Related Articles Biosynthesis pathway of indole-3-acetyl-myo-inositol during development of maize (Zea mays L.) seeds. J Plant Physiol. 2020 Feb;245:153082 Authors: Ostrowski M, Ciarkowska A, Dalka A, Wilmowicz E, Jakubowska A Abstract Indole-3-acetic acid (IAA) conjugation is one of the mechanisms responsible for auxin homeostasis. IAA ester conjugates biosynthesis has been studied during development of maize seeds where IAA-inositol (IAInos)...
Fri Jul 03, 2020 13:37
Compared to American and French ice creams, Italian-style gelato is made with less cream. <a href="http://www.saveur.com/pistachio-gelato-recipe">Get the recipe for Pistachio Gelato Ice Cream »</a> (Matt Taylor-Gross/)This story originally featured on Saveur.Gelato is a totem.Yes, it's a dessert, but at this point in the collective American unconscious, it's also an idea. An aspiration. Gelato is the sophisticated European answer to everything crassly American. More pure. More worldly,...
Sun Jul 05, 2020 00:00
Be honest, you want to play the skateboarding bird game. (Microsoft/)Before consoles made their way onto the internet, game demos came on discs. You’d get a handful of titles, each of which would allow you to play a single level or a small piece of the overall game to get you hooked. I remember one PlayStation demo disk with a level of Twisted Metal that I could have beaten blindfolded because I played it so much. Now, however, demos are easily accessible via download and Microsoft is trying to fill...
Sat Jul 04, 2020 12:00
A mural in Minneapolis, Minnesota, made by community artists, commemorates George Floyd, who was killed while being restrained by city police officers in May. Video of his death, taken primarily by a teenager, has since flooded the internet. (munshots/Unsplash/)The next time you decide to hit the retweet button, think again. That video of Derek Chauvin pressing his knee into George Floyd’s neck for nearly nine minutes could have deleterious mental health impacts on the Black community. From abolitionist...
Fri Jul 03, 2020 19:00
Some cities will have special fireworks displays for the pandemic with a three-mile-radius viewing range. (Alexander Popov/Unsplash/)Follow all of PopSci’s COVID-19 coverage here, including a tutorial on making your own mask, a guide on where to go swimming, and advice for visiting the dentist.Many US states have seen a recent spike in COVID-19 infections, which makes a crowded Fourth of July fireworks show an inherently risky place to be—even if you’re not concerned about long-term hearing damage....
Fri Jul 03, 2020 17:00
Stay in touch. (Luke Chesser/Unsplash/)Touch screen watches are more than simple time pieces. Packed with features like fitness trackers, sedentary reminders, email alerts, and built-in payment systems, these small but mighty gadgets will keep you organized and active throughout the day. Plus, they make for a very stylish accessory.Here are some of our favorites.Send texts and make calls. (Amazon/)The Apple Watch Series 3 is sleek, water-resistant, and connects directly to your iPhone so you can...
Fri Jul 03, 2020 15:01
Researchers are working at unprecedented rates to create a COVID-19 vaccine. (Pixabay/)As COVID-19 cases continue to surge in the United States and abroad, researchers are racing to develop a vaccine at record-breaking speeds. In a June 23 hearing before the House Energy and Commerce Committee, Anthony Fauci, the director of the National Institute of Allergy and Infectious Diseases, reiterated that he is “cautiously optimistic” about the possibility of a coronavirus vaccine being ready by early 2021.“The...
Fri Jul 03, 2020 15:00
Illuminate your workspace. (Shuvro Mojumder via Unsplash/)It’s hard to overstate the impact a lamp can have on a room. In a spot where your eyes once strained to see, suddenly they are devouring a book. In a room where you were once plagued by screen glare and headaches, suddenly staring at a screen becomes not that big a deal. Controlling your workspace can mean the world if you’re trapped in an office with buzzing fluorescent lights overhead, or assigned to a dark corner of a room. Modern desk...
Fri Jul 03, 2020 14:45
Related Articles Prediction of heart disease and classifiers' sensitivity analysis. BMC Bioinformatics. 2020 Jul 02;21(1):278 Authors: Almustafa KM Abstract BACKGROUND: Heart disease (HD) is one of the most common diseases nowadays, and an early diagnosis of such a disease is a crucial task for many health care providers to prevent their patients for such a disease and to save lives. In this paper, a comparative analysis of different classifiers...
Sun Jul 05, 2020 22:54
Related Articles USMPep: universal sequence models for major histocompatibility complex binding affinity prediction. BMC Bioinformatics. 2020 Jul 02;21(1):279 Authors: Vielhaben J, Wenzel M, Samek W, Strodthoff N Abstract BACKGROUND: Immunotherapy is a promising route towards personalized cancer treatment. A key algorithmic challenge in this process is to decide if a given peptide (neoepitope) binds with the major histocompatibility complex...
Sun Jul 05, 2020 22:54
Related Articles Accounting for grouped predictor variables or pathways in high-dimensional penalized Cox regression models. BMC Bioinformatics. 2020 Jul 02;21(1):277 Authors: Belhechmi S, Bin R, Rotolo F, Michiels S Abstract BACKGROUND: The standard lasso penalty and its extensions are commonly used to develop a regularized regression model while selecting candidate predictor variables on a time-to-event outcome in high-dimensional data. However,...
Sun Jul 05, 2020 22:54
Related Articles DiNeR: a Differential graphical model for analysis of co-regulation Network Rewiring. BMC Bioinformatics. 2020 Jul 02;21(1):281 Authors: Zhang J, Liu J, Lee D, Lou S, Chen Z, Gürsoy G, Gerstein M Abstract BACKGROUND: During transcription, numerous transcription factors (TFs) bind to targets in a highly coordinated manner to control the gene expression. Alterations in groups of TF-binding profiles (i.e. "co-binding changes")...
Sun Jul 05, 2020 22:54
Related Articles A cell-level quality control workflow for high-throughput image analysis. BMC Bioinformatics. 2020 Jul 02;21(1):280 Authors: Qiu M, Zhou B, Lo F, Cook S, Chyba J, Quackenbush D, Matzen J, Li Z, Mak PA, Chen K, Zhou Y Abstract BACKGROUND: Image-based high throughput (HT) screening provides a rich source of information on dynamic cellular response to external perturbations. The large quantity of data generated necessitates computer-aided...
Sun Jul 05, 2020 22:54
Related Articles RainDrop: Rapid activation matrix computation for droplet-based single-cell RNA-seq reads. BMC Bioinformatics. 2020 Jul 01;21(1):274 Authors: Niebler S, Müller A, Hankeln T, Schmidt B Abstract BACKGROUND: Obtaining data from single-cell transcriptomic sequencing allows for the investigation of cell-specific gene expression patterns, which could not be addressed a few years ago. With the advancement of droplet-based protocols...
