Brain Sciences, Vol. 10, Pages 168: No Longer Underappreciated: The Emerging Concept of Astrocyte Heterogeneity in Neuroscience Brain Sciences doi: 10.3390/brainsci10030168 Authors: Francisco Pestana Gabriela Edwards-Faret T. Grant Belgard Araks Martirosyan Matthew G. Holt Astrocytes are ubiquitous in the central nervous system (CNS). These cells possess thousands of individual processes, which extend out into the neuropil, interacting with neurons, other glia and blood vessels....
Fri Mar 13, 2020 02:00
Brain Sciences, Vol. 10, Pages 165: Pre-School Teachers’ Knowledge, Belief, Identification Skills, and Self-Efficacy in Identifying Autism Spectrum Disorder (ASD): A Conceptual Framework to Identify Children with ASD Brain Sciences doi: 10.3390/brainsci10030165 Authors: Sahar Taresh Nor Aniza Ahmad Samsilah Roslan Aini Marina Ma’rof Sumaia Zaid Recently, the identification and detection of children with autism spectrum disorder (ASD) has become an essential issue under ASD...
Fri Mar 13, 2020 02:00
Brain Sciences, Vol. 10, Pages 164: Association between Exposure to Air Pollution and Total Gray Matter and Total White Matter Volumes in Adults: A Cross-Sectional Study Brain Sciences doi: 10.3390/brainsci10030164 Authors: Lance D. Erickson Shawn D. Gale Jacqueline E. Anderson Bruce L. Brown Dawson W. Hedges Total brain gray-matter and white-matter volumes can be indicators of overall brain health. Among the factors associated with gray-matter and white-matter volumes is...
Fri Mar 13, 2020 02:00
Cancers, Vol. 12, Pages 696: Factors Associated with Health-Related Quality of Life in Women with Breast Cancer in the Middle East: A Systematic Review Cancers doi: 10.3390/cancers12030696 Authors: Rana El Haidari Linda Abou Abbas Virginie Nerich Amélie Anota Objectives: The aim of the present systematic review was to identify the factors that potentially influence health-related quality of life (HRQoL) in women with breast cancer (BC) in the Middle East. Methods: A systematic...
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Cancers, Vol. 12, Pages 695: Emerging Role of Circulating Tumor Cells in Gastric Cancer Cancers doi: 10.3390/cancers12030695 Authors: Phung Thanh Huong Sanjeev Gurshaney Nguyen Thanh Binh Anh Gia Pham Huy Hoang Nguyen Xuan Thanh Nguyen Hai Pham-The Phuong-Thao Tran Khanh Truong Vu Nhuong Xuan Duong Claudio Pelucchi Carlo La Vecchia Paolo Boffetta Hung D. Nguyen Hung N. Luu With over 1 million incidence cases and more than 780,000 deaths in 2018,...
Sun Mar 15, 2020 02:00
Cancers, Vol. 12, Pages 694: Establishment and Molecular Phenotyping of Organoids from the Squamocolumnar Junction Region of the Uterine Cervix Cancers doi: 10.3390/cancers12030694 Authors: Yoshiaki Maru Akira Kawata Ayumi Taguchi Yoshiyuki Ishii Satoshi Baba Mayuyo Mori Takeshi Nagamatsu Katsutoshi Oda Iwao Kukimoto Yutaka Osuga Tomoyuki Fujii Yoshitaka Hippo The metaplastic epithelium of the transformation zone (TZ) including the squamocolumnar junction...
Sun Mar 15, 2020 02:00
Cancers, Vol. 12, Pages 693: Imaging Features and Patterns of Metastasis in Non-Small Cell Lung Cancer with RET Rearrangements Cancers doi: 10.3390/cancers12030693 Authors: Subba R. Digumarthy Dexter P. Mendoza Jessica J. Lin Marguerite Rooney Andrew Do Emily Chin Beow Y. Yeap Alice T. Shaw Justin F. Gainor Rearranged during transfection proto-oncogene (RET) fusions represent a potentially targetable oncogenic driver in non-small cell lung cancer (NSCLC). Imaging...
Sun Mar 15, 2020 02:00
Cancers, Vol. 12, Pages 692: Hypoxia-Induced Adaptations of miRNomes and Proteomes in Melanoma Cells and Their Secreted Extracellular Vesicles Cancers doi: 10.3390/cancers12030692 Authors: Geoffroy Walbrecq Odile Lecha Anthoula Gaigneaux Miriam R. Fougeras Demetra Philippidou Christiane Margue Milène Tetsi Nomigni François Bernardin Gunnar Dittmar Iris Behrmann Stephanie Kreis Reduced levels of intratumoural oxygen are associated with hypoxia-induced pro-oncogenic...
