IJMS, Vol. 21, Pages 4775: Effect of Heat Stress on Seed Protein Composition and Ultrastructure of Protein Storage Vacuoles in the Cotyledonary Parenchyma Cells of Soybean Genotypes That Are Either Tolerant or Sensitive to Elevated Temperatures International Journal of Molecular Sciences doi: 10.3390/ijms21134775 Authors: Hari B. Krishnan Won-Seok Kim Nathan W. Oehrle James R. Smith Jason D. Gillman High growth temperatures negatively affect soybean (Glycine max (L.) Merr)...
Sun Jul 05, 2020 03:00
IJMS, Vol. 21, Pages 4770: Effects of Lipids and Lipoproteins on Mesenchymal Stem Cells Used in Cardiac Tissue Regeneration International Journal of Molecular Sciences doi: 10.3390/ijms21134770 Authors: Yi-Hsiung Lin Lin Kang Wen-Han Feng Tsung-Lin Cheng Wei-Chung Tsai Hsuan-Ti Huang Hsiang-Chun Lee Chung-Hwan Chen Mesenchymal stem cells (MSCs) have two characteristics of interest for this paper: the ability to self-renew, and the potential for multiple-lineage differentiation...
Sun Jul 05, 2020 03:00
IJMS, Vol. 21, Pages 4774: Reproducible Large-Scale Isolation of Exosomes from Adipose Tissue-Derived Mesenchymal Stem/Stromal Cells and Their Application in Acute Kidney Injury International Journal of Molecular Sciences doi: 10.3390/ijms21134774 Authors: Jun Ho Lee Dae Hyun Ha Hyeon-kyu Go Jinkwon Youn Hyun-keun Kim Richard C. Jin Randy B. Miller Do-hyung Kim Byong Seung Cho Yong Weon Yi Acute kidney injury (AKI) is a fatal medical episode caused by sudden...
Sun Jul 05, 2020 03:00
IJMS, Vol. 21, Pages 4772: Indonesian Ginger (Bangle) Extract Promotes Neurogenesis of Human Neural Stem Cells through WNT Pathway Activation International Journal of Molecular Sciences doi: 10.3390/ijms21134772 Authors: Kazumi Hirano Miwa Kubo Yoshiyasu Fukuyama Masakazu Namihira Indonesian ginger (Zingiber purpureum Rosc.), also known as Bangle, exhibits neurotrophic effects on cultured murine cortical neurons and in the adult mouse brain, but the underlying mechanisms remain...
Sun Jul 05, 2020 03:00
IJMS, Vol. 21, Pages 4773: The Impact of Single-Cell Genomics on Adipose Tissue Research International Journal of Molecular Sciences doi: 10.3390/ijms21134773 Authors: Alana Deutsch Daorong Feng Jeffrey E. Pessin Kosaku Shinoda Adipose tissue is an important regulator of whole-body metabolism and energy homeostasis. The unprecedented growth of obesity and metabolic disease worldwide has required paralleled advancements in research on this dynamic endocrine organ system. Single-cell...
Sun Jul 05, 2020 03:00
IJMS, Vol. 21, Pages 4771: Aspirin Induces Mitochondrial Ca2+ Remodeling in Tumor Cells via ROS‒Depolarization‒Voltage-Gated Ca2+ Entry International Journal of Molecular Sciences doi: 10.3390/ijms21134771 Authors: Itsuho Fujikawa Takashi Ando Manami Suzuki-Karasaki Miki Suzuki-Karasaki Toyoko Ochiai Yoshihiro Suzuki-Karasaki Aspirin (acetylsalicylic acid) and its metabolite salicylate, have an anti-melanoma effect by evoking mitochondrial dysfunction through poorly understood...
Sun Jul 05, 2020 03:00
IJMS, Vol. 21, Pages 4769: Aquatic Mosses as Adaptable Bio-Filters for Heavy Metal Removal from Contaminated Water International Journal of Molecular Sciences doi: 10.3390/ijms21134769 Authors: Paride Papadia Fabrizio Barozzi Danilo Migoni Makarena Rojas Francesco P. Fanizzi Gian-Pietro Di Di Sansebastiano Heavy metals (HMs) are released into the environment by many human activities and persist in water even after remediation. The efficient filtration of solubilized HMs...
