Cells, Vol. 9, Pages 717: Restoring Apoptosis with BH3 Mimetics in Mature B-Cell Malignancies Cells doi: 10.3390/cells9030717 Authors: Maxime Jullien Patricia Gomez-Bougie David Chiron Cyrille Touzeau Apoptosis is a highly conserved mechanism enabling the removal of unwanted cells. Mitochondrial apoptosis is governed by the B-cell lymphoma (BCL-2) family, including anti-apoptotic and pro-apoptotic proteins. Apoptosis evasion by dysregulation of anti-apoptotic BCL-2 members (BCL-2,...
Sat Mar 14, 2020 02:00
Cells, Vol. 9, Pages 716: Mechanical Forces between Mycobacterial Antigen 85 Complex and Fibronectin
Cells, Vol. 9, Pages 716: Mechanical Forces between Mycobacterial Antigen 85 Complex and Fibronectin Cells doi: 10.3390/cells9030716 Authors: Albertus Viljoen David Alsteens Yves Dufrêne Adhesion to extracellular matrix proteins is an important first step in host invasion, employed by many bacterial pathogens. In mycobacteria, the secreted Ag85 complex proteins, involved in the synthesis of the cell envelope, are known to bind to fibronectin (Fn) through molecular forces that are...
Sat Mar 14, 2020 02:00
Cells, Vol. 9, Pages 715: Glycogen Metabolism Supports Early Glycolytic Reprogramming and Activation in Dendritic Cells in Response to Both TLR and Syk-Dependent CLR Agonists Cells doi: 10.3390/cells9030715 Authors: Kylie D. Curtis Portia R. Smith Hannah W. Despres Julia P. Snyder Tyler C. Hogan Princess D. Rodriguez Eyal Amiel Dendritic cells (DCs) increase their metabolic dependence on glucose and glycolysis to support their maturation, activation-associated cytokine...
Sat Mar 14, 2020 02:00
Cells, Vol. 9, Pages 714: Ets Family Transcription Factor Fli-1 Promotes Leukocyte Recruitment and Production of IL-17A in the MRL/Lpr Mouse Model of Lupus Nephritis Cells doi: 10.3390/cells9030714 Authors: Shuzo Sato Xian K. Zhang Jumpei Temmoku Yuya Fujita Naoki Matsuoka Makiko Yashiro-Furuya Tomoyuki Asano Hiroko Kobayashi Hiroshi Watanabe Kiyoshi Migita The transcription factor Friend leukemia integration 1 (Fli-1) regulates the expression of numerous cytokines...
Sat Mar 14, 2020 02:00
Cells, Vol. 9, Pages 712: Mitochondria in the Nuclei of Rat Myocardial Cells Cells doi: 10.3390/cells9030712 Authors: Chupalav M. Eldarov Irina M. Vangely Valeriya B. Vays Eugene V. Sheval Susanne Holtze Thomas B. Hildebrandt Natalia G. Kolosova Vasily A. Popkov Egor Y. Plotnikov Dmitry B. Zorov Lora E. Bakeeva Vladimir P. Skulachev Electron microscopic study of cardiomyocytes taken from healthy Wistar and OXYS rats and naked mole rats (Heterocephalus...
Sat Mar 14, 2020 02:00
Cells, Vol. 9, Pages 711: miR-7 Controls the Dopaminergic/Oligodendroglial Fate through Wnt/β-catenin Signaling Regulation Cells doi: 10.3390/cells9030711 Authors: Lavanya Adusumilli Nicola Facchinello Cathleen Teh Giorgia Busolin Minh TN Le Henry Yang Giorgia Beffagna Stefano Campanaro Wai Leong Tam Francesco Argenton Bing Lim Vladimir Korzh Natascia Tiso During the development of the central nervous system, the proliferation of neural progenitors...
Fri Mar 13, 2020 02:00
Cells, Vol. 9, Pages 713: Activation of Human γδ T Cells: Modulation by Toll-Like Receptor 8 Ligands and Role of Monocytes Cells doi: 10.3390/cells9030713 Authors: Ruben Serrano Daniela Wesch Dieter Kabelitz Background: Human Vγ9Vδ2 γδ T cells can kill a variety of cancer cells and have attracted substantial interest for cancer immunotherapy. Toll-like receptor (TLR) ligands are promising adjuvants for cancer immunotherapy, but TLR7/8 ligand...
