Abstract Osteogenesis Imperfecta (OI) is a rare genetic disorder also known as a “brittle bone disease”. Around 90% of OI patients harbor loss‐of‐function or dominant negative pathogenic variants in the COL1A1 and COL1A2 genes, which code for collagen type I α1 and α2 chains. Collagen‐related forms of the disorder are classified as Sillence OI types I‐IV. OI phenotype expression ranges from mild to lethal. The current study aims to evaluate associations between inter‐ and intrafamilial phenotypic...
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Abstract Pharmacogenetics (PGx) aims to improve drug therapy using the individual patients’ genetic make‐up. Little is known about the potential impact of PGx on the population level, possibly hindering implementation of PGx in clinical care. Therefore, we investigated how many patients use actionable PGx drugs, have actionable geno‐ or phenotypes and which patients could benefit the most of PGx testing. We included PGx recommendations from two international PGx consortia (CPIC and DPWG). Using...
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Abstract Drug lag – delayed approval or reimbursement – is a major barrier to accessing cutting‐edge drugs. Unlike approval lag, reimbursement lag is under‐researched. We investigated the key determinants of reimbursement lag under Taiwan National Health Insurance (NHI), and compared this lag to those in the United Kingdom (UK), Canada, Australia, Japan, and South Korea. Using retrospective data on 190 new NHI‐reimbursed drugs from 2007–2014, we studied reimbursement lag in Taiwan versus other...
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Abstract In vitro studies have indicated that the P2Y12 receptor antagonist selatogrel is a substrate of organic‐anion‐transporting‐polypeptide (OATP)1B1 and OATP1B3 that are known to mediate hepatic uptake. Selatogrel is primarily eliminated via the biliary route. Therefore, the study aim was to investigate the effect of rifampin‐mediated OATP1B1 and OATP1B3 inhibition on the pharmacokinetics (PK) of selatogrel. This was a randomized, double‐blind, placebo‐controlled, two‐period, cross‐over study...
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Deutetrabenazine (Austedo, Teva Pharmaceuticals) is a deuterated form of tetrabenazine. It is the first deuterated drug to receive US regulatory approval and is approved for treatment of chorea in Huntington’s disease and tardive dyskinesia. Two oral single dose studies comparing deutetrabenazine (25 mg) with tetrabenazine (25 mg) in healthy volunteers evaluated the impact of deuteration on pharmacokinetics of the active metabolites, alpha‐dihydrotetrabenazine (α‐HTBZ) and beta‐dihydrotetrabenazine...
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Abstract Imaging has not only an established role in screening and diagnosis of hepatocellular carcinoma (HCC) in patients with chronic liver inflammatory diseases, but also a crucial importance for patient stratification and treatment allocation, as well as for assessing treatment response. In the setting of increasing therapeutic options for HCC, the Barcelona Clinic Liver Cancer (BCLC) system still remains the most appropriate way to select candidate cohorts for best treatments....
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Abstract Purpose To evaluate the outcomes of emergency endovascular treatments for delayed bleeding after pancreaticobiliary surgery. Methods We retrospectively evaluated 21 patients (M:F = 13:8, median age = 64 years) undergoing 23 endovascular treatments, performed from 2010 to 2017 in a single center. Data collected were patient characteristics; surgery;...
Sat Mar 14, 2020 02:00
Abstract Purpose There is an unmet need for new systems with quantitative pancreatic imaging assessments to support better diagnosis and understand development of chronic pancreatitis (CP). The aims were to present such an approach for assessment of imaging features in CP, to apply this system in a multi-center cohort of CP patients (feasibility study), and to report inter-reader agreement between expert radiologists (validation study)....
Fri Mar 13, 2020 02:00
Abstract Currently there is a lot of interest in the use of a “biparametric” or “abbreviated” prostate MR protocol, which usually refers to removal of the dynamic contrast-enhanced (DCE) MRI, in the detection of clinically significant prostate cancer. In this article we describe the benefits of DCE as part of the PI-RADS lexicon, with particular reference to its role in PI-RADS V2 category 3 peripheral zone lesions. We also discuss the benefits of triplanar T2-weighted images,...