Sun Jul 05, 2020 03:00
IJMS, Vol. 21, Pages 4768: Role of Macrophages and Microglia in Zebrafish Regeneration International Journal of Molecular Sciences doi: 10.3390/ijms21134768 Authors: Susanna R. Var Christine A. Byrd-Jacobs Currently, there is no treatment for recovery of human nerve function after damage to the central nervous system (CNS), and there are limited regenerative capabilities in the peripheral nervous system. Since fish are known for their regenerative abilities, understanding how these...
Sun Jul 05, 2020 03:00
IJMS, Vol. 21, Pages 4767: Could Protons and Carbon Ions Be the Silver Bullets Against Pancreatic Cancer? International Journal of Molecular Sciences doi: 10.3390/ijms21134767 Authors: Camille Huart Jia-Wei Chen Benjamin Le Calvé Carine Michiels Anne-Catherine Wéra Pancreatic cancer is a very aggressive cancer type associated with one of the poorest prognostics. Despite several clinical trials to combine different types of therapies, none of them resulted in significant improvements...
Sat Jul 04, 2020 03:00
IJMS, Vol. 21, Pages 4765: Absolute Binding Free Energy Calculations for Highly Flexible Protein MDM2 and Its Inhibitors International Journal of Molecular Sciences doi: 10.3390/ijms21134765 Authors: Singh Li Reliable prediction of binding affinities for ligand-receptor complex has been the primary goal of a structure-based drug design process. In this respect, alchemical methods are evolving as a popular choice to predict the binding affinities for biomolecular complexes. However,...
Sat Jul 04, 2020 03:00
IJMS, Vol. 21, Pages 4766: Caffeine: An Overview of Its Beneficial Effects in Experimental Models and Clinical Trials of Parkinson’s Disease International Journal of Molecular Sciences doi: 10.3390/ijms21134766 Authors: Schepici Silvestro Bramanti Mazzon Parkinson’s Disease (PD) is a neurological disease characterized by the progressive degeneration of the nigrostriatal dopaminergic pathway with consequent loss of neurons in the substantia nigra pars compacta and...
Sat Jul 04, 2020 03:00
IJMS, Vol. 21, Pages 4762: Extracellular Matrix Stiffness and Composition Regulate the Myofibroblast Differentiation of Vaginal Fibroblasts International Journal of Molecular Sciences doi: 10.3390/ijms21134762 Authors: Alejandra M. Ruiz-Zapata Andrea Heinz Manon H. Kerkhof Cindy van de Westerlo-van Rijt Christian E. H. Schmelzer Reinout Stoop Kirsten B. Kluivers Egbert Oosterwijk Fibroblast to myofibroblast differentiation is a key feature of wound-healing in soft...
Sat Jul 04, 2020 03:00
IJMS, Vol. 21, Pages 4763: The Differential Effect of Carbon Dots on Gene Expression and DNA Methylation of Human Embryonic Lung Fibroblasts as a Function of Surface Charge and Dose International Journal of Molecular Sciences doi: 10.3390/ijms21134763 Authors: Michal Sima Kristyna Vrbova Tana Zavodna Katerina Honkova Irena Chvojkova Antonin Ambroz Jiri Klema Andrea Rossnerova Katerina Polakova Tomas Malina Jan Belza Jan Topinka Pavel Rossner This study...
Sat Jul 04, 2020 03:00
IJMS, Vol. 21, Pages 4764: BMP-Induced MicroRNA-101 Expression Regulates Vascular Smooth Muscle Cell Migration International Journal of Molecular Sciences doi: 10.3390/ijms21134764 Authors: Nanju Park Hara Kang Proliferation and migration of vascular smooth muscle cells (VSMCs) are implicated in blood vessel development, maintenance of vascular homeostasis, and pathogenesis of vascular disorders. MicroRNAs (miRNAs) mediate the regulation of VSMC functions in response to microenvironmental...
Sat Jul 04, 2020 03:00
IJMS, Vol. 21, Pages 4761: Role of Extracellular Matrix in Pathophysiology of Patent Ductus Arteriosus: Emphasis on Vascular Remodeling International Journal of Molecular Sciences doi: 10.3390/ijms21134761 Authors: Ting-Yi Lin Jwu-Lai Yeh Jong-Hau Hsu The ductus arteriosus (DA) is a shunt vessel between the aorta and the pulmonary artery during the fetal period that is essential for the normal development of the fetus. Complete closure usually occurs after birth but the vessel...