Fri Mar 13, 2020 02:00
Cells, Vol. 9, Pages 708: The Transcription Factor Nfix Requires RhoA-ROCK1 Dependent Phagocytosis to Mediate Macrophage Skewing during Skeletal Muscle Regeneration Cells doi: 10.3390/cells9030708 Authors: Saclier Lapi Bonfanti Rossi Antonini Messina Macrophages (MPs) are immune cells which are crucial for tissue repair. In skeletal muscle regeneration, pro-inflammatory cells first infiltrate to promote myogenic cell proliferation, then they switch into an anti-inflammatory...
Fri Mar 13, 2020 02:00
Cells, Vol. 9, Pages 709: Basal-Type Breast Cancer Stem Cells Over-Express Chromosomal Passenger Complex Proteins Cells doi: 10.3390/cells9030709 Authors: Angela Schwarz-Cruz y Celis Gisela Ceballos-Cancino Karla Vazquez-Santillan Magali Espinosa Cecilia Zampedri Ivan Bahena Victor Ruiz Vilma Maldonado Jorge Melendez-Zajgla (1) Aim: In the present paper we analyzed the transcriptome of CSCs (Cancer Stem Cells), in order to find defining molecular processes of...
Fri Mar 13, 2020 02:00
Cells, Vol. 9, Pages 707: Therapeutic Advances of Stem Cell-Derived Extracellular Vesicles in Regenerative Medicine Cells doi: 10.3390/cells9030707 Authors: Lei Yin Xiaotian Liu Yinghong Shi Dickson Kofi Wiredu Ocansey Yuyan Hu Xiaoxi Li Chenxiao Zhang Wenrong Xu Hui Qian Extracellular vesicles (EVs), which are the main paracrine components of stem cells, mimic the regenerative capacity of these cells. Stem cell-derived EVs (SC-EVs) have been used for the treatment...
Fri Mar 13, 2020 02:00
Cells, Vol. 9, Pages 710: Scalable Generation of Mesenchymal Stem Cells and Adipocytes from Human Pluripotent Stem Cells Cells doi: 10.3390/cells9030710 Authors: Manale Karam Ihab Younis Noor R. Elareer Sara Nasser Essam M. Abdelalim Human pluripotent stem cells (hPSCs) can provide unlimited supply for mesenchymal stem cells (MSCs) and adipocytes that can be used for therapeutic applications. Here we developed a simple and highly efficient all-trans-retinoic acid (RA)-based...
Fri Mar 13, 2020 02:00
Cells, Vol. 9, Pages 705: From Rust to Quantum Biology: The Role of Iron in Retina Physiopathology Cells doi: 10.3390/cells9030705 Authors: Picard Daruich Youale Courtois Behar-Cohen Iron is essential for cell survival and function. It is a transition metal, that could change its oxidation state from Fe2+ to Fe3+ involving an electron transfer, the key of vital functions but also organ dysfunctions. The goal of this review is to illustrate the primordial role of iron...
Fri Mar 13, 2020 02:00
Cells, Vol. 9, Pages 704: Carbonic Anhydrase III Promotes Cell Migration and Epithelial–Mesenchymal Transition in Oral Squamous Cell Carcinoma Cells doi: 10.3390/cells9030704 Authors: Chu Su Hsieh Chen Lin Yang Epithelial–mesenchymal transition (EMT) is strongly correlated with tumor metastasis and contains several protein markers, such as E-cadherin. Carbonic anhydrase III (CA III) exhibits low carbon dioxide hydratase activity in cancer. However, the...
Fri Mar 13, 2020 02:00
Cells, Vol. 9, Pages 706: Role of c-Jun N-terminal Kinase (JNK) in Obesity and Type 2 Diabetes Cells doi: 10.3390/cells9030706 Authors: Justin Hou Ming Yung Adria Giacca Obesity has been described as a global epidemic and is a low-grade chronic inflammatory disease that arises as a consequence of energy imbalance. Obesity increases the risk of type 2 diabetes (T2D), by mechanisms that are not entirely clarified. Elevated circulating pro-inflammatory cytokines and free fatty acids...
Fri Mar 13, 2020 02:00
Cells, Vol. 9, Pages 703: A 3D Cell Death Assay to Quantitatively Determine Ferroptosis in Spheroids
Cells, Vol. 9, Pages 703: A 3D Cell Death Assay to Quantitatively Determine Ferroptosis in Spheroids Cells doi: 10.3390/cells9030703 Authors: Robin Demuynck Iuliia Efimova Abraham Lin Heidi Declercq Dmitri V. Krysko The failure of drug efficacy in clinical trials remains a big issue in cancer research. This is largely due to the limitations of two-dimensional (2D) cell cultures, the most used tool in drug screening. Nowadays, three-dimensional (3D) cultures, including spheroids,...