Fri Mar 13, 2020 02:00
Objective The aim of this study was to identify quantitative tools to classify the severity of trigonocephaly to guide surgical management and predict outcome. Methods We reviewed high-resolution computed tomography images of 59 patients with metopic synostosis. We assessed the craniofacial sutural pattern as well as interfrontal and metopic angles, and we related the frontal angulation degree with the sutural pattern, the surgical management, and clinical outcome. Results We identified...
Thu Mar 12, 2020 02:00
Purpose According to certain cancer treatment protocols, the response to induction chemotherapy of lymph node metastases based on radiographic measurements guides further management. The aim of this study is to verify the observation that cystic metastatic lymph nodes tend not to shrink as rapidly as solid metastatic lymph nodes in response to induction chemotherapy in patients with human papillomavirus–related oropharyngeal squamous cell carcinoma. Methods The lymphadenopathy in a cohort...
Thu Mar 12, 2020 02:00
Airway complications (ACs) after lung transplant remain a challenge and include bronchial dehiscence, bronchial stenosis, tracheobronchomalacia, infections, and bronchial fistulas. The spectrum of complications may coexist along a continuum and can be classified as early (1 month), and anastomotic or nonanastomotic. Bronchiolitis obliterans is the most common form of chronic lung allograft rejection. Airway compromise is seen in rare instances of lung torsion, and imaging may provide helpful diagnostic...
Thu Mar 12, 2020 02:00
Objective We compared 40- to 70-keV virtual monoenergetic to conventional computed tomography (CT) perfusion reconstructions with respect to quality of perfusion maps. Methods Conventional CT perfusion (CTP) images were acquired at 80 kVp in 25 patients, and 40- to 70-keV images were acquired with a dual-layer CT at 120 kVp in 25 patients. First, time-attenuation-curve contrast-to-noise ratio was assessed. Second, the perfusion maps of both groups were qualitatively analyzed by observers....
Thu Mar 12, 2020 02:00
Cancers, Vol. 12, Pages 696: Factors Associated with Health-Related Quality of Life in Women with Breast Cancer in the Middle East: A Systematic Review Cancers doi: 10.3390/cancers12030696 Authors: Rana El Haidari Linda Abou Abbas Virginie Nerich Amélie Anota Objectives: The aim of the present systematic review was to identify the factors that potentially influence health-related quality of life (HRQoL) in women with breast cancer (BC) in the Middle East. Methods: A...
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Cancers, Vol. 12, Pages 695: Emerging Role of Circulating Tumor Cells in Gastric Cancer Cancers doi: 10.3390/cancers12030695 Authors: Phung Thanh Huong Sanjeev Gurshaney Nguyen Thanh Binh Anh Gia Pham Huy Hoang Nguyen Xuan Thanh Nguyen Hai Pham-The Phuong-Thao Tran Khanh Truong Vu Nhuong Xuan Duong Claudio Pelucchi Carlo La Vecchia Paolo Boffetta Hung D. Nguyen Hung N. Luu With over 1 million incidence cases and more than 780,000...
Sun Mar 15, 2020 02:00
Cancers, Vol. 12, Pages 694: Establishment and Molecular Phenotyping of Organoids from the Squamocolumnar Junction Region of the Uterine Cervix Cancers doi: 10.3390/cancers12030694 Authors: Yoshiaki Maru Akira Kawata Ayumi Taguchi Yoshiyuki Ishii Satoshi Baba Mayuyo Mori Takeshi Nagamatsu Katsutoshi Oda Iwao Kukimoto Yutaka Osuga Tomoyuki Fujii Yoshitaka Hippo The metaplastic epithelium of the transformation zone (TZ) including the squamocolumnar...
