IJMS, Vol. 21, Pages 2309: The Encystment-Related MicroRNAs and Its Regulation Molecular Mechanism in Pseudourostyla cristata Revealed by High Throughput Small RNA Sequencing International Journal of Molecular Sciences doi: 10.3390/ijms21072309 Authors: Nan Pan Muhammad Zeeshan Bhatti Haiyang Zhang Bing Ni Xinpeng Fan Jiwu Chen MicroRNAs (miRNAs) regulate the expression of target genes in diverse cellular processes and play important roles in different physiological processes....
Thu Mar 26, 2020 02:00
IJMS, Vol. 21, Pages 2287: Influence of POR*28 Polymorphisms on CYP3A5*3-Associated Variations in Tacrolimus Blood Levels at an Early Stage after Liver Transplantation International Journal of Molecular Sciences doi: 10.3390/ijms21072287 Authors: Nakamura Fukuda Matsukane Suetsugu Harada Yoshizumi Egashira Mori Masuda It is well known that the CYP3A5*3 polymorphism is an important marker that correlates with the tacrolimus dose requirement after organ...
Thu Mar 26, 2020 02:00
IJMS, Vol. 21, Pages 2288: Knockout of the OsNAC006 Transcription Factor Causes Drought and Heat Sensitivity in Rice International Journal of Molecular Sciences doi: 10.3390/ijms21072288 Authors: Wang Zhong Wang Han Yu Wang Song Zheng Chen Zhang Rice (Oryza sativa) responds to various abiotic stresses during growth. Plant-specific NAM, ATAF1/2, and CUC2 (NAC) transcription factors (TFs) play an important role in controlling numerous vital growth...
Thu Mar 26, 2020 02:00
IJMS, Vol. 21, Pages 2289: Musashi-1: An Example of How Polyalanine Tracts Contribute to Self-Association in the Intrinsically Disordered Regions of RNA-Binding Proteins International Journal of Molecular Sciences doi: 10.3390/ijms21072289 Authors: Chen Huang RNA-binding proteins (RBPs) have intrinsically disordered regions (IDRs) whose biophysical properties have yet to be explored to the same extent as those of the folded RNA interacting domains. These IDRs are essential to the...
Thu Mar 26, 2020 02:00
IJMS, Vol. 21, Pages 2290: Upregulation of CASP9 through NF-κB and Its Target MiR-1276 Contributed to TNFα-promoted Apoptosis of Cancer Cells Induced by Doxorubicin International Journal of Molecular Sciences doi: 10.3390/ijms21072290 Authors: Zhou Li Huang Wu Wu Zhu Wang ：Under some conditions, nuclear factor-κB (NF-κB) has a pro-apoptotic role, but the mechanisms underlying this function remain unclear. This study demonstrated that NF-κB...
Thu Mar 26, 2020 02:00
IJMS, Vol. 21, Pages 2291: Cold Atmospheric Plasma Treatment of Chondrosarcoma Cells Affects Proliferation and Cell Membrane Permeability International Journal of Molecular Sciences doi: 10.3390/ijms21072291 Authors: Haralambiev Nitsch Jacoby Strakeljahn Bekeschus Mustea Ekkernkamp Stope Chondrosarcoma is the second most common malign bone tumor in adults. Surgical resection of the tumor is recommended because of its resistance to clinical treatment such...
Thu Mar 26, 2020 02:00
IJMS, Vol. 21, Pages 2292: The Expression of Selected Factors Related to T Lymphocyte Activity in Canine Mammary Tumors International Journal of Molecular Sciences doi: 10.3390/ijms21072292 Authors: Bujak Szopa Pingwara Kruczyk Krzemińska Mucha Majchrzak-Kuligowska Crosstalk between neoplastic and immune cells in the tumor microenvironment (TME) influences the progression of disease in human and canine cancer patients. Given that canine mammary tumors are a useful...
Thu Mar 26, 2020 02:00
IJMS, Vol. 21, Pages 2286: Extracellular Vesicles and Tumor-Immune Escape: Biological Functions and Clinical Perspectives International Journal of Molecular Sciences doi: 10.3390/ijms21072286 Authors: Raimondo Pucci Alessandro Fontana The modulation of the immune system is one of the hallmarks of cancer. It is now widely described that cancer cells are able to evade the immune response and thus establish immune tolerance. The exploration of the mechanisms underlying this...
