IJMS, Vol. 21, Pages 1990: Deletion and Randomization of Structurally Variable Regions in B. subtilis Lipase A (BSLA) Alter Its Stability and Hydrolytic Performance Against Long Chain Fatty Acid Esters International Journal of Molecular Sciences doi: 10.3390/ijms21061990 Authors: Ronny Martínez Claudia Bernal Rodrigo Álvarez Christopher Concha Fernando Araya Ricardo Cabrera Gaurao V. Dhoke Mehdi D. Davari The continuous search for novel enzyme backbones and the engineering...
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IJMS, Vol. 21, Pages 1989: Biochemical Markers in Alzheimer’s Disease International Journal of Molecular Sciences doi: 10.3390/ijms21061989 Authors: Alessandro Rabbito Maciej Dulewicz Agnieszka Kulczyńska-Przybik Barbara Mroczko Alzheimer’s disease (AD) is one of the most frequent neurodegenerative diseases affecting more than 35 million people in the world, and its incidence is estimated to triple by 2050. Alzheimer’s disease is an age-related disease characterized...
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IJMS, Vol. 21, Pages 1991: Biology and Therapeutic Targets of Colorectal Serrated Adenocarcinoma; Clues for a Histologically Based Treatment against an Aggressive Tumor International Journal of Molecular Sciences doi: 10.3390/ijms21061991 Authors: Begoña Alburquerque-González Fernando F. López-Calderón María Dolores López-Abellán Ángel Esteban-Gil José García-Solano Pablo Conesa-Zamora Serrated adenocarcinoma (SAC) is a tumor recognized by the WHO as a histological subtype...
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IJMS, Vol. 21, Pages 1987: TMT-Based Quantitative Proteomic Analysis Reveals the Crucial Biological Pathways Involved in Self-Incompatibility Responses in Camellia oleifera International Journal of Molecular Sciences doi: 10.3390/ijms21061987 Authors: Yifan He Qianqian Song Yuefeng Wu Shutao Ye Shipin Chen Hui Chen Camellia oleifera is a valuable woody oil plant belonging to the Theaceae, Camellia oil extracted from the seed is an excellent edible oil source. Self-incompatibility...
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IJMS, Vol. 21, Pages 1988: Docking and Molecular Dynamics Predictions of Pesticide Binding to the Calyx of Bovine β-Lactoglobulin International Journal of Molecular Sciences doi: 10.3390/ijms21061988 Authors: Paulina Cortes-Hernandez Roberto Vázquez Nuñez Lenin Domínguez-Ramírez Pesticides are used extensively in agriculture, and their residues in food must be monitored to prevent toxicity. The most abundant protein in cow’s milk, β-lactoglobulin (BLG), shows...
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IJMS, Vol. 21, Pages 1986: Isolation and Quantification of Uremic Toxin Precursor-Generating Gut Bacteria in Chronic Kidney Disease Patients International Journal of Molecular Sciences doi: 10.3390/ijms21061986 Authors: Tessa Gryp Geert R.B. Huys Marie Joossens Wim Van Biesen Griet Glorieux Mario Vaneechoutte In chronic kidney disease (CKD), impaired kidney function results in accumulation of uremic toxins, which exert deleterious biological effects and contribute to inflammation...
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IJMS, Vol. 21, Pages 1985: Potential Role of Venular Amyloid in Alzheimer’s Disease Pathogenesis International Journal of Molecular Sciences doi: 10.3390/ijms21061985 Authors: Christopher D. Morrone Jossana Bishay JoAnne McLaurin Insurmountable evidence has demonstrated a strong association between Alzheimer’s disease (AD) and cerebral amyloid angiopathy (CAA), along with various other cerebrovascular diseases. One form of CAA, which is the accumulation of amyloid-beta...
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IJMS, Vol. 21, Pages 1984: Candida albicans Shields the Periodontal Killer Porphyromonas gingivalis from Recognition by the Host Immune System and Supports the Bacterial Infection of Gingival Tissue International Journal of Molecular Sciences doi: 10.3390/ijms21061984 Authors: Dominika Bartnicka Miriam Gonzalez-Gonzalez Joanna Sykut Joanna Koziel Izabela Ciaston Karina Adamowicz Grazyna Bras Marcin Zawrotniak Justyna Karkowska-Kuleta Dorota Satala Andrzej Kozik...