Fri Jul 03, 2020 14:39
Related Articles Proteus: An algorithm for proposing stabilizing mutation pairs based on interactions observed in known protein 3D structures. BMC Bioinformatics. 2020 Jul 01;21(1):275 Authors: Barroso JRMS, Mariano D, Dias SR, Rocha REO, Santos LH, Nagem RAP, de Melo-Minardi RC Abstract BACKGROUND: Protein engineering has many applications for industry, such as the development of new drugs, vaccines, treatment therapies, food, and biofuel production....
Fri Jul 03, 2020 14:39
Related Articles Loqusdb: added value of an observations database of local genomic variation. BMC Bioinformatics. 2020 Jul 01;21(1):273 Authors: Magnusson M, Eisfeldt J, Nilsson D, Rosenbaum A, Wirta V, Lindstrand A, Wedell A, Stranneheim H Abstract BACKGROUND: Exome and genome sequencing is becoming the method of choice for rare disease diagnostics. One of the key challenges remaining is distinguishing the disease causing variants from the...
Fri Jul 03, 2020 14:39
Related Articles Chromatin 3D structure reconstruction with consideration of adjacency relationship among genomic loci. BMC Bioinformatics. 2020 Jul 01;21(1):272 Authors: Li FZ, Liu ZE, Li XY, Bu LM, Bu HX, Liu H, Zhang CM Abstract BACKGROUND: Chromatin 3D conformation plays important roles in regulating gene or protein functions. High-throughout chromosome conformation capture (3C)-based technologies, such as Hi-C, have been exploited to acquire...
Fri Jul 03, 2020 14:39
Related Articles Pharmacovigilance in healthcare education: students' knowledge, attitude and perception: a cross-sectional study in Saudi Arabia. BMC Med Educ. 2020 Jul 02;20(1):210 Authors: Alwhaibi M, Alhindi G, Alshamrani M, Essa MB, A Al Aloola N, Alhawassi TM Abstract BACKGROUND: Medication safety and pharmacovigilance (PV) remains as an important discipline worldwide. However, there is a significant lack of knowledge of PV and adverse...
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Related Articles Modified paramedian versus conventional paramedian technique in the residency training: an observational study. BMC Med Educ. 2020 Jul 02;20(1):211 Authors: Chen SH, Chen SS, Lai CL, Su FY, Tzeng IS, Chen LK Abstract BACKGROUND: Residency training includes positive and negative aspects. Well-trained doctors must be educated, but the process may bring additional risks to patients. Anesthesiologists' performance when conducting...
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Related Articles Use of profession-role exchange in an interprofessional student team-based community health service-learning experience. BMC Med Educ. 2020 Jul 02;20(1):212 Authors: Wang J, Guo J, Wang Y, Yan D, Liu J, Zhang Y, Hu X Abstract BACKGROUND: During interprofessional clinical practice, compared to understanding of one's own professional role and function, it might be more difficult to clarify the roles and contributions of the other...
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Related Articles Nursing staff's and physicians' acquisition of competences and attitudes to interprofessional education and interprofessional collaboration in pediatrics. BMC Med Educ. 2020 Jul 02;20(1):213 Authors: Straub C, Heinzmann A, Krueger M, Bode SFN Abstract BACKGROUND: Interprofessional education (IPE) is deemed essential for interprofessional collaboration (IPC) in healthcare systems. IPC has positive effects for both patients and...
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Related Articles The influence of income on medical school admissions in Canada: a retrospective cohort study. BMC Med Educ. 2020 Jul 01;20(1):209 Authors: Pitre T, Thomas A, Evans K, Jones A, Mountjoy M, Costa AP Abstract BACKGROUND: The socioeconomic status of applicants to Canadian medical schools has been understudied in the past two decades. Institutional efforts have been made to address the lack of socioeconomic diversity across Canada...
Fri Jul 03, 2020 13:02
Related Articles Becoming a coach: experiences of faculty educators learning to coach medical students. BMC Med Educ. 2020 Jul 01;20(1):208 Authors: Brooks JV, Istas K, Barth BE Abstract BACKGROUND: Despite the growth of coaching in medical education, many questions remain about the process of becoming a coach for medical students. We sought to understand the process through which faculty acclimated to this new role, and what benefits and challenges...
Fri Jul 03, 2020 13:02
Related Articles Food supplements to reduce stunting in Pakistan: a process evaluation of community dynamics shaping uptake. BMC Public Health. 2020 Jul 02;20(1):1046 Authors: Zaidi S, Das JK, Khan GN, Najmi R, Shah MM, Soofi SB Abstract BACKGROUND: There is an increasing interest in use of food supplements to prevent childhood stunting, however the evidence on the process indicators is scarce. We in this study explore the barriers to the effective...
Sun Jul 05, 2020 23:11
Related Articles Disclosure, reporting and help seeking among child survivors of violence: a cross-country analysis. BMC Public Health. 2020 Jul 02;20(1):1051 Authors: Pereira A, Peterman A, Neijhoft AN, Buluma R, Daban RA, Islam A, Kainja ETV, Kaloga IF, Kheam T, Johnson AK, Maternowska MC, Potts A, Rottanak C, Samnang C, Shawa M, Yoshikawa M, Palermo T Abstract BACKGROUND: Violence against children is a pervasive public health issue, with...
Sun Jul 05, 2020 23:11
Related Articles Prevalence, awareness, treatment, and control of hypertension in older people: results from the population-based KORA-age 1 study. BMC Public Health. 2020 Jul 02;20(1):1049 Authors: Muli S, Meisinger C, Heier M, Thorand B, Peters A, Amann U Abstract BACKGROUND: Hypertension remains a significant modifiable risk factor for cardiovascular diseases and a major determinant of morbidity and mortality. We aimed to describe sex-stratified...
Sun Jul 05, 2020 23:11
Related Articles Wellness project implementation within Houston's Faith and Diabetes initiative: a mixed methods study. BMC Public Health. 2020 Jul 02;20(1):1050 Authors: Wells R, Breckenridge ED, Linder SH Abstract BACKGROUND: Faith-based health promotion has shown promise for supporting healthy lifestyles, but has limited evidence of reaching scale or sustainability. In one recent such effort, volunteers from a diverse range of faith organizations...
Sun Jul 05, 2020 23:11
Related Articles Crowdsourcing to promote hepatitis C testing and linkage-to-care in China: a randomized controlled trial protocol. BMC Public Health. 2020 Jul 02;20(1):1048 Authors: Wong WCW, Yang NS, Li J, Li H, Wan EYF, Fitzpatrick T, Xiong Y, Seto WK, Chan P, Liu R, Tang W, Tucker JD Abstract BACKGROUND: Hepatitis C virus (HCV) is a growing public health problem with a large disease burden worldwide. In China many people living with HCV...
Sun Jul 05, 2020 23:11
Related Articles "Knock Knock": a qualitative study exploring the experience of household contacts on home visits and their attitude towards people living with TB in South Africa. BMC Public Health. 2020 Jul 02;20(1):1047 Authors: Sathar F, Velen K, Peterson M, Charalambous S, Chetty-Makkan CM Abstract BACKGROUND: Household contract tracing (HHCT) is an important strategy for active tuberculosis case finding and offers an opportunity for testing...