Fri Mar 13, 2020 02:00
Cells, Vol. 9, Pages 702: Tissue-Specific Metabolic Regulation of FOXO-Binding Protein: FOXO Does Not Act Alone Cells doi: 10.3390/cells9030702 Authors: Noriko Kodani Jun Nakae The transcription factor forkhead box (FOXO) controls important biological responses, including proliferation, apoptosis, differentiation, metabolism, and oxidative stress resistance. The transcriptional activity of FOXO is tightly regulated in a variety of cellular processes. FOXO can convert the external...
Fri Mar 13, 2020 02:00
Chemosensors, Vol. 8, Pages 21: Polymer Nanoparticle Identification and Concentration Measurement Using Fiber-Enhanced Raman Spectroscopy Chemosensors doi: 10.3390/chemosensors8010021 Authors: Mark R. Pollard Katia Sparnacci Lars J. Wacker Hugo Kerdoncuff We present a measurement technique for chemical identification and concentration measurement of polymer nanoparticles in aqueous solution, which is achieved using Raman spectroscopy. This work delivers an improvement in measurement...
Sat Mar 14, 2020 02:00
Climate, Vol. 8, Pages 43: The Future of Semi-Arid Regions: A Weak Fabric Unravels Climate doi: 10.3390/cli8030043 Authors: Scholes The regions of the world where average precipitation is between one fifth and half of the potential plant water demand are termed ‘semi-arid’. They make up 15.2% of the global land surface, and the approximately 1.1 billion people who live there are among the world’s poorest. The inter-annual variability of rainfall in semi-arid...
Fri Mar 13, 2020 02:00
Climate, Vol. 8, Pages 42: Ecological Niche Models Reveal Climate Change Effect on Biogeographical Regions: The Iberian Peninsula as a Case Study Climate doi: 10.3390/cli8030042 Authors: Sousa-Guedes Arenas-Castro Sillero How species are distributed on Earth depends largely on climate factors. Whenever these environmental conditions change, species tend to shift their distributions to reach more favourable conditions. Distinct sets of species similarly distributed (i.e. chorotypes)...
Fri Mar 13, 2020 02:00
Diagnostics, Vol. 10, Pages 159: Non-Alcoholic Fatty Liver Disease in Patients with Type 2 Diabetes: Evaluation of Hepatic Fibrosis and Steatosis Using Fibroscan Diagnostics doi: 10.3390/diagnostics10030159 Authors: Tran Thi Khanh Tuong Dang Khoa Tran Pham Quang Thien Phu Tong Nguyen Diem Hong Thien Chu Dinh Dinh Toi Chu Patients with type 2 diabetes mellitus (T2DM) are at increased risk of non-alcoholic fatty liver disease (NAFLD) and might eventually progress to advanced...
Sat Mar 14, 2020 02:00
Diagnostics, Vol. 10, Pages 160: Advanced Ankle and Foot Sonoanatomy: Imaging Beyond the Basics Diagnostics doi: 10.3390/diagnostics10030160 Authors: Chen-Yu Hung Ke-Vin Chang Kamal Mezian Ondřej Naňka Wei-Ting Wu Po-Cheng Hsu Levent Özçakar Ankle/foot pain is a common complaint encountered in clinical practice. Currently, due to the complex anatomy, the diagnosis and management of the underlying musculoskeletal disorders are extremely challenging. Nowadays, high-resolution...
Sat Mar 14, 2020 02:00
Diagnostics, Vol. 10, Pages 158: Health Economic Decision Tree Models of Diagnostics for Dummies: A Pictorial Primer Diagnostics doi: 10.3390/diagnostics10030158 Authors: Tamlyn Rautenberg Annette Gerritsen Martin Downes Health economics is a discipline of economics applied to health care. One method used in health economics is decision tree modelling, which extrapolates the cost and effectiveness of competing interventions over time. Such decision tree models are the basis of...
Sat Mar 14, 2020 02:00
Diagnostics, Vol. 10, Pages 157: High-grade B-cell Lymphoma with MYC and BCL2 Rearrangement Arising from Follicular Lymphoma: Presentation as a Large Peripancreatic Mass Diagnostics doi: 10.3390/diagnostics10030157 Authors: Anna Shestakova Sherif Rezk Dara Ghasemizadeh Ali Nael Xiaohui Zhao Follicular lymphoma, the second most common non-Hodgkin lymphoma (NHL), primarily affects adults and shows an indolent clinical course. Rare cases of follicular lymphoma transform to a...