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IJMS, Vol. 21, Pages 1983: Aryl Hydrocarbon Receptor in Post-Mortem Hippocampus and in Serum from Young, Elder, and Alzheimer’s Patients International Journal of Molecular Sciences doi: 10.3390/ijms21061983 Authors: Nicte Alaide Ramos-García Marisol Orozco-Ibarra Enrique Estudillo Guillermo Elizondo Erick Gómez Apo Laura Graciela Chávez Macías Ana Luisa Sosa-Ortiz Mónica Adriana Torres-Ramos One of the characteristics of the cerebral aging process is the presence...
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IJMS, Vol. 21, Pages 1981: Maternal N-Acetyl Cysteine Intake Improved Glucose Tolerance in Obese Mice Offspring International Journal of Molecular Sciences doi: 10.3390/ijms21061981 Authors: Michal Michlin Lital Argaev-Frenkel Liza Weinstein-Fudim Asher Ornoy Tovit Rosenzweig Exposure to certain environmental factors during the early stages of development was found to affect health in adulthood. Among other environmental factors, oxidative stress has been suggested to be...
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IJMS, Vol. 21, Pages 1982: Overexpression of Barley Transcription Factor HvERF2.11 in Arabidopsis Enhances Plant Waterlogging Tolerance International Journal of Molecular Sciences doi: 10.3390/ijms21061982 Authors: Luan Guo Shen Pan Hong Lv Xu Waterlogging stress significantly affects the growth, development, and productivity of crop plants. However, manipulation of gene expression to enhance waterlogging tolerance is very limited. In this study, we identified...
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IJMS, Vol. 21, Pages 1979: Antimicrobial and Physicochemical Properties of Artificial Saliva Formulations Supplemented with Core-Shell Magnetic Nanoparticles International Journal of Molecular Sciences doi: 10.3390/ijms21061979 Authors: Katarzyna Niemirowicz-Laskowska Joanna Mystkowska Dawid Łysik Sylwia Chmielewska Grażyna Tokajuk Iwona Misztalewska-Turkowicz Agnieszka Z. Wilczewska Robert Bucki Saliva plays a crucial role in oral cavity. In addition to its buffering...
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IJMS, Vol. 21, Pages 1980: Association between Pericytes in Intraplaque Neovessels and Magnetic Resonance Angiography Findings International Journal of Molecular Sciences doi: 10.3390/ijms21061980 Authors: Ogata Wakamiya Nishihara Tanaka Mizokami Masuoka Momozaki Sakata Irie Abe (1) Background: Pericytes are involved in intraplaque neovascularization of advanced and complicated atherosclerotic lesions. However, the role of pericytes in human carotid...
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IJMS, Vol. 21, Pages 1976: Mitophagy in the Retinal Pigment Epithelium of Dry Age-Related Macular Degeneration Investigated in the NFE2L2/PGC-1α-/- Mouse Model International Journal of Molecular Sciences doi: 10.3390/ijms21061976 Authors: Iswariyaraja Sridevi Gurubaran Johanna Viiri Ali Koskela Juha M.T. Hyttinen Jussi J. Paterno Gréta Kis Miklós Antal Arto Urtti Anu Kauppinen Szabolcs Felszeghy Kai Kaarniranta Increased oxidative stress and mitochondrial...
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IJMS, Vol. 21, Pages 1978: Real-Time 3D Imaging and Inhibition Analysis of Various Amyloid Aggregations Using Quantum Dots International Journal of Molecular Sciences doi: 10.3390/ijms21061978 Authors: Xuguang Lin Nuomin Galaqin Reina Tainaka Keiya Shimamori Masahiro Kuragano Taro Q. P. Noguchi Kiyotaka Tokuraku Amyloidosis refers to aggregates of protein that accumulate and are deposited as amyloid fibrils into plaques. When these are detected in organs, they are the...
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IJMS, Vol. 21, Pages 1975: Curcumin in Health and Diseases: Alzheimer’s Disease and Curcumin Analogues, Derivatives, and Hybrids International Journal of Molecular Sciences doi: 10.3390/ijms21061975 Authors: Eirini Chainoglou Dimitra Hadjipavlou-Litina Worldwide, Alzheimer’s disease (AD) is the most common neurodegenerative multifactorial disease influencing the elderly population. Nowadays, several medications, among them curcumin, are used in the treatment of AD. Curcumin,...