Sun Jul 05, 2020 23:11
Related Articles Secular trends in cardiovascular risk factors among women aged 45-54 years in Gothenburg, Sweden, from 1980 to 2014. BMC Public Health. 2020 Jul 01;20(1):1042 Authors: Persson CU, Collén AC, Rosengren A, Mandalenakis Z, Zverkova Sandström T, Fu M, Dellborg M, Johansson S, Hansson PO Abstract BACKGROUND: A declining trend in mean cholesterol levels and smoking has been observed in high-income western countries during the last...
Fri Jul 03, 2020 14:59
Related Articles Does social cohesion mediate neighbourhood effects on mental and physical health? Longitudinal analysis using German Socio-Economic Panel data. BMC Public Health. 2020 Jul 01;20(1):1043 Authors: Kress S, Razum O, Zolitschka KA, Breckenkamp J, Sauzet O Abstract BACKGROUND: Neighbourhood has risen as a relevant determinant of health. While there is substantial evidence that environmental factors affect health, far less evidence...
Fri Jul 03, 2020 14:59
Related Articles Experiences and needs concerning health related information for newly arrived refugees in Sweden. BMC Public Health. 2020 Jul 01;20(1):1044 Authors: Mårtensson L, Lytsy P, Westerling R, Wångdahl J Abstract BACKGROUND: Owing to communication challenges and a lack of knowledge about the health care system, refugees may be at risk of having limited health literacy, meaning that they will have problems in achieving, understanding,...
Fri Jul 03, 2020 14:59
Related Articles The effect of occupational stress on depression and insomnia: a cross-sectional study among employees in a Ghanaian telecommunication company. BMC Public Health. 2020 Jul 01;20(1):1045 Authors: Kploanyi EE, Dwomoh D, Dzodzomenyo M Abstract BACKGROUND: Depression and insomnia are major psychiatric conditions predicted by occupational stress. However, the influence of occupational stress on these two conditions is under-explored...
Fri Jul 03, 2020 14:59
Related Articles Associations of physical partner violence and sexual violence victimization on health risk behaviours and mental health among university students from 25 countries. BMC Public Health. 2020 Jul 02;20(1):937 Authors: Pengpid S, Peltzer K Abstract BACKGROUND: The study aimed to investigate the associations between physical partner violence victimization (IPV) and/or sexual violence victimization and various health risk behaviours...
Fri Jul 03, 2020 14:59
Related Articles Prevalence and predictors of road crash involvement among medical doctors in Malaysia: a cross-sectional study protocol. BMJ Open. 2020 Jul 02;10(7):e037653 Authors: Rashid AA, Devaraj NK, Mohd Yusof H, Mustapha F, Wong SV, Ismail AF, Ismail KI, Qureshi AM, Nordin RB Abstract INTRODUCTION: Medical doctors are often subjected to long working hours with minimal rest in between the shifts. This has led to many fatal and non-fatal...
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Related Articles Knowledge and attitude of healthcare professionals to frailty screening in primary care: a systematic review protocol. BMJ Open. 2020 Jul 02;10(7):e037523 Authors: Okpechi I, Randhawa G, Hewson D Abstract INTRODUCTION: Frailty is an increasingly common condition in which physiological decline as a result of accumulated deficits renders older people more vulnerable to adverse outcomes. An increasing range of frailty screening...
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Related Articles Incidence and risk factors of type 2 diabetes mellitus in an overweight and obese population: a long-term retrospective cohort study from a Gulf state. BMJ Open. 2020 Jul 02;10(7):e035813 Authors: Regmi D, Al-Shamsi S, Govender RD, Al Kaabi J Abstract OBJECTIVES: A high body mass index (BMI) is associated with risk of type 2 diabetes mellitus (DM). The United Arab Emirates (UAE) is experiencing a marked increase in obesity....
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Related Articles Sex-specific association of serum uric acid dynamics with the incidence of metabolic syndrome in a health check-up Chinese population: a prospective cohort study. BMJ Open. 2020 Jul 02;10(7):e035289 Authors: Liu Y, Fan Y, Liu Q, Liu K, Chen F, Tang X, Li G, Hu D, Song G Abstract OBJECTIVE: Many studies have demonstrated that elevated serum uric acid (SUA) level is linked with metabolic syndrome (MetS). However, whether there...
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Related Articles Impact of a nutritional supplement (Impryl) on male fertility: study protocol of a multicentre, randomised, double-blind, placebo-controlled clinical trial (SUppleMent Male fERtility, SUMMER trial). BMJ Open. 2020 Jul 02;10(7):e035069 Authors: Smits R, D'Hauwers K, IntHout J, Braat D, Fleischer K Abstract INTRODUCTION: Infertility is a worldwide problem and about 10%-15% of all couples will be affected by the inability to have...
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Related Articles Chronic diseases and multimorbidity among unemployed and employed persons in the Netherlands: a register-based cross-sectional study. BMJ Open. 2020 Jul 02;10(7):e035037 Authors: Yildiz B, Schuring M, Knoef MG, Burdorf A Abstract OBJECTIVES: The first objective of this study was to describe the age-specific prevalence of chronic diseases and multimorbidity among unemployed and employed persons. The second objective was to examine...
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Related Articles Prior surgical uterine evacuation of pregnancy and infertility: protocol for systematic review and meta-analysis. BMJ Open. 2020 Jul 02;10(7):e034837 Authors: Tu P, Pei K Abstract INTRODUCTION: Prior surgical uterine evacuation is associated with an increased risk of infertility. However, findings are inconsistent, highlighting the need for a clear consensus on the effect of prior surgical uterine evacuation on the risk of...
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Related Articles Scoping review protocol on maternal, newborn and child health research in Ethiopia. BMJ Open. 2020 Jul 02;10(7):e034307 Authors: Chan GJ, Getnet M, Olowojesiku R, Min-Swe T, Hunegnaw B, Bekele D Abstract INTRODUCTION: There has been a tremendous reduction in maternal and child mortality in the last decade. However, a significant number of deaths still occur disproportionately in low-income country settings. Ethiopia is the...
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Related Articles Is there an association between long-term antibiotics for acne and subsequent infection sequelae and antimicrobial resistance? A systematic review protocol. BMJ Open. 2020 Jul 02;10(7):e033662 Authors: Bhate K, Lin LY, Barbieri J, Leyrat C, Hopkins S, Stabler R, Shallcross L, Smeeth L, Francis NA, Mathur R, Langan SM, Sinnott SJ Abstract INTRODUCTION: Antimicrobial resistance (AMR) is a global health emergency. Acne vulgaris...