Thu Mar 26, 2020 02:00
IJMS, Vol. 21, Pages 2284: Nutrition and Cardiovascular Health International Journal of Molecular Sciences doi: 10.3390/ijms21072284 Authors: Tappia Blewett There is unequivocal experimental, epidemiological and clinical evidence demonstrating a correlation between diet and increased risk of cardiovascular disease (CVD) [...]
Thu Mar 26, 2020 02:00
IJMS, Vol. 21, Pages 2283: Flotillins: At the Intersection of Protein S-Palmitoylation and Lipid-Mediated Signaling International Journal of Molecular Sciences doi: 10.3390/ijms21072283 Authors: Kwiatkowska Matveichuk Fronk Ciesielska Flotillin-1 and flotillin-2 are ubiquitously expressed, membrane-associated proteins involved in multifarious cellular events from cell signaling, endocytosis, and protein trafficking to gene expression. They also contribute to oncogenic signaling....
Thu Mar 26, 2020 02:00
IJMS, Vol. 21, Pages 2285: An Updated Overview on Nanonutraceuticals: Focus on Nanoprebiotics and Nanoprobiotics International Journal of Molecular Sciences doi: 10.3390/ijms21072285 Authors: Durazzo Nazhand Lucarini Atanasov Souto Novellino Capasso Santini Over the last few years, the application of nanotechnology to nutraceuticals has been rapidly growing due to its ability to enhance the bioavailability of the loaded active ingredients, resulting in improved...
Thu Mar 26, 2020 02:00
IJMS, Vol. 21, Pages 2282: Disorders of Sex Development—Novel Regulators, Impacts on Fertility, and Options for Fertility Preservation International Journal of Molecular Sciences doi: 10.3390/ijms21072282 Authors: Nathalia Lisboa Gomes Tarini Chetty Anne Jorgensen Rod T Mitchell Disorders (or differences) of sex development (DSD) are a heterogeneous group of congenital conditions with variations in chromosomal, gonadal, or anatomical sex. Impaired gonadal development is central...
Thu Mar 26, 2020 02:00
IJMS, Vol. 21, Pages 2281: A Multiparametric Study of Internalization of Fullerenol C60(OH)36 Nanoparticles into Peripheral Blood Mononuclear Cells: Cytotoxicity in Oxidative Stress Induced by Ionizing Radiation International Journal of Molecular Sciences doi: 10.3390/ijms21072281 Authors: Lichota Piwoński Michlewska Krokosz The aim of this study was to investigate the uptake and accumulation of fullerenol C60(OH)36 into peripheral blood mononuclear cells (PBMCs). Some additional...
Thu Mar 26, 2020 02:00
IJMS, Vol. 21, Pages 2279: n–3 Polyunsaturated Fatty Acid Amides: New Avenues in the Prevention and Treatment of Breast Cancer International Journal of Molecular Sciences doi: 10.3390/ijms21072279 Authors: Giordano Plastina Barone Catalano Bonofiglio Over the last decades a renewed interest in n−3 very long polyunsaturated fatty acids (PUFAs), derived mainly from fish oils in the human diet, has been observed because of their potential effects against cancer...
Thu Mar 26, 2020 02:00
IJMS, Vol. 21, Pages 2278: Phylogeny and Functions of LOB Domain Proteins in Plants International Journal of Molecular Sciences doi: 10.3390/ijms21072278 Authors: Zhang Li Ma Hou Wan Lateral organ boundaries (LOB) domain (LBD) genes, a gene family encoding plant-specific transcription factors, play important roles in plant growth and development. At present, though there have been a number of genome-wide analyses on LBD gene families and functional studies on individual...
Thu Mar 26, 2020 02:00
IJMS, Vol. 21, Pages 2280: A Comparative In Vitro Analysis of the Osteogenic Potential of Human Dental Pulp Stem Cells Using Various Differentiation Conditions International Journal of Molecular Sciences doi: 10.3390/ijms21072280 Authors: Okajcekova Strnadel Pokusa Zahumenska Janickova Halasova Skovierova Dental pulp stem cells (DPSCs) have excellent proliferative properties, mineralization potential and can be easily obtained from third molar teeth. Recently,...
