Related ArticlesBeta-blocker exposure for short-term outcomes following non-cardiac surgery: a meta-analysis of observational studies. Int J Surg. 2020 Mar 10;: Authors: Nan Y, Jia F, Du X, Mei Z Abstract BACKGROUND: It remains uncertain whether there is a benefit to perioperative beta-blocker use on outcomes after non-cardiac surgery. This meta-analysis aims to update the evidence regarding the associations between beta-blocker exposure and patient...
Sun Mar 15, 2020 13:18
Related ArticlesImmediate Weightbearing after Intramedullary Fixation of Extra-articular Distal Tibial Fractures Reduces the Nonunion Rate Compared with Traditional Weight-bearing Protocol: A Cohort study. Int J Surg. 2020 Mar 10;: Authors: Weng S, Bi C, Gu S, Qi X, Huang Y Abstract OBJECTIVES: To investigate whether immediate weightbearing after intramedullary fixation of extra-articular distal tibial fractures could avoid secondary replacement....
Sun Mar 15, 2020 13:18
Related ArticlesCardiac tumors prevalence and mortality: A systematic review and meta-analysis. Int J Surg. 2020 Mar 10;: Authors: Rahouma M, Arisha MJ, Elmously A, El-Sayed Ahmed MM, Spadaccio C, Mehta K, Baudo M, Kamel M, Mansor E, Ruan Y, Morsi M, Shmushkevich S, Eldessouki I, Rahouma M, Mohamed A, Gambardella I, Girardi L, Gaudino M Abstract OBJECTIVES: Cardiac tumors and their associated outcomes are poorly characterized. This study sought to...
Sun Mar 15, 2020 13:18
Related ArticlesAn Invited Commentary on "World Health Organization declares Global Emergency: A review of the 2019 Novel Coronavirus (COVID-19)": Emergency or New Reality? Int J Surg. 2020 Mar 10;: Authors: Purcell LN, Charles AG PMID: 32169565 [PubMed - as supplied by publisher]
Sun Mar 15, 2020 13:18
Related ArticlesKinesio tape reduces pain in patients with lateral epicondylitis: a meta-analysis of randomized controlled trials. Int J Surg. 2020 Mar 09;: Authors: Zhong Y, Zheng C, Zheng J, Xu S Abstract BACKGROUND: The efficacy of Kinesio tape (KT) in lateral epicondylitis (LE) is widely discussed, but the results of these studies are conflicting. We perform this meta-analysis from randomized controlled trials (RCTs) in order to evaluate the...
Sat Mar 14, 2020 12:58
Related ArticlesComparison of Preliminary Clinical Outcomes between Percutaneous Endoscopic and Minimally Invasive Transforaminal Lumbar Interbody Fusion for Lumbar Degenerative Diseases in A Tertiary Hospital: Is Percutaneous Endoscopic Procedure Superior to MIS-TLIF? A Prospective Cohort Study. Int J Surg. 2020 Mar 09;: Authors: Ao S, Zheng W, Wu J, Tang Y, Zhang C, Zhou Y, Li C Abstract BACKGROUND: Percutaneous endoscopic transforaminal lumbar...
Sat Mar 14, 2020 12:58
Related ArticlesUncovered p1 and p2 waves preceding the N3 vestibular evoked neurogenic potential in profound sensorineural hearing loss. Physiol Rep. 2020 Mar;8(5):e14392 Authors: Pascual-Rubio V, Domènech-Vadillo E, Cárdenas-Escalante P, Avilés-Jurado FX, Pellisé-Guinjoan A, Figuerola-Massana E Abstract BACKGROUND: The N3 wave is a vestibular evoked neurogenic potential detected in some patients with profound sensorineural hearing loss (PSNHL)...
Sun Mar 15, 2020 13:17
Related ArticlesBilateral superior semicircular canal dehiscence: bilateral conductive hearing loss with subtle vestibular symptoms. BMJ Case Rep. 2020 Mar 12;13(3): Authors: Pereira D, Leonardo A, Duarte D, Oliveira N Abstract Superior semicircular canal dehiscence is caused by a bone defect on the roof of the superior semicircular canal. The estimated prevalence when unilateral varies between 0.4% and 0.7% and is still unknown when bilateral. Patients...