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Related Articles Impact of COVID-19 pandemic on mental health of young people and adults: a systematic review protocol of observational studies. BMJ Open. 2020 Jul 01;10(7):e039426 Authors: Silva Junior FJGD, Sales JCES, Monteiro CFS, Costa APC, Campos LRB, Miranda PIG, Monteiro TAS, Lima RAG, Lopes-Junior LC Abstract INTRODUCTION: Since the WHO declared COVID-19 as a pandemic, the spread of the new coronavirus has been the focus of attention...
Fri Jul 03, 2020 16:35
Related Articles Flare-IBD: development and validation of a questionnaire based on patients' messages on an internet forum for early detection of flare in inflammatory bowel disease: study protocol. BMJ Open. 2020 Jul 01;10(7):e037211 Authors: Ricci L, Epstein J, Buisson A, Devos C, Toussaint Y, Peyrin-Biroulet L, Guillemin F Abstract INTRODUCTION: Crohn's disease and ulcerative colitis, the two major forms of inflammatory bowel disease (IBD),...
Fri Jul 03, 2020 16:35
Related Articles Competencies for collaboration between general practitioners and medical specialists: a qualitative study of the patient perspective. BMJ Open. 2020 Jul 01;10(7):e037043 Authors: Janssen M, Fluit CRMG, Sagasser MH, Kusters LHJ, Scherpbier-de Haan ND, de Graaf J Abstract OBJECTIVES: To explore the patient view of competencies essential for doctors to provide good collaboration at the primary-secondary care interface. ...
Fri Jul 03, 2020 16:35
Related Articles Effect of RaceRunning on cardiometabolic disease risk factors and functional mobility in young people with moderate-to-severe cerebral palsy: protocol for a feasibility study. BMJ Open. 2020 Jul 01;10(7):e036469 Authors: Ryan J, Theis N, Koufaki P, Phillips S, Anokye N, Andreopoulou G, Kennedy F, Jagadamma KC, vanSchie P, Dines H, van der Linden ML Abstract INTRODUCTION: There is consistent evidence that people with cerebral...
Fri Jul 03, 2020 16:35
Related Articles Cohort profile: Resettlement in Uprooted Groups Explored (REFUGE)-a longitudinal study of mental health and integration in adult refugees from Syria resettled in Norway between 2015 and 2017. BMJ Open. 2020 Jul 01;10(7):e036101 Authors: Nissen A, Cauley P, Saboonchi F, Andersen A, Solberg Ø Abstract PURPOSE: In the field of forced migration and mental health research, longitudinal studies with large sample sizes and rigorous...
Fri Jul 03, 2020 16:35
Related Articles Prioritising outcomes for evaluating eosinophil-guided corticosteroid therapy among patients with acute COPD exacerbations requiring hospitalisation: a Delphi consensus study. BMJ Open. 2020 Jul 01;10(7):e035811 Authors: Suehs CM, Zysman M, Chenivesse C, Burgel PR, Couturaud F, Deslee G, Berger P, Raherison C, Devouassoux G, Brousse C, Roche N, Molimard M, Chinet T, Devillier P, Chanez P, Kessler R, Didier A, Martinat Y, Le Rouzic O, Bourdin...
Fri Jul 03, 2020 16:35
Related Articles Challenges and facilitators of hospice decision-making: a retrospective review of family caregivers of home hospice patients in a rural US-Mexico border region-a qualitative study. BMJ Open. 2020 Jul 01;10(7):e035634 Authors: Ko E, Fuentes D, Singh-Carlson S, Nedjat-Haiem F Abstract OBJECTIVES: Hospice care (HC) is seen as a comprehensive approach, that enhances quality of end-of-life (EOL) care, for terminally ill patients....
Fri Jul 03, 2020 16:35
Related Articles International prospective observational study investigating the disease course and heterogeneity of paediatric-onset inflammatory bowel disease: the protocol of the PIBD-SETQuality inception cohort study. BMJ Open. 2020 Jul 01;10(7):e035538 Authors: Aardoom MA, Kemos P, Tindemans I, Aloi M, Koletzko S, Levine A, Turner D, Veereman G, Neyt M, Russell RK, Walters TD, Ruemmele FM, Samsom JN, Croft NM, de Ridder L, PIBD-SETQuality consortium and...
Fri Jul 03, 2020 16:35
Related Articles Mapping adolescent sexual and reproductive health research in sub-Saharan Africa: protocol for a scoping review. BMJ Open. 2020 Jul 01;10(7):e035335 Authors: Ajayi AI, Ushie BA, Mwoka M, Igonya EK, Ouedraogo R, Juma K, Aboderin I Abstract INTRODUCTION: Previous studies have attempted to review the vast body of evidence on adolescent sexual and reproductive health (ASRH), but none has focused on a complete mapping and synthesis...
Fri Jul 03, 2020 16:35
Related Articles Protocol for a multinational risk-stratified randomised controlled trial in paediatric Crohn's disease: methotrexate versus azathioprine or adalimumab for maintaining remission in patients at low or high risk for aggressive disease course. BMJ Open. 2020 Jul 01;10(7):e034892 Authors: Harris RE, Aloi M, de Ridder L, Croft NM, Koletzko S, Levine A, Turner D, Veereman G, Neyt M, Bigot L, Ruemmele FM, Russell RK, PIBD SETQuality consortium and PIBDnet...
Fri Jul 03, 2020 16:35
Related Articles Eleven-year multimorbidity burden among 637 255 people with and without type 2 diabetes: a population-based study using primary care and linked hospitalisation data. BMJ Open. 2020 Jul 01;10(7):e033866 Authors: Zghebi SS, Steinke DT, Rutter MK, Ashcroft DM Abstract OBJECTIVES: To compare the patterns of 18 physical and mental health comorbidities between people with recently diagnosed type 2 diabetes (T2D) and people without...
Fri Jul 03, 2020 16:35
Related Articles New Insights in Gene Expression Alteration as Effect of Paclitaxel Drug Resistance in Triple Negative Breast Cancer Cells. Cell Physiol Biochem. 2020 Jul 04;54(4):648-664 Authors: Jurj A, Pop LA, Zanoaga O, Ciocan-Cârtiţă CA, Cojocneanu R, Moldovan C, Raduly L, Pop-Bica C, Trif M, Irimie A, Berindan-Neagoe I, Braicu C Abstract BACKGROUND/AIMS: Triple negative breast cancer (TNBC) is a highly aggressive form of cancer which...
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Related Articles Identification of novel genes in testicular cancer microenvironment based on ESTIMATE algorithm-derived immune scores. J Cell Physiol. 2020 Jul 02;: Authors: Ke ZB, Wu YP, Huang P, Hou J, Chen YH, Dong RN, Lin F, Wei Y, Xue XY, Ng CF, Xu N Abstract Testicular cancer is the most common solid malignancy among young men. We downloaded data of testicular cancer patients from The Cancer Genome Atlas database to find novel genes...