Thu Mar 26, 2020 02:00
IJNS, Vol. 6, Pages 26: Use of Dried Blood Spot Specimens to Monitor Patients with Inherited Metabolic Disorders International Journal of Neonatal Screening doi: 10.3390/ijns6020026 Authors: Moat George Carling Monitoring of patients with inherited metabolic disorders (IMDs) using dried blood spot (DBS) specimens has been routinely used since the inception of newborn screening (NBS) for phenylketonuria in the 1960s. The introduction of flow injection analysis tandem mass spectrometry...
Thu Mar 26, 2020 02:00
JCM, Vol. 9, Pages 911: Ventricular Repolarization is Associated with Cognitive Function, but Not with Cognitive Decline and Brain Magnetic Resonance Imaging (MRI) Measurements in Older Adults Journal of Clinical Medicine doi: 10.3390/jcm9040911 Authors: Zonneveld Noordam Grond Sabayan Mooijaart Mcfarlane Jukema Trompet We aimed to investigate the cross-sectional and longitudinal associations of electrocardiogram (ECG)-based QT, QTc, JT, JTc, and QRS intervals...
Thu Mar 26, 2020 02:00
JCM, Vol. 9, Pages 909: Prevalence of Depression in Coronary Artery Bypass Surgery: A Systematic Review and Meta-Analysis Journal of Clinical Medicine doi: 10.3390/jcm9040909 Authors: Correa-Rodríguez Abu Ejheisheh Suleiman-Martos Membrive-Jiménez Velando-Soriano Schmidt-RioValle Gómez-Urquiza Coronary artery bypass graft surgery (CABG) might adversely affect the health status of the patients, producing cognitive deterioration, with depression being the most...
Thu Mar 26, 2020 02:00
JCM, Vol. 9, Pages 912: Impact of Glucose-Lowering Medications on Cardiovascular and Metabolic Risk in Type 2 Diabetes Journal of Clinical Medicine doi: 10.3390/jcm9040912 Authors: Patti Rizvi Giglio Stoian Ligi Mannello Type 2 Diabetes Mellitus (T2DM) is associated with a high risk of atherosclerotic cardiovascular (CV) disease. Among the well-known pathophysiologic factors, crucial roles are played by endothelial dysfunction (caused by oxidative stress and inflammation...
Thu Mar 26, 2020 02:00
JCM, Vol. 9, Pages 910: Methotrexate Decreases the Level of PCSK9—A Novel Indicator of the Risk of Proatherogenic Lipid Profile in Psoriasis. The Preliminary Data Journal of Clinical Medicine doi: 10.3390/jcm9040910 Authors: Krahel Baran Kamiński Maciaszek Flisiak Background: Proprotein convertase subtilisin/kexin type 9 (PCSK9) exerts an important role in inflammatory processes, lipids homeostasis, and cardiometabolic disorders that are closely associated with psoriasis....
Thu Mar 26, 2020 02:00
JCM, Vol. 9, Pages 908: The Development of the Ascending Aortic Wall in Tricuspid and Bicuspid Aortic Valve: A Process from Maturation to Degeneration Journal of Clinical Medicine doi: 10.3390/jcm9040908 Authors: Grewal Gittenberger-de Groot Thusen Wisse Bartelings DeRuiter Klautz Poelmann Background: Patients with a bicuspid aortic valve (BAV) have an increased risk for aortic dilation and dissection. In this study, we provide a histological stratification...
Thu Mar 26, 2020 02:00
JCM, Vol. 9, Pages 913: Physiopathological Bases of the Disease Caused by HACE1 Mutations: Alterations in Autophagy, Mitophagy and Oxidative Stress Response Journal of Clinical Medicine doi: 10.3390/jcm9040913 Authors: Ugarteburu Sánchez-Vilés Ramos Barcos-Rodríguez Garrabou García-Villoria Ribes Tort Recessive HACE1 mutations are associated with a severe neurodevelopmental disorder (OMIM: 616756). However, the physiopathologycal bases of the disease are...
Thu Mar 26, 2020 02:00
JDB, Vol. 8, Pages 8: Delta-Notch Signaling: The Long and The Short of a Neuron’s Influence on Progenitor Fates Journal of Developmental Biology doi: 10.3390/jdb8020008 Authors: Moore Alexandre Maintenance of the neural progenitor pool during embryonic development is essential to promote growth of the central nervous system (CNS). The CNS is initially formed by tightly compacted proliferative neuroepithelial cells that later acquire radial glial characteristics and continue to divide...