Sun Mar 15, 2020 13:17
Design, synthesis, and evaluation of N-phenyl-4-(2-phenylsulfonamido)-benzamides as microtubule-targeting agents in drug-resistant cancer cells, displaying HDAC inhibitory response. Eur J Med Chem. 2020 Feb 20;192:112158 Authors: Wu WC, Liu YM, Lin MH, Liao YH, Lai MJ, Chuang HY, Hung TY, Chen CH, Liou JP Abstract Microtubule-targeting agents (MTA) have enjoyed significant clinical success for decades. However, several mechanisms may cause inactivation...
Sun Mar 15, 2020 13:15
Chromosomal aberration dynamics through the cell cycle. DNA Repair (Amst). 2020 Mar 06;89:102838 Authors: Pujol-Canadell M, Puig R, Armengol G, Barrios L, Barquinero JF Abstract DNA double-strand breaks are the crucial lesions underlying the formation of chromosomal aberrations, their formation and kinetics have been extensively studied, although dynamics of the repair process has not been fully understood. By using a combination of different cytogenetic...
Sun Mar 15, 2020 13:15
A Cyclin D1-Specific Single-Chain Variable Fragment Antibody that Inhibits HepG2 Cell Growth and Proliferation. Biotechnol J. 2020 Mar 14;:e1900430 Authors: Wu Y, Tang W, Cao Y, Jiang D, Zhao L, Zhao J, Zhang Y, Li C, Cheng C, Wang S, Yang F, Zhu X, Li G Abstract Cyclin D1 is a key regulatory factor of the G1 to S transition during cell cycle progression. Aberrant cyclin D gene amplification and abnormal protein expression have been linked to hepatocellular...
Sun Mar 15, 2020 13:15
Related ArticlesCell cycle synchronisation using thiazolidinediones affects cellular glucose metabolism and enhances the therapeutic effect of 2-deoxyglucose in colon cancer. Sci Rep. 2020 Mar 13;10(1):4713 Authors: Yoon JK, Byeon HE, Ko SA, Park BN, An YS, Lee HY, Lee YW, Lee SJ Abstract The effect of cell cycle synchronisation on glucose metabolism in cancer cells is not known. We assessed how cell cycle synchronisation by thiazolidinediones (TZDs)...
Sun Mar 15, 2020 13:15
Related ArticlesCell-type-specific role of CHK2 in mediating DNA damage-induced G2 cell cycle arrest. Oncogenesis. 2020 Mar 13;9(3):35 Authors: van Jaarsveld MTM, Deng D, Ordoñez-Rueda D, Paulsen M, Wiemer EAC, Zi Z Abstract Cancer is a life-threatening disease that affects one in three people. Although most cases are sporadic, cancer risk can be increased by genetic factors. It remains unknown why certain genes predispose for specific forms of cancer...
Sun Mar 15, 2020 13:15
Related ArticlesIdentification of a stemness-related gene panel associated with BET inhibition in triple negative breast cancer. Cell Oncol (Dordr). 2020 Mar 12;: Authors: Serrano-Oviedo L, Nuncia-Cantarero M, Morcillo-Garcia S, Nieto-Jimenez C, Burgos M, Corrales-Sanchez V, Perez-Peña J, Győrffy B, Ocaña A, Galán-Moya EM Abstract PURPOSE: Triple negative breast cancers (TNBCs) are enriched in cells bearing stem-like features, i.e., cancer stem cells...
Sat Mar 14, 2020 12:13
Related ArticlesBoth BRCA1-wild type and -mutant triple-negative breast cancers show sensitivity to the NAE inhibitor MLN4924 which is enhanced upon MLN4924 and cisplatin combination treatment. Oncotarget. 2020 Feb 25;11(8):784-800 Authors: Misra S, Zhang X, Wani NA, Sizemore S, Ray A Abstract Triple-negative breast cancer (TNBC) shows limited therapeutic efficacy. PARP inhibitor has been approved to treat advanced BRCA-mutant breast cancer but shows...
Sat Mar 14, 2020 12:13
Related ArticlesCancer immune control needs senescence induction by interferon-dependent cell cycle regulator pathways in tumours. Nat Commun. 2020 Mar 12;11(1):1335 Authors: Brenner E, Schörg BF, Ahmetlić F, Wieder T, Hilke FJ, Simon N, Schroeder C, Demidov G, Riedel T, Fehrenbacher B, Schaller M, Forschner A, Eigentler T, Niessner H, Sinnberg T, Böhm KS, Hömberg N, Braumüller H, Dauch D, Zwirner S, Zender L, Sonanini D, Geishauser A, Bauer J, Eichner M, Jarick KJ,...