Sat Jul 04, 2020 03:00
IJMS, Vol. 21, Pages 4760: Choroid Plexus: The Orchestrator of Long-Range Signalling Within the CNS International Journal of Molecular Sciences doi: 10.3390/ijms21134760 Authors: Karol Kaiser Vitezslav Bryja Cerebrospinal fluid (CSF) is the liquid that fills the brain ventricles. CSF represents not only a mechanical brain protection but also a rich source of signalling factors modulating diverse processes during brain development and adulthood. The choroid plexus (CP) is a major source...
Sat Jul 04, 2020 03:00
IJMS, Vol. 21, Pages 4759: Signaling Pathways that Control Muscle Mass International Journal of Molecular Sciences doi: 10.3390/ijms21134759 Authors: Anna Vainshtein Marco Sandri The loss of skeletal muscle mass under a wide range of acute and chronic maladies is associated with poor prognosis, reduced quality of life, and increased mortality. Decades of research indicate the importance of skeletal muscle for whole body metabolism, glucose homeostasis, as well as overall health and...
Sat Jul 04, 2020 03:00
IJMS, Vol. 21, Pages 4758: Lipid Signaling in Ocular Neovascularization International Journal of Molecular Sciences doi: 10.3390/ijms21134758 Authors: Ryo Terao Hiroki Kaneko Vasculogenesis and angiogenesis play a crucial role in embryonic development. Pathological neovascularization in ocular tissues can lead to vision-threatening vascular diseases, including proliferative diabetic retinopathy, retinal vein occlusion, retinopathy of prematurity, choroidal neovascularization, and...
Sat Jul 04, 2020 03:00
IJMS, Vol. 21, Pages 4757: Induction of ER Stress in Acute Lymphoblastic Leukemia Cells by the Deubiquitinase Inhibitor VLX1570 International Journal of Molecular Sciences doi: 10.3390/ijms21134757 Authors: Paola Pellegrini Karthik Selvaraju Elena Faustini Arjan Mofers Xiaonan Zhang Jens Ternerot Alice Schubert Stig Linder Pádraig D′Arcy The proteasome is a validated target of cancer therapeutics. Inhibition of proteasome activity results in the activation of...
Sat Jul 04, 2020 03:00
IJMS, Vol. 21, Pages 4756: Role of Human Leukocyte Antigens at the Feto-Maternal Interface in Normal and Pathological Pregnancy: An Update International Journal of Molecular Sciences doi: 10.3390/ijms21134756 Authors: Chiara Tersigni Federica Meli Caterina Neri Azzurra Iacoangeli Rita Franco Antonio Lanzone Giovanni Scambia Nicoletta Di Simone The successful maternal tolerance of the semi-allogeneic fetus provides an apparent immunologic paradox. Indeed, deep invasion...
Sat Jul 04, 2020 03:00
IJMS, Vol. 21, Pages 4755: Eckol Alleviates Intestinal Dysfunction during Suckling-to-Weaning Transition via Modulation of PDX1 and HBEGF International Journal of Molecular Sciences doi: 10.3390/ijms21134755 Authors: Sang In Lee In Ho Kim Maintaining intestinal health in livestock is critical during the weaning period. The precise mechanisms of intestinal dysfunction during this period are not fully understood, although these can be alleviated by phlorotannins, including eckol. This...
Fri Jul 03, 2020 03:00
IJMS, Vol. 21, Pages 4753: Lipidomic Biomarkers in Polycystic Ovary Syndrome and Endometrial Cancer International Journal of Molecular Sciences doi: 10.3390/ijms21134753 Authors: Mohamad Nasir Shafiee Catharine A. Ortori David A. Barrett Nigel P. Mongan Jafaru Abu William Atiomo Women with polycystic ovary syndrome (PCOS) are more likely to develop endometrial cancer (EC). The molecular mechanisms which increase the risk of EC in PCOS are unclear. Derangements in lipid...
Fri Jul 03, 2020 03:00
IJMS, Vol. 21, Pages 4754: A Comprehensive Proteomic SWATH-MS Workflow for Profiling Blood Extracellular Vesicles: A New Avenue for Glioma Tumour Surveillance International Journal of Molecular Sciences doi: 10.3390/ijms21134754 Authors: Susannah Hallal Ali Azimi Heng Wei Nicholas Ho Maggie Yuk Ting Lee Hao-Wen Sim Joanne Sy Brindha Shivalingam Michael Edward Buckland Kimberley Louise Alexander-Kaufman Improving outcomes for diffuse glioma patients requires...
