Cancers, Vol. 12, Pages 671: Statin Use and the Risk of Hepatocellular Carcinoma: A Meta-Analysis of Observational Studies Cancers doi: 10.3390/cancers12030671 Authors: Islam Poly Walther Yang (Jack) Li Background and Aims: Statins are the first-line medication to treating hypercholesterolemia. Several studies have investigated the impact of statins on the risk of hepatocellular carcinoma (HCC). However, the extent to which statins may prevent HCC remains uncertain....
Fri Mar 13, 2020 02:00
Cancers, Vol. 12, Pages 672: Identification of PLK1 as a New Therapeutic Target in Mucinous Ovarian Carcinoma Cancers doi: 10.3390/cancers12030672 Authors: Affatato Carrassa Chilà Lupi Restelli Damia Mucinous epithelial ovarian cancer (mEOC) is a rare subset of epithelial ovarian cancer. When diagnosed at a late stage, its prognosis is very poor, as it is quite chemo-resistant. To find new therapeutic options for mEOC, we performed high-throughput screening...
Fri Mar 13, 2020 02:00
Cancers, Vol. 12, Pages 673: Natural Compounds with Potential to Modulate Cancer Therapies and Self-Reactive Immune Cells Cancers doi: 10.3390/cancers12030673 Authors: Rhiane Moody Kirsty Wilson Anthony Jaworowski Magdalena Plebanski Cancer-related deaths are approaching 10 million each year. Survival statistics for some cancers, such as ovarian cancer, have remained unchanged for decades, with women diagnosed at stage III or IV having over 80% chance of a lethal cancer...
Fri Mar 13, 2020 02:00
Cancers, Vol. 12, Pages 669: Sexual Dimorphism in Cellular and Molecular Features in Human ACTH-Secreting Pituitary Adenomas Cancers doi: 10.3390/cancers12030669 Authors: Francesca Pecori Giraldi Maria Francesca Cassarino Antonella Sesta Mariarosa Terreni Giovanni Lasio Marco Losa (1) Background. Cushing’s disease presents gender disparities in prevalence and clinical course. Little is known, however, about sexual dimorphism at the level of the corticotrope...
Fri Mar 13, 2020 02:00
Cancers, Vol. 12, Pages 668: Metformin as an Adjuvant to Photodynamic Therapy in Resistant Basal Cell Carcinoma Cells Cancers doi: 10.3390/cancers12030668 Authors: Marta Mascaraque Pablo Delgado-Wicke Cristina Nuevo-Tapioles Tamara Gracia-Cazaña Edgar Abarca-Lachen Salvador González José M. Cuezva Yolanda Gilaberte Ángeles Juarranz Photodynamic Therapy (PDT) with methyl-aminolevulinate (MAL-PDT) is being used for the treatment of Basal Cell Carcinoma...
Fri Mar 13, 2020 02:00
Cancers, Vol. 12, Pages 670: The Second Generation Antibody-Drug Conjugate SYD985 Overcomes Resistances to T-DM1 Cancers doi: 10.3390/cancers12030670 Authors: Nadal-Serrano Morancho Escrivá-de-Romaní Morales Luque Escorihuela Espinosa Bravo Peg Dijcks Dokter Cortés Saura Arribas Trastuzumab-emtansine (T-DM1) is an antibody-drug conjugate (ADC) approved for the treatment of HER2 (human epidermal growth factor receptor 2)-positive...
Fri Mar 13, 2020 02:00
Abstract Purpose Radioiodine-131 treatment has been a well-established therapy for benign thyroid diseases for more than 75 years. However, the physiological reasons of the so-called stunning phenomenon, defined as a reduced radioiodine uptake after previous diagnostic radioiodine administration, are still discussed controversially. In a recent study, a significant dependence of thyroid stunning on the pre-therapeutically administered...
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Abstract Diabetes is one of the most common metabolic diseases. Aside from the genetic factor, previous studies stated that other factors such as environment, lifestyle, and paternal–maternal condition play critical roles in diabetes through DNA methylation in specific areas of the genome. One of diabetic cases is caused by insulin resistance and changing the homeostasis of blood glucose control so glucose concentration stood beyond normal rate (hyperglycemia). High fat diet has...
Sat Mar 14, 2020 02:00
Abstract Purpose To identify the volume changes of hippocampus subfields in T2DM patients with cognitive impairment and to determine how these atrophy patterns associate with impairments in different cognitive domain. Methods A total of 117 individuals were recruited, including T2DM patients with cognitive impairment (T2DM-CI) (n = 34), T2DM patients...