Sat Mar 14, 2020 02:00
Cancers, Vol. 12, Pages 691: A Comprehensive Molecular Characterization of the Pancreatic Neuroendocrine Tumor Cell Lines BON-1 and QGP-1 Cancers doi: 10.3390/cancers12030691 Authors: Kim B. Luley Shauni B. Biedermann Axel Künstner Hauke Busch Sören Franzenburg Jörg Schrader Patricia Grabowski Ulrich F. Wellner Tobias Keck Georg Brabant Sebastian M. Schmid Hendrik Lehnert Hendrik Ungefroren Experimental models of neuroendocrine tumor disease are scarce,...
Sat Mar 14, 2020 02:00
Cancers, Vol. 12, Pages 689: Cancer-testis Antigen FATE1 Expression in Adrenocortical Tumors Is Associated with A Pervasive Autoimmune Response and Is A Marker of Malignancy in Adult, but Not Children, ACC Cancers doi: 10.3390/cancers12030689 Authors: Mabrouka Doghman-Bouguerra Pascal Finetti Nelly Durand Ivy Zortéa S. Parise Silviu Sbiera Giulia Cantini Letizia Canu Ségolène Hescot Mirna M. O. Figueiredo Heloisa Komechen Iuliu Sbiera Gabriella Nesi Angelo...
Sat Mar 14, 2020 02:00
Cancers, Vol. 12, Pages 690: Comparative Molecular Analysis of Cancer Behavior Cultured In Vitro, In Vivo, and Ex Vivo Cancers doi: 10.3390/cancers12030690 Authors: Nicholas R. Hum Aimy Sebastian Sean F. Gilmore Wei He Kelly A. Martin Aubree Hinckley Karen R. Dubbin Monica L. Moya Elizabeth K. Wheeler Matthew A. Coleman Gabriela G. Loots Current pre-clinical models of cancer fail to recapitulate the cancer cell behavior in primary tumors primarily because...
Sat Mar 14, 2020 02:00
Cancers, Vol. 12, Pages 687: ATM-Deficient Cancers Provide New Opportunities for Precision Oncology Cancers doi: 10.3390/cancers12030687 Authors: Nicholas R. Jette Mehul Kumar Suraj Radhamani Greydon Arthur Siddhartha Goutam Steven Yip Michael Kolinsky Gareth J. Williams Pinaki Bose Susan P. Lees-Miller Poly-ADP ribose polymerase (PARP) inhibitors are currently used in the treatment of several cancers carrying mutations in the breast and ovarian cancer susceptibility...
Sat Mar 14, 2020 02:00
Cancers, Vol. 12, Pages 688: Long-Term Deleterious Effects of Short-term Hyperoxia on Cancer Progression—Is Brain-Derived Neurotrophic Factor an Important Mediator? An Experimental Study Cancers doi: 10.3390/cancers12030688 Authors: Adrian Tiron Irina Ristescu Paula A. Postu Crina E. Tiron Florin Zugun-Eloae Ioana Grigoras Perioperative factors promoting cancer recurrence and metastasis are under scrutiny. While oxygen toxicity is documented in several acute circumstances,...
Sat Mar 14, 2020 02:00
Cancers, Vol. 12, Pages 685: Vitamin C Restricts the Emergence of Acquired Resistance to EGFR-Targeted Therapies in Colorectal Cancer Cancers doi: 10.3390/cancers12030685 Authors: Annalisa Lorenzato Alessandro Magrì Vittoria Matafora Valentina Audrito Pamela Arcella Luca Lazzari Monica Montone Simona Lamba Silvia Deaglio Salvatore Siena Andrea Bertotti Livio Trusolino Angela Bachi Federica Di Nicolantonio Alberto Bardelli Sabrina Arena The...
Sat Mar 14, 2020 02:00
Cancers, Vol. 12, Pages 686: Pathogenesis and Clinical Management of Uterine Serous Carcinoma Cancers doi: 10.3390/cancers12030686 Authors: Li Zhang Suet Ying Kwan Kwong Kwok Wong Pamela T. Solaman Karen H. Lu Samuel C. Mok Uterine serous carcinoma (USC) is an aggressive variant of endometrial cancer that has not been well characterized. It accounts for less than 10% of all endometrial cancers and 80% of endometrial cancer–related deaths. Currently, staging surgery...
