prevalent disturbance in end stage kidney disease. SDB improves early on after renal transplantation...
Wed Jun 10, 2020 13:12
Related ArticlesAmbulatory Blood Pressure Monitoring in Pediatrics. Curr Hypertens Rep. 2019 07 26;21(9):71 Authors: Patel SS, Daniels SR Abstract PURPOSE OF REVIEW: This is a review of ambulatory blood pressure monitoring (ABPM) use in pediatrics, summarizing current knowledge and uses of ABPM. RECENT FINDINGS: Updated guidelines from the American Academy of Pediatrics have emphasized the value of ABPM. ABPM is necessary to diagnose white...
Wed Jun 10, 2020 13:12
Purpose Treatment with abiraterone acetate or enzalutamide is one of the approved approaches in men with metastatic castration-resistant prostate cancer (mCRPC) in the post-docetaxel setting. However, a significant fraction of patients do not respond to treatment, and we aimed to determine their characteristics. Methods From April 2015 to May 2019, 71 patients with mCRPC were treated with abiraterone acetate (N = 34) or enzalutamide (N = 37) at our institution. Resistance to treatment...
Sun Jun 07, 2020 03:00
Related ArticlesAccuracy of pathologic diagnosis for thymic epithelial tumors: a brief report from an Italian reference Center. Lung Cancer. 2020 May 27;146:66-69 Authors: Galli G, Trama A, Abate-Daga L, Brambilla M, Garassino MC, Fabbri A Abstract Objectives - Rare tumors are diagnostic challenges for pathologists. Consultation or referral to Centers with expertise is crucial for the right diagnosis. This is particularly true for Thymic Epithelial Tumors...
Wed Jun 10, 2020 15:14
Related ArticlesLong noncoding RNAs as potential biomarkers in retinoblastoma: a systematic review and meta-analysis. Cancer Cell Int. 2020;20:201 Authors: Wu J, Qian D, Sun X Abstract Background: Retinoblastoma is the most common malignant rare intraocular tumor of childhood. Long noncoding RNAs (lncRNAs) have been reported participating in its progression, but their significance remains inconclusive. We conducted this systematic review and meta-analysis...
Wed Jun 10, 2020 13:06
Related ArticlesR269C variant of ESR1: high prevalence and differential function in a subset of pancreatic cancers. BMC Cancer. 2020 Jun 08;20(1):531 Authors: Boldes T, Merenbakh-Lamin K, Journo S, Shachar E, Lipson D, Yeheskel A, Pasmanik-Chor M, Rubinek T, Wolf I Abstract BACKGROUND: Estrogen receptor α (ESR1) plays a critical role in promoting growth of various cancers. Yet, its role in the development of pancreatic cancer is not well-defined. A less...
Wed Jun 10, 2020 13:06
Related ArticlesAn Overview of Candidate Therapeutic Target Genes in Ovarian Cancer. Cancers (Basel). 2020 Jun 04;12(6): Authors: Alexandrova E, Pecoraro G, Sellitto A, Melone V, Ferravante C, Rocco T, Guacci A, Giurato G, Nassa G, Rizzo F, Weisz A, Tarallo R Abstract Ovarian cancer (OC) shows the highest mortality rate among gynecological malignancies and, because of the absence of specific symptoms, it is frequently diagnosed at an advanced stage,...
Wed Jun 10, 2020 13:06
Related ArticlesPotential Onco-Suppressive Role of miR122 and miR144 in Uveal Melanoma through ADAM10 and C-Met Inhibition. Cancers (Basel). 2020 Jun 04;12(6): Authors: Amaro A, Croce M, Ferrini S, Barisione G, Gualco M, Perri P, Pfeffer U, Jager MJ, Coupland SE, Mosci C, Filaci G, Fabbi M, Queirolo P, Gangemi R Abstract Uveal melanoma (UM) is a rare tumor of the eye that leads to deadly metastases in about half of the patients. ADAM10 correlates with...
Wed Jun 10, 2020 13:06
Related ArticlesAnal Cancer. Surg Clin North Am. 2020 Jun;100(3):629-634 Authors: Young AN, Jacob E, Willauer P, Smucker L, Monzon R, Oceguera L Abstract Anal cancer is a rare cancer, comprising less than 5% of gastrointestinal tract malignancies. Diagnosis of anal canal cancer can be difficult given that presenting symptoms are similar to those of benign anorectal diseases. General surgeons who encounter suspected anal canal cancer need to have a...
