Pathogens, Vol. 9, Pages 246: Cold Exposure-Induced Up-Regulation of Hsp70 Positively Regulates PEDV mRNA Synthesis and Protein Expression In Vitro Pathogens doi: 10.3390/pathogens9040246 Authors: Kong Xu Ran Yin Feng Sun Porcine epidemic diarrhea (PED) is a highly contagious, intestinal infectious disease caused by porcine epidemic diarrhea virus (PEDV). PEDV as an emerging and re-emerging epizootic virus of swine causes substantial economic losses to the pig industry...
Thu Mar 26, 2020 02:00
Pharmaceuticals, Vol. 13, Pages 55: Antioxidant, Anti-inflammatory Activities and Polyphenol Profile of Rhamnus prinoides Pharmaceuticals doi: 10.3390/ph13040055 Authors: Chen Munyao Mutie Xu Saleri Hu Guo Rhamnus prinoides L’Herit (R. prinoides) has long been widely consumed as folk medicine in Kenya and other Africa countries. Previous studies indicated that polyphenols were abundant in genus Rhamnus and exhibited outstanding antioxidant and anti-inflammatory...
Thu Mar 26, 2020 02:00
Pharmaceuticals, Vol. 13, Pages 54: Improved Surface Display of Human Hyal1 and Identification of Testosterone Propionate and Chicoric Acid as New Inhibitors Pharmaceuticals doi: 10.3390/ph13040054 Authors: Lengers Herrmann Le Borgne Jose Degradation of high molecular weight hyaluronic acid (HA) in humans is mainly catalyzed by hyaluronidase Hyal1. This enzyme is involved in many pathophysiological processes and therefore appears an interesting target for drug discovery....
Thu Mar 26, 2020 02:00
Pharmaceuticals, Vol. 13, Pages 53: Study of In Vitro and In Vivo Carbamazepine Release from Coarse and Nanometric Pharmaceutical Emulsions Obtained via Ultra-High-Pressure Homogenization Pharmaceuticals doi: 10.3390/ph13040053 Authors: Echeverri Alhajj Montero Yarce Barrera-Ocampo Salamanca In the past decade, pharmaceutical nanotechnology has proven to be a promising alternative for improving the physicochemical and biopharmaceutical features for conventional pharmaceutical...
Thu Mar 26, 2020 02:00
Pharmaceutics, Vol. 12, Pages 302: Nanoantioxidant–Based Silica Particles as Flavonoid Carrier for Drug Delivery Applications Pharmaceutics doi: 10.3390/pharmaceutics12040302 Authors: Arriagada Günther Morales Nanosystems used in pharmaceutical formulations have shown promising results in enhancing the administration of drugs of difficult formulations. In particular, porous silica nanoparticles have demonstrated excellent properties for application in biological systems; however,...
Thu Mar 26, 2020 02:00
Pharmaceutics, Vol. 12, Pages 301: Phenformin Attenuates Renal Injury in Unilateral Ureteral Obstructed Mice without Affecting Immune Cell Infiltration Pharmaceutics doi: 10.3390/pharmaceutics12040301 Authors: Nørgård Christensen A.M. Mutsaers Nørregaard Phenformin and metformin are antihyperglycemic drugs that belong to the class of biguanides. Previously, we demonstrated that metformin elicits renoprotective effects in unilateral ureteral obstructed mice by reducing the...
Thu Mar 26, 2020 02:00
Pharmaceutics, Vol. 12, Pages 300: Optimization of Thiolated Chitosan Nanoparticles for the Enhancement of in Vivo Hypoglycemic Efficacy of Sitagliptin in Streptozotocin-Induced Diabetic Rats Pharmaceutics doi: 10.3390/pharmaceutics12040300 Authors: Prabahar Udhumansha Qushawy Sitagliptin (SGN) is an antidiabetic drug used for treatment of diabetes mellitus type II. The objectives of this study were to formulate SGN in form of thiolated chitosan (TC) nanoparticles to enhance...
Thu Mar 26, 2020 02:00
Pharmacy, Vol. 8, Pages 50: Practice, Skill Mix, and Education: The Evolving Role of Pharmacy Technicians in Great Britain Pharmacy doi: 10.3390/pharmacy8020050 Authors: Boughen Fenn Pharmacy technicians’ roles are rapidly evolving in Great Britain (GB) as they undertake more extended activities with increased autonomy across the different pharmacy sectors. This paper compares the GB pharmacy regulator initial education and training standards recently introduced (2017)...
