Related ArticlesComprehensive tumor profiling reveals unique molecular differences between peritoneal metastases and primary colorectal adenocarcinoma. J Surg Oncol. 2020 Mar 12;: Authors: Stein MK, Williard FW, Xiu J, Tsao MW, Martin MG, Deschner BW, Dickson PV, Glazer ES, Yakoub D, Shibata D, Grothey AF, Philip PA, Hwang JJ, Shields AF, Marshall JL, Korn WM, Lenz HJ, Deneve JL Abstract BACKGROUND AND OBJECTIVES: Peritoneal metastases (PM) from primary...
Sat Mar 14, 2020 12:52
Related ArticlesSpinal meningiomas: is Simpson grade II resection radical enough? Acta Neurochir (Wien). 2020 Mar 12;: Authors: Voldřich R, Netuka D, Beneš V Abstract BACKGROUND: The optimal treatment for spinal meningioma is complete resection. The radicality of resection is the most important predictive factor for future tumor recurrence. Although clinical series dedicated to spinal meningiomas are relatively frequent, only a minimum of these defines...
Sat Mar 14, 2020 12:52
Related ArticlesDiffusion-weighted MRI in the assessment of nephroblastoma: results of a multi-center trial. Abdom Radiol (NY). 2020 Mar 12;: Authors: Hötker AM, Lollert A, Mazaheri Y, Müller S, Schenk JP, Mildenberger PC, Akin O, Graf N, Staatz G Abstract PURPOSE: To assess the value of diffusion-weighted MRI in the pre-therapeutic evaluation of pediatric renal cortical tumors. METHODS: This IRB-approved, retrospective multi-center study included...
Sat Mar 14, 2020 12:52
Related ArticlesA Pilot Study on Continuous Infusion of 4% Albumin in Critically Ill Patients: Impact on Nosocomial Infection via a Reduction Mechanism for Oxidized Substrates. Crit Care Explor. 2019 Sep;1(9):e0044 Authors: Schneider F, Dureau AF, Hellé S, Betscha C, Senger B, Cremel G, Boulmedais F, Strub JM, Corti A, Meyer N, Guillot M, Schaaf P, Metz-Boutigue MH Abstract Care-related infections affect up to 11% of ICU patients. Running therapeutic...
Sat Mar 14, 2020 12:52
Related ArticlesNoninvasive diagnosis in alcohol-related liver disease. Health Sci Rep. 2020 Mar;3(1):e146 Authors: Hadefi A, Degré D, Trépo E, Moreno C Abstract Background: Alcohol-related liver disease (ALD) represents a major cause of death worldwide, and unfortunately, most patients are diagnosed at an advanced stage of the disease, which is related to poorer outcomes. Liver biopsy has historically been the gold standard for identifying advanced...
Sat Mar 14, 2020 12:52
Related ArticlesDose-time fractionation schedules of preoperative radiotherapy and timing to surgery for rectal cancer. Ther Adv Med Oncol. 2020;12:1758835920907537 Authors: Jin F, Luo H, Zhou J, Wu Y, Sun H, Liu H, Zheng X, Wang Y Abstract Chemoradiotherapy (CRT) is extensively used prior to surgery for rectal cancer to provide significantly better local control, but the radiotherapy (RT), as the other component of CRT, has been subject to less interest...
Sat Mar 14, 2020 12:52
Related ArticlesMetabolic Profiling of Formalin-Fixed Paraffin-Embedded Tissues Discriminates Normal Colon from Colorectal Cancer. Mol Cancer Res. 2020 Mar 12;: Authors: Arima K, Lau MC, Zhao M, Haruki K, Kosumi K, Mima K, Gu M, Väyrynen JP, Twombly TS, Baba Y, Fujiyoshi K, Kishikawa J, Guo C, Baba H, Richards WG, Chan AT, Nishihara R, Meyerhardt JA, Nowak JA, Giannakis M, Fuchs CS, Ogino S Abstract Accumulating evidence suggests that metabolic reprogramming...
Sat Mar 14, 2020 12:52
Related ArticlesCombined therapy of AXL and HDAC inhibition reverses mesenchymal transition in diffuse intrinsic pontine glioma. Clin Cancer Res. 2020 Mar 12;: Authors: Meel MH, de Gooijer MC, Metselaar DS, Sewing ACP, Zwaan K, Waranecki P, Breur M, Buil LCM, Lagerweij T, Wedekind LE, Twisk JWR, Koster J, Hashizume R, Raabe EH, Montero-Carcaboso A, Bugiani M, Phoenix TN, van Tellingen O, van Vuurden DG, Kaspers GJL, Hulleman E Abstract PURPOSE: Diffuse...
