Metabolites, Vol. 10, Pages 110: Color Mutations Alter the Biochemical Composition in the San Marzano Tomato Fruit Metabolites doi: 10.3390/metabo10030110 Authors: Gabriella Dono Jose Luis Rambla Sarah Frusciante Antonio Granell Gianfranco Diretto Andrea Mazzucato San Marzano (SM) is a traditional Italian landrace characterized by red elongated fruits, originating in the province of Naples (Italy) and cultivated worldwide. Three mutations, yellow flesh (r), green flesh...
Sun Mar 15, 2020 02:00
Metabolites, Vol. 10, Pages 109: Metabolic Phenotypes of Hypoxic-Ischemic Encephalopathy with Normal vs. Pathologic Magnetic Resonance Imaging Outcomes Metabolites doi: 10.3390/metabo10030109 Authors: José David Piñeiro-Ramos Antonio Núñez-Ramiro Roberto Llorens-Salvador Anna Parra-Llorca Ángel Sánchez-Illana Guillermo Quintás Nuria Boronat-González Juan Martínez-Rodilla Julia Kuligowski Máximo Vento The HYPOTOP Study Group The HYPOTOP Study Group Hypoxic-Ischemic...
Sat Mar 14, 2020 02:00
Metabolites, Vol. 10, Pages 108: Deciphering the Metabolic Pathways of Pitaya Peel after Postharvest Red Light Irradiation Metabolites doi: 10.3390/metabo10030108 Authors: Qixian Wu Huijun Gao Zhengke Zhang Taotao Li Hongxia Qu Yueming Jiang Ze Yun Red light irradiation can effectively prolong the shelf-life of many fruit. However, little is known about red light-induced metabolite and enzyme activities. In this study, pitaya fruit was treated with 100 Lux red light...
Sat Mar 14, 2020 02:00
Metabolites, Vol. 10, Pages 107: The Interrelations between Biological and Targeted Synthetic Agents Used in Inflammatory Joint Diseases, and Obesity or Body Composition Metabolites doi: 10.3390/metabo10030107 Authors: Eric Toussirot Obesity is a comorbidity that plays a role in the development and severity of inflammatory joint diseases, including rheumatoid arthritis, psoriatic arthritis and axial spondyloarthritis. The relationships between obesity and adipose tissue and the treatments...
Fri Mar 13, 2020 02:00
Microorganisms, Vol. 8, Pages 416: There is No Distinctive Gut Microbiota Signature in the Metabolic Syndrome: Contribution of Cardiovascular Disease Risk Factors and Associated Medication Microorganisms doi: 10.3390/microorganisms8030416 Authors: Cortés-Martín Iglesias-Aguirre Meoro Selma Espín The gut microbiota (GM) has attracted attention as a new target to combat several diseases, including metabolic syndrome (MetS), a pathological condition with many factors (diabetes,...
Sun Mar 15, 2020 02:00
Microorganisms, Vol. 8, Pages 415: Extensive Therapeutic Drug Monitoring of Colistin in Critically Ill Patients Reveals Undetected Risks Microorganisms doi: 10.3390/microorganisms8030415 Authors: Stefan Felix Ehrentraut Stefan Muenster Stefan Kreyer Nils Ulrich Theuerkauf Christian Bode Folkert Steinhagen Heidi Ehrentraut Jens-Christian Schewe Matthias Weber Christian Putensen Thomas Muders (1) Background: With the rise of multi-/pan-drug resistant (MDR/PDR)...
Sun Mar 15, 2020 02:00
Microorganisms, Vol. 8, Pages 414: Contamination Pathways can Be Traced along the Poultry Processing Chain by Whole Genome Sequencing of Listeria innocua Microorganisms doi: 10.3390/microorganisms8030414 Authors: Mayada Gwida Stefanie Lüth Maged El-Ashker Amira Zakaria Fatma El-Gohary Mona Elsayed Sylvia Kleta Sascha Al Dahouk Foodborne infection with Listeria causes potentially life-threatening disease listeriosis. Listeria monocytogenes is widely recognized as...
Sat Mar 14, 2020 02:00
Microorganisms, Vol. 8, Pages 413: Proteomic Adaptation of Streptococcus pneumoniae to the Human Antimicrobial Peptide LL-37 Microorganisms doi: 10.3390/microorganisms8030413 Authors: Pierre-Alexander Mücke Sandra Maaß Thomas P. Kohler Sven Hammerschmidt Dörte Becher Secreted antimicrobial peptides (AMPs) are an important part of the human innate immune system and prevent local and systemic infections by inhibiting bacterial growth in a concentration-dependent manner. In...