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IJMS, Vol. 21, Pages 1977: Identification and Characterization of NPR1 and PR1 Homologs in Cymbidium orchids in Response to Multiple Hormones, Salinity and Viral Stresses International Journal of Molecular Sciences doi: 10.3390/ijms21061977 Authors: Rui Ren Yonglu Wei Sagheer Ahmad Jianpeng Jin Jie Gao Chuqiao Lu Genfa Zhu Fengxi Yang The plant nonexpressor of pathogenesis-related 1 (NPR1) and pathogenesis-associated 1 (PR1) genes play fundamental roles in plant...
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IJMS, Vol. 21, Pages 1974: Prevention of Cognitive Decline in Alzheimer’s Disease by Novel Antioxidative Supplements International Journal of Molecular Sciences doi: 10.3390/ijms21061974 Authors: Koh Tadokoro Yasuyuki Ohta Haruhiko Inufusa Alan Foo Nyuk Loon Koji Abe Oxidative stress plays a crucial role in Alzheimer’s disease (AD) from its prodromal stage of mild cognitive impairment. There is an interplay between oxidative stress and the amyloid β (Aβ)...
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IJMS, Vol. 21, Pages 1973: Physiologic Events of Embryo Implantation and Decidualization in Human and Non-Human Primates International Journal of Molecular Sciences doi: 10.3390/ijms21061973 Authors: Maria Ariadna Ochoa-Bernal Asgerally T. Fazleabas Reproduction is a fundamental process for the preservation of the human species. This process requires a sequence of orchestrated events that are necessary for a successful pregnancy. Two of the most critical steps in the establishment...
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IJMS, Vol. 21, Pages 1971: The Control of Developmental Phase Transitions by microRNAs and Their Targets in Seed Plants International Journal of Molecular Sciences doi: 10.3390/ijms21061971 Authors: Jingyi Ma Pan Zhao Shibiao Liu Qi Yang Huihong Guo Seed plants usually undergo various developmental phase transitions throughout their lifespan, mainly including juvenile-to-adult and vegetative-to-reproductive transitions, as well as developmental transitions within organ/tissue...
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IJMS, Vol. 21, Pages 1967: Ganglioside GM3 Up-Regulate Chondrogenic Differentiation by Transform Growth Factor Receptors International Journal of Molecular Sciences doi: 10.3390/ijms21061967 Authors: Jae-Sung Ryu Sang Young Seo Eun-Jeong Jeong Jong-Yeup Kim Yong-Gon Koh Yong Il Kim Young-Kug Choo Mesenchymal stem cells, also known as multipotent stromal progenitor cells, can differentiate into cells of mesodermal lineage. Gangliosides are sialic acid-conjugated glycosphingolipids...
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IJMS, Vol. 21, Pages 1972: Benefit of Later-Time-Point PET Imaging of HER3 Expression Using Optimized Radiocobalt-Labeled Affibody Molecules International Journal of Molecular Sciences doi: 10.3390/ijms21061972 Authors: Sara S. Rinne Charles Dahlsson Leitao Zahra Saleh-nihad Bogdan Mitran Vladimir Tolmachev Stefan Ståhl John Löfblom Anna Orlova HER3-binding affibody molecules are a promising format for visualization of HER3 expression. Cobalt-55, a positron-emitting...
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IJMS, Vol. 21, Pages 1969: An Exploratory Gene Expression Study of the Intestinal Mucosa of Patients with Non-Celiac Wheat Sensitivity International Journal of Molecular Sciences doi: 10.3390/ijms21061969 Authors: Konstantinos Efthymakis Emanuela Clemente Michele Marchioni Marta Di Nicola Matteo Neri Michele Sallese Non-celiac wheat sensitivity (NCWS) is a recently recognized syndrome triggered by a gluten-containing diet. The pathophysiological mechanisms engaged in NCWS...
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IJMS, Vol. 21, Pages 1965: Tenogenic Contribution to Skeletal Muscle Regeneration: The Secretome of Scleraxis Overexpressing Mesenchymal Stem Cells Enhances Myogenic Differentiation In Vitro International Journal of Molecular Sciences doi: 10.3390/ijms21061965 Authors: Maximilian Strenzke Paolo Alberton Attila Aszodi Denitsa Docheva Elisabeth Haas Christian Kammerlander Wolfgang Böcker Maximilian Michael Saller Integrity of the musculoskeletal system is essential...