Fri Jul 03, 2020 03:00
IJMS, Vol. 21, Pages 4751: YUCCA-Mediated Biosynthesis of the Auxin IAA is Required during the Somatic Embryogenic Induction Process in Coffea canephora International Journal of Molecular Sciences doi: 10.3390/ijms21134751 Authors: Miguel A. Uc-Chuc Cleyre Pérez-Hernández Rosa M. Galaz-Ávalos Ligia Brito-Argaez Víctor Aguilar-Hernández Víctor M. Loyola-Vargas Despite the existence of considerable research on somatic embryogenesis (SE), the molecular mechanism that regulates...
Fri Jul 03, 2020 03:00
IJMS, Vol. 21, Pages 4750: MOTILIPERM Ameliorates Immobilization Stress-Induced Testicular Dysfunction Via Inhibition of Oxidative Stress and Modulation of the Nrf2/HO-1 Pathway in SD Rats International Journal of Molecular Sciences doi: 10.3390/ijms21134750 Authors: Keshab Kumar Karna Kiran Kumar Soni Jae Hyung You Na Young Choi Hye Kyung Kim Chul Young Kim Sung Won Lee Yu Seob Shin Jong Kwan Park It is well established that physiological stress has an adverse...
Fri Jul 03, 2020 03:00
IJMS, Vol. 21, Pages 4752: Reversible Growth-Arrest of a Spontaneously-Derived Human MSC-Like Cell Line International Journal of Molecular Sciences doi: 10.3390/ijms21134752 Authors: Catharina Melzer Roland Jacobs Thomas Dittmar Andreas Pich Juliane von der Ohe Yuanyuan Yang Ralf Hass Life cycle limitation hampers the production of high amounts of primary human mesenchymal stroma-/stem-like cells (MSC) and limits cell source reproducibility for clinical applications....
Fri Jul 03, 2020 03:00
IJMS, Vol. 21, Pages 4749: Osteoporosis in Skin Diseases International Journal of Molecular Sciences doi: 10.3390/ijms21134749 Authors: Maria Maddalena Sirufo Francesca De Pietro Enrica Maria Bassino Lia Ginaldi Massimo De Martinis Osteoporosis (OP) is defined as a generalized skeletal disease characterized by low bone mass and an alteration of the microarchitecture that lead to an increase in bone fragility and, therefore, an increased risk of fractures. It must be considered...
Fri Jul 03, 2020 03:00
IJMS, Vol. 21, Pages 4748: Role of Inflammation in Pathophysiology of Colonic Disease: An Update International Journal of Molecular Sciences doi: 10.3390/ijms21134748 Authors: Noha Ahmed Nasef Sunali Mehta Diseases of the colon are a big health burden in both men and women worldwide ranging from acute infection to cancer. Environmental and genetic factors influence disease onset and outcome in multiple colonic pathologies. The importance of inflammation in the onset, progression and...
Fri Jul 03, 2020 03:00
IJMS, Vol. 21, Pages 4747: In Vitro Assessment of the Genotoxic Hazard of Novel Hydroxamic Acid- and Benzamide-Type Histone Deacetylase Inhibitors (HDACi) International Journal of Molecular Sciences doi: 10.3390/ijms21134747 Authors: Annabelle Friedrich Ann-Sophie Assmann Lena Schumacher Jana v. Stuijvenberg Matthias U. Kassack Wolfgang A. Schulz Wynand P. Roos Finn K. Hansen Marc Pflieger Thomas Kurz Gerhard Fritz Histone deacetylase inhibitors (HDACi)...
Fri Jul 03, 2020 03:00
IJMS, Vol. 21, Pages 4746: The Fungal Iron Chelator Desferricoprogen inhibits atherosclerotic plaque formation International Journal of Molecular Sciences doi: 10.3390/ijms21134746 Authors: László Potor Sikura Katalin Éva Hajnalka Hegedűs Dávid Pethő Zsuzsa Szabó Zsuzsa M Szigeti István Pócsi György Trencsényi Dezső Szikra Ildikó Garai Tamás Gáll Zsolt Combi János Kappelmayer György Balla József Balla Hemoglobin, heme and iron are implicated in...
Fri Jul 03, 2020 03:00
IJMS, Vol. 21, Pages 4745: Effective Photodynamic Therapy for Colon Cancer Cells Using Chlorin e6 Coated Hyaluronic Acid-Based Carbon Nanotubes International Journal of Molecular Sciences doi: 10.3390/ijms21134745 Authors: Prabhavathi Sundaram Heidi Abrahamse Colon cancer is the third major cancer contributor to mortality worldwide. Nanosized particles have attracted attention due to their possible contribution towards cancer treatment and diagnosis. Photodynamic therapy (PDT) is...