Thu Mar 26, 2020 02:00
JoF, Vol. 6, Pages 42: Exposure of Aspergillus fumigatus to Atorvastatin Leads to Altered Membrane Permeability and Induction of an Oxidative Stress Response Journal of Fungi doi: 10.3390/jof6020042 Authors: Ajdidi Sheehan Kavanagh Aspergillus fumigatus is a serious cause of disease in immune-deficient patients and in those with pulmonary malfunction (e.g., cystic fibrosis (CF), asthma). Atorvastatin is a member of the statin drug family, which are the main therapeutic agents...
Thu Mar 26, 2020 02:00
JoF, Vol. 6, Pages 41: Underlying Conditions and Clinical Spectrum of Chronic Pulmonary Aspergillosis (CPA): An Experience from a Tertiary Care Hospital in Karachi, Pakistan Journal of Fungi doi: 10.3390/jof6020041 Authors: Iqbal Irfan Mushtaq Jabeen The incidence of chronic pulmonary aspergillosis (CPA) is especially increasing in high tuberculosis (TB) burden countries. Despite a high estimated CPA burden in Pakistan, actual data on CPA are not available. The aim of the...
Thu Mar 26, 2020 02:00
JoF, Vol. 6, Pages 40: Phosphate in Virulence of Candida albicans and Candida glabrata Journal of Fungi doi: 10.3390/jof6020040 Authors: Köhler Acosta-Zaldívar Qi Candida species are the most commonly isolated invasive human fungal pathogens. A role for phosphate acquisition in their growth, resistance against host immune cells, and tolerance of important antifungal medications is becoming apparent. Phosphorus is an essential element in vital components of the cell, including...
Thu Mar 26, 2020 02:00
JPM, Vol. 10, Pages 20: Flotillin: A Promising Biomarker for Alzheimer’s Disease Journal of Personalized Medicine doi: 10.3390/jpm10020020 Authors: Angelopoulou Paudel Shaikh Piperi Alzheimer’s disease (AD) is characterized by the accumulation of beta amyloid (Aβ) in extracellular senile plaques and intracellular neurofibrillary tangles (NFTs) mainly consisting of tau protein. Although the exact etiology of the disease remains elusive, accumulating evidence...
Thu Mar 26, 2020 02:00
Life, Vol. 10, Pages 32: Implementation of a Renal Precision Medicine Program: Clinician Attitudes and Acceptance Life doi: 10.3390/life10040032 Authors: Spiech Tripathy Woodcock Sheth Collins Kannegolla Sinha Sharfuddin Pratt Khalid Hains Moe Skaar Moorthi Eadon A precision health initiative was implemented across a multi-hospital health system, wherein a panel of genetic variants was tested and utilized in the clinical care of...
Thu Mar 26, 2020 02:00
Medicina, Vol. 56, Pages 149: Adaptation of a Health Education Program for Improving the Uptake of HIV Self-Testing by Men in Rwanda: A Study Protocol Medicina doi: 10.3390/medicina56040149 Authors: Dzinamarira Mashamba-Thompson Background and objectives: Available evidence shows a low uptake of HIV services among men in Rwanda. HIV self-testing (HIVST), a new intervention, may have the potential to improve the uptake of HIV testing services among men. The current study aims to...
Thu Mar 26, 2020 02:00
Membranes, Vol. 10, Pages 57: Influence of Spacer Design and Module Geometry on the Filtration Performance during Skim Milk Microfiltration with Flat Sheet and Spiral-Wound Membranes Membranes doi: 10.3390/membranes10040057 Authors: Hartinger Napiwotzki Schmid Hoffmann Kurz Kulozik Spacer design in spiral-wound membranes (SWMs) significantly affects the axial pressuredrop in the flow channel but also the deposit layer removal. However, the effects of the spacerdesign...