Thu Mar 26, 2020 02:00
Pharmacy, Vol. 8, Pages 49: Pharmacist Segments Identified from 2009, 2014, and 2019 National Pharmacist Workforce Surveys: Implications for Pharmacy Organizations and Personnel Pharmacy doi: 10.3390/pharmacy8020049 Authors: Schommer Doucette Witry Arya Bakken Gaither Kreling Mott Background/Objective: Findings from the 2009 and 2014 National Pharmacist Workforce Surveys showed that approximately 40% of U.S. pharmacists devoted their time primarily to medication...
Thu Mar 26, 2020 02:00
Plants, Vol. 9, Pages 411: In Vitro Propagation, Phytochemical and Neuropharmacological Profiles of Bacopa monnieri (L.) Wettst.: A Review Plants doi: 10.3390/plants9040411 Authors: Saha Sarkar Jeyasri Muthuramalingam Ramesh Jha Bacopa monnieri has been used as a reputed drug in the Indian traditional ayurvedic system for centuries. This medicinal herb with important phytopharmaceuticals has been popularly known as “Brahmi”. In recent years, B....
Thu Mar 26, 2020 02:00
Plants, Vol. 9, Pages 410: Foliar Application of Calcium and Growth Regulators Modulate Sweet Cherry (Prunus avium L.) Tree Performance Plants doi: 10.3390/plants9040410 Authors: Correia Queirós Ferreira Morais Afonso Silva Gonçalves : Cracking of sweet cherry (Prunus avium L.) fruits is caused by rain events close to harvest. This problem has occurred in most cherry growing regions with significant economic losses. Several orchard management practices have been...
Thu Mar 26, 2020 02:00
Publications, Vol. 8, Pages 17: How Frequently are Articles in Predatory Open Access Journals Cited Publications doi: 10.3390/publications8020017 Authors: Björk Kanto-Karvonen Harviainen Predatory journals are Open Access journals of highly questionable scientific quality. Such journals pretend to use peer review for quality assurance, and spam academics with requests for submissions, in order to collect author payments. In recent years predatory journals have received a lot...
Thu Mar 26, 2020 02:00
Religions, Vol. 11, Pages 153: Wisdom’s Guiding Compass: Lady Prudence as a Pedagogical Model Religions doi: 10.3390/rel11040153 Authors: Davis Many educators desire to cultivate wisdom in their students but feel this goal is too vague to be clearly articulated and encouraged. One possible way around this problem is to learn from classical and medieval depictions of wisdom and particular virtues, which were often personified. I will examine one highly illustrative artistic depiction...
Thu Mar 26, 2020 02:00
Resources, Vol. 9, Pages 36: Measurable Effects of Metropolitan Gas Purchasing Group in the Light of Gas Market Functioning in Poland Resources doi: 10.3390/resources9040036 Authors: Karolina Mucha-Kuś As a result of the gas market liberalization, new business models are emerging and one that brings positive effects to market players is purchasing group functioning. This paper adopts the approach of gas market review and provides a synthesis of its functioning in Poland. The review focuses...
Thu Mar 26, 2020 02:00
Social Sciences, Vol. 9, Pages 34: Toward a Model of Just Tourism: A Proposal Social Sciences doi: 10.3390/socsci9040034 Authors: Oliver Mtapuri Andrea Giampiccoli Inequality is growing within and between countries. Tourism is a growing sector affecting lives, with a vibrancy of its own and malleable structures that can benefit a majority, if social justice and equality are the goals. Cooperatives are one of these structures, and have the potential to drive a development trajectory...
Thu Mar 26, 2020 02:00
Social Sciences, Vol. 9, Pages 33: Painting Practical Support: A Study about the Usage of Painting Materials in Children’s Painting Works Social Sciences doi: 10.3390/socsci9040033 Authors: Lan Yu Yukari Nagai Painting materials are one of the mediums that help painters to show the effects of paintings. The use of different painting materials can help the painter to display different painting styles and artistic conception. Six hundred sixty-seven children aged 7 to 13 participated...