Sat Mar 14, 2020 02:00
Microorganisms, Vol. 8, Pages 412: Plant Growth Promotion Abilities of Phylogenetically Diverse Mesorhizobium Strains: Effect in the Root Colonization and Development of Tomato Seedlings Microorganisms doi: 10.3390/microorganisms8030412 Authors: Esther Menéndez Juan Pérez-Yépez Mercedes Hernández Ana Rodríguez-Pérez Encarna Velázquez Milagros León-Barrios Mesorhizobium contains species widely known as nitrogen-fixing bacteria with legumes, but their ability to promote...
Sat Mar 14, 2020 02:00
Microorganisms, Vol. 8, Pages 410: Application of Recombinase-Based In Vivo Expression Technology to Bifidobacterium longum subsp. longum for Identification of Genes Induced in the Gastrointestinal Tract of Mice Microorganisms doi: 10.3390/microorganisms8030410 Authors: Hiroka Koguchi Natsumi Ishigami Mikiyasu Sakanaka Kako Yoshida Sayaka Hiratou Mina Shimada Satoru Fukiya Kei Sonoyama Atsushi Yokota Bifidobacteria are one of the major components in human gut...
Fri Mar 13, 2020 02:00
Microorganisms, Vol. 8, Pages 409: Ivermectin Inhibits Bovine Herpesvirus 1 DNA Polymerase Nuclear Import and Interferes with Viral Replication Microorganisms doi: 10.3390/microorganisms8030409 Authors: Raza Shahin Zhai Li Alvisi Yang Chen Chen Chen Hu Chen Guo Bovine herpesvirus1 (BoHV-1) is a major bovine pathogen. Despite several vaccines being available to prevent viral infection, outbreaks are frequent and cause important economic consequences...
Fri Mar 13, 2020 02:00
Microorganisms, Vol. 8, Pages 407: Salmonella Virulence and Immune Escape Microorganisms doi: 10.3390/microorganisms8030407 Authors: Wang Qazi Wang Zhou Han Salmonella genus represents the most common foodborne pathogens causing morbidity, mortality, and burden of disease in all regions of the world. The introduction of antimicrobial agents and Salmonella-specific phages has been considered as an effective intervention strategy to reduce Salmonella contamination. However,...
Fri Mar 13, 2020 02:00
Microorganisms, Vol. 8, Pages 408: Fate and Biofilm Formation of Wild-Type and Pressure-Stressed Pathogens of Public Health Concern in Surface Water and on Abiotic Surfaces Microorganisms doi: 10.3390/microorganisms8030408 Authors: Md Niamul Kabir Sadiye Aras Sabrina Wadood Shahid Chowdhury Aliyar Cyrus Fouladkhah Since the historic outbreak near Broad Street in London, which serves as cornerstone of modern epidemiology, infectious diseases spread in surface and sub-surface...
Fri Mar 13, 2020 02:00
Microorganisms, Vol. 8, Pages 411: Differences in Gut Microbial Diversity are Driven by Drug Use and Drug Cessation by Either Compulsory Detention or Methadone Maintenance Treatment Microorganisms doi: 10.3390/microorganisms8030411 Authors: Li Chen Liu Long Liu Jing Huang In this work, we investigate differences in gut microbial diversity driven by drug use or by the widely used methods for drug cessation: methadone maintenance treatment (MMT) and compulsory...
Fri Mar 13, 2020 02:00
Microorganisms, Vol. 8, Pages 405: Agroforestry Management Systems Drive the Composition, Diversity, and Function of Fungal and Bacterial Endophyte Communities in Theobroma Cacao Leaves Microorganisms doi: 10.3390/microorganisms8030405 Authors: Wemheuer Berkelmann Wemheuer Daniel Vidal Bisseleua Daghela Cacao (Theobroma cacao L.) is one of the most economically important crops worldwide. Despite the important role of endophytes for plant growth and health, very little...
Fri Mar 13, 2020 02:00
Microorganisms, Vol. 8, Pages 406: Investigating the Gut Microbiota Composition of Individuals with Attention-Deficit/Hyperactivity Disorder and Association with Symptoms Microorganisms doi: 10.3390/microorganisms8030406 Authors: Joanna Szopinska-Tokov Sarita Dam Jilly Naaijen Prokopis Konstanti Nanda Rommelse Clara Belzer Jan Buitelaar Barbara Franke Esther Aarts Alejandro Arias Vasquez Attention-deficit/hyperactivity disorder (ADHD) is a common neurodevelopmental...