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Related Articles Enalapril and treadmill running reduce adiposity, but only the latter causes adipose tissue browning in mice. J Cell Physiol. 2020 Jul 02;: Authors: Giori IG, Magliano DC, Alexandre-Santos B, Fernandes T, Oliveira EM, Vieira CP, Conte-Junior CA, Ceddia RB, Nobrega ACL, Frantz EDC Abstract This study investigated whether regulation of the renin-angiotensin system (RAS) by enalapril and/or aerobic exercise training (AET) causes...
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Related Articles Bovine peripheral blood MSCs chemotax towards inflammation and embryo implantation stimuli. J Cell Physiol. 2020 Jul 02;: Authors: Calle A, Gutiérrez-Reinoso MÁ, Re M, Blanco J, De la Fuente J, Monguió-Tortajada M, Borràs FE, Yáñez-Mó M, Ramírez MÁ Abstract Mesenchymal stem cells (MSCs) have a great potential in regenerative medicine because of their multipotential and immunoregulatory capacities, while in early pregnancy they...
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Related Articles Pathophysiological roles of chronic low-grade inflammation mediators in polycystic ovary syndrome. J Cell Physiol. 2020 Jul 02;: Authors: Rostamtabar M, Esmaeilzadeh S, Tourani M, Rahmani A, Baee M, Shirafkan F, Saleki K, Mirzababayi SS, Ebrahimpour S, Nouri HR Abstract Polycystic ovary syndrome (PCOS) is the most common hormonal imbalance disease in reproductive-aged women. Its basic characteristics are ovulatory dysfunction...
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Related Articles Proper E-cadherin membrane location in colon requires Dab2 and it modifies by inflammation and cancer. J Cell Physiol. 2020 Jul 02;: Authors: Vazquez-Carretero MD, García-Miranda P, Balda MS, Matter K, Ilundáin AA, Peral MJ Abstract We reported that Disabled-2 (Dab2) is located at the apical membrane in suckling rat intestine. Here, we discovered that, in colon of suckling and adult mouse and of adult human, Dab2 is only at...
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Related Articles Function of DHX33 in promoting Warburg effect via regulation of glycolytic genes. J Cell Physiol. 2020 Jul 02;: Authors: Peng C, Hou ST, Deng CX, Zhang Y Abstract Cancer cells metabolize glucose through glycolysis to promote cell proliferation even with abundant oxygen. Multiple glycolysis genes are deregulated during cancer development. Despite intensive effort, the cause of their deregulation remains incompletely understood....
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Related Articles A divergent mode of activation of a nitrosyl iron complex with unusual antiangiogenic activity. J Inorg Biochem. 2020 Jun 20;210:111133 Authors: Carvalho EM, Ridnour LA, Júnior FSG, Cabral PHB, do Nascimento NRF, Wink DA, Franco DW, de Medeiros MJC, de Lima Pontes D, Longhinotti E, de Freitas Paulo T, Bernardes-Génisson V, Chauvin R, Sousa EHS, Lopes LGF Abstract Nitric oxide (NO) and nitroxyl (HNO) have gained broad attention...
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Related Articles Protein dynamics of [Cu-Zn] superoxide dismutase (SOD1): How protein motions at the global and local levels impact the reactivity of SOD1. J Inorg Biochem. 2020 Jun 24;210:111161 Authors: Healy EF, Flores R, Lynch VM, Toledo S Abstract This work explores the pivotal role that protein mobility plays in facilitating the catalytic activity of Copper-Zinc superoxide dismutase (SOD1). Through both localized active site distortions...
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Related Articles Changes in Dietary Intake of Major Nutrients and Food Sources among Costa Rican Adolescents in the Last 20 Years. J Nutr. 2020 Jul 03;: Authors: Monge-Rojas R, Vargas-Quesada R, Chinnock A, Colón-Ramos U Abstract BACKGROUND: Adolescence offers a window of opportunity to prevent adult obesity and noncommunicable disease risk factors. With the rising prevalence of adolescent obesity over the last 20 y, identifying any changes...
Sun Jul 05, 2020 23:46
Related Articles Activation of the Farnesoid X Receptor (FXR) Suppresses Linoleic Acid-Induced Inflammation in the Large Yellow Croaker (Larimichthys crocea). J Nutr. 2020 Jul 02;: Authors: Du J, Chen Q, Li Y, Xiang X, Xu W, Mai K, Ai Q Abstract BACKGROUND: High linoleic acid (LA) intake leads to inflammation that adversely influences health in fish. However, whether the farnesoid X receptor (FXR) could be an effective target for regulating...
Fri Jul 03, 2020 16:34
Related Articles Vitamin A Absorption Efficiency Determined by Compartmental Analysis of Postprandial Plasma Retinyl Ester Kinetics in Theoretical Humans. J Nutr. 2020 Jul 02;: Authors: Green MH, Green JB, Ford JL Abstract BACKGROUND: Better methods are needed for determining vitamin A absorption efficiency in humans to support development of dietary recommendations and to improve the accuracy of predictions of vitamin A status. OBJECTIVES:...
Fri Jul 03, 2020 16:34
Related Articles Psychosocial Risk Factors for Food Insecurity in Puerto Ricans Living in the USA from Baseline to 5-Year Follow-Up. J Nutr. 2020 Jul 02;: Authors: Dou N, Xie D, Gao X, Palacios N, Falcon LM, Tucker KL, Na M Abstract BACKGROUND: Food insecurity is prevalent among Puerto Rican adults in the USA and is associated with adverse psychosocial outcomes. However, the direction of this association has not been established in this understudied...
Fri Jul 03, 2020 16:34
Related Articles Infant Rhesus Macaque Brain α-Tocopherol Stereoisomer Profile Is Differentially Impacted by the Source of α-Tocopherol in Infant Formula. J Nutr. 2020 Jul 02;: Authors: Kuchan MJ, Ranard KM, Dey P, Jeon S, Sasaki GY, Schimpf KJ, Bruno RS, Neuringer M, Erdman JW Abstract BACKGROUND: α-Tocopherol (αT) in its natural form [2'R, 4'R, 8'R αT (RRR-αT)] is more bioactive than synthetic α-tocopherol (all rac-αT). All rac-αT is widely...
Fri Jul 03, 2020 16:34
Related Articles Lack of collagen XVIII leads to lipodystrophy and perturbs hepatic glucose and lipid homeostasis. J Physiol. 2020 Jul 03;: Authors: Braun JL, Geromella MS, Hamstra SI PMID: 32618368 [PubMed - as supplied by publisher]
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Related Articles Intra-gastrointestinal amyloid-β1-42 oligomers perturb enteric function and induce Alzheimer's disease pathology. J Physiol. 2020 Jul 02;: Authors: Sun Y, Sommerville NR, Liu JYH, Ngan MP, Poon D, Ponomarev ED, Lu Z, Kung JSC, Rudd JA Abstract KEY POINTS: Alzheimer's disease (AD) patients and transgenic mice have beta-amyloid (Aβ) aggregation in the gastrointestinal (GI) tract. It is possible that Aβ from the periphery contributes...