Sat Mar 14, 2020 12:13
Related ArticlesLong noncoding RNA pncRNA-D reduces cyclin D1 gene expression and arrests cell cycle through RNA m6A modification. J Biol Chem. 2020 Mar 12;: Authors: Yoneda R, Ueda N, Uranishi K, Hirasaki M, Kurokawa R Abstract pncRNA-D is an irradiation-induced 602-nt-long long noncoding RNA (lncRNA) transcribed from the promoter region of the cyclin D1 (CCND1) gene. CCND1 expression is predicted to be inhibited through an interplay between pncRNA-D...
Sat Mar 14, 2020 12:13
Related ArticlesIn vitro evaluation of cytotoxic properties of 5-Aminolevulinic acid (5-ALA) on bladder cancer cells. Photodiagnosis Photodyn Ther. 2020 Mar 09;:101714 Authors: Fahmy UA, Fahmy O Abstract INTRODUCTION: 5-Aminolevulinic (5-ALA) is used as a photo diagnostic agent in bladder cancer; patients with bladder cancer receive a diagnosis of non-muscle invasive disease however, it is unknown whether 5-ALA possess anti-cancer properties. The...
Sat Mar 14, 2020 12:13
Related ArticlesNovel retinoic acid derivative induces differentiation and growth arrest in neuroblastoma. J Pediatr Surg. 2020 Feb 28;: Authors: Marayati R, Williams AP, Bownes LV, Quinn CH, Stewart JE, Mroczek-Musulman E, Atigadda VR, Beierle EA Abstract INTRODUCTION: Retinoic acid (RA) is a differentiating agent utilized as maintenance therapy for high-risk neuroblastoma (NB), but associated toxicities limit its use. We have previously shown that...
Sat Mar 14, 2020 12:13
Related ArticlesErlotinib. Profiles Drug Subst Excip Relat Methodol. 2020;45:93-117 Authors: Abdelgalil AA, Al-Kahtani HM, Al-Jenoobi FI Abstract Erlotinib (OSI-774), marketed by Genentech as Tarceva®, is anticancer drug approved by US-FDA for the treatment of Non-Small Cell Lung Cancer (NSCLC) and Pancreatic Cancer. Erlotinib inhibited epidermal growth factor receptor (EGFR) that blocks tumor cell division, produces cell cycle arrest, and initiates...
Sat Mar 14, 2020 12:13
Related ArticlesSenescence in post-mitotic cells: a driver of ageing? Antioxid Redox Signal. 2020 Mar 13;: Authors: von Zglinicki T, Wan T, Miwa S Abstract SIGNIFICANCE: Cell senescence was originally defined by an acute loss of replicative capacity and thus thought to be restricted to proliferation-competent cells. More recently, senescence has been recognised as a cellular stress and damage response encompassing multiple pathways or senescence...
Sat Mar 14, 2020 12:13
Related ArticlesGlioblastoma Multiforme Stem Cell Cycle Arrest by Alkylaminophenol Through the Modulation of EGFR and CSC Signaling Pathways. Cells. 2020 Mar 10;9(3): Authors: Doan P, Musa A, Murugesan A, Sipilä V, Candeias NR, Emmert-Streib F, Ruusuvuori P, Granberg K, Yli-Harja O, Kandhavelu M Abstract Cancer stem cells (CSCs), a small subpopulation of cells existing in the tumor microenvironment promoting cell proliferation and growth. Targeting...
Sat Mar 14, 2020 12:13
Related ArticlesImmune Clearance of Senescent Cells to Combat Ageing and Chronic Diseases. Cells. 2020 Mar 10;9(3): Authors: Song P, An J, Zou MH Abstract Senescent cells are generally characterized by permanent cell cycle arrest, metabolic alteration and activation, and apoptotic resistance in multiple organs due to various stressors. Excessive accumulation of senescent cells in numerous tissues leads to multiple chronic diseases, tissue dysfunction,...