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IJMS, Vol. 21, Pages 1968: IQGAP2 Inhibits Migration and Invasion of Gastric Cancer Cells via Elevating SHIP2 Phosphatase Activity International Journal of Molecular Sciences doi: 10.3390/ijms21061968 Authors: Liang Xu Yuling Shao Lin Ren Xiansheng Liu Yunyun Li Jiegou Xu Yan Ye Previous studies have shown reduced expression of Src homology 2-containing inositol 5-phosphatase 2 (SHIP2) and its tumor-suppressive role in gastric cancer (GC). However, the precise role...
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IJMS, Vol. 21, Pages 1966: Vaccarin Regulates Diabetic Chronic Wound Healing through FOXP2/AGGF1 Pathways International Journal of Molecular Sciences doi: 10.3390/ijms21061966 Authors: Yixiao Liu Jiangnan Sun Xinyu Ma Shuangshuang Li Min Ai Fei Xu Liying Qiu Background: Diabetes mellitus is a growing global health issue nearly across the world. Diabetic patients who are prone to develop diabetes-related complications often exhibit progressive neuropathy (painless and...
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IJMS, Vol. 21, Pages 1970: Actin Depolymerizing Factor Modulates Rhizobial Infection and Nodule Organogenesis in Common Bean International Journal of Molecular Sciences doi: 10.3390/ijms21061970 Authors: Yolanda Ortega-Ortega Janet Carrasco-Castilla Marco A. Juárez-Verdayes Roberto Toscano-Morales Citlali Fonseca-García Noreide Nava Luis Cárdenas Carmen Quinto Actin plays a critical role in the rhizobium–legume symbiosis. Cytoskeletal rearrangements and...
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IJMS, Vol. 21, Pages 1964: Trifunctionalized Naphthalene Diimides and Dimeric Analogues as G-Quadruplex-Targeting Anticancer Agents Selected by Affinity Chromatography International Journal of Molecular Sciences doi: 10.3390/ijms21061964 Authors: Chiara Platella Valentina Pirota Domenica Musumeci Federica Rizzi Sara Iachettini Pasquale Zizza Annamaria Biroccio Mauro Freccero Daniela Montesarchio Filippo Doria A focused library of newly designed monomeric and...
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IJMS, Vol. 21, Pages 1963: Tuning the Polymorphism of the Anti-VEGF G-rich V7t1 Aptamer by Covalent Dimeric Constructs International Journal of Molecular Sciences doi: 10.3390/ijms21061963 Authors: Claudia Riccardi Domenica Musumeci Chiara Platella Rosa Gaglione Angela Arciello Daniela Montesarchio In the optimization process of nucleic acid aptamers, increased affinity and/or activity are generally searched by exploring structural analogues of the lead compound. In many...
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IJMS, Vol. 21, Pages 1961: Animal Model for Prodromal Parkinson’s Disease International Journal of Molecular Sciences doi: 10.3390/ijms21061961 Authors: Tomoyuki Taguchi Masashi Ikuno Hodaka Yamakado Ryosuke Takahashi Parkinson’s disease (PD) is characterized by the loss of dopaminergic neurons in the substantia nigra and subsequent motor symptoms, but various non-motor symptoms (NMS) often precede motor symptoms. Recently, NMS have attracted much attention as a clue...
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IJMS, Vol. 21, Pages 1960: The Roles of Cyclin-Dependent Kinases in Cell-Cycle Progression and Therapeutic Strategies in Human Breast Cancer International Journal of Molecular Sciences doi: 10.3390/ijms21061960 Authors: Lei Ding Jiaqi Cao Wen Lin Hongjian Chen Xianhui Xiong Hongshun Ao Min Yu Jie Lin Qinghua Cui Cyclin-dependent kinases (CDKs) are serine/threonine kinases whose catalytic activities are regulated by interactions with cyclins and CDK inhibitors...