Thu Mar 26, 2020 02:00
Societies, Vol. 10, Pages 29: Are Danes’ Immigration Policy Preferences Based on Accurate Stereotypes? Societies doi: 10.3390/soc10020029 Authors: Emil O.W. Kirkegaard Noah Carl Julius D. Bjerrekær Stereotypes about 32 country-of-origin groups were measured using an online survey of the adult, non-elderly Danish population (n = 476 after quality control). Participants were asked to estimate each group’s net fiscal contribution in Denmark. These estimates were then compared...
Thu Mar 26, 2020 02:00
Sports, Vol. 8, Pages 39: Movement Competency Training Delivery: At School or Online? A Pilot Study of High-School Athletes Sports doi: 10.3390/sports8040039 Authors: Simon A Rogers Peter Hassmén Alexandra H Roberts Alison Alcock Wendy L Gilleard John S Warmenhoven Movement competency (MC) development of high-school athletes can prepare them for the requirements of physical preparation training and the demands of sport. The aim of this study was to explore the physical...
Thu Mar 26, 2020 02:00
Toxins, Vol. 12, Pages 211: Using Microcystin Gene Copies to Determine Potentially-Toxic Blooms, Example from a Shallow Eutrophic Lake Peipsi Toxins doi: 10.3390/toxins12040211 Authors: Kristel Panksep Marju Tamm Evanthia Mantzouki Anne Rantala-Ylinen Reet Laugaste Kaarina Sivonen Olga Tammeorg Veljo Kisand Global warming, paired with eutrophication processes, is shifting phytoplankton communities towards the dominance of bloom-forming and potentially toxic cyanobacteria....
Thu Mar 26, 2020 02:00
Toxins, Vol. 12, Pages 210: Biological Activities of Alkaloids: From Toxicology to Pharmacology Toxins doi: 10.3390/toxins12040210 Authors: Adamski Blythe Milella Bufo Plants produce many secondary metabolites, which reveal biological activity [...]
Thu Mar 26, 2020 02:00
Toxins, Vol. 12, Pages 209: Phenyllactic Acid Produced by Geotrichum candidum Reduces Fusarium sporotrichioides and F. langsethiae Growth and T-2 Toxin Concentration Toxins doi: 10.3390/toxins12040209 Authors: Hiba Kawtharani Selma Pascale Snini Sorphea Heang Jalloul Bouajila Patricia Taillandier Florence Mathieu Sandra Beaufort Fusarium sporotrichioides and F. langsethiae are present in barley crops. Their toxic metabolites, mainly T-2 toxin, affect the quality and...
Thu Mar 26, 2020 02:00
Vaccines, Vol. 8, Pages 148: Healthcare Workers’ Knowledge, Attitudes, and Practices about Vaccinations: A Cross-Sectional Study in Italy Vaccines doi: 10.3390/vaccines8020148 Authors: Concetta P. Pelullo Giorgia Della Polla Francesco Napolitano Gabriella Di Giuseppe Italo F. Angelillo The cross-sectional study assessed the knowledge, attitudes, and practices regarding the recommended vaccinations and factors affecting such outcomes among a sample of healthcare workers (HCWs)...
Thu Mar 26, 2020 02:00
Vaccines, Vol. 8, Pages 147: Novel Genetic Melanoma Vaccines Based on Induced Pluripotent Stem Cells or Melanosphere-Derived Stem-Like Cells Display High Efficacy in a Murine Tumor Rejection Model Vaccines doi: 10.3390/vaccines8020147 Authors: Agnieszka Gąbka-Buszek Eliza Kwiatkowska-Borowczyk Jakub Jankowski Anna Karolina Kozłowska Andrzej Mackiewicz Therapeutic cancer vaccines have elicited renewed interest due to the development of immune checkpoint inhibitors. The role...
Thu Mar 26, 2020 02:00
Vaccines, Vol. 8, Pages 146: Mucosal Vaccination with Lactococcus lactis-Secreting Surface Immunological Protein Induces Humoral and Cellular Immune Protection against Group B Streptococcus in a Murine Model Vaccines doi: 10.3390/vaccines8020146 Authors: Diaz-Dinamarca Hernandez Escobar Soto Muñoz Badilla Manzo Carrión Kalergis Vasquez Group B Streptococcus (GBS) is the primary etiological agent of sepsis and meningitis in newborns and is associated...