Sat Mar 14, 2020 02:00
Cancers, Vol. 12, Pages 684: The Cancer Stem Cell in Hepatocellular Carcinoma Cancers doi: 10.3390/cancers12030684 Authors: Lucas-Alexander Schulte Juan Carlos López-Gil Bruno Sainz Patrick C. Hermann The recognition of intra-tumoral cellular heterogeneity has given way to the concept of the cancer stem cell (CSC). According to this concept, CSCs are able to self-renew and differentiate into all of the cancer cell lineages present within the tumor, placing the CSC at the top...
Sat Mar 14, 2020 02:00
Cancers, Vol. 12, Pages 683: Adoptive Cell Therapy—Harnessing Antigen-Specific T Cells to Target Solid Tumours Cancers doi: 10.3390/cancers12030683 Authors: Chruściel Urban-Wójciuk Arcimowicz Kurkowiak Kowalski Gliwiński Marjański Rzyman Biernat Dziadziuszko Montesano Bernardini Marek-Trzonkowska In recent years, much research has been focused on the field of adoptive cell therapies (ACT) that use native or genetically modified T cells...
Fri Mar 13, 2020 02:00
Cancers, Vol. 12, Pages 682: Targeting Epigenetic Dependencies in Solid Tumors: Evolutionary Landscape Beyond Germ Layers Origin Cancers doi: 10.3390/cancers12030682 Authors: Francesca Citron Linda Fabris Extensive efforts recently witnessed the complexity of cancer biology; however, molecular medicine still lacks the ability to elucidate hidden mechanisms for the maintenance of specific subclasses of rare tumors characterized by the silent onset and a poor prognosis (e.g., ovarian...
Fri Mar 13, 2020 02:00
Cancers, Vol. 12, Pages 681: Recellularized Colorectal Cancer Patient-derived Scaffolds as in vitro Pre-clinical 3D Model for Drug Screening Cancers doi: 10.3390/cancers12030681 Authors: Sensi D’Angelo Piccoli Pavan Mastrotto Caliceti Biccari Corallo Urbani Fassan Spolverato Riello Pucciarelli Agostini Colorectal cancer (CRC) shows highly ineffective therapeutic management. An urgent unmet need is the random assignment to adjuvant...
Fri Mar 13, 2020 02:00
Cancers, Vol. 12, Pages 678: N-Ethyl-n-Nitrosourea Induced Leukaemia in a Mouse Model through Upregulation of Vascular Endothelial Growth Factor and Evading Apoptosis Cancers doi: 10.3390/cancers12030678 Authors: Abdullahi Aliyu Mohd Rosly Shaari Nurul Syahirah Ahmad Sayuti Mohd Farhan Hanif Reduan Shanmugavelu Sithambaram Mustapha Mohamed Noordin Khozirah Shaari Hazilawati Hamzah Chemical carcinogens are commonly used to investigate the biology and prognoses of...
Fri Mar 13, 2020 02:00
Cancers, Vol. 12, Pages 680: Global RNA Expression and DNA Methylation Patterns in Primary Anaplastic Thyroid Cancer Cancers doi: 10.3390/cancers12030680 Authors: Ravi Yang Mylona Wennerberg Paulsson Anaplastic thyroid cancer (ATC) is one of the most malignant tumors, with a median survival of only a few months. The tumorigenic processes of this disease have not yet been completely unraveled. Here, we report an mRNA expression and DNA methylation analysis of fourteen...
Fri Mar 13, 2020 02:00
Cancers, Vol. 12, Pages 679: Prediction of Soft Tissue Sarcoma from Clinical Characteristics and Laboratory Data Cancers doi: 10.3390/cancers12030679 Authors: Taketsugu Fujibuchi Joji Miyawaki Teruki Kidani Hiroshi Imai Hiromasa Miura The accurate diagnosis of soft tissue tumors may be difficult. Simple clinical characteristics or laboratory data that can predict tumor malignancy can be useful tools for diagnosing soft tissue tumors. Between 2003 and 2018, 588 patients with...
Fri Mar 13, 2020 02:00
Cancers, Vol. 12, Pages 677: A Model of a Zebrafish Avatar for Co-Clinical Trials Cancers doi: 10.3390/cancers12030677 Authors: Alice Usai Gregorio Di Franco Patrizia Colucci Luca Emanuele Pollina Enrico Vasile Niccola Funel Matteo Palmeri Luciana Dente Alfredo Falcone Luca Morelli Vittoria Raffa Animal “avatars” and co-clinical trials are being developed for possible use in personalized medicine in oncology. In a co-clinical trial, the...