Sat Mar 14, 2020 02:00
Diagnostics, Vol. 10, Pages 156: Diffusion-Tensor-Tractography-Based Diagnosis for Injury of Corticospinal Tract in a Patient with Hemiplegia Following Traumatic Brain Injury Diagnostics doi: 10.3390/diagnostics10030156 Authors: Park Kim Jung This paper reports a mechanism for corticospinal tract injury in a patient with hemiplegia following traumatic brain injury (TBI) based on diffusion tensor tractography (DTT) finding. A 73-year-old male with TBI resulting from a fall, without...
Fri Mar 13, 2020 02:00
Diagnostics, Vol. 10, Pages 155: Elevated LysoGb3 Concentration in the Neuronopathic Forms of Mucopolysaccharidoses Diagnostics doi: 10.3390/diagnostics10030155 Authors: Galina Baydakova Alex Ilyushkina Lidia Gaffke Karolina Pierzynowska Igor Bychkov Agnieszka Ługowska Grzegorz Wegrzyn Anna Tylki-Szymanska Ekaterina Zakharova Mucopolysaccharidoses (MPSs) are a group of lysosomal storage disorders associated with impaired glycosaminoglycans (GAGs) catabolism. In...
Fri Mar 13, 2020 02:00
Diseases, Vol. 8, Pages 7: Chronic Stress and Cardiovascular Disease among Individuals Exposed to Lead: A Pilot Study Diseases doi: 10.3390/diseases8010007 Authors: Emmanuel Obeng-Gyasi Barnabas Obeng-Gyasi Chronic stress and cardiovascular disease risk were explored in a predominately middle-aged adult population exposed to elevated lead levels in this cross-sectional study using data from the National Health and Nutrition Examination Survey (NHANES) from the period 2007-2010. Elevated...
Sun Mar 15, 2020 02:00
Diseases, Vol. 8, Pages 6: Are Steroid Hormones Dysregulated in Autistic Girls? Diseases doi: 10.3390/diseases8010006 Authors: Benedikt Andreas Gasser Johann Kurz Bernhard Dick Markus Georg Mohaupt Evidence of altered cholesterol and steroid hormones in autism is increasing. However, as boys are more often affected, evidence mainly relates to autistic males, whereas evidence for affected autistic girls is sparse. Therefore, a comprehensive gas chromatography mass spectrometry-based...
Sat Mar 14, 2020 02:00
Diversity, Vol. 12, Pages 102: The Minute Alga Schizocladia ischiensis (Schizocladiophyceae, Ochrophyta) Isolated by Germling Emergence from 24 m Depth off Rhodes (Greece) Diversity doi: 10.3390/d12030102 Authors: Anastasia Rizouli Frithjof C. Küpper Paraskevi Louizidou Andrew O. M. Mogg Elaine Azzopardi Martin D. J. Sayer Hiroshi Kawai Takeaki Hanyuda Akira F. Peters Substratum collected during diving surveys of sublittoral communities off the Greek island of...
Sat Mar 14, 2020 02:00
Diversity, Vol. 12, Pages 101: Unimodal Relationships of Understory Alpha and Beta Diversity along Chronosequence in Coppiced and Unmanaged Beech Forests Diversity doi: 10.3390/d12030101 Authors: Sándor Bartha Roberto Canullo Stefano Chelli Giandiego Campetella Patterns of diversity across spatial scales in forest successions are being overlooked, despite their importance for developing sustainable management practices. Here, we tested the recently proposed U-shaped biodiversity...
Fri Mar 13, 2020 02:00
Diversity, Vol. 12, Pages 100: Exquisitely Preserved Fossil Snakes of Messel: Insight into the Evolution, Biogeography, Habitat Preferences and Sensory Ecology of Early Boas Diversity doi: 10.3390/d12030100 Authors: Agustín Scanferla Krister T. Smith Our knowledge of early evolution of snakes is improving, but all that we can infer about the evolution of modern clades of snakes such as boas (Booidea) is still based on isolated bones. Here, we resolve the phylogenetic relationships...
Fri Mar 13, 2020 02:00
Diversity, Vol. 12, Pages 99: Austrian COLOSS Survey of Honey Bee Colony Winter Losses 2018/19 and Analysis of Hive Management Practices Diversity doi: 10.3390/d12030099 Authors: Hannes Oberreiter Robert Brodschneider We conducted a citizen science survey on overwinter honey bee colony losses in Austria. A total of 1534 beekeepers with 33,651 colonies reported valid loss rates. The total winter loss rate for Austria was 15.2% (95% confidence interval: 14.4–16.1%). Young...