Fri Jul 03, 2020 03:00
IJMS, Vol. 21, Pages 4744: Sodium Intake and Chronic Kidney Disease International Journal of Molecular Sciences doi: 10.3390/ijms21134744 Authors: Silvio Borrelli Michele Provenzano Ida Gagliardi Michael Ashour Maria Elena Liberti Luca De Nicola Giuseppe Conte Carlo Garofalo Michele Andreucci In Chronic Kidney Disease (CKD) patients, elevated blood pressure (BP) is a frequent finding and is traditionally considered a direct consequence of their sodium sensitivity....
Fri Jul 03, 2020 03:00
IJMS, Vol. 21, Pages 4741: Theoretical Prediction of Dual-Potency Anti-Tumor Agents: Combination of Oxoplatin with Other FDA-Approved Oncology Drugs International Journal of Molecular Sciences doi: 10.3390/ijms21134741 Authors: José Pedro Cerón-Carrasco Although Pt(II)-based drugs are widely used to treat cancer, very few molecules have been approved for routine use in chemotherapy due to their side-effects on healthy tissues. A new approach to reducing the toxicity of these drugs is...
Fri Jul 03, 2020 03:00
IJMS, Vol. 21, Pages 4742: How Do Yeast Cells Contend with Prions? International Journal of Molecular Sciences doi: 10.3390/ijms21134742 Authors: Reed B. Wickner Herman K. Edskes Moonil Son Songsong Wu Madaleine Niznikiewicz Infectious proteins (prions) include an array of human (mammalian) and yeast amyloid diseases in which a protein or peptide forms a linear β-sheet-rich filament, at least one functional amyloid prion, and two functional infectious proteins unrelated...
Fri Jul 03, 2020 03:00
IJMS, Vol. 21, Pages 4743: Evolutionary and Predictive Functional Insights into the Aquaporin Gene Family in the Allotetraploid Plant Nicotiana tabacum International Journal of Molecular Sciences doi: 10.3390/ijms21134743 Authors: Jahed Ahmed Sébastien Mercx Marc Boutry François Chaumont Aquaporins (AQPs) are a class of integral membrane proteins that facilitate the membrane diffusion of water and other small solutes. Nicotiana tabacum is an important model plant, and its allotetraploid...
Fri Jul 03, 2020 03:00
IJMS, Vol. 21, Pages 4740: The HSP90 Inhibitor, AUY-922, Ameliorates the Development of Nitrogen Mustard-Induced Pulmonary Fibrosis and Lung Dysfunction in Mice International Journal of Molecular Sciences doi: 10.3390/ijms21134740 Authors: Pavel Solopov Ruben M. L. Colunga Biancatelli Margarita Marinova Christiana Dimitropoulou John D. Catravas Increased levels of heat shock protein 90 (HSP90) have been recently implicated in the pathogenesis of pulmonary fibrosis and the...
Fri Jul 03, 2020 03:00
IJMS, Vol. 21, Pages 4738: Positive Effect of Cold Atmospheric Nitrogen Plasma on the Behavior of Mesenchymal Stem Cells Cultured on a Bone Scaffold Containing Iron Oxide-Loaded Silica Nanoparticles Catalyst International Journal of Molecular Sciences doi: 10.3390/ijms21134738 Authors: Agata Przekora Maïté Audemar Joanna Pawlat Cristina Canal Jean-Sébastien Thomann Cédric Labay Michal Wojcik Michal Kwiatkowski Piotr Terebun Grazyna Ginalska Sophie Hermans David...
Fri Jul 03, 2020 03:00
IJMS, Vol. 21, Pages 4739: Shedding “LIGHT” on the Link between Bone and Fat in Obese Children and Adolescents International Journal of Molecular Sciences doi: 10.3390/ijms21134739 Authors: Giacomina Brunetti Maria Felicia Faienza Laura Piacente Giuseppina Storlino Angela Oranger Gabriele D'Amato Gianpaolo De Filippo Silvia Colucci Maria Grano Obesity may affect bone health, but literature reports are contradictory about the correlation of body mass index (BMI)...
Fri Jul 03, 2020 03:00
IJMS, Vol. 21, Pages 4737: Elucidating Potential Profibrotic Mechanisms of Emerging Biomarkers for Early Prognosis of Hepatic Fibrosis International Journal of Molecular Sciences doi: 10.3390/ijms21134737 Authors: Mishghan Zehra James C. Curry Sneha S. Pillai Hari Vishal Lakhani Cory E. Edwards Komal Sodhi Hepatic fibrosis has been associated with a series of pathophysiological processes causing excessive accumulation of extracellular matrix proteins. Several cellular...