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Related Articles Evidence for improved systemic and local vascular function after long-term passive static stretching training of the musculoskeletal system. J Physiol. 2020 Jul 01;: Authors: Bisconti AV, Cè E, Longo S, Venturelli M, Coratella G, Limonta E, Doria C, Rampichini S, Esposito F Abstract KEY POINTS: Vascular function and arterial stiffness are important markers of cardiovascular health and cardiovascular co-morbidity. Transitional...
Fri Jul 03, 2020 13:04
Related Articles Conserved Ark1-related kinases function in a TORC2 signaling network. Mol Biol Cell. 2020 Jul 02;:mbcE19120685 Authors: Alcaide-Gavilán M, Lucena R, Banuelos S, Kellogg DR Abstract In all orders of life, cell cycle progression in proliferating cells is dependent upon cell growth, and the extent of growth required for cell cycle progression is proportional to growth rate. Thus, cells growing rapidly in rich nutrients are substantially...
Fri Jul 03, 2020 16:04
Related Articles The ARF GAP ELMOD2 acts with different GTPases to regulate centrosomal microtubule nucleation and cytokinesis. Mol Biol Cell. 2020 Jul 02;:mbcE20010012 Authors: Turn RE, East MP, Prekeris R, Kahn RA Abstract ELMOD2 is a ∼32 kDa protein first purified by its GAP activity towards ARL2 and later shown to have uniquely broad specificity toward ARF family GTPases in in vitro assays. To begin the task of defining its functions in...
Fri Jul 03, 2020 16:04
Related Articles The N- or C-terminal cytoplasmic regions of P4-ATPases determine their cellular localization. Mol Biol Cell. 2020 Jul 02;:mbcE20040225 Authors: Okamoto S, Naito T, Shigetomi R, Kosugi Y, Nakayama K, Takatsu H, Shin HW Abstract Mammalian P4-ATPases specifically localize to the plasma membrane and the membranes of intracellular compartments. P4-ATPases contain ten transmembrane domains, and their N- and C-terminal (NT and CT)...
Fri Jul 03, 2020 16:04
Related Articles Genetic Suppression of Defective Profilin by Attenuated Myosin II Reveals a Potential Role for Myosin II in Actin Dynamics in vivo in fission yeast. Mol Biol Cell. 2020 Jul 02;:mbcE20040224 Authors: Zambon P, Palani S, Jadhav SS, Gayathri P, Balasubramanian MK Abstract The actin cytoskeleton plays a variety of roles in eukaryotic cell physiology, ranging from cell polarity and migration to cytokinesis. Key to the function of...
Fri Jul 03, 2020 16:04
Related Articles Characterizing the cellular architecture of dynamically remodeling vascular tissue using 3-D image analysis and virtual reconstruction. Mol Biol Cell. 2020 Jul 02;:mbcE20020091 Authors: Madhu R, Rodriguez D, Guzik C, Singh S, De Tomaso AW, Valentine MT, Loerke D Abstract Epithelial tubules form critical structures in lung, kidney and vascular tissues. However, the processes that control their morphogenesis and physiological...
Fri Jul 03, 2020 16:04
Related Articles The challenges of modeling and forecasting the spread of COVID-19. Proc Natl Acad Sci U S A. 2020 Jul 02;: Authors: Bertozzi AL, Franco E, Mohler G, Short MB, Sledge D Abstract The coronavirus disease 2019 (COVID-19) pandemic has placed epidemic modeling at the forefront of worldwide public policy making. Nonetheless, modeling and forecasting the spread of COVID-19 remains a challenge. Here, we detail three regional-scale models...
Sat Jul 04, 2020 16:29
Related Articles Revealing 29 sets of independently modulated genes in Staphylococcus aureus, their regulators, and role in key physiological response. Proc Natl Acad Sci U S A. 2020 Jul 02;: Authors: Poudel S, Tsunemoto H, Seif Y, Sastry AV, Szubin R, Xu S, Machado H, Olson CA, Anand A, Pogliano J, Nizet V, Palsson BO Abstract The ability of Staphylococcus aureus to infect many different tissue sites is enabled, in part, by its transcriptional...
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Related Articles Premature termination codons in the DMD gene cause reduced local mRNA synthesis. Proc Natl Acad Sci U S A. 2020 Jul 02;: Authors: García-Rodríguez R, Hiller M, Jiménez-Gracia L, van der Pal Z, Balog J, Adamzek K, Aartsma-Rus A, Spitali P Abstract Duchenne muscular dystrophy (DMD) is caused by mutations in the DMD gene leading to the presence of premature termination codons (PTC). Previous transcriptional studies have shown reduced...
Sat Jul 04, 2020 16:29
Related Articles Evaporating droplets on oil-wetted surfaces: Suppression of the coffee-stain effect. Proc Natl Acad Sci U S A. 2020 Jul 02;: Authors: Li Y, Diddens C, Segers T, Wijshoff H, Versluis M, Lohse D Abstract The evaporation of suspension droplets is the underlying mechanism in many surface-coating and surface-patterning applications. However, the uniformity of the final deposit suffers from the coffee-stain effect caused by contact...
Sat Jul 04, 2020 16:29
Related Articles An engineered chimeric toxin that cleaves activated mutant and wild-type RAS inhibits tumor growth. Proc Natl Acad Sci U S A. 2020 Jul 02;: Authors: Vidimar V, Beilhartz GL, Park M, Biancucci M, Kieffer MB, Gius DR, Melnyk RA, Satchell KJF Abstract Despite nearly four decades of effort, broad inhibition of oncogenic RAS using small-molecule approaches has proven to be a major challenge. Here we describe the development of a...
Sat Jul 04, 2020 16:29
Related Articles Extensive sequence and structural evolution of Arginase 2 inhibitory antibodies enabled by an unbiased approach to affinity maturation. Proc Natl Acad Sci U S A. 2020 Jul 02;: Authors: Chan DTY, Jenkinson L, Haynes SW, Austin M, Diamandakis A, Burschowsky D, Seewooruthun C, Addyman A, Fiedler S, Ryman S, Whitehouse J, Slater LH, Gowans E, Shibata Y, Barnard M, Wilkinson RW, Vaughan TJ, Holt SV, Cerundolo V, Carr MD, Groves MAT Abstract...
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Related Articles Base rate neglect and neural computations for subjective weight in decision under uncertainty. Proc Natl Acad Sci U S A. 2020 Jul 02;: Authors: Yang YY, Wu SW Abstract Base rate neglect, an important bias in estimating probability of uncertain events, describes humans' tendency to underweight base rate (prior) relative to individuating information (likelihood). However, the neural mechanisms that give rise to this bias remain...
Sat Jul 04, 2020 16:29
Related Articles Extracellular proteolytic cascade in tomato activates immune protease Rcr3. Proc Natl Acad Sci U S A. 2020 Jul 02;: Authors: Paulus JK, Kourelis J, Ramasubramanian S, Homma F, Godson A, Hörger AC, Hong TN, Krahn D, Ossorio Carballo L, Wang S, Win J, Smoker M, Kamoun S, Dong S, van der Hoorn RAL Abstract Proteolytic cascades regulate immunity and development in animals, but these cascades in plants have not yet been reported....