Sat Mar 14, 2020 02:00
Abstract There is a lack of evidence on timing, frequency, and duration of postoperative endocrine, radiologic, and ophthalmologic assessments that should be performed after pituitary surgery (PS). However, it is known that careful optimization of treatment and follow-up strategies as well as a multidisciplinary approach may have a significant impact on long-term outcomes, improving surgical results, minimize complications and facilitate their correct treatment if occurring, and...
Fri Mar 13, 2020 02:00
Analyst, 2020, Accepted ManuscriptDOI: 10.1039/D0AN00137F, PaperYifei Xu, Marco BonizzoniWe describe a method for the differentiation of carboxylate anions on disposable paper supports (common printer paper, filter paper, chromatography paper), based on differential patterns of interactions between carboxylates and...The content of this RSS Feed (c) The Royal Society of Chemistry
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Using the interfacial barrier effects of p-n junction on electrochemistry for detection of phosphate
Analyst, 2020, Accepted ManuscriptDOI: 10.1039/C9AN02579K, CommunicationYu Ding, Minggang Zhao, Jiatuo Yu, Xiaomin Zhang, Zhengming Li, Hui LiA novel type of electrochemical sensor for detection of phosphate in water environment was developed by combining the interfacial barrier of p-n junction with the adsorption of phosphate. The electrochemical...The content of this RSS Feed (c) The Royal Society of Chemistry
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Analyst, 2020, Accepted ManuscriptDOI: 10.1039/D0AN00345J, PaperZhaoyi Liu, Yong Zhang, Bing Li, Xiang Ren, Hongmin Ma, Qin WeiNo-wash detection of small molecules in real samples has been arousing attention in the field of electroanalytical biosensors or sensors. Based on the direct electrochemical oxidation of Fluorene-9-bisphenol (BHPF) on...The content of this RSS Feed (c) The Royal Society of Chemistry
Fri Mar 13, 2020 02:00
Analyst, 2020, Accepted ManuscriptDOI: 10.1039/D0AN00393J, PaperHuizhen Wang, Dinggeng He, Kejing Wan, Xiaowu Sheng, Hong Cheng, Jin Huang, Xiao Zhou, Xiaoxiao He, Kemin WangHerein, a simple all-in-one biosensor based on DNA three-way junction has been constructed for in situ simultaneous detection of multiple miRNAs by competitive strand displacement. In our design, three oligonucleotides...The content of this RSS Feed (c) The Royal Society of Chemistry
Fri Mar 13, 2020 02:00
Analyst, 2020, Accepted ManuscriptDOI: 10.1039/D0AN00339E, Critical ReviewZhengquan Yan, Hua Yuan, Qi Zhao, Lin Xing, Xiaoyu Zheng, Weiguo Wang, Yulei Zhao, Yang Yu, Lei Hu, Wenli YaoHeavy metal contamination has posed a great threat to human survival and social development. For this, a series of nanoenzyme-based colorimetric sensors, i.e., metal nanoparticles, metal oxides, metal sulfides, graphene-based...The content of this RSS Feed (c) The Royal Society of Chemistry
Fri Mar 13, 2020 02:00
Abstract Skull base osteomyelitis (SBO) is a severe condition that mostly occurs in diabetic patients. The duration of treatment is variable, and depends on the extent of the disease. There is currently no consensus on the best criteria for ending treatment. The objective of this study was to assess the value of 99mTc‐HMPAO‐leukocyte scintigraphy (LS) and [18F]‐fluoro‐desoxyglucose Positron Emission Tomography combined with CT ([18F]FDG‐PET/CT) for the diagnosis and the end‐of‐treatment assessment...
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A review of findings from the MarkeTrak 10 consumer survey of hearing aid owners and non-owners conducted by Hearing Industries Association, with takeaways for audiologists and hearing aid dispensers.
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Abstract Rationale Social attachment plays an important role in offspring development. Different parenting experiences during lactation may shape offspring behavior and later alcohol use. Objectives We tested the hypothesis that differential rearing conditions (single mother, SM or biparental, BP) in the non-monogamous C57BL/6J mice may affect (1) parental...
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British Journal of Cancer, Published online: 16 March 2020; doi:10.1038/s41416-020-0788-8Decreased vitamin C uptake mediated by SLC2A3 promotes leukaemia progression and impedes TET2 restoration
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British Journal of Cancer, Published online: 16 March 2020; doi:10.1038/s41416-020-0783-0Targeting CD133 reverses drug-resistance via the AKT/NF-κB/MDR1 pathway in colorectal cancer
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British Journal of Cancer, Published online: 16 March 2020; doi:10.1038/s41416-020-0786-xLong-term cardiac outcomes of patients with HER2-positive breast cancer treated in the adjuvant lapatinib and/or trastuzumab Treatment Optimization Trial
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British Journal of Cancer, Published online: 16 March 2020; doi:10.1038/s41416-020-0791-0Comments on “Use of hydrochlorothiazide and risk of skin cancer: a nationwide Taiwanese case-control study”
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Purpose: Previous studies suggest that androgen deprivation therapy (ADT) promotes antitumor immunity in prostate cancer. Whether a vaccine-based approach can augment this effect remains unknown. Experimental Design: Therefore, we conducted a neoadjuvant, randomized study to quantify the immunologic effects of a granulocyte-macrophage colony-stimulating factor (GM-CSF)-secreting allogeneic cellular vaccine in combination with low-dose cyclophosphamide (Cy/GVAX) followed by degarelix versus degarelix...
Sun Mar 15, 2020 09:05
Purpose: Existing cell-free DNA (cfDNA) methods lack the sensitivity needed for detecting minimal residual disease (MRD) following therapy. We developed a test for tracking hundreds of patient-specific mutations to detect MRD with a 1000-fold lower error rate than conventional sequencing. Experimental Design: We compared the sensitivity of our approach to digital droplet PCR (ddPCR) in a dilution series, then retrospectively identified two cohorts of patients who had undergone prospective plasma...
Fri Mar 13, 2020 15:43
Phoresy is a behavior in which an organism, the phoront, travels from one location to another by 'hitching a ride' on the body of a host as it disperses. Some phoronts are generalists, taking advantage of any available host. Others are specialists and travel only when specific hosts are located using chemical cues to identify and move (chemotax) toward the preferred host. Free-living nematodes, like Caenorhabditis elegans, are often found in natural environments that contain terrestrial isopods and...
Sun Mar 15, 2020 02:00
Cichlids fishes exhibit extensive phenotypic diversification and speciation. Encounters with new environments alone are not sufficient to explain this striking diversity of cichlid radiation because other taxa coexistent with the Cichlidae demonstrate lower species richness. Wagner et al analyzed cichlid diversification in 46 African lakes and reported that both extrinsic environmental factors and intrinsic lineage-specific traits related to sexual selection have strongly influenced the cichlid radiation...
Sun Mar 15, 2020 02:00
Contamination from present-day DNA is a fundamental issue when studying ancient DNA from historical or archaeological material, and quantifying the amount of contamination is essential for downstream analyses. We present AuthentiCT, a command-line tool to estimate the proportion of present-day DNA contamination in ancient DNA datasets generated from single-stranded DNA libraries. The prediction is based solely on the patterns of post-mortem damage observed on ancient DNA sequences. The method has...
Sun Mar 15, 2020 02:00
The Siberian Altai mountains have been intermittently occupied by both Neandertals and Denisovans, two extinct hominin groups. While they diverged at least 390,000 years ago, later contacts lead to gene flow from Neandertals into Denisovans. Using a new population genetic method that is capable of inferring signatures of admixture from highly degraded genetic data, I show that this gene flow was much more widespread than previously thought. While the two earliest Denisovans both have substantial...
Sun Mar 15, 2020 02:00
Fossils show that fly-speck fungi have been reproducing with small, black thyriothecia on leaf surfaces for ~250 million years. We analyze morphological characters of extant thyriothecial fungi to develop a phylogenetic framework for interpreting fossil taxa. We placed 59 extant fly-speck fungi in a phylogeny of 320 Ascomycota using nuclear ribosomal large and small subunit sequences, including newly determined sequences from nine taxa. We reconstructed ancestral character states using BayesTraits...
Sat Mar 14, 2020 02:00
Environmental limits of animal life are invariably revised upwards when the animals themselves are investigated in their natural habitats. Here we report results of a scientific mountaineering expedition to survey the high-altitude rodent fauna of Volcan Llullaillaco in the Puna de Atacama of northern Chile, an effort motivated by video documentation of mice (genus Phyllotis) at a record altitude of 6205 m. Among numerous trapping records at altitudes >5000 m, we captured a specimen of the yellow-rumped...
Sat Mar 14, 2020 02:00
As we enter the Anthropocene, the evolutionary dynamics of species will change drastically, and as yet unpredictably, due to human activity. Already today, increases in global human traffic have resulted in the rapid spread of species to new areas, leading to the formation of geographically isolated populations. These go on to evolve in allopatry, which can lead to reproductive isolation, and potentially, the formation of new species. Surprisingly, little is known about such eco-evolutionary processes...
Sat Mar 14, 2020 02:00
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