Fri Jul 03, 2020 03:00
IJMS, Vol. 21, Pages 4736: Molecular Cloning, Characterization, and Expression Regulation of Acyl-CoA Synthetase 6 Gene and Promoter in Common Carp Cyprinus carpio International Journal of Molecular Sciences doi: 10.3390/ijms21134736 Authors: Dizhi Xie Zijie He Yewei Dong Zhiyuan Gong Guoxing Nie Yuanyou Li Omega-3 long chain polyunsaturated fatty acids (n-3 LC-PUFA), particularly docosahexaenoic acids (22:6n-3, DHA), have positive effects on multiple biologic and pathologic...
Fri Jul 03, 2020 03:00
IJNS, Vol. 6, Pages 55: Establishing Pompe Disease Newborn Screening: The Role of Industry International Journal of Neonatal Screening doi: 10.3390/ijns6030055 Authors: Joan M Keutzer When clinical trials for enzyme replacement therapy for Pompe disease commenced, a need for newborn screening (NBS) for Pompe disease was recognized. Two methods for NBS for Pompe disease by measuring acid α-glucosidase in dried blood spots on filter paper were developed in an international collaborative...
Sun Jul 05, 2020 03:00
IJNS, Vol. 6, Pages 54: The Changing Face of Cystic Fibrosis and Its Implications for Screening International Journal of Neonatal Screening doi: 10.3390/ijns6030054 Authors: Lutz Naehrlich Early diagnosis, multidisciplinary care, and optimized and preventive treatments have changed the face of cystic fibrosis. Life expectancy has been expanded in the last decades. Formerly a pediatric disease, cystic fibrosis has reached adulthood. Mutation-specific treatments will expand treatment options...
Fri Jul 03, 2020 03:00
JCM, Vol. 9, Pages 2121: Nomogram Predicting the Likelihood of Parametrial Involvement in Early-Stage Cervical Cancer: Avoiding Unjustified Radical Hysterectomies Journal of Clinical Medicine doi: 10.3390/jcm9072121 Authors: Louise Benoit Vincent Balaya Benedetta Guani Arnaud Bresset Laurent Magaud Helene Bonsang-Kitzis Charlotte Ngô Patrice Mathevet Fabrice Lécuru Background: We aimed to establish a tool predicting parametrial involvement (PI) in patients with...
Sun Jul 05, 2020 03:00
JCM, Vol. 9, Pages 2120: Three‐Dimensional Radiographic Outcome of Free‐Handed Flaplessly Placed Mini Dental Implants in Edentulous Maxillae after 2‐Years Function Journal of Clinical Medicine doi: 10.3390/jcm9072120 Authors: Van Doorne Gholami D’haese Hommez Meijer De Bruyn Background: Free‐handed, flaplessly placed mini dental implants (MDIs) are a valuable, more affordable and minimally invasive treatment to support overdentures in fully edentulous jaws, especially...
Sun Jul 05, 2020 03:00
JCM, Vol. 9, Pages 2119: The Use of Demoralization Scale in Italian Kidney Transplant Recipients Journal of Clinical Medicine doi: 10.3390/jcm9072119 Authors: Yuri Battaglia Luigi Zerbinati Giulia Piazza Elena Martino Sara Massarenti Michele Provenzano Pasquale Esposito Michele Andreucci Alda Storari Luigi Grassi Demoralization is a commonly observed syndrome in medically ill patients. The risk of demoralization may increase in patients after a kidney transplant...
Sun Jul 05, 2020 03:00
JCM, Vol. 9, Pages 2118: Living Donor Kidney Transplantation Improves Graft and Recipient Survival in Patients with Multiple Kidney Transplants Journal of Clinical Medicine doi: 10.3390/jcm9072118 Authors: Maria Irene Bellini Aisling E Courtney Jennifer A McCaughan Background: Failed kidney transplant recipients benefit from a new graft as the general incident dialysis population, although additional challenges in the management of these patients are often limiting the long-term...
Sun Jul 05, 2020 03:00
JCM, Vol. 9, Pages 2117: Effect of Non-Surgical Periodontal Treatment on Oxidative Stress Markers in Leukocytes and Their Interaction with the Endothelium in Obese Subjects with Periodontitis: A Pilot Study Journal of Clinical Medicine doi: 10.3390/jcm9072117 Authors: Mayte Martínez-Herrera Zaida Abad-Jiménez Francisco Javier Silvestre Sandra López-Domènech Cecilia Fabiana Márquez-Arrico Javier Silvestre-Rangil Víctor M. Víctor Milagros Rocha Aim: The primary objective...