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Related Articles Dynamic neural and glial responses of a head-specific model for traumatic brain injury in Drosophila. Proc Natl Acad Sci U S A. 2020 Jul 01;: Authors: Saikumar J, Byrns CN, Hemphill M, Meaney DF, Bonini NM Abstract Traumatic brain injury (TBI) is the strongest environmental risk factor for the accelerated development of neurodegenerative diseases. There are currently no therapeutics to address this due to lack of insight into...
Fri Jul 03, 2020 16:08
Related Articles Male reproductive aging arises via multifaceted mating-dependent sperm and seminal proteome declines, but is postponable in Drosophila. Proc Natl Acad Sci U S A. 2020 Jul 01;: Authors: Sepil I, Hopkins BR, Dean R, Bath E, Friedman S, Swanson B, Ostridge HJ, Harper L, Buehner NA, Wolfner MF, Konietzny R, Thézénas ML, Sandham E, Charles PD, Fischer R, Steinhauer J, Kessler BM, Wigby S Abstract Declining ejaculate performance with...
Fri Jul 03, 2020 16:08
Related Articles Stem cell lineage survival as a noisy competition for niche access. Proc Natl Acad Sci U S A. 2020 Jul 01;: Authors: Corominas-Murtra B, Scheele CLGJ, Kishi K, Ellenbroek SIJ, Simons BD, van Rheenen J, Hannezo E Abstract Understanding to what extent stem cell potential is a cell-intrinsic property or an emergent behavior coming from global tissue dynamics and geometry is a key outstanding question of systems and stem cell biology....
Fri Jul 03, 2020 16:08
Related Articles Screen identifies DYRK1B network as mediator of transcription repression on damaged chromatin. Proc Natl Acad Sci U S A. 2020 Jul 01;: Authors: Dong C, West KL, Tan XY, Li J, Ishibashi T, Yu CH, Sy SMH, Leung JWC, Huen MSY Abstract DNA double-strand breaks (DSBs) trigger transient pausing of nearby transcription, an emerging ATM-dependent response that suppresses chromosomal instability. We screened a chemical library designed...
Fri Jul 03, 2020 16:08
Related Articles Time-dependent plasticity in silicon microbeams mediated by dislocation nucleation. Proc Natl Acad Sci U S A. 2020 Jul 01;: Authors: Elhebeary M, Harzer T, Dehm G, Saif MTA Abstract Understanding deformation mechanisms in silicon is critical for reliable design of miniaturized devices operating at high temperatures. Bulk silicon is brittle, but it becomes ductile at about 540 °C. It creeps (deforms plastically with time) at...
Fri Jul 03, 2020 16:08
Related Articles Inner Workings: Was Jupiter born beyond the current orbits of Neptune and Pluto? Proc Natl Acad Sci U S A. 2020 Jul 01;: Authors: Croswell K PMID: 32611813 [PubMed - as supplied by publisher]
Fri Jul 03, 2020 16:08
Related Articles Nur77 controls tolerance induction, terminal differentiation, and effector functions in semi-invariant natural killer T cells. Proc Natl Acad Sci U S A. 2020 Jul 01;: Authors: Kumar A, Hill TM, Gordy LE, Suryadevara N, Wu L, Flyak AI, Bezbradica JS, Van Kaer L, Joyce S Abstract Semi-invariant natural killer T (iNKT) cells are self-reactive lymphocytes, yet how this lineage attains self-tolerance remains unknown. iNKT cells constitutively...
Fri Jul 03, 2020 16:08
Related Articles Intercepting second-messenger signaling by rationally designed peptides sequestering c-di-GMP. Proc Natl Acad Sci U S A. 2020 Jul 01;: Authors: Hee CS, Habazettl J, Schmutz C, Schirmer T, Jenal U, Grzesiek S Abstract The bacterial second messenger cyclic diguanylate (c-di-GMP) regulates a wide range of cellular functions from biofilm formation to growth and survival. Targeting a second-messenger network is challenging because...
Fri Jul 03, 2020 16:08
Related Articles Cofactor-enabled functional expression of fruit fly, honeybee, and bumblebee nicotinic receptors reveals picomolar neonicotinoid actions. Proc Natl Acad Sci U S A. 2020 Jul 01;: Authors: Ihara M, Furutani S, Shigetou S, Shimada S, Niki K, Komori Y, Kamiya M, Koizumi W, Magara L, Hikida M, Noguchi A, Okuhara D, Yoshinari Y, Kondo S, Tanimoto H, Niwa R, Sattelle DB, Matsuda K Abstract The difficulty of achieving robust functional...
Fri Jul 03, 2020 16:08
Related Articles Bioinspired nervous signal transmission system based on two-dimensional laminar nanofluidics: From electronics to ionics. Proc Natl Acad Sci U S A. 2020 Jul 01;: Authors: Teng Y, Liu P, Fu L, Kong XY, Jiang L, Wen L Abstract Mammalian nervous systems, as natural ionic circuitries, stand out in environmental perception and sophisticated information transmission, relying on protein ionic channels and additional necessary structures....
Fri Jul 03, 2020 16:08
Η πλειοψηφία όσων εργάστηκε από το σπίτι στη διάρκεια του lockdown, εργαζόταν περισσότερες ώρες από ότι στο γραφείο, σύμφωνα με τα αποτελέσματα έρευνας της Βlueground που διεξήχθη μεταξύ Απριλίου και Μαΐου και έλαβαν μέρος πάνω από 500 ενοικιαστές της σε Ευρώπη, Αμερική και Μέση Ανατολή. Ειδικότερα, σύμφωνα με την έρευνα της Blueground το 68% δήλωσε πως εργαζόταν όσο και πριν αν όχι και περισσότερο. Ενώ ένας στους 4 (24%) δήλωσε πως η παραγωγικότητα μειώθηκε αρκετά. Ίσως φταίει το γεγονός πως 1...
Fri Jul 03, 2020 14:03
Η περιεμμηνόπαυση αποτελεί μία περίοδο στη ζωή της γυναίκας κατά την οποία γίνεται πιο ευάλωτη σε διάφορα προβλήματα υγείας. Στο πλαίσιο αυτό, μια νέα μελέτη αναγνώρισε την εμμηνόπαυση ως παράγοντα κινδύνου για την ανάπτυξη του μεταβολικού συνδρόμου ή κάποιων από τα στοιχεία του, όπως η υπέρταση, η κεντρική παχυσαρκία και το υψηλό σάκχαρο. Συγκεντρώνοντας στοιχεία από δεδομένα της Μακροχρόνιας Μελέτης της Γήρανσης του Καναδά, η έρευνα που δημοσιεύθηκε στο Menopause, βρήκε ένα θετικό συσχετισμό μεταξύ...