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IJMS, Vol. 21, Pages 1959: Comparative Mitogenome Analysis of the Genus Trifolium Reveals Independent Gene Fission of ccmFn and Intracellular Gene Transfers in Fabaceae International Journal of Molecular Sciences doi: 10.3390/ijms21061959 Authors: In-Su Choi Tracey A. Ruhlman Robert K. Jansen The genus Trifolium is the largest of the tribe Trifolieae in the subfamily Papilionoideae (Fabaceae). The paucity of mitochondrial genome (mitogenome) sequences has hindered comparative analyses...
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IJMS, Vol. 21, Pages 1962: Comprehensive Phosphoproteomic Analysis of Pepper Fruit Development Provides Insight into Plant Signaling Transduction International Journal of Molecular Sciences doi: 10.3390/ijms21061962 Authors: Zhoubin Liu Junheng Lv Yuhua Liu Jing Wang Zhuqing Zhang Wenchao Chen Jingshuang Song Bozhi Yang Fangjun Tan Xuexiao Zou Lijun Ou Limited knowledge is available for phosphorylation modifications in pepper (Capsicum annuum L.), especially...
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IJMS, Vol. 21, Pages 1958: Altered Levels of Sphingosine, Sphinganine and Their Ceramides in Atopic Dermatitis Are Related to Skin Barrier Function, Disease Severity and Local Cytokine Milieu International Journal of Molecular Sciences doi: 10.3390/ijms21061958 Authors: Ruzica Jurakic Toncic Ivone Jakasa Suzana Ljubojevic Hadzavdic Susan MI Goorden Karen JM Ghauharali-van der Vlugt Femke S Stet Anamaria Balic Mikela Petkovic Borna Pavicic Kristina Zuzul Branka...
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IJMS, Vol. 21, Pages 1957: Circulating Tumor Necrosis Factor Receptors: A Potential Biomarker for the Progression of Diabetic Kidney Disease International Journal of Molecular Sciences doi: 10.3390/ijms21061957 Authors: Maki Murakoshi Tomohito Gohda Yusuke Suzuki Despite considerable advancements in medicine, the optimal treatment for chronic kidney disease (CKD), especially diabetic kidney disease (DKD), remains a major challenge. More patients with DKD succumb to death due to...
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IJMS, Vol. 21, Pages 1955: Chondroitin Sulfate Promotes the Proliferation of Keloid Fibroblasts Through Activation of the Integrin and Protein Kinase B Pathways International Journal of Molecular Sciences doi: 10.3390/ijms21061955 Authors: Yasuhiro Katayama Motoko Naitoh Hiroshi Kubota Satoko Yamawaki Rino Aya Toshihiro Ishiko Naoki Morimoto Keloids are dermal fibroproliferative tumors that arise beyond the boundary of the original wound edges and invades adjacent tissue....
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IJMS, Vol. 21, Pages 1956: Distribution of Intracranial Major Artery Stenosis/Occlusion According to RNF213 Polymorphisms International Journal of Molecular Sciences doi: 10.3390/ijms21061956 Authors: Jinkwon Kim Young Seok Park Min-Hee Woo Hui Jeong An Jung Oh Kim Han Sung Park Chang Soo Ryu Ok Joon Kim Nam Keun Kim Intracranial major artery stenosis/occlusion (ICASO) is the major cause of ischemic stroke. Recent studies have suggested that variants of RNF213,...
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IJMS, Vol. 21, Pages 1954: Role of Neutrophils and Myeloid-Derived Suppressor Cells in Glioma Progression and Treatment Resistance International Journal of Molecular Sciences doi: 10.3390/ijms21061954 Authors: Sabbir Khan Sandeep Mittal Kain McGee Kristin D. Alfaro-Munoz Nazanin Majd Veerakumar Balasubramaniyan John F. de Groot Recent efforts in brain tumor research have been directed towards the modulation of the immune system for therapeutic interventions. Several...
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IJMS, Vol. 21, Pages 1953: The Protective Effect of Dabigatran and Rivaroxaban on DNA Oxidative Changes in a Model of Vascular Endothelial Damage with Oxidized Cholesterol International Journal of Molecular Sciences doi: 10.3390/ijms21061953 Authors: Ewelina Woźniak Marlena Broncel Bożena Bukowska Paulina Gorzelak-Pabiś Background: Atherosclerotic plaques are unstable, and their release may result in thrombosis; therefore, currently, antiplatelet therapy with anticoagulants...
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