Sat Jul 04, 2020 03:00
JCM, Vol. 9, Pages 2113: Comparative Analysis of Three Machine-Learning Techniques and Conventional Techniques for Predicting Sepsis-Induced Coagulopathy Progression Journal of Clinical Medicine doi: 10.3390/jcm9072113 Authors: Daisuke Hasegawa Kazuma Yamakawa Kazuki Nishida Naoki Okada Shuhei Murao Osamu Nishida Sepsis-induced coagulopathy has poor prognosis; however, there is no established tool for predicting it. We aimed to create predictive models for coagulopathy...
Sat Jul 04, 2020 03:00
JCM, Vol. 9, Pages 2111: The Multifaced Perspectives of Genetic Testing in Pediatric Cardiomyopathies and Channelopathies Journal of Clinical Medicine doi: 10.3390/jcm9072111 Authors: Nicoleta-Monica Popa-Fotea Cosmin Cojocaru Alexandru Scafa-Udriste Miruna Mihaela Micheu Maria Dorobantu Pediatric inherited cardiomyopathies (CMPs) and channelopathies (CNPs) remain important causes of death in this population, therefore, there is a need for prompt diagnosis and tailored treatment....
Sat Jul 04, 2020 03:00
JCM, Vol. 9, Pages 2116: Factors for Predicting Noninvasive Ventilation Failure in Elderly Patients with Respiratory Failure Journal of Clinical Medicine doi: 10.3390/jcm9072116 Authors: Min Jeong Park Jae Hwa Cho Youjin Chang Jae Young Moon Sunghoon Park Tai Sun Park Young Seok Lee Noninvasive ventilation (NIV) is useful when managing critically ill patients. However, it is not easy to apply to elderly patients, particularly those with pneumonia, due to the possibility...
Sat Jul 04, 2020 03:00
JCM, Vol. 9, Pages 2112: Diagnostic Value of 18F-FDG-PET/CT in Patients with FUO Journal of Clinical Medicine doi: 10.3390/jcm9072112 Authors: Stamata Georga Paraskevi Exadaktylou Ioannis Petrou Dimitrios Katsampoukas Vasilios Mpalaris Efstratios-Iordanis Moralidis Kostoula Arvaniti Christos Papastergiou Georgios Arsos Conventional diagnostic imaging is often ineffective in revealing the underlying cause in a considerable proportion of patients with fever of unknown...
Sat Jul 04, 2020 03:00
JCM, Vol. 9, Pages 2115: Venous Thromboembolism in Patients with Inflammatory Bowel Disease: The Role of Pharmacological Therapy and Surgery Journal of Clinical Medicine doi: 10.3390/jcm9072115 Authors: Alfredo Papa Antonio Tursi Silvio Danese Gianludovico Rapaccini Antonio Gasbarrini Valerio Papa Patients with inflammatory bowel disease (IBD) have an increased risk of venous thromboembolism (VTE). Alongside the traditional acquired and genetic risk factors for VTE, patients...
Sat Jul 04, 2020 03:00
JCM, Vol. 9, Pages 2114: Ultrasound-Guided Percutaneous Tenotomy of the Long Head of Biceps Tendon in Patients with Symptomatic Complete Rotator Cuff Tear: In Vivo Non-contRolled Prospective Study Journal of Clinical Medicine doi: 10.3390/jcm9072114 Authors: Luca Maria Sconfienza Domenico Albano Carmelo Messina Salvatore Gitto Vincenzo Guarrella Carlo Perfetti Ettore Taverna Paolo Arrigoni Pietro Simone Randelli Background: We prospectively tested technical feasibility...
Sat Jul 04, 2020 03:00
JCM, Vol. 9, Pages 2108: Temperature-Induced Changes in Reperfused Stroke: Inflammatory and Thrombolytic Biomarkers Journal of Clinical Medicine doi: 10.3390/jcm9072108 Authors: Paulo Ávila-Gómez Pablo Hervella Andrés Da Silva-Candal María Pérez-Mato Manuel Rodríguez-Yáñez Iria López-Dequidt José M. Pumar José Castillo Tomás Sobrino Ramón Iglesias-Rey Francisco Campos Although hyperthermia is associated with poor outcomes in ischaemic stroke (IS), some studies...