Thu Mar 26, 2020 02:00
Membranes, Vol. 10, Pages 55: Selective Separation of 1-Butanol from Aqueous Solution through Pervaporation Using PTSMP-Silica Nano Hybrid Membrane Membranes doi: 10.3390/membranes10040055 Authors: VSSL Prasad Talluri Aiym Tleuova Seyedmehdi Hosseini Ondrej Vopicka In this work, a poly(1-trimethylsilyl-1-propyne) (PTMSP) mixed-matrix membrane was fabricated for the selective removal of 1-butanol from aqueous solutions through pervaporation. Silica nanoparticles (SNPs), which...
Thu Mar 26, 2020 02:00
Metabolites, Vol. 10, Pages 126: Comparing Targeted vs. Untargeted MS2 Data-Dependent Acquisition for Peak Annotation in LC–MS Metabolomics Metabolites doi: 10.3390/metabo10040126 Authors: Ten-Doménech Martínez-Sena Moreno-Torres Sanjuan-Herráez Castell Parra-Llorca Vento Quintás Kuligowski One of the most widely used strategies for metabolite annotation in untargeted LCMS is based on the analysis of MSn spectra acquired using data-dependent acquisition...
Thu Mar 26, 2020 02:00
Metabolites, Vol. 10, Pages 127: Bile Acid Profile and its Changes in Response to Cefoperazone Treatment in MR1 Deficient Mice Metabolites doi: 10.3390/metabo10040127 Authors: Sun Cao Smith Carlson Coryell Chen Beger Mucosal associated invariant T-cells (MAIT cells) are activated following recognition of bacterial antigens (riboflavin intermediates) presented on major histocompatibility complex class I-related molecule (MR1). Our previous study showed that MR1-/-...
Thu Mar 26, 2020 02:00
Metabolites, Vol. 10, Pages 125: Enzyme Assembly for Compartmentalized Metabolic Flux Control Metabolites doi: 10.3390/metabo10040125 Authors: Xueqin Lv Shixiu Cui Yang Gu Jianghua Li Guocheng Du Long Liu Enzyme assembly by ligand binding or physically sequestrating enzymes, substrates, or metabolites into isolated compartments can bring key molecules closer to enhance the flux of a metabolic pathway. The emergence of enzyme assembly has provided both opportunities and...
Thu Mar 26, 2020 02:00
MPs, Vol. 3, Pages 25: A Green and Simple Protocol for Extraction and Application of a Peroxidase-Rich Enzymatic Extract Methods and Protocols doi: 10.3390/mps3020025 Authors: Rosa Barreto Pinto Seca Recently there is a great social expectation that scientists should produce more sustainable and environmentally friendly chemical processes. Within this necessity, biocatalysis presents many attractive features because reactions are often performed in water, under mild conditions,...
Thu Mar 26, 2020 02:00
Microorganisms, Vol. 8, Pages 473: New Insights into the Microbial Degradation of D-Cyphenothrin in Contaminated Water/Soil Environments Microorganisms doi: 10.3390/microorganisms8040473 Authors: Huang Lin Zhang Pang Bhatt Rene Kumar Chen Persistent use of the insecticide D-cyphenothrin has resulted in heavy environmental contamination and public concern. However, microbial degradation of D-cyphenothrin has never been investigated and the mechanism remains...
Thu Mar 26, 2020 02:00
Microorganisms, Vol. 8, Pages 470: Role of Sinorhizobium meliloti and Escherichia coli Long-Chain Acyl-CoA Synthetase FadD in Long-Term Survival Microorganisms doi: 10.3390/microorganisms8040470 Authors: Pech-Canul Rivera-Hernández Nogales Geiger Soto López-Lara FadD is an acyl-coenzyme A (CoA) synthetase specific for long-chain fatty acids (LCFA). Strains mutated in fadD cannot produce acyl-CoA and thus cannot grow on exogenous LCFA as the sole carbon source. Mutants...
Thu Mar 26, 2020 02:00
Microorganisms, Vol. 8, Pages 474: Assessment of Diversity of Culturable Marine Yeasts Associated with Corals and Zoanthids in the Gulf of Thailand, South China Sea Microorganisms doi: 10.3390/microorganisms8040474 Authors: Kaewkrajay Chanmethakul Limtong Marine yeasts can occur in a wide range of habitats, including in marine invertebrates, in which they may play important roles; however, investigation of marine yeasts in marine invertebrates is scarce. Therefore, this study...
Thu Mar 26, 2020 02:00
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