Thiotepa is a common alkylating agent known to precipitate cutaneous reactions consistent with toxic erythema of chemotherapy, including erythema and hyperpigmentation. Herein, we describe an atypical case of malignant intertrigo involving preferential erythema and desquamation not only of skin folds but also of occluded areas after thiotepa-based conditioning. The diagnosis was complicated by concurrent stomatitis and oral petechiae in the setting of autologous stem cell transplant 11 days prior...
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Nevus sebaceus is a benign skin hamartoma of congenital onset that grows during puberty, and in adulthood can develop secondary benign and malignant neoplasms. The most common benign neoplasms occurring in nevus sebaceus are believed to be syringocystadenoma papilliferum, trichilemmoma, and trichoblastoma. A patient with nevus sebaceus developed not only syringocystadenoma papilliferum but also prurigo nodularis within her hamartomatous lesion; multiple biopsies were necessary to establish the diagnoses....
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Follicular occlusion triad is a symptom complex of three conditions with a similar pathophysiology including hidradenitis suppurativa (HS), dissecting cellulitis of the scalp, and acne conglobata. Although the exact pathogenesis of the triad is unknown, it appears to be related to follicular occlusion in areas with apocrine glands. Wolf isotopic response refers to the occurrence of a new dermatosis at the site of another, unrelated, previously healed dermatosis. We present a 26-year-old man with...
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Background Folliculitis decalvans is a neutrophilic cicatricial alopecia whose etiology remains unknown. It is frequently associated with staphylococcal infections. We aimed to determine the rate of gram-negative infections in patients with folliculitis decalvans. Methods A retrospective chart review was performed of patients with biopsy-proven folliculitis decalvans seen at a tertiary hair referral center. The results of bacterial cultures were evaluated. Subjects were determined to have no infection,...
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Grover disease (GD) is an acquired, nonfamilial, nonimmune mediated, transient or persistent acantholytic dermatosis. Herein, we present a 72-year-old man who had clinical and histopathologic findings of GD following two weeks of treatment with vemurafenib without MEK inhibitor. The patient was successfully treated with topical emollients and a high-potency corticosteroid. Meanwhile, vemurafenib was temporarily discontinued. Drug-induced GD has increasingly been reported in patients on BRAF inhibitor...
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Prurigo pigmentosa is a rare inflammatory dermatosis that primarily affects Japanese patients. Various triggers have been identified, including the ketogenic diet. Given the current popularity of the ketogenic diet, the incidence of prurigo pigmentosa may be on the rise. Herein, to the best of our knowledge, we present the first case of prurigo pigmentosa reported in a Hispanic patient in the United States.
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Porokeratotic eccrine ostial and dermal duct nevus (PEODDN) is a rare dermatosis initially described as ‘comedo nevus’ and renamed ‘PEODDN’; it has also been referred to as linear eccrine nevus with comedones, porokeratotic eccrine ostial and hair follicle nevus, and porokeratotic adnexal ostial nevus. PEODDN is usually present at birth or develops early in life. Rarely, PEODDN can develop in adults. The treatment of this puzzling condition is not standardized. We report herein a new case of adultonset...
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Erythema nodosum (EN) is a form of septal panniculitis, which is believed to represent a delayed hypersensitivity reaction activated by infectious agents, drugs, granulomatous and autoimmune diseases, pregnancy, and malignancies. There are only four reported cases of EN during oral isotretinoin therapy to our knowledge, all of them occurring in patients with severe acne. Since acne itself can trigger EN, the question as to whether there is indeed a causative relationship between isotretinoin and...
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Plasmablastic lymphoma (PBL) is a rare and aggressive malignancy associated with immunosuppression and the oncogenic effects of the Epstein-Barr virus (EBV). We present an HIV-positive man with PBL that presented as ulcers and violaceous exophytic nodules on the legs. The clinical features, histologic appearance, and differential diagnosis of this malignancy are briefly reviewed.
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An 89-year-old woman presented with plaque-like lesions, accompanied with pustules and desquamation on the back and front of the trunk for approximately one year. Long term use of potent topical corticosteroids was ineffective. Because of the chronicity of her condition, the diagnoses of subcorneal dermatosis or subcorneal pustular dermatosis type of IgA pemphigus were considered. However, fungal hyphae were observed in the potassium hydroxide examination. Therefore, we present this case since this...
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The original article was published on February 15, 2020 and corrected on March 26, 2020. The revised version of the article amends the table and figure, while leaving the text largely unchanged. The changes appear in the revised online PDF copy of this article.
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Dermatomyositis is an auto-immune inflammatory myopathy that primarily affects the skin and muscle and can be triggered by exposure to various environmental factors. We present a patient with active syphilis infection who developed dermatomyositis and discuss the significance of anti-NXP2 autoantibody positivity.
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Transient acantholytic dermatosis (TAD) is a relatively common entity that has been also noted to occur in patients with cancer. Herein, we describe a case of transient acantholytic dermatosis occurring in a patient with a history of prostate cancer status post radiation, now being treated with combination therapy with pembrolizumab and carboplatin-pemetrexed for advanced lung adenocarcinoma. Our case emphasizes the importance of being cognizant of TAD and its associations, particularly in cancer...
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A 60-year old man developed skin hardening and edema on his extremities. Although he had been treated with oral prednisolone at another hospital, skin stiffness relapsed during tapering of prednisolone. At the initial visit to our department, physical examination showed skin hardening of the extremities and also symmetric erythematous macules on the back. Histological examination revealed fasciitis on the forearm and morphea on the back. Eosinophilic fasciitis is occasionally associated with morphea....