Fri Mar 13, 2020 02:00
Epigenomes, Vol. 4, Pages 5: Role of m6A in Embryonic Stem Cell Differentiation and in Gametogenesis
Epigenomes, Vol. 4, Pages 5: Role of m6A in Embryonic Stem Cell Differentiation and in Gametogenesis Epigenomes doi: 10.3390/epigenomes4010005 Authors: Lior Lasman Jacob H Hanna Noa Novershtern The rising field of RNA modifications is stimulating massive research nowadays. m6A, the most abundant mRNA modification is highly conserved during evolution. Through the last decade, the essential components of this dynamic mRNA modification machinery were found and classified into writer,...
Sat Mar 14, 2020 02:00
Foods, Vol. 9, Pages 341: Fast Quantification of Honey Adulteration with Laser-Induced Breakdown Spectroscopy and Chemometric Methods Foods doi: 10.3390/foods9030341 Authors: Jiyu Peng Weiyue Xie Jiandong Jiang Zhangfeng Zhao Fei Zhou Fei Liu Honey adulteration is a major issue in food production, which may reduce the effective components in honey and have a detrimental effect on human health. Herein, laser-induced breakdown spectroscopy (LIBS) combined with chemometric...
Sat Mar 14, 2020 02:00
Foods, Vol. 9, Pages 340: Health Benefits and Molecular Mechanisms of Resveratrol: A Narrative Review Foods doi: 10.3390/foods9030340 Authors: Meng Zhou Zhao Gan Li Resveratrol is a bioactive compound in many foods. Since its anticancer activity was reported in 1997, its health benefits have been intensively investigated. Resveratrol has antioxidant, anti-inflammatory, immunomodulatory, glucose and lipid regulatory, neuroprotective, and cardiovascular protective effects,...
Sat Mar 14, 2020 02:00
Foods, Vol. 9, Pages 339: Sensory Profile and Physico-Chemical Properties of Artisanal Honey from Zulia, Venezuela Foods doi: 10.3390/foods9030339 Authors: Deyanira Araujo Pilar Ruiz Pérez-Cacho Salud Serrano Rafaela Dios-Palomares Hortensia Galán-Soldevilla The physico-chemical parameters and the sensory profile were determined in honeys from apiaries of the Mara and Maracaibo of Zulia State (Venezuela). The analysis of variance showed that there were no significant differences...
Sat Mar 14, 2020 02:00
Foods, Vol. 9, Pages 338: Lactic Acid Bacteria: Variability Due to Different Pork Breeds, Breeding Systems and Fermented Sausage Production Technology Foods doi: 10.3390/foods9030338 Authors: Giuseppe Comi Alessia Muzzin Mirco Corazzin Lucilla Iacumin Changes in the ecology of the various lactic acid bacteria (LAB) species, which are involved in traditional fermented sausages, were investigated in the light of the use of different breeds of pork, each of which was raised in...
Fri Mar 13, 2020 02:00
Foods, Vol. 9, Pages 337: Isolation of Exopolysaccharide-Producing Yeast and Lactic Acid Bacteria from Quinoa (Chenopodium Quinoa) Sourdough Fermentation Foods doi: 10.3390/foods9030337 Authors: Wendy Franco Ilenys M. Pérez-Díaz Lauren Connelly Joscelin T. Diaz Quinoa, a nutritional grain, can be used as an ingredient in gluten-free sourdoughs. This study characterizes quinoa flour spontaneous fermentation with emphasis in the isolation of exopolysaccharide (EPS) producer bacteria....
Fri Mar 13, 2020 02:00
Healthcare, Vol. 8, Pages 59: Monitoring of Nesting Songbirds Detects Established Population of Blacklegged Ticks and Associated Lyme Disease Endemic Area in Canada Healthcare doi: 10.3390/healthcare8010059 Authors: John D. Scott Emily L. Pascoe Muhammad S. Sajid Janet E. Foley This study provides a novel method of documenting established populations of bird-feeding ticks. Single populations of the blacklegged tick, Ixodes scapularis, and the rabbit tick, Haemaphysalis leporispalustris,...
Fri Mar 13, 2020 02:00
IJERPH, Vol. 17, Pages 1920: Investing Time and Resources for Work–Life Balance: The Effect on Talent Retention International Journal of Environmental Research and Public Health doi: 10.3390/ijerph17061920 Authors: José-Luis Rodríguez-Sánchez Thais González-Torres Antonio Montero-Navarro Rocío Gallego-Losada The study of work–life balance has undergone significant development in recent years as a result of changes in society and the growing importance of human resources...
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