Sun Mar 15, 2020 02:00
Cancers, Vol. 12, Pages 693: Imaging Features and Patterns of Metastasis in Non-Small Cell Lung Cancer with RET Rearrangements Cancers doi: 10.3390/cancers12030693 Authors: Subba R. Digumarthy Dexter P. Mendoza Jessica J. Lin Marguerite Rooney Andrew Do Emily Chin Beow Y. Yeap Alice T. Shaw Justin F. Gainor Rearranged during transfection proto-oncogene (RET) fusions represent a potentially targetable oncogenic driver in non-small cell lung cancer...
Sun Mar 15, 2020 02:00
Cancers, Vol. 12, Pages 692: Hypoxia-Induced Adaptations of miRNomes and Proteomes in Melanoma Cells and Their Secreted Extracellular Vesicles Cancers doi: 10.3390/cancers12030692 Authors: Geoffroy Walbrecq Odile Lecha Anthoula Gaigneaux Miriam R. Fougeras Demetra Philippidou Christiane Margue Milène Tetsi Nomigni François Bernardin Gunnar Dittmar Iris Behrmann Stephanie Kreis Reduced levels of intratumoural oxygen are associated with hypoxia-induced...
Sat Mar 14, 2020 02:00
Cancers, Vol. 12, Pages 691: A Comprehensive Molecular Characterization of the Pancreatic Neuroendocrine Tumor Cell Lines BON-1 and QGP-1 Cancers doi: 10.3390/cancers12030691 Authors: Kim B. Luley Shauni B. Biedermann Axel Künstner Hauke Busch Sören Franzenburg Jörg Schrader Patricia Grabowski Ulrich F. Wellner Tobias Keck Georg Brabant Sebastian M. Schmid Hendrik Lehnert Hendrik Ungefroren Experimental models of neuroendocrine tumor...
Sat Mar 14, 2020 02:00
Cancers, Vol. 12, Pages 690: Comparative Molecular Analysis of Cancer Behavior Cultured In Vitro, In Vivo, and Ex Vivo Cancers doi: 10.3390/cancers12030690 Authors: Nicholas R. Hum Aimy Sebastian Sean F. Gilmore Wei He Kelly A. Martin Aubree Hinckley Karen R. Dubbin Monica L. Moya Elizabeth K. Wheeler Matthew A. Coleman Gabriela G. Loots Current pre-clinical models of cancer fail to recapitulate the cancer cell behavior in primary tumors primarily...
Sat Mar 14, 2020 02:00
Cancers, Vol. 12, Pages 689: Cancer-testis Antigen FATE1 Expression in Adrenocortical Tumors Is Associated with A Pervasive Autoimmune Response and Is A Marker of Malignancy in Adult, but Not Children, ACC Cancers doi: 10.3390/cancers12030689 Authors: Mabrouka Doghman-Bouguerra Pascal Finetti Nelly Durand Ivy Zortéa S. Parise Silviu Sbiera Giulia Cantini Letizia Canu Ségolène Hescot Mirna M. O. Figueiredo Heloisa Komechen Iuliu Sbiera Gabriella...
Sat Mar 14, 2020 02:00
Cancers, Vol. 12, Pages 687: ATM-Deficient Cancers Provide New Opportunities for Precision Oncology Cancers doi: 10.3390/cancers12030687 Authors: Nicholas R. Jette Mehul Kumar Suraj Radhamani Greydon Arthur Siddhartha Goutam Steven Yip Michael Kolinsky Gareth J. Williams Pinaki Bose Susan P. Lees-Miller Poly-ADP ribose polymerase (PARP) inhibitors are currently used in the treatment of several cancers carrying mutations in the breast and ovarian...
Sat Mar 14, 2020 02:00
Cancers, Vol. 12, Pages 688: Long-Term Deleterious Effects of Short-term Hyperoxia on Cancer Progression—Is Brain-Derived Neurotrophic Factor an Important Mediator? An Experimental Study Cancers doi: 10.3390/cancers12030688 Authors: Adrian Tiron Irina Ristescu Paula A. Postu Crina E. Tiron Florin Zugun-Eloae Ioana Grigoras Perioperative factors promoting cancer recurrence and metastasis are under scrutiny. While oxygen toxicity is documented in several acute...