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In this study, polypharmacy during the 6-month time period pre-IV chemotherapy was highly predictive of post-chemotherapy inpatient hospitalization. (Source: CancerNetwork)
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The FDA has approved a phase III clinical trial to assess the safety and efficacy of intravenous tocilizumab (Actemra) plus standard of care in hospitalized adult patients with severe COVID-19 pneumonia. (Source: CancerNetwork)
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The European Society for Medical Oncology released key answers to questions about the coronavirus disease 2019 (COVID-19) as it pertains to cancer care. (Source: CancerNetwork)
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Favorable toxicity profiles and antitumor activity seen in this phase II study of pembrolizumab supports further evaluation of the drug in this patient population. (Source: CancerNetwork)
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This study examined the acquired resistance found from treatment with third-generation EGFR TKIs to see if it was associated with diverse pathways, with an eye for the EGFR T790M mutation. (Source: CancerNetwork)
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In a webinar, clinical oncologists spoke about the ways that their treatment practices and workplaces have had to change during the coronavirus disease 2019 pandemic and the ways they should continue to change. (Source: CancerNetwork)
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A study analyzed a test for specific gene patterns that could indicate that a patient will not respond to standard treatment for newly diagnosed multiple myeloma. (Source: CancerNetwork)
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Biomarkers of carcinogens, including several with a strong link to bladder cancer, were found to be present in the urine of e-cigarette users. (Source: CancerNetwork)
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Planta MedDOI: 10.1055/a-1130-4856Recently, the isolation and elucidation of a series of polyhydroxyanthraquinones were reported from an organic extract of a solid phase culture of an endophytic fungus, Penicillium restrictum (strain G85). One of these compounds, ω-hydroxyemodin (1), showed promising quorum-sensing inhibition against clinical isolates of methicillin-resistant Staphylococcus aureus (MRSA) in both in vitro and in vivo models. The initial supply of 1 was 19 mg, and this amount needed...
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Planta MedDOI: 10.1055/a-1127-7503The hepatotoxic potential of the methanolic extract of the stems of Tinospora crispa and of its furano-diterpenoid–borapetosides B, C, and F–was investigated in normal and health-compromised mice. Health-compromised condition was established by a single intraperitoneal injection of LPS (6 mg/kg). Two different sets of experiments were conducted to evaluate the hepatotoxic potential. A 21-day study where the mice were dosed with the extract of T. crispa (1 gm/kg b. wt./day)...
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ACS NanoDOI: 10.1021/acsnano.9b09974
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ACS NanoDOI: 10.1021/acsnano.9b07888
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ACS NanoDOI: 10.1021/acsnano.0c01119
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ACS NanoDOI: 10.1021/acsnano.9b09259
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ACS NanoDOI: 10.1021/acsnano.9b09998
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ACS NanoDOI: 10.1021/acsnano.9b09062
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ACS NanoDOI: 10.1021/acsnano.0c01395
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Cancer cells differ fundamentally from normal cells, as a result of having acquired hallmark capabilities that enable tumor growth and progression [1]. Due to their high metabolic demands, growing solid tumors depend on vascularization for provision of nutrients and oxygen and disposal of metabolic waste products. Vascularization can be promoted by angiogenesis, i.e. the generation of new blood vessels by sprouting from existing blood vessels. In normal physiology, angiogenesis plays a vital role...
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On March 15, the UK Department of Health and Social Care announced funding to make pre-exposure prophylaxis (PrEP) medication available on the National Health Service in England for HIV prevention. This decision will be met, finally, with a sense of achievement by HIV activists and care providers, who have fought long and hard to make tenofovir-based PrEP drugs widely accessible in the UK, 8 years after the US Food and Drug Administration approved them and more than 4 years after WHO recommended...
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Unit number 4 of the Chernobyl nuclear power plant exploded on April 26, 1986, causing radiation injuries to hundreds of people within a couple of weeks. High levels of radiation affected clean-up workers (liquidators) involved in the emergency response, more than 500 000 liquidators involved in later decontamination and containment, and the general population in the surrounding Soviet states. 116 000 people were evacuated, 220 000 were permanently relocated, and a 30 km exclusion zone still exists...
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A third of the children who used to ride the number 6 bus to school in Yamhill, OR, USA, in the 1970s died before their time, mostly by suicide or from drugs, alcohol, or reckless accidents. Nicholas Kristof, columnist for The New York Times, is one of the survivors. He recalls one family of five siblings, four of whom succumbed as adults: Farlan died of liver failure from drink and drugs; Rogena died of hepatitis linked to drug use; Zealan burned to death in a house fire while passed out drunk;...
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Humanitarian organisations are concerned that border closures and health-care shortages are amplifying the challenges posed by COVID-19. Joe Parkin Daniels reports from Bogotá.
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Two colleagues have recently raised the issue of medical professional shortages in Italy, which places the health-care system in a serious crisis. They offered different explanations: Marta Paterlini1 based this crisis on the mismatch between the number of specialists entering the workforce and the number of doctors retiring, whereas Luca La Colla2 attributes this shortage to the number of doctors entering versus those leaving, either through retirement or working abroad. The Italian health-care...
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The identification of molecular targets and the growing knowledge of their cellular functions have led to the development of small molecule inhibitors as a major therapeutic class for cancer treatment. Both multitargeted and highly selective kinase inhibitors are used for the treatment of advanced treatment-resistant cancers, and many have also achieved regulatory approval for early clinical settings as adjuvant therapies or as first-line options for recurrent or metastatic disease. Lessons learned...
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