Fri Mar 13, 2020 02:00
Microorganisms, Vol. 8, Pages 404: Understanding the Response of Nitrifying Communities to Disturbance in the McMurdo Dry Valleys, Antarctica Microorganisms doi: 10.3390/microorganisms8030404 Authors: Maria Monteiro Mafalda S. Baptista Joana Séneca Luís Torgo Charles K. Lee S. Craig Cary Catarina Magalhães Polar ecosystems are generally limited in nitrogen (N) nutrients, and the patchy availability of N is partly determined by biological pathways, such as nitrification,...
Fri Mar 13, 2020 02:00
Microorganisms, Vol. 8, Pages 403: Differential Analysis of Proteins Involved in Ester Metabolism in two Saccharomyces cerevisiae Strains during the Second Fermentation in Sparkling Wine Elaboration Microorganisms doi: 10.3390/microorganisms8030403 Authors: González-Jiménez Moreno-García García-Martínez Moreno Puig-Pujol Capdevilla Mauricio The aromatic metabolites derived from yeast metabolism determine the characteristics of aroma and taste in wines, so they...
Fri Mar 13, 2020 02:00
Microorganisms, Vol. 8, Pages 402: Differential Microbial Composition of Monovarietal and Blended Extra Virgin Olive Oils Determines Oil Quality During Storage Microorganisms doi: 10.3390/microorganisms8030402 Authors: Zullo Ciafardini Extra virgin olive oil (EVOO) contains a biotic fraction, which is characterized by various microorganisms, including yeasts. The colonization of microorganisms in the freshly produced EVOO is determined by the physicochemical characteristics of the...
Fri Mar 13, 2020 02:00
Microorganisms, Vol. 8, Pages 401: Bioactive Secondary Metabolites from Trichoderma spp. against Phytopathogenic Bacteria and Root-Knot Nematode Microorganisms doi: 10.3390/microorganisms8030401 Authors: Raja Asad Ali Khan Saba Najeeb Zhenchuan Mao Jian Ling Yuhong Yang Yan Li Bingyan Xie Losses in crops caused by plant pathogenic bacteria and parasitic nematode are increasing because of a decrease in efficacy of traditional management measures. There is an urgent need...
Fri Mar 13, 2020 02:00
Molecules, Vol. 25, Pages 1339: Design, Synthesis, and Antimicrobial Evaluation of New Annelated Pyrimido[2,1-c][1,2,4]triazolo[3,4-f][1,2,4]triazines Molecules doi: 10.3390/molecules25061339 Authors: El Azab Elkanzi A series of 34 new pyrimido[2,1-c][1,2,4]triazine-3,4-diones were synthesized and fully characterized using IR, NMR, MS, and microanalytical analysis. In vitro investigation of 12 compounds of this series revealed promising antimicrobial activity of the conjugates...
Sun Mar 15, 2020 02:00
Molecules, Vol. 25, Pages 1338: 2-(Arylamino)-6-(trifluoromethyl)nicotinic Acid Derivatives: New HIV-1 RT Dual Inhibitors Active on Viral Replication Molecules doi: 10.3390/molecules25061338 Authors: Angela Corona Valentina Onnis Claudia Del Vecchio Francesca Esposito Yung-Chi Cheng Enzo Tramontano The persistence of the AIDS epidemic, and the life-long treatment required, indicate the constant need of novel HIV-1 inhibitors. In this scenario the HIV-1 Reverse Transcriptase...
Sun Mar 15, 2020 02:00
Molecules, Vol. 25, Pages 1337: Anti-Adipogenic and Anti-Inflammatory Activities of (−)-epi-Osmundalactone and Angiopteroside from Angiopteris helferiana C.Presl Molecules doi: 10.3390/molecules25061337 Authors: Lamichhane Pandeya Lee Kim Devkota Jung Angiopteris helferiana C.Presl is a gigantic fleshy-type fern, belonging to Marattiaceae family. In previous study, we reported the potent anti-adipogenic and anti-inflammatory activities of ethylacetate (EtOAc) and...
Sun Mar 15, 2020 02:00
Molecules, Vol. 25, Pages 1335: Selective Extraction of Cannabinoid Compounds from Cannabis Seed Using Pressurized Hot Water Extraction Molecules doi: 10.3390/molecules25061335 Authors: Yannick Nuapia Hlanganani Tutu Luke Chimuka Ewa Cukrowska Phytochemicals of Cannabis sativa mainly for the use in the different industries are that of delta-9-tetrahydrocannabinol (THC) and cannabidiol (CBD). Pressurized hot water extraction (PHWE) is seen as an efficient, fast, green extraction...