Sat Mar 14, 2020 02:00
Cancers, Vol. 12, Pages 685: Vitamin C Restricts the Emergence of Acquired Resistance to EGFR-Targeted Therapies in Colorectal Cancer Cancers doi: 10.3390/cancers12030685 Authors: Annalisa Lorenzato Alessandro Magrì Vittoria Matafora Valentina Audrito Pamela Arcella Luca Lazzari Monica Montone Simona Lamba Silvia Deaglio Salvatore Siena Andrea Bertotti Livio Trusolino Angela Bachi Federica Di Nicolantonio Alberto Bardelli Sabrina...
Sat Mar 14, 2020 02:00
Cancers, Vol. 12, Pages 686: Pathogenesis and Clinical Management of Uterine Serous Carcinoma Cancers doi: 10.3390/cancers12030686 Authors: Li Zhang Suet Ying Kwan Kwong Kwok Wong Pamela T. Solaman Karen H. Lu Samuel C. Mok Uterine serous carcinoma (USC) is an aggressive variant of endometrial cancer that has not been well characterized. It accounts for less than 10% of all endometrial cancers and 80% of endometrial cancer–related deaths. Currently,...
Sat Mar 14, 2020 02:00
Cancers, Vol. 12, Pages 684: The Cancer Stem Cell in Hepatocellular Carcinoma Cancers doi: 10.3390/cancers12030684 Authors: Lucas-Alexander Schulte Juan Carlos López-Gil Bruno Sainz Patrick C. Hermann The recognition of intra-tumoral cellular heterogeneity has given way to the concept of the cancer stem cell (CSC). According to this concept, CSCs are able to self-renew and differentiate into all of the cancer cell lineages present within the tumor, placing the CSC at...
Sat Mar 14, 2020 02:00
Cancers, Vol. 12, Pages 683: Adoptive Cell Therapy—Harnessing Antigen-Specific T Cells to Target Solid Tumours Cancers doi: 10.3390/cancers12030683 Authors: Chruściel Urban-Wójciuk Arcimowicz Kurkowiak Kowalski Gliwiński Marjański Rzyman Biernat Dziadziuszko Montesano Bernardini Marek-Trzonkowska In recent years, much research has been focused on the field of adoptive cell therapies (ACT) that use native or genetically...
Fri Mar 13, 2020 02:00
Cancers, Vol. 12, Pages 682: Targeting Epigenetic Dependencies in Solid Tumors: Evolutionary Landscape Beyond Germ Layers Origin Cancers doi: 10.3390/cancers12030682 Authors: Francesca Citron Linda Fabris Extensive efforts recently witnessed the complexity of cancer biology; however, molecular medicine still lacks the ability to elucidate hidden mechanisms for the maintenance of specific subclasses of rare tumors characterized by the silent onset and a poor prognosis (e.g.,...
Fri Mar 13, 2020 02:00
Cancers, Vol. 12, Pages 681: Recellularized Colorectal Cancer Patient-derived Scaffolds as in vitro Pre-clinical 3D Model for Drug Screening Cancers doi: 10.3390/cancers12030681 Authors: Sensi D’Angelo Piccoli Pavan Mastrotto Caliceti Biccari Corallo Urbani Fassan Spolverato Riello Pucciarelli Agostini Colorectal cancer (CRC) shows highly ineffective therapeutic management. An urgent unmet need is the random assignment...
Fri Mar 13, 2020 02:00
Cancers, Vol. 12, Pages 677: A Model of a Zebrafish Avatar for Co-Clinical Trials Cancers doi: 10.3390/cancers12030677 Authors: Alice Usai Gregorio Di Franco Patrizia Colucci Luca Emanuele Pollina Enrico Vasile Niccola Funel Matteo Palmeri Luciana Dente Alfredo Falcone Luca Morelli Vittoria Raffa Animal “avatars” and co-clinical trials are being developed for possible use in personalized medicine in oncology. In a co-clinical...
