Microfluidic Device Simulates Blinking to Study Eye Drugs:
Drugs that are used to treat conditions of the eyes, or ones that simply use the eyes as a route into the rest of the body, can be very difficult to test in pre-clinical trials. Rabbits are often utilized for this, as they lack tear ducts and so don’t blink very often, allowing substances to penetrate the eye without being washed away first. But humans blink all the time, and our blinking is more complex, has greater consequences, and is more important than may first meet the eye, if you will forgive the pun.
To study what impact all this blinking has on the eyes, and to study how blinking will affect trial drugs that are delivered through the eyes, researchers at Kyoto University in Japan have developed a device that mimics blinking using living corneal cells and microfluidics. The new device will hopefully help not only to test new drugs, but also to study the impact of blinking on the cornea.
The device has four upper chambers within which corneal cells are allowed to grow. These are linked up to four lower chambers via a porous polyester membrane. As the cells grow in the upper chamber, they create a corneal barrier to block off the lower chamber. Pushing liquid up into the upper chambers and over the corneal cells simulates the forces that the cornea experiences when we blink. The four identical parallel channels within the device allow four different compounds or scenarios to be tested under similar conditions in a single experiment.
The device has already led to some new discoveries, including the fact blinking seems to affect the overall shape of corneal cells. Moreover, it looks like blinking also promotes the growth of filaments that provide flexibility and elasticity to the cornea.
Study in Lab on a Chip: Multi-corneal barrier-on-a-chip to recapitulate eye blinking shear stress forces
Via: Kyoto University
Medicine RSS-Feeds by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,00306932607174,alsfakia@gmail.com
Πληροφορίες
Πέμπτη 26 Μαρτίου 2020
Microfluidic Device Simulates Blinking to Study Eye Drugs
Αναρτήθηκε από
Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,00306932607174,alsfakia@gmail.com,
στις
11:53 μ.μ.
Ετικέτες
00302841026182,
00306932607174,
alsfakia@gmail.com,
Anapafseos 5 Agios Nikolaos 72100 Crete Greece,
Medicine by Alexandros G. Sfakianakis,
Telephone consultation 11855 int 1193
Εγγραφή σε:
Σχόλια ανάρτησης (Atom)
Αρχειοθήκη ιστολογίου
-
►
2023
(366)
- ► Φεβρουαρίου (184)
- ► Ιανουαρίου (182)
-
►
2022
(2814)
- ► Δεκεμβρίου (182)
- ► Σεπτεμβρίου (213)
- ► Φεβρουαρίου (264)
- ► Ιανουαρίου (262)
-
►
2021
(3815)
- ► Δεκεμβρίου (229)
- ► Σεπτεμβρίου (276)
- ► Φεβρουαρίου (64)
-
▼
2020
(5754)
- ► Δεκεμβρίου (401)
- ► Σεπτεμβρίου (365)
-
▼
Μαρτίου
(804)
-
▼
Μαρ 26
(67)
- Screening Children with a Family History of Centra...
- Prognostic impact of elevated lactate levels on mo...
- A Phase 3 Trial of Luspatercept in Patients with T...
- Fostemsavir in Adults with Multidrug-Resistant HIV...
- Whole brain radiation therapy plus focal boost may...
- Analysis of HPV-Positive and HPV-Negative Head and...
- Ionizing Radiation and Complex DNA Damage: Quantif...
- A new approach at diabetic foot treatment: phospho...
- Hyperglycemia and the novel Covid-19 infection: po...
- First-line pembrolizumab in advanced non–small cel...
- Wolfram syndrome (WS) is a rare disorder caused by...
- Immunocyte density in parathyroid carcinoma is cor...
- Effects of oral contraceptives on thyroid function...
- Comparison of outcomes between patients with de‐no...
- Microfluidic Device Simulates Blinking to Study Ey...
- Pandemic Drone to Detect People with Respiratory C...
- Associations between Aquaglyceroporin Gene Polymor...
- Oral Appliances for Snoring and Obstructive Sleep ...
- An unusual presentation of supernumerary teeth in ...
- Study of fixation of a mandibular plate for favour...
- Use of the sublingual gland for reconstruction of ...
- Cerebral white matter microstructural changes in i...
- FDA Approval Summary: Ado-trastuzumab emtansine fo...
- Resistance to First-Line Osimertinib in EGFR-mutan...
- Children with reported penicillin allergy: Public ...
- Our evolving understanding of the pathogenesis and...
- We continue to fail black children with asthma and...
- Reliability of CT Angiography in Cerebral Vasospas...
- Hippocampal Sclerosis Detection with NeuroQuant Co...
- Identification of novel biomarkers, MUC5AC , MUC1 ...
- RFA of primary and metastatic lung tumors: long-te...
- Multi-perspective clustering of obstructive sleep ...
- Prospects for Redifferentiating Agents in the Use ...
- Hyperthyroidism and Dementia
- Incidence and Mortality of Myocardial Infarction a...
- Complement Activation in Association with Markers ...
- Pitanguy Ligamentous Flap: A New Method to Prevent...
- The Role of Staged Cryosurgery and Three-Dimension...
- Hyoid Bone Position and Head Posture in Patients W...
- Efficacy of Low Mandible Maneuver on Mutational Fa...
- Risk assessment of obstructive sleep apnea among g...
- Long-term impacts of tonsillectomy on children's i...
- Evaluation of Spodick's Sign and Other Electrocard...
- Thiotepa hyperpigmentation preceding epiderma...
- Water,
- Pathogens
- Microorga
- International Journal of Molecular Sciences
- International Journal of Environmental Resear...
- Cells, Vo
- Antibioti
- Medicine by Alexandros G. Sfakianakis
-
▼
Μαρ 26
(67)
- ► Φεβρουαρίου (754)
- ► Ιανουαρίου (894)
-
►
2019
(146)
- ► Δεκεμβρίου (19)
- ► Σεπτεμβρίου (54)
Δεν υπάρχουν σχόλια:
Δημοσίευση σχολίου