Sat Mar 14, 2020 12:13
Related ArticlesProton Pump Inhibitors Reduce Pancreatic Adenocarcinoma Progression by Selectively Targeting H+, K+-ATPases in Pancreatic Cancer and Stellate Cells. Cancers (Basel). 2020 Mar 10;12(3): Authors: Tozzi M, Sørensen CE, Magni L, Christensen NM, Bouazzi R, Buch CM, Stefanini M, Duranti C, Arcangeli A, Novak I Abstract Pancreatic duct cells are equipped with acid/base transporters important for exocrine secretion. Pancreatic ductal adenocarcinoma...
Sat Mar 14, 2020 12:13
Related Articles[Hepatocellular Carcinoma Cells with Downregulated ZEB2 Become Resistant to Resveratrol by Concomitant Induction of ABCG2 Expression]. Mol Biol (Mosk). 2020 Jan-Feb;54(1):87-94 Authors: Balcik-Ercin P, Cetin M, Yalim-Camci I, Uygur T, Yagci T Abstract In hepatocellular carcinoma (HCC), the presence of cancer stem cells (CSCs) have been linked to drug resistance, epithelial-mesenchymal transition (EMT), and cancer relapse. This study...
Fri Mar 13, 2020 14:02
Related ArticlesThe Optimal Outcome of Suppressing Ewing Sarcoma Growth in vivo With Biocompatible Bioengineered miR-34a-5p Prodrug. Front Oncol. 2020;10:222 Authors: Li DF, Yuan Y, Tu MJ, Hu X, Li YZ, Yi WR, Li PC, Zhao Y, Cheng Z, Yu AM, Jian C, Yu AX Abstract Being the second most common type of primary bone malignancy in children and adolescents, Ewing Sarcoma (ES) encounters the dilemma of low survival rate with a lack of effective treatments....
Fri Mar 13, 2020 12:02
Related ArticlesPathological Complete Response After a Single Dose of Anti-PD-1 Therapy in Combination with Chemotherapy as a First-Line Setting in an Unresectable Locally Advanced Gastric Cancer with PD-L1 Positive and Microsatellite Instability. Onco Targets Ther. 2020;13:1751-1756 Authors: Jin H, Li P, Mao C, Zhu K, Chen H, Gao Y, Yu J Abstract Programmed cell death-1 (PD-1) immune checkpoint inhibitors have exhibited promising efficacy in various...
Fri Mar 13, 2020 12:02
Related ArticlesYeast Extract Induces Apoptosis and Cell Cycle Arrest via Activating p38 Signal Pathway in Colorectal Cancer Cells. Ann Clin Lab Sci. 2020 Jan;50(1):31-44 Authors: Moon D, Kang HK, Kim J, Yoon SP Abstract The microbiome has recently become a key interest for cancer research. Anti-tumor effects of reinforced clostridium media (RCM) were investigated for all ingredients of RCM, which showed that yeast extract could be a candidate for...
Fri Mar 13, 2020 14:02
Related ArticlesPI3K abrogation using pan PI3K inhibitor BKM120 give rise to a weighty anti-cancer effect on AML-derived KG-1 cells by inducing apoptosis and G2/M arrest Turk J Haematol. 2020 Mar 12;: Authors: Sadeghi S, Esmaeili S, Pourbagheri-Sigaroodi A, Safaroghli-Azar A, Bashash D Abstract The association between the PI3K over-expression and the acquisition of chemo-resistance has attracted tremendous attentions to this axis as an appealing...
Fri Mar 13, 2020 12:02
Related ArticlesAlisol A Suppresses Proliferation, Migration, and Invasion in Human Breast Cancer MDA-MB-231 Cells. Molecules. 2019 Oct 10;24(20): Authors: Lou C, Xu X, Chen Y, Zhao H Abstract Natural products are a precious source of promising leads for the development of novel cancer therapeutics. Recently, triterpenoids in Alismatis rhizoma has been widely demonstrated for their anti-cancer activities in cancer cells. In this study, we examined the...
Fri Mar 13, 2020 12:02
Related ArticlesPreparation of Cell Cycle-Synchronized Saccharomyces cerevisiae Cells for Hi-C. Methods Mol Biol. 2019;2004:155-165 Authors: Schalbetter SA, Baxter J Abstract The chromosome organization activities of SMC complexes are crucial for correct gene expression and genetic inheritance in cells. Hi-C assays have revealed previously unsuspected levels of chromosome structure, with different types of chromosome structure facilitating function...