Fri Mar 13, 2020 02:00
Cancers, Vol. 12, Pages 675: Vitamin D3 Metabolites Demonstrate Prognostic Value in EGFR-Mutant Lung Adenocarcinoma and Can be Deployed to Oppose Acquired Therapeutic Resistance Cancers doi: 10.3390/cancers12030675 Authors: Shaurova Dy Battaglia Hutson Zhang Zhang Lovly Seshadri Goodrich Johnson Hershberger EGFR tyrosine kinase inhibitors (EGFR TKIs) are the standard of care treatment for patients with EGFR-mutant lung adenocarcinoma (LUAD). Although...
Fri Mar 13, 2020 02:00
Cancers, Vol. 12, Pages 676: Maximizing the Clinical Benefit of Radiotherapy in Solitary Plasmacytoma: An International Multicenter Analysis Cancers doi: 10.3390/cancers12030676 Authors: Khaled Elsayad Michael Oertel Laila König Sebastian Hüske Emmanuelle Le Ray Mohamed A.M. Meheissen Amr Abdelaziz Elsaid Essam Elfaham Jürgen Debus Youlia Kirova Klaus Herfarth Hans Theodor Eich Objective: Although local definitive radiotherapy (RT) is considered the standard...
Fri Mar 13, 2020 02:00
Cancers, Vol. 12, Pages 674: Ependymoma Pediatric Brain Tumor Protein Fingerprinting by Integrated Mass Spectrometry Platforms: A Pilot Investigation Cancers doi: 10.3390/cancers12030674 Authors: Diana Valeria Rossetti Luca Massimi Claudia Martelli Federica Vincenzoni Susanna Di Silvestre Gianluca Scorpio Gianpiero Tamburrini Massimo Caldarelli Andrea Urbani Claudia Desiderio Ependymoma pediatric brain tumor occurs at approximate frequencies of 10–15%...
Fri Mar 13, 2020 02:00
Cancers, Vol. 12, Pages 671: Statin Use and the Risk of Hepatocellular Carcinoma: A Meta-Analysis of Observational Studies Cancers doi: 10.3390/cancers12030671 Authors: Islam Poly Walther Yang (Jack) Li Background and Aims: Statins are the first-line medication to treating hypercholesterolemia. Several studies have investigated the impact of statins on the risk of hepatocellular carcinoma (HCC). However, the extent to which statins may prevent HCC remains uncertain....
Fri Mar 13, 2020 02:00
Cancers, Vol. 12, Pages 672: Identification of PLK1 as a New Therapeutic Target in Mucinous Ovarian Carcinoma Cancers doi: 10.3390/cancers12030672 Authors: Affatato Carrassa Chilà Lupi Restelli Damia Mucinous epithelial ovarian cancer (mEOC) is a rare subset of epithelial ovarian cancer. When diagnosed at a late stage, its prognosis is very poor, as it is quite chemo-resistant. To find new therapeutic options for mEOC, we performed high-throughput screening using...
Fri Mar 13, 2020 02:00
Cancers, Vol. 12, Pages 673: Natural Compounds with Potential to Modulate Cancer Therapies and Self-Reactive Immune Cells Cancers doi: 10.3390/cancers12030673 Authors: Rhiane Moody Kirsty Wilson Anthony Jaworowski Magdalena Plebanski Cancer-related deaths are approaching 10 million each year. Survival statistics for some cancers, such as ovarian cancer, have remained unchanged for decades, with women diagnosed at stage III or IV having over 80% chance of a lethal cancer recurrence...
Fri Mar 13, 2020 02:00
Cancers, Vol. 12, Pages 669: Sexual Dimorphism in Cellular and Molecular Features in Human ACTH-Secreting Pituitary Adenomas Cancers doi: 10.3390/cancers12030669 Authors: Francesca Pecori Giraldi Maria Francesca Cassarino Antonella Sesta Mariarosa Terreni Giovanni Lasio Marco Losa (1) Background. Cushing’s disease presents gender disparities in prevalence and clinical course. Little is known, however, about sexual dimorphism at the level of the corticotrope adenoma...
Fri Mar 13, 2020 02:00
Cancers, Vol. 12, Pages 668: Metformin as an Adjuvant to Photodynamic Therapy in Resistant Basal Cell Carcinoma Cells Cancers doi: 10.3390/cancers12030668 Authors: Marta Mascaraque Pablo Delgado-Wicke Cristina Nuevo-Tapioles Tamara Gracia-Cazaña Edgar Abarca-Lachen Salvador González José M. Cuezva Yolanda Gilaberte Ángeles Juarranz Photodynamic Therapy (PDT) with methyl-aminolevulinate (MAL-PDT) is being used for the treatment of Basal Cell Carcinoma (BCC), although...