Wed Jun 10, 2020 13:06
Related ArticlesSolitary metastasis to the penis from prostate adenocarcinoma - a case report. J Radiol Case Rep. 2019 Dec;13(12):20-28 Authors: Wong HL, Shi H, Koh LT Abstract Penile metastasis from prostate adenocarcinoma is rare and the disease is usually disseminated at presentation. We present a case of an 83-year-old man with solitary metastasis to the penis from prostate adenocarcinoma. The clinical presentation and imaging features of penile...
Wed Jun 10, 2020 13:06
Related ArticlesExtramedullary multiple myeloma with central nervous system and multiorgan involvement: Case report and literature review. J Radiol Case Rep. 2019 Dec;13(12):1-12 Authors: Lee W, Chen RC, Swaminathan SK, Ho CL Abstract Multiple myeloma is a hematologic malignancy due to monoclonal plasma cell proliferation. It is usually confined to the bone marrow, although extramedullary involvement is known to occur in almost any organ system; myelomatous...
Wed Jun 10, 2020 13:06
Related ArticlesNasolabial cyst: case report and review of management options. BMC Surg. 2020 Jan 10;20(1):10 Authors: Almutairi A, Alaglan A, Alenezi M, Alanazy S, Al-Wutayd O Abstract BACKGROUND: Nasolabial cysts are rare, non-odontogenic, soft-tissue cysts that develop between the upper lip and nasal vestibule with an overall incidence of 0.7% out of all maxillofacial cysts. The predominant presentation of a nasolabial cyst is a painless localized...
Wed Jun 10, 2020 13:06
Related ArticlesClinical Features of Head and Neck Solitary Extramedullary Plasmacytoma in Taiwan. In Vivo. 2020 Jan-Feb;34(1):261-265 Authors: Lai CY, Hsieh HH, Chen HK, Chao CY, Hua CH, Tai CJ, Bau DT, Tsai MH, Shih LC Abstract BACKGROUND/AIM: Solitary extramedullary plasmacytoma (SEP) is a rare, malignant plasma-cell tumor, which mainly occurs in the head and neck regions. Globally the disease has been rarely happening up to 2019, with only about...
Wed Jun 10, 2020 13:06
Related ArticlesLow-grade Fibromyxoid Sarcoma: Treatment Outcomes and Efficacy of Chemotherapy. In Vivo. 2020 Jan-Feb;34(1):239-245 Authors: Chamberlain F, Engelmann B, Al-Muderis O, Messiou C, Thway K, Miah A, Zaidi S, Constantinidou A, Benson C, Gennatas S, Jones RL Abstract BACKGROUND: Low-grade fibromyxoid sarcoma (LGFMS) is a rare sarcoma subtype with a generally indolent pattern of clinical behaviour, but treatments for advanced disease are limited....
Wed Jun 10, 2020 13:06
Related ArticlesMetastasis and the evolution of dispersal. Proc Biol Sci. 2019 12 04;286(1916):20192186 Authors: Tissot T, Massol F, Ujvari B, Alix-Panabieres C, Loeuille N, Thomas F Abstract Despite significant progress in oncology, metastasis remains the leading cause of mortality of cancer patients. Understanding the foundations of this phenomenon could help contain or even prevent it. As suggested by many ecologists and cancer biologists, metastasis...
Wed Jun 10, 2020 13:06
Related ArticlesRare Pulmonary Neuroendocrine Cells Are Stem Cells Regulated by Rb, p53, and Notch. Cell. 2019 10 03;179(2):403-416.e23 Authors: Ouadah Y, Rojas ER, Riordan DP, Capostagno S, Kuo CS, Krasnow MA Abstract Pulmonary neuroendocrine (NE) cells are neurosensory cells sparsely distributed throughout the bronchial epithelium, many in innervated clusters of 20-30 cells. Following lung injury, NE cells proliferate and generate other cell types...
Wed Jun 10, 2020 13:06
Related ArticlesDiaphragmatic Peritoneal Stripping Versus Full-Thickness Resection in CRS/HIPEC: Is There a Difference? Ann Surg Oncol. 2020 Jan;27(1):250-258 Authors: Sullivan BJ, Bekhor EY, Carpiniello M, Leigh NL, Pletcher ER, Solomon D, Magge DR, Sarpel U, Labow DM, Golas BJ Abstract BACKGROUND: Pleural recurrence after cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) is rare and poorly delineated. Specifically,...
Wed Jun 10, 2020 13:06
Related ArticlesThree-year follow-up from a phase 3 study of SB3 (a trastuzumab biosimilar) versus reference trastuzumab in the neoadjuvant setting for human epidermal growth factor receptor 2-positive breast cancer. Eur J Cancer. 2019 10;120:1-9 Authors: Pivot X, Pegram M, Cortes J, Lüftner D, Lyman GH, Curigliano G, Bondarenko I, Yoon YC, Kim Y, Kim C Abstract BACKGROUND: We assessed long-term cardiac safety and efficacy in patients with human epidermal...