Sat Mar 14, 2020 12:52
Related ArticlesAPC/C ubiquitin ligase: functions and mechanisms in tumorigenesis. Semin Cancer Biol. 2020 Mar 09;: Authors: Schrock MS, Stromberg BR, Scarberry L, Summers MK Abstract The anaphase promoting complex/ cyclosome (APC/C), is an evolutionarily conserved protein complex essential for cellular division due to its role in regulating the mitotic transition from metaphase to anaphase. In this review, we highlight recent work that has shed light...
Sat Mar 14, 2020 12:52
Related ArticlesRecent advances and future directions in the management of the immunocompromised host. Semin Oncol. 2020 Feb 24;: Authors: Bochennek K, Luckowitsch M, Lehrnbecher T Abstract Infectious complications are still a major cause of morbidity and mortality in children receiving therapy for cancer or undergoing hematopoietic stem cell transplantation. Current supportive care strategies consider numerous factors for defining the risk for an infection,...
Sat Mar 14, 2020 12:52
Related ArticlesEstimating breast tissue-specific DNA methylation age using next-generation sequencing data. Clin Epigenetics. 2020 Mar 12;12(1):45 Authors: Castle JR, Lin N, Liu J, Storniolo AMV, Shendre A, Hou L, Horvath S, Liu Y, Wang C, He C Abstract BACKGROUND: DNA methylation (DNAm) age has been widely accepted as an epigenetic biomarker for biological aging. Emerging evidence suggests that DNAm age can be tissue-specific and female breast tissue...
Sat Mar 14, 2020 12:52
Related ArticlesFondazione Italiana Linfomi (FIL) expert consensus on the use of intensity-modulated and image-guided radiotherapy for Hodgkin's lymphoma involving the mediastinum. Radiat Oncol. 2020 Mar 12;15(1):62 Authors: Filippi AR, Meregalli S, DI Russo A, Levis M, Ciammella P, Buglione M, Guerini AE, De Marco G, De Sanctis V, Vagge S, Ricardi U, Simontacchi G, Fondazione Italiana Linfomi (FIL) Radiotherapy Committee Abstract AIM: Advances in therapy...
Sat Mar 14, 2020 12:52
Related ArticlesDevelopment and internal validation of prediction models for colorectal cancer survivors to estimate the 1-year risk of low health-related quality of life in multiple domains. BMC Med Inform Decis Mak. 2020 Mar 12;20(1):54 Authors: Révész D, van Kuijk SMJ, Mols F, van Duijnhoven FJB, Winkels RM, Hoofs H, Kant IJ, Smits LJ, Breukink SO, van de Poll-Franse LV, Kampman E, Beijer S, Weijenberg MP, Bours MJL Abstract BACKGROUND: Many colorectal...
Sat Mar 14, 2020 12:52
Related ArticlesMutational landscape differences between young-onset and older-onset breast cancer patients. BMC Cancer. 2020 Mar 12;20(1):212 Authors: Mealey NE, O'Sullivan DE, Pader J, Ruan Y, Wang E, Quan ML, Brenner DR Abstract BACKGROUND: The incidence of breast cancer among young women (aged ≤40 years) has increased in North America and Europe. Fewer than 10% of cases among young women are attributable to inherited BRCA1 or BRCA2 mutations, suggesting...
Sat Mar 14, 2020 12:52
Related ArticlesInformal caregivers' views on the quality of healthcare services provided to older patients aged 80 or more in the hospital and 30 days after discharge. BMC Geriatr. 2020 Mar 12;20(1):97 Authors: Lilleheie I, Debesay J, Bye A, Bergland A Abstract BACKGROUND: In the European Union (EU), informal caregivers provide 60% of all care. Informal caregiving ranges from assistance with daily activities and provision of direct care to helping care...
Sat Mar 14, 2020 12:52
Related ArticlesReview of the current methods of Chinese Hamster Ovary (CHO) cells cultivation for production of therapeutic protein. Curr Drug Discov Technol. 2020 Mar 11;: Authors: Sharker SM, Rahman MA Abstract Most of clinical approved protein-based drugs or under in clinical trial have a profound impact in the treatment of critical diseases. The mammalian eukaryotic cells culture approaches, particularly the CHO (Chinese Hamster Ovary) cells are...