Fri Mar 13, 2020 02:00
Cancers, Vol. 12, Pages 670: The Second Generation Antibody-Drug Conjugate SYD985 Overcomes Resistances to T-DM1 Cancers doi: 10.3390/cancers12030670 Authors: Nadal-Serrano Morancho Escrivá-de-Romaní Morales Luque Escorihuela Espinosa Bravo Peg Dijcks Dokter Cortés Saura Arribas Trastuzumab-emtansine (T-DM1) is an antibody-drug conjugate (ADC) approved for the treatment of HER2 (human epidermal growth factor receptor 2)-positive breast...
Fri Mar 13, 2020 02:00
Cells, Vol. 9, Pages 724: Message in a Bottle: Upgrading Cardiac Repair into Rejuvenation Cells doi: 10.3390/cells9030724 Authors: Carolina Balbi Ambra Costa Lucio Barile Sveva Bollini Ischaemic cardiac disease is associated with a loss of cardiomyocytes and an intrinsic lack of myocardial renewal. Recent work has shown that the heart retains limited cardiomyocyte proliferation, which remains inefficient when facing pathological conditions. While broadly active in the neonatal...
Sun Mar 15, 2020 02:00
Cells, Vol. 9, Pages 723: The Significance of the Dysregulation of Canonical Wnt Signaling in Head and Neck Squamous Cell Carcinomas Cells doi: 10.3390/cells9030723 Authors: Jarosław Paluszczak The knowledge about the molecular alterations which are found in head and neck squamous cell carcinomas (HNSCC) has much increased in recent years. However, we are still awaiting the translation of this knowledge to new diagnostic and therapeutic options. Among the many molecular changes that...
Sun Mar 15, 2020 02:00
Cells, Vol. 9, Pages 722: STAT3 Inhibitor ODZ10117 Suppresses Glioblastoma Malignancy and Prolongs Survival in a Glioblastoma Xenograft Model Cells doi: 10.3390/cells9030722 Authors: Byung-Hak Kim Haeri Lee Cheol Gyu Park Ae Jin Jeong Song-Hee Lee Kum Hee Noh Jong Bae Park Chung-Gi Lee Sun Ha Paek Hyunggee Kim Sang-Kyu Ye Constitutively activated STAT3 plays an essential role in the initiation, progression, maintenance, malignancy, and drug resistance of...
Sun Mar 15, 2020 02:00
Cells, Vol. 9, Pages 721: Patients with Cholangiocarcinoma Present Specific RNA Profiles in Serum and Urine Extracellular Vesicles Mirroring the Tumor Expression: Novel Liquid Biopsy Biomarkers for Disease Diagnosis Cells doi: 10.3390/cells9030721 Authors: Lapitz Arbelaiz O’Rourke Lavin Casta Ibarra Jimeno Santos-Laso Izquierdo-Sanchez Krawczyk Perugorria Jimenez-Aguero Sanchez-Campos Riaño Gónzalez Lammert Marzioni Macias...
Sat Mar 14, 2020 02:00
Cells, Vol. 9, Pages 720: An Overview on ERAP Roles in Infectious Diseases Cells doi: 10.3390/cells9030720 Authors: Irma Saulle Chiara Vicentini Mario Clerici Mara Biasin Endoplasmic reticulum (ER) aminopeptidases ERAP1 and ERAP2 (ERAPs) are crucial enzymes shaping the major histocompatibility complex I (MHC I) immunopeptidome. In the ER, these enzymes cooperate in trimming the N-terminal residues from precursors peptides, so as to generate optimal-length antigens to fit into...
Sat Mar 14, 2020 02:00
Cells, Vol. 9, Pages 719: Ovarian Cancer, Cancer Stem Cells and Current Treatment Strategies: A Potential Role of Magmas in the Current Treatment Methods Cells doi: 10.3390/cells9030719 Authors: Nuzhat Ahmed Elif Kadife Ali Raza Mary Short Paul T. Jubinsky George Kannourakis Epithelial ovarian cancer (EOC) constitutes 90% of ovarian cancers (OC) and is the eighth most common cause of cancer-related death in women. The cancer histologically and genetically is very complex...
Sat Mar 14, 2020 02:00
Cells, Vol. 9, Pages 718: Role of the Nuclear Lamina in Age-Associated Nuclear Reorganization and Inflammation Cells doi: 10.3390/cells9030718 Authors: Lidya Kristiani Miri Kim Youngjo Kim Aging is characterized by the gradual loss of tissue function and integrity. Activation of inflammatory responses accelerates the deterioration of cells and tissues. Many studies have shown that alteration of the components of the nuclear lamina is associated with inflammation, both in vivo and...
Sat Mar 14, 2020 02:00
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