Thu Mar 26, 2020 02:00
Viruses, Vol. 12, Pages 367: Structure-Based Design of Antivirals against Envelope Glycoprotein of Dengue Virus Viruses doi: 10.3390/v12040367 Authors: Anasir Ramanathan Poh Dengue virus (DENV) presents a significant threat to global public health with more than 500,000 hospitalizations and 25,000 deaths annually. Currently, there is no clinically approved antiviral drug to treat DENV infection. The envelope (E) glycoprotein of DENV is a promising target for drug discovery as...
Thu Mar 26, 2020 02:00
Viruses, Vol. 12, Pages 366: Complete Genome Sequencing, Molecular Epidemiological, and Pathogenicity Analysis of Pigeon Paramyxoviruses Type 1 Isolated in Guangxi, China during 2012–2018 Viruses doi: 10.3390/v12040366 Authors: Ying He Bingxia Lu Kiril M. Dimitrov Jiaxing Liang Zhongwei Chen Wu Zhao Yibin Qin Qunpeng Duan Yingning Zhou Lei Liu Bin Li Lingtian Yu Zhenhua Duan Qi Liu Newcastle disease is an important poultry disease that also affects...
Thu Mar 26, 2020 02:00
Viruses, Vol. 12, Pages 365: Key Role of the Influenza A Virus PA Gene Segment in the Emergence of Pandemic Viruses Viruses doi: 10.3390/v12040365 Authors: Michael M. Lutz IV Megan M. Dunagan Yuki Kurebayashi Toru Takimoto Influenza A viruses (IAVs) are a significant human pathogen that cause seasonal epidemics and occasional pandemics. Avian waterfowl are the natural reservoir of IAVs, but a wide range of species can serve as hosts. Most IAV strains are adapted to one host...
Thu Mar 26, 2020 02:00
Viruses, Vol. 12, Pages 362: Isolation and Characterisation of Alongshan Virus in Russia Viruses doi: 10.3390/v12040362 Authors: Ivan S. Kholodilov Alexander G. Litov Alexander S. Klimentov Oxana A. Belova Alexandra E. Polienko Nikolai A. Nikitin Alexey M. Shchetinin Anna Y. Ivannikova Lesley Bell-Sakyi Alexander S. Yakovlev Sergey V. Bugmyrin Liubov A. Bespyatova Larissa V. Gmyl Svetlana V. Luchinina Anatoly P. Gmyl Vladimir A. Gushchin Galina...
Thu Mar 26, 2020 02:00
Viruses, Vol. 12, Pages 364: Survey on Non-Human Primates and Mosquitoes Does not Provide Evidences of Spillover/Spillback between the Urban and Sylvatic Cycles of Yellow Fever and Zika Viruses Following Severe Outbreaks in Southeast Brazil Viruses doi: 10.3390/v12040364 Authors: Filipe Vieira Santos de Abreu Anielly Ferreira-de-Brito Adriana de Souza Azevedo José Henrique Rezende Linhares Vanessa de Oliveira Santos Emily Hime Miranda Maycon Sebastião Alberto Santos Neves...
Thu Mar 26, 2020 02:00
Viruses, Vol. 12, Pages 361: Genetic Adaptations, Biases, and Evolutionary Analysis of Canine Distemper Virus Asia-4 Lineage in a Fatal Outbreak of Wild-Caught Civets in Thailand Viruses doi: 10.3390/v12040361 Authors: Piewbang Chansaenroj Kongmakee Banlunara Poovorawan Techangamsuwan Canine morbillivirus (CDV) is a serious pathogen that can cause fatal systemic disease in a wide range of domestic and wildlife carnivores. Outbreaks of CDV in wildlife species lead...
Thu Mar 26, 2020 02:00
Viruses, Vol. 12, Pages 363: The Tomato spotted wilt virus (TSWV) Genome is Differentially Targeted in TSWV-Infected Tomato (Solanum lycopersicum) with or without Sw-5 Gene Viruses doi: 10.3390/v12040363 Authors: Olaya Fletcher Zhai Peters Margaria Winter Mitter Pappu Tospoviruses cause significant losses to a wide range of agronomic and horticultural crops worldwide. The type member, Tomato spotted wilt tospovirus (TSWV), causes systemic infection in susceptible...