Wed Jun 10, 2020 13:06
Related ArticlesImmune checkpoint blocker-related sarcoid-like granulomatous inflammation: a rare adverse event detected in lymph node aspiration cytology of patients treated for advanced malignant melanoma. Hum Pathol. 2019 09;91:69-76 Authors: Rodriguez EF, Lipson E, Suresh K, Cappelli LC, Monaco SE, Maleki Z Abstract Immune checkpoint inhibitors are a major breakthrough in the field of oncology. Targets for approved immune checkpoint inhibitors are...
Wed Jun 10, 2020 13:06
Related ArticlesFrom clinic to mechanism: Proteomics-based assessment of angiogenesis in adrenal pheochromocytoma. J Cell Physiol. 2019 12;234(12):22057-22070 Authors: Sun F, Zhuo R, Ma W, Yang D, Su T, Ye L, Xu D, Wang W Abstract Adrenal pheochromocytoma (PCC) is a very rare tumor that stems from chromaffin cells, which can develop into malignant tumor. During the operation, abundant blood vessels were often observed in PCC than other adrenal tumors,...
Wed Jun 10, 2020 13:06
Related ArticlesDesmoplastic Small Round Cell Tumor: Long-Term Complications After Cytoreduction and Hyperthermic Intraperitoneal Chemotherapy. Ann Surg Oncol. 2020 Jan;27(1):171-178 Authors: Stiles ZE, Murphy AJ, Anghelescu DL, Brown CL, Davidoff AM, Dickson PV, Glazer ES, Bishop MW, Furman WL, Pappo AS, Lucas JT, Deneve JL Abstract BACKGROUND: Desmoplastic small round cell tumor (DSRCT) is a rare intra-abdominal soft tissue sarcoma affecting adolescents...
Wed Jun 10, 2020 13:06
Related ArticlesTreatment patterns, health care resource use and outcomes in metastatic triple-negative breast cancer in Germany: retrospective chart review study (OBTAIN). Curr Med Res Opin. 2019 08;35(8):1405-1414 Authors: Schilling J, Busch S, Heinrich G, Heinig K, Martin Kurbacher C, Klare P, Pöllinger B Abstract Background: There is limited data on the real-life situation and outcomes of patients with metastatic triple-negative breast cancer (mTNBC)...
Wed Jun 10, 2020 13:06
Related ArticlesThe Risk of Heart Failure and Other Cardiovascular Hospitalizations After Early Stage Breast Cancer: A Matched Cohort Study. J Natl Cancer Inst. 2019 08 01;111(8):854-862 Authors: Abdel-Qadir H, Thavendiranathan P, Austin PC, Lee DS, Amir E, Tu JV, Fung K, Anderson GM Abstract BACKGROUND: Data are limited regarding the risk of heart failure (HF) requiring hospital-based care after early stage breast cancer (EBC) and its relationship...
Wed Jun 10, 2020 13:06
Related ArticlesHigh-grade squamous cell carcinoma arising in a tibial adamantinoma. Hum Pathol. 2019 09;91:123-128 Authors: Dashti NK, Howe BM, Inwards CY, Fritchie KJ, Carter JM Abstract Adamantinoma of the long bones is a rare, typically low-grade malignant tumor that frequently involves the tibia. Radiographically, adamantinoma is characteristically a lytic, intracortical, and expansile lesion with variable margins. Histologically, adamantinoma...
Wed Jun 10, 2020 13:06
The handling, capturing, butchering, and transportation of wildmeat can increase the risk of zoonoses, including the Ebola virus disease (EVD). Guinea, West Africa, experienced a catastrophic outbreak of EVD between 2013 and 2016. This study aimed to understand local people’s sources of information concerning EVD, their perceptions of potential wildlife carriers of EVD and their meat and fish consumption behavior during this period. A semi-structured questionnaire was administered to 332 participants...
Wed Jun 10, 2020 03:00
Lectin receptor-like kinases (LecRLKs) are involved in responses to diverse environmental stresses and pathogenic microbes. A comprehensive acknowledgment of the family members in potato (Solanum tuberosum) genome is largely limited until now. In total, 113 potato LecRLKs (StLecRLKs) were first identified, including 85 G-type, 26 L-type and 2 C-type members. Based on phylogenetic analysis, StLecRLKs were sub-grouped into seven clades, including C-type, L-type, G-I, G-II, G-III G-IV and G-V. Chromosomal...