Sun Mar 15, 2020 02:00
Molecules, Vol. 25, Pages 1333: Flow-Based Dynamic Approach to Assess Bioaccessible Zinc in Dry Dog Food Samples Molecules doi: 10.3390/molecules25061333 Authors: Bruno J. R. Gregório Ana Margarida Pereira Sara R. Fernandes Elisabete Matos Francisco Castanheira Agostinho A. Almeida António J. M. Fonseca Ana Rita J. Cabrita Marcela A. Segundo This work proposes a simple and easy-to-use flow-through system for the implementation of dynamic extractions, aiming at...
Sun Mar 15, 2020 02:00
Molecules, Vol. 25, Pages 1336: Inhibitory Effects of Aucklandia lappa Decne. Extract on Inflammatory and Oxidative Responses in LPS-Treated Macrophages Molecules doi: 10.3390/molecules25061336 Authors: Jae Sung Lim Sung Ho Lee Sang Rok Lee Hyung-Ju Lim Yoon-Seok Roh Eun Jeong Won Namki Cho Changju Chun Young-Chang Cho Aucklandia lappa Decne., known as “Mok-hyang” in Korea, has been used for the alleviation of abdominal pain, vomiting, diarrhea,...
Sun Mar 15, 2020 02:00
Molecules, Vol. 25, Pages 1332: Effects of Inclusion of Fresh Forage in the Diet for Lactating Buffaloes on Volatile Organic Compounds of Milk and Mozzarella Cheese Molecules doi: 10.3390/molecules25061332 Authors: Raffaele Sacchi Andrea Marrazzo Felicia Masucci Antonio Di Francia Francesco Serrapica Alessandro Genovese This paper aimed to assess the effects of feeding fresh forage on volatile organic compounds (VOCs) of buffalo milk and mozzarella cheese. Sixteen lactating...
Sun Mar 15, 2020 02:00
Molecules, Vol. 25, Pages 1334: Polyvinyl Alcohol/Chitosan/Polyhexamethylene Biguanide Phase Separation System: A Potential Topical Antibacterial Formulation with Enhanced Antimicrobial Effect Molecules doi: 10.3390/molecules25061334 Authors: Yunzhou Ni Zhixiang Qian Yu Yin Weien Yuan Fei Wu Tuo Jin An aqueous polyvinyl alcohol (PVA)/chitosan (CHT)/polyhexamethylene biguanide (PHMB) blends (PVA/CHT/PHMB blends) has been developed as a potential low dose topical antibacterial...
Sun Mar 15, 2020 02:00
Molecules, Vol. 25, Pages 1331: Anticatabolic and Anti-Inflammatory Effects of Myricetin 3-O-β-d-Galactopyranoside in UVA-Irradiated Dermal Cells via Repression of MAPK/AP-1 and Activation of TGFβ/Smad Molecules doi: 10.3390/molecules25061331 Authors: Oh Karadeniz Lee Park Seo Kong UV irradiation is one of the main causes of extrinsic skin aging. UV-mediated skin aging, also known as photoaging, causes excessive breakdown of extracellular matrix which leads skin...
Sat Mar 14, 2020 02:00
Molecules, Vol. 25, Pages 1329: Design, Synthesis and Biological Evaluation of New Antioxidant and Neuroprotective Multitarget Directed Ligands Able to Block Calcium Channels Molecules doi: 10.3390/molecules25061329 Authors: Irene Pachòn Angona Solene Daniel Helene Martin Alexandre Bonet Artur Wnorowski Maciej Maj Krzysztof Jóźwiak Tiago Barros Silva Bernard Refouvelet Fernanda Borges José Marco-Contelles Lhassane Ismaili We report herein the design,...
Sat Mar 14, 2020 02:00
Molecules, Vol. 25, Pages 1330: Synthesis of Samarium OxysulfateSm2O2SO4 in the High-Temperature Oxidation Reaction and Its Structural, Thermal and Luminescent Properties Molecules doi: 10.3390/molecules25061330 Authors: Yu. G. Denisenko E. I. Sal’nikova S. A. Basova M. S. Molokeev A. S. Krylov A. S. Aleksandrovsky A. S. Oreshonkov V. V. Atuchin S. S. Volkova N. A. Khritokhin O. V. Andreev The oxidation process of samariumoxysulfide was studied in the temperature...