Sat Mar 14, 2020 12:52
Related ArticlesMolecular Heterogeneity and Cellular Diversity: Implications for Precision Treatment in Medulloblastoma. Cancers (Basel). 2020 Mar 10;12(3): Authors: Zou H, Poore B, Broniscer A, Pollack IF, Hu B Abstract Medulloblastoma, the most common pediatric malignant brain tumor, continues to have a high rate of morbidity and mortality in childhood. Recent advances in cancer genomics, single-cell sequencing, and sophisticated tumor models have...
Sat Mar 14, 2020 12:52
Related ArticlesErdafitinib for the treatment of urothelial cancer. Expert Rev Anticancer Ther. 2019 10;19(10):835-846 Authors: Marandino L, Raggi D, Giannatempo P, Farè E, Necchi A Abstract Introduction: Fibroblast growth-factor receptor (FGFR) inhibition is a promising strategy of treatment in urothelial cancer (UC). FGFR3 mutations or fusions (mut/fus) are common in luminal-1 UC subtype, which exhibits poor responses to immunotherapy. Erdafitinib...
Sat Mar 14, 2020 12:52
Related ArticlesFracture Risk Assessment and Clinical Decision Making for Patients with Metastatic Bone Disease. J Orthop Res. 2020 Mar 12;: Authors: Damron TA, Mann KA Abstract Metastatic breast, prostate, lung and other cancers often affect bone, causing pain, increasing fracture risk, and decreasing function. Management of metastatic bone disease (MBD) is clinically challenging when there is potential but uncertain risk of pathological fracture. Management...
Fri Mar 13, 2020 13:31
Related ArticlesRole of Cellular, Molecular, and Tumor Microenvironment in Hepatocellular Carcinoma: Possible Targets and Future Directions in the Regorafenib Era. Int J Cancer. 2020 Mar 12;: Authors: Juengpanich S, Topatana W, Lu C, Staiculescu D, Li S, Cao J, Lin J, Hu J, Chen M, Chen J, Cai X Abstract Hepatocellular carcinoma (HCC) remains as one of the major causes of cancer-related mortality, despite the recent development of new therapeutic options....
Fri Mar 13, 2020 13:31
Related ArticlesKEYNOTE-676: Phase III study of BCG and pembrolizumab for persistent/recurrent high-risk NMIBC. Future Oncol. 2020 Mar 12;: Authors: Kamat AM, Shore N, Hahn N, Alanee S, Nishiyama H, Shariat S, Nam K, Kapadia E, Frenkl T, Steinberg G Abstract Background: Nonmuscle-invasive bladder cancer (NMIBC) is the most common form of bladder cancer, with high rates of disease recurrence and progression. Current treatment for high-risk NMIBC involves...
Fri Mar 13, 2020 13:31
Related ArticlesPrimary immunodeficiencies and their associated risk of malignancies in children: an overview. Eur J Pediatr. 2020 Mar 11;: Authors: Renzi S, Langenberg-Ververgaert KPS, Waespe N, Ali S, Bartram J, Michaeli O, Upton J, Cada M Abstract Primary immunodeficiency disorders represent a heterogeneous spectrum of diseases, predisposing to recurrent infections, allergy, and autoimmunity. While an association between primary immunodeficiency disorders...
Fri Mar 13, 2020 12:33
Related ArticlesThe in vivo role of Rev1 in mutagenesis and carcinogenesis. Genes Environ. 2020;42:9 Authors: Sasatani M, Zaharieva EK, Kamiya K Abstract Translesion synthesis (TLS) is an error-prone pathway required to overcome replication blockage by DNA damage. Aberrant activation of TLS has been suggested to play a role in tumorigenesis by promoting genetic mutations. However, the precise molecular mechanisms underlying TLS-mediated tumorigenesis...
Fri Mar 13, 2020 12:33
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Fri Mar 13, 2020 12:33
Related ArticlesMeasurements for Sulfide-Mediated Inhibition of Myeloperoxidase Activity. Methods Mol Biol. 2019;2007:179-203 Authors: Garai D, Pálinkás Z, Balla J, Kettle AJ, Nagy P Abstract Oxidative stress-alleviating and inflammation-mediatory functions of hydrogen sulfide were reported to be key features of its biological actions. However, the underlying molecular mechanisms of these biological observations are not fully understood. In conditions...
Fri Mar 13, 2020 12:33
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