Sat Jul 04, 2020 03:00
JCM, Vol. 9, Pages 2109: The Association between Neighborhood Amenities and Cognitive Function: Role of Lifestyle Activities Journal of Clinical Medicine doi: 10.3390/jcm9072109 Authors: Osamu Katayama Sangyoon Lee Keitaro Makino Ippei Chiba Seongryu Bae Yohei Shinkai Kenji Harada Hiroyuki Shimada Many of the modifiable risk factors for dementia are lifestyle-related, and multidomain interventions tailored to individual lifestyles are recommended to prevent cognitive...
Sat Jul 04, 2020 03:00
JCM, Vol. 9, Pages 2110: The Role of Ranolazine for the Treatment of Residual Angina beyond the Percutaneous Coronary Revascularization Journal of Clinical Medicine doi: 10.3390/jcm9072110 Authors: Calcagno Infusino Salvi Taccheri Colantonio Bruno Birtolo Severino Lavalle Pucci Sardella Mancone Fedele Introduction. Despite a successful percutaneous coronary intervention (PCI), several studies reported that the recurrence of angina after...
Sat Jul 04, 2020 03:00
JCM, Vol. 9, Pages 2107: Clinical Performance of Partial and Full-Coverage Fixed Dental Restorations Fabricated from Hybrid Polymer and Ceramic CAD/CAM Materials: A Systematic Review and Meta-Analysis Journal of Clinical Medicine doi: 10.3390/jcm9072107 Authors: Nadin Al-Haj Al-Haj Husain Mutlu Özcan Pedro Molinero-Mourelle Tim Joda The aim of this systematic review and meta-analysis was to evaluate the clinical performance of tooth-borne partial and full-coverage fixed dental...
Sat Jul 04, 2020 03:00
JCM, Vol. 9, Pages 2106: Frailty and COVID-19: A Systematic Scoping Review Journal of Clinical Medicine doi: 10.3390/jcm9072106 Authors: Giuseppe Maltese Andrea Corsonello Mirko Di Rosa Luca Soraci Cristiana Vitale Francesco Corica Fabrizia Lattanzio Older people have paid a huge toll in terms of mortality during the coronavirus disease-19 (COVID-19) pandemic. Frailty may have contributed to the vulnerability of older people to more severe clinical presentation. We...
Sat Jul 04, 2020 03:00
JCM, Vol. 9, Pages 2104: Use of Platelet-Rich Fibrin in the Treatment of Grade 2 Furcation Defects: Systematic Review and Meta-Analysis Journal of Clinical Medicine doi: 10.3390/jcm9072104 Authors: Francesco Tarallo Leonardo Mancini Luciano Pitzurra Sergio Bizzarro Michele Tepedino Enrico Marchetti In periodontitis patients, furcation defects are crucial sites to regenerate due to their complex anatomy. Various modern surgical techniques and use of biomaterials have been...
Fri Jul 03, 2020 03:00
JCM, Vol. 9, Pages 2105: Familial Dysalbuminemic Hyperthyroxinemia: An Underdiagnosed Entity Journal of Clinical Medicine doi: 10.3390/jcm9072105 Authors: Xavier Dieu Nathalie Bouzamondo Claire Briet Frédéric Illouz Valérie Moal Florence Boux de Boux de Casson Natacha Bouhours-Nouet Pascal Reynier Régis Coutant Patrice Rodien Delphine Mirebeau-Prunier Resistance to thyroid hormone (RTH) is a syndrome characterized by impaired sensitivity of tissues to thyroid...
Fri Jul 03, 2020 03:00
JCM, Vol. 9, Pages 2102: Enhanced Salivary and General Oxidative Stress in Hashimoto’s Thyroiditis Women in Euthyreosis Journal of Clinical Medicine doi: 10.3390/jcm9072102 Authors: Katarzyna Morawska Mateusz Maciejczyk Łukasz Popławski Anna Popławska-Kita Adam Kretowski Anna Zalewska Hashimoto’s thyroiditis (HT) is one of the most common autoimmune diseases. Although HT is inextricably linked to oxidative stress, there have been no studies assessing salivary...
Fri Jul 03, 2020 03:00
JCM, Vol. 9, Pages 2103: Lipoprotein(a) Lowering—From Lipoprotein Apheresis to Antisense Oligonucleotide Approach Journal of Clinical Medicine doi: 10.3390/jcm9072103 Authors: Maria Francesca Greco Cesare R. Sirtori