Fri Mar 13, 2020 02:00
Cancers, Vol. 12, Pages 679: Prediction of Soft Tissue Sarcoma from Clinical Characteristics and Laboratory Data Cancers doi: 10.3390/cancers12030679 Authors: Taketsugu Fujibuchi Joji Miyawaki Teruki Kidani Hiroshi Imai Hiromasa Miura The accurate diagnosis of soft tissue tumors may be difficult. Simple clinical characteristics or laboratory data that can predict tumor malignancy can be useful tools for diagnosing soft tissue tumors. Between 2003 and 2018, 588 patients...
Fri Mar 13, 2020 02:00
Cancers, Vol. 12, Pages 678: N-Ethyl-n-Nitrosourea Induced Leukaemia in a Mouse Model through Upregulation of Vascular Endothelial Growth Factor and Evading Apoptosis Cancers doi: 10.3390/cancers12030678 Authors: Abdullahi Aliyu Mohd Rosly Shaari Nurul Syahirah Ahmad Sayuti Mohd Farhan Hanif Reduan Shanmugavelu Sithambaram Mustapha Mohamed Noordin Khozirah Shaari Hazilawati Hamzah Chemical carcinogens are commonly used to investigate the biology and prognoses...
Fri Mar 13, 2020 02:00
Cancers, Vol. 12, Pages 680: Global RNA Expression and DNA Methylation Patterns in Primary Anaplastic Thyroid Cancer Cancers doi: 10.3390/cancers12030680 Authors: Ravi Yang Mylona Wennerberg Paulsson Anaplastic thyroid cancer (ATC) is one of the most malignant tumors, with a median survival of only a few months. The tumorigenic processes of this disease have not yet been completely unraveled. Here, we report an mRNA expression and DNA methylation analysis of...
Fri Mar 13, 2020 02:00
Cancers, Vol. 12, Pages 675: Vitamin D3 Metabolites Demonstrate Prognostic Value in EGFR-Mutant Lung Adenocarcinoma and Can be Deployed to Oppose Acquired Therapeutic Resistance Cancers doi: 10.3390/cancers12030675 Authors: Shaurova Dy Battaglia Hutson Zhang Zhang Lovly Seshadri Goodrich Johnson Hershberger EGFR tyrosine kinase inhibitors (EGFR TKIs) are the standard of care treatment for patients with EGFR-mutant lung adenocarcinoma...
Fri Mar 13, 2020 02:00
Cancers, Vol. 12, Pages 674: Ependymoma Pediatric Brain Tumor Protein Fingerprinting by Integrated Mass Spectrometry Platforms: A Pilot Investigation Cancers doi: 10.3390/cancers12030674 Authors: Diana Valeria Rossetti Luca Massimi Claudia Martelli Federica Vincenzoni Susanna Di Silvestre Gianluca Scorpio Gianpiero Tamburrini Massimo Caldarelli Andrea Urbani Claudia Desiderio Ependymoma pediatric brain tumor occurs at approximate frequencies of...
Fri Mar 13, 2020 02:00
Cancers, Vol. 12, Pages 676: Maximizing the Clinical Benefit of Radiotherapy in Solitary Plasmacytoma: An International Multicenter Analysis Cancers doi: 10.3390/cancers12030676 Authors: Khaled Elsayad Michael Oertel Laila König Sebastian Hüske Emmanuelle Le Ray Mohamed A.M. Meheissen Amr Abdelaziz Elsaid Essam Elfaham Jürgen Debus Youlia Kirova Klaus Herfarth Hans Theodor Eich Objective: Although local definitive radiotherapy (RT) is...
Fri Mar 13, 2020 02:00
Cancers, Vol. 12, Pages 671: Statin Use and the Risk of Hepatocellular Carcinoma: A Meta-Analysis of Observational Studies Cancers doi: 10.3390/cancers12030671 Authors: Islam Poly Walther Yang (Jack) Li Background and Aims: Statins are the first-line medication to treating hypercholesterolemia. Several studies have investigated the impact of statins on the risk of hepatocellular carcinoma (HCC). However, the extent to which statins may prevent HCC remains uncertain....
Fri Mar 13, 2020 02:00
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