Wed Jun 10, 2020 03:00
P-glycoprotein (P-gp) is one of the highly expressed cancer cell efflux transporters that cause the failure of chemotherapy. To reverse P-gp induced multidrug resistance, we employed a flaxseed-derived lignan; secoisolariciresinol (SECO) that acts as an inhibitor of breast cancer resistance protein; another efflux transporter that shares some substrate/inhibitor specificity with P-gp. Molecular dynamics (MD) simulation identified SECO as a possible P-gp inhibitor. Comparing root mean square deviation...
Wed Jun 10, 2020 03:00
Restriction site Associated DNA Sequencing (RAD-Seq) is a technique characterized by the sequencing of specific loci along the genome that is widely employed in the field of evolutionary biology since it allows to exploit variants (mainly Single Nucleotide Polymorphism—SNPs) information from entire populations at a reduced cost. Common RAD dedicated tools, such as STACKS or IPyRAD, are based on all-vs-all read alignments, which require consequent time and computing resources. We present an original...
Wed Jun 10, 2020 03:00
It has been hypothesised that high-intensity fires prevent fire-dependent fynbos from being replaced by fire-avoiding subtropical thicket on dune landscapes of the Cape Floristic Region (CFR). Recent extensive fires provided an opportunity to test this hypothesis. We posit that (1) fire-related thicket shrub mortality would be size dependent, with smaller individuals suffering higher mortality than larger ones; and (2) that survival and resprouting vigour of thicket shrubs would be negatively correlated...
Wed Jun 10, 2020 03:00
Background DNA-binding one zinc finger (Dof) proteins are plant-specific transcription factors important for seed development, hormone regulation, and defense against abiotic stress. Although drought stress is a key determinant of plant physiology and metabolic homeostasis, the role of Dof genes in different degrees of PEG6000-induced drought stress has received little attention. Methods Tea plants (Camellia sinensis)...
Wed Jun 10, 2020 03:00
Aluminum (Al) toxicity in acid soil is a worldwide agricultural problem that inhibits crop growth and productivity. However, the signal pathways associated with Al tolerance in plants remain largely unclear. In this study, tandem mass tag (TMT)-based quantitative proteomic methods were used to identify the differentially expressed plasma membrane (PM) proteins in Tamba black soybean (TBS) root tips under Al stress. Data are available via ProteomeXchange with identifier PXD017160. In addition, parallel...
Wed Jun 10, 2020 03:00
The decomposition of carrion is carried out by a suite of macro- and micro-organisms who interact with each other in a variety of ecological contexts. The ultimate result of carrion decomposition is the recycling of carbon and nutrients from the carrion back into the ecosystem. Exploring these ecological interactions among animals and microbes is a critical aspect of understanding the nutrient cycling of an ecosystem. Here we investigate the potential impacts that vertebrate scavenging may have on...
Wed Jun 10, 2020 03:00
Background Dextrorotatory borneol (D-borneol), a cyclic monoterpene, is widely used in traditional Chinese medicine as an efficient topical analgesic drug. Fresh leaves of Cinnamomum trees, e.g., C. burmannii and C. camphor, are the main sources from which D-borneol is extracted by steam distillation, yet with low yields. Insufficient supply of D-borneol has hampered its clinical use and production of patent remedies for a long time. Biological synthesis of D-borneol offers an additional...
Wed Jun 10, 2020 03:00
Global warming has a known impact on ecosystems but there is a lack of understanding about its impact on ecosystem processes. Net ecosystem productivity (NEP) and its components play a key part in the global carbon cycle. Analysing the impact of global warming on NEP will improve our understanding of how warming affects ecosystems. In our study, conducted in 2018, five warming treatments were manipulated (0 W, 500 W, 1000 W, 1500 W, and 3000 W) using three repetitions of far infrared open warming...
Wed Jun 10, 2020 03:00
Background Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been declared a pandemic by the World Health Organization, and the identification of effective therapeutic strategy is a need of the hour to combat SARS-CoV-2 infection. In this scenario, the drug repurposing approach is widely used for the rapid identification of potential drugs against SARS-CoV-2, considering viral and host factors. Methods We adopted a host transcriptome-based...
Wed Jun 10, 2020 03:00
Rejuvenation Research, Ahead of Print.
Mon Jun 08, 2020 10:00
Abstract ABBV-176 is an antibody-drug conjugate composed of the humanized antibody h16f (PR-1594804) conjugated to a highly potent, cytotoxic cross-linking pyrrolobenzodiazepine dimer (PBD; SGD-1882) targeting the prolactin receptor (PRLR), which is overexpressed in several solid tumor types. This phase 1, dose-escalation study (NCT03145909) evaluated the safety, pharmacokinetics, and preliminary activity of ABBV-176 in patients with advanced solid tumors likely to exhibit elevated...
Wed Jun 10, 2020 03:00
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