Sat Mar 14, 2020 02:00
Molecules, Vol. 25, Pages 1328: A Halogen Bonding Perspective on Iodothyronine Deiodinase Activity Molecules doi: 10.3390/molecules25061328 Authors: Eric S. Marsan Craig A. Bayse Iodothyronine deiodinases (Dios) are involved in the regioselective removal of iodine from thyroid hormones (THs). Deiodination is essential to maintain TH homeostasis, and disruption can have detrimental effects. Halogen bonding (XB) to the selenium of the selenocysteine (Sec) residue in the Dio active site...
Sat Mar 14, 2020 02:00
Molecules, Vol. 25, Pages 1327: Spectrofluorometric Analysis of Autofluorescing Components of Crude Serum from a Rat Liver Model of Ischemia and Reperfusion Molecules doi: 10.3390/molecules25061327 Authors: Anna C. Croce Andrea Ferrigno Clarissa Berardo Giovanni Bottiroli Mariapia Vairetti Laura G. Di Pasqua Autofluorescence (AF) of crude serum was investigated with reference to the potential of its intrinsic AF biomarkers for the noninvasive diagnosis of liver injury....
Sat Mar 14, 2020 02:00
Molecules, Vol. 25, Pages 1325: The Effect of Rutin and Extracts of Uncaria guianensis (Aubl.) J. F. Gmeland on Primary Endometriotic Cells: A 2D and 3D Study Molecules doi: 10.3390/molecules25061325 Authors: Hernandes de Oliveira de Souza Santos Malvezzi Cestari de Azevedo Gueuvoghlanian-Silva Pereira Podgaec There is increasing interest in the potential of natural compounds to treat diseases, such as endometriosis, a gynecological disorder that affects...
Fri Mar 13, 2020 02:00
Molecules, Vol. 25, Pages 1326: Effects of Different Drying Methods on Untargeted Phenolic Metabolites, and Antioxidant Activity in Chinese Cabbage (Brassica rapa L. subsp. chinensis) and Nightshade (Solanum retroflexum Dun.) Molecules doi: 10.3390/molecules25061326 Authors: Millicent G. Managa Yasmina Sultanbawa Dharini Sivakumar Chinese cabbage (Brassica rapa L. subsp. chinensis) and Nightshade (Solanum retroflexum are popular traditional leafy vegetables consumed predominantly...
Fri Mar 13, 2020 02:00
Molecules, Vol. 25, Pages 1324: Pharmacological Update Properties of Aloe Vera and its Major Active Constituents Molecules doi: 10.3390/molecules25061324 Authors: Marta Sánchez Elena González-Burgos Irene Iglesias M. Pilar Gómez-Serranillos Aloe vera has been traditionally used to treat skin injuries (burns, cuts, insect bites, and eczemas) and digestive problems because its anti-inflammatory, antimicrobial, and wound healing properties. Research on this medicinal plant has...
Fri Mar 13, 2020 02:00
Molecules, Vol. 25, Pages 1323: Various Strategies in Post-Polymerization Functionalization of Organic Polymer-Based Monoliths Used in Liquid Phase Separation Techniques Molecules doi: 10.3390/molecules25061323 Authors: Sarah Alharthi Ziad El Rassi This review article is aimed at summarizing the various strategies that have been developed so far for post-polymerization functionalization (PPF) of organic polymer-based monoliths used in liquid phase separation techniques, namely HPLC...
Fri Mar 13, 2020 02:00
Molecules, Vol. 25, Pages 1322: A 1,5-Oligosilanylene Dianion as Building Block for Oligosiloxane Containing Cages, Ferrocenophanes, and Cyclic Germylenes and Stannylenes Molecules doi: 10.3390/molecules25061322 Authors: Zitz Pöcheim Baumgartner Marschner Starting out from dipotassium 1,5-oligosiloxanylene diide 2, a 3,7,10-trioxa-octasilabicyclo[3.3.3]undecane was prepared, which represents the third known example of this cage structure type. Reaction of 1,3-dichlorotetramethyldisiloxane...
Fri Mar 13, 2020 02:00
Molecules, Vol. 25, Pages 1318: Cytotoxic Evaluation and Anti-Angiogenic Effects of Two Furano-Sesquiterpenoids from Commiphora myrrh Resin Molecules doi: 10.3390/molecules25061318 Authors: Ali S. Alqahtani Fahd A. Nasr Omar M. Noman Muhammad Farooq Tariq Alhawassi Wajhul Qamar Ali El-Gamal Commiphora myrrh resin (Myrrh) has been used in traditional Arabic medicine to treat various inflammatory diseases. Two furano-sesquiterpenoids, 2-methoxyfuranodiene (CM1) and 2-acetoxyfuranodiene...
Fri Mar 13, 2020 02:00
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