Thu Mar 26, 2020 02:00
Water, Vol. 12, Pages 946: The Recovery of Phosphorus from Acidic Ultra-High Phosphorous Wastewater by the Struvite Crystallization Water doi: 10.3390/w12040946 Authors: Qiang Li Song Wang Lifang Wang Li Zhang Xiaohui Wan Zhiguo Sun Phosphorus recovery from industrial wastewater has attracted considerable interest. In this study, struvite crystallization method has been used for treatment of high phosphorus wastewater. The new combination agents of Mg5(CO3)4(OH)2·4H2O...
Thu Mar 26, 2020 02:00
Water, Vol. 12, Pages 947: Experimental Evaluation for the Impacts of Conservation Agriculture with Drip Irrigation on Crop Coefficient and Soil Properties in the Sub-Humid Ethiopian Highlands Water doi: 10.3390/w12040947 Authors: Yimam Assefa Adane Tilahun Jha Reyes A field experiment consists of conservation agriculture (CA) and conventional tillage (CT) practices were set up in two areas, Robit and Dangishta, in sub-humid Ethiopian highlands. Irrigation water...
Thu Mar 26, 2020 02:00
Water, Vol. 12, Pages 945: The Effect of Human Impact on the Water Quality and Biocoenoses of the Soft Water Lake with Isoetids: Lake Jeleń, NW Poland Water doi: 10.3390/w12040945 Authors: Klimaszyk Borowiak Piotrowicz Rosińska Szeląg-Wasielewska Kraska Soft water lakes with isoetids (SLI) are ecosystems prone to degradation due to the low buffer capacity of their waters. One of the main threats resulting from human impact is eutrophication due to agriculture, catchment...
Thu Mar 26, 2020 02:00
Water, Vol. 12, Pages 941: A Generic Method for Predicting Environmental Concentrations of Hydraulic Fracturing Chemicals in Soil and Shallow Groundwater Water doi: 10.3390/w12040941 Authors: Dirk Mallants Elise Bekele Wolfgang Schmid Konrad Miotlinski Andrew Taylor Kirill Gerke Bruce Gray Source-pathway-receptor analyses involving solute migration pathways through soil and shallow groundwater are typically undertaken to assess how people and the environment could come...
Thu Mar 26, 2020 02:00
Water, Vol. 12, Pages 943: Improved Land Evapotranspiration Simulation of the Community Land Model Using a Surrogate-Based Automatic Parameter Optimization Method Water doi: 10.3390/w12040943 Authors: Zhang Di Duan Xie Gong Land surface evapotranspiration (ET) is important in land-atmosphere interactions of water and energy cycles. However, regional ET simulation has a great uncertainty. In this study, a highly-efficient parameter optimization framework was applied to...
Thu Mar 26, 2020 02:00
Water, Vol. 12, Pages 942: Levee Breaching: A New Extension to the LISFLOOD-FP Model Water doi: 10.3390/w12040942 Authors: Iuliia Shustikova Jeffrey C. Neal Alessio Domeneghetti Paul D. Bates Sergiy Vorogushyn Attilio Castellarin Levee failures due to floods often cause considerable economic damage and life losses in inundated dike-protected areas, and significantly change flood hazard upstream and downstream the breach location during the event. We present a new extension...
Thu Mar 26, 2020 02:00
Water, Vol. 12, Pages 940: Laboratory Analysis of a Piston-Actuated Pressure-Reducing Valve under Low Flow Conditions Water doi: 10.3390/w12040940 Authors: Valentina Marsili Riccardo Zarbo Stefano Alvisi Marco Franchini The effectiveness of pressure-reducing valves (PRVs) for optimal pressure management of water distribution networks (WDNs) is proven, but problems and operational limitations have been highlighted by some recent experiences. In this study, we analyse the functioning...
Thu Mar 26, 2020 02:00
Water, Vol. 12, Pages 944: Modelling Recharge from Irrigation Developments with a Perched Water Table and Deep Unsaturated Zone Water doi: 10.3390/w12040944 Authors: Glen R. Walker Dougal Currie Tony Smith Modelling of recharge under irrigation zones for input to groundwater modelling is important for assessment and management of environmental risks. Deep vadose zones, when coupled with perched water tables, affect the timing and magnitude of recharge. Despite the temporal and...
Thu Mar 26, 2020 02:00
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