Fri Jul 03, 2020 13:35
Πολλοί είναι οι άνθρωποι που προσπαθούν να αναπληρώσουν τις χαμένες ώρες ύπνου της εβδομάδας κατά τη διάρκεια του Σαββατοκύριακου. Σύμφωνα με Γάλλους επιστήμονες, όμως, ο ύπνος των δύο ημερών δεν αρκεί για να αντισταθμίσει την έλλειψη ύπνου της υπόλοιπης εβδομάδας. Τα ευρήματα της έρευνας που δημοσιεύθηκε στο Sleep Medicine επικεντρώθηκαν σε ενήλικες που κοιμούνται τακτικά έξι ώρες ή λιγότερο κατά τη διάρκεια της εβδομάδας, διάστημα πολύ μικρότερο των 7-8 ωρών που χρειάζονται οι περισσότεροι άνθρωποι...
Fri Jul 03, 2020 12:45
Η μουρμούρα και η αδιάκοπη αρνητική κριτική προς τον ή τη σύντροφο αποδεικνύεται κάτι παραπάνω από αιτία πονοκεφάλων και τσακωμών. Νέα έρευνα δίνει οντότητα στη λαϊκή ρήση που θέλει τη συνεχή γκρίνια προς το έτερον ήμισυ να το οδηγεί νωρίτερα στο επέκεινα. Οι ειδικοί επεσήμαναν πως οι συνεχείς υποδείξεις και επικρίσεις σε λάθη του συντρόφου όχι μόνο δεν επιλύουν το όποιο πρόβλημα αλλά, αντιθέτως, δυσχεραίνουν την κατάσταση της υγείας του, αφαιρώντας έως και πέντε χρόνια από το προσδόκιμο ζωής του....
Fri Jul 03, 2020 12:28
Η παχυσαρκία έχει συνδεθεί κατά κύριο λόγο με καρδιαγγειακά προβλήματα. Νέα έρευνα, ωστόσο, δείχνει πως η νόσος μπορεί να βλάψει την εγκεφαλική λειτουργία. Σύμφωνα με τα στοιχεία πρόσφατης μελέτης που δημοσιεύτηκε στο Journal of Epidemiology, οι παχύσαρκοι ασθενείς κινδυνεύουν περισσότερο να εμφανίσουν άνοια στην πορεία της ζωής τους, επισημαίνοντας ξανά την ανάγκη περιορισμού της ολοένα αυξανόμενης νόσου. Με βάση τα ποσοστά που αναδείχθηκαν κατά τη μελέτη, ο κίνδυνος άνοιας για τους παχύσαρκους...
Fri Jul 03, 2020 12:10
Πιστεύετε ότι γνωρίζετε τα μυστικά του επιτυχημένου φλερτ; Αν η ευφυΐα, η καλή εμφάνιση και η προβολή των σημείων ταύτισης σας πέρασαν από το μυαλό, η πρόσφατη έρευνα από το Πανεπιστήμιο της Λευκωσίας στην Κύπρο μάλλον σας επιφυλάσσει εκπλήξεις. Οι ερευνητές Μενέλαος Αποστόλου και Χριστόφορος Χριστοφόρου, ζήτησαν από τους συμμετέχοντες στην έρευνα να απαντήσουν σχετικά με τις στρατηγικές φλερτ στις οποίες ενέδωσαν στο πρόσφατο παρελθόν. Οι απαντήσεις έδωσαν μια λίστα σαράντα επτά διαφορετικών προσεγγίσεων,...
Fri Jul 03, 2020 09:00
Τη σημασία της διατροφής στην αποτροπή και αντιστροφή της γήρανσης των αρτηριών ανέδειξε πρόσφατη έρευνα του Πανεπιστημίου του Κολοράντο στο Boulder. Μια ένωση που παράγεται στο έντερο από την κατανάλωση κόκκινου κρέατος βλάπτει τις αρτηρίες και μπορεί να αυξήσει τον κίνδυνο καρδιοπαθειών στην πάροδο του χρόνου, επισημαίνουν τα ευρήματα που δημοσιεύτηκαν στην έκδοση Hypertension της Αμερικανικής Καρδιολογικής Εταιρείας. Παρεμβάσεις και αλλαγές στις διατροφικές συνήθειες συνεπώς, μπορούν να απομακρύνουν...
Fri Jul 03, 2020 08:40
Σε όλα σχεδόν τα κύτταρα του ανθρώπινου οργανισμού, οι λειτουργίες ρυθμίζονται από βιολογικά ρολόγια, ευαίσθητα σε εξωτερικές αλλαγές όπως οι μεταβολές στην ένταση του φωτός κατά τη διάρκεια της ημέρας ή στην ώρα του δείπνου. Η διαταραχή της εύρυθμης λειτουργία των βιορυθμών επιφυλάσσει κινδύνους για την υγεία. Τον παραπάνω κίνδυνο, ο οποίος απειλεί κατ’ εξοχήν όσους εργάζονται τη νύχτα και τους καρδιοπαθείς, μπορεί να αποσοβήσει μια συνήθεια ευρέως διαδεδομένη: η γυμναστική. Όπως έδειξε πρόσφατη...
Fri Jul 03, 2020 08:30
Ένα κοινό πρόσθετο τροφίμων, που απαγορεύθηκε πρόσφατα στη Γαλλία αλλά συνεχίζει να χρησιμοποιείται στις ΗΠΑ και άλλες χώρες, διαπιστώθηκε πως αλλάζει σημαντικά το εντερικό μικροβίωμα των ποντικιών, προκαλώντας φλεγμονή στο παχύ έντερο και αλλαγές στην έκφραση των πρωτεϊνών στο ήπαρ, σύμφωνα με μελέτη επιστημόνων από το Πανεπιστήμιο της Μασαχουσέτης Amherst που δημοσιεύθηκε στο Small. «Πιστεύω ότι τα αποτελέσματά μας θα έχουν αρκετές συνέπειες στη βιομηχανία τροφίμων και στην ανθρώπινη υγεία και...
Fri Jul 03, 2020 08:20
Σε μια νέα μελέτη που δημοσιεύθηκε στο Aging Cell, οι επιστήμονες Alexandra K. Kiemer και Jessica Hoppstädter από το Πανεπιστήμιο Saarland αποκαλύπτουν διαδικασίες του ανοσοποιητικού συστήματος του ανθρώπου που συμβάλλουν στη γήρανση. Συγκεκριμένα, έδειξαν ότι τα χαμηλά επίπεδα της ορμόνης κορτιζόλης και μιας πρωτεΐνης γνωστής ως GILZ μπορούν να πυροδοτήσουν χρόνιες φλεγμονώδεις αποκρίσεις στο σώμα που συντελούν στη γήρανση. Το φαινόμενο της γήρανσης στον άνθρωπο είναι αποτέλεσμα μιας πολύπλοκης...
Fri Jul 03, 2020 08:00
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