Fri Mar 13, 2020 12:02
Rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisolone combined with high-dose methotrexate plus intrathecal chemotherapy for newly diagnosed intravascular large B-cell lymphoma (PRIMEUR-IVL): a multicentre, single-arm, phase 2 trial. Lancet Oncol. 2020 Mar 11;: Authors: Shimada K, Yamaguchi M, Atsuta Y, Matsue K, Sato K, Kusumoto S, Nagai H, Takizawa J, Fukuhara N, Nagafuji K, Miyazaki K, Ohtsuka E, Okamoto M, Sugita Y, Uchida T, Kayukawa S, Wake A,...
Sun Mar 15, 2020 13:12
Related ArticlesDifferential expression of Tim-3, PD-1, and CCR5 on peripheral T and B lymphocytes in hepatitis C virus-related hepatocellular carcinoma and their impact on treatment outcomes. Cancer Immunol Immunother. 2020 Mar 13;: Authors: Zahran AM, Hetta HF, Rayan A, Eldin AS, Hassan EA, Fakhry H, Soliman A, El-Badawy O Abstract BACKGROUND AND OBJECTIVE: Activation of the immune checkpoints and expression of chemokines and chemokine receptors...
Sun Mar 15, 2020 13:12
Related ArticlesCirculating leptin levels are associated with adiposity in survivors of childhood brain tumors. Sci Rep. 2020 Mar 13;10(1):4711 Authors: Sims ED, Jennings WJ, Empringham B, Fleming A, Portwine C, Johnston DL, Zelcer SM, Rassekh SR, Burrow S, Thabane L, Samaan MC Abstract Survivors of Childhood Brain Tumors (SCBT) are at a higher risk of developing cardiovascular disease and type 2 diabetes compared to the general population. Adiposity...
Sun Mar 15, 2020 13:12
Related ArticlesDesign and development of 99mTc labeled FAPI-tracers for SPECT-imaging and 188Re therapy. J Nucl Med. 2020 Mar 13;: Authors: Lindner T, Altmann A, Kraemer S, Kleist C, Loktev A, Kratochwil C, Giesel F, Mier W, Marme F, Debus J, Haberkorn U Abstract The majority of epithelial tumors recruits fibroblasts and other non-malignant cells and activates them into cancer-associated fibroblasts. This often leads to overexpression of the membrane...
Sun Mar 15, 2020 13:12
Related ArticlesDysphagia prevalence and associated survival differences in older patients with lung Cancer: A SEER-Medicare population-based study. J Geriatr Oncol. 2020 Mar 10;: Authors: Marmor S, Cohen S, Fujioka N, Cho LC, Bhargava A, Misono S Abstract INTRODUCTION: The impact of dysphagia in persons with lung cancer is unknown. The objective of this study is to measure the prevalence and survival differences associated with dysphagia in older...
Sun Mar 15, 2020 13:12
Related ArticlesAge differences in patterns and confidence of using internet and social media for cancer-care among cancer survivors. J Geriatr Oncol. 2020 Mar 10;: Authors: Eng L, Bender J, Hueniken K, Kassirian S, Mitchell L, Aggarwal R, Paulo C, Smith EC, Geist I, Balaratnam K, Magony A, Liang M, Yang D, Jones JM, Brown MC, Xu W, Grover SC, Alibhai SMH, Liu G, Gupta AA Abstract OBJECTIVES: The internet and social media provide information and...
Sun Mar 15, 2020 13:12
Related ArticlesA Cost-Utility Analysis of Magnetic Resonance (MR) Guided Brachytherapy versus Two Dimensional and Computed Tomography (CT) Guided Brachytherapy for Locally Advanced Cervical Cancer. Int J Radiat Oncol Biol Phys. 2020 Mar 10;: Authors: Perdrizet J, D'Souza D, Skliarenko J, Ang M, Barbera L, Gutierrez E, Ravi A, Tanderup K, Warde P, Chan KKW, Isaranuwatchai W, Milosevic M Abstract BACKGROUND: and Purpose: The standard treatment for...
Sun Mar 15, 2020 13:12
Related ArticlesPediatric Robotic Surgery. Surg Clin North Am. 2020 Apr;100(2):431-443 Authors: Denning NL, Kallis MP, Prince JM Abstract Pediatric robotic-assisted surgery is quickly gaining traction in pediatric surgical disciplines but presents unique challenges as compared to adult robotic surgery. Small abdominal and thoracic cavities limit working space and operative indications differ from the adult population. This article describes the development...
Sun Mar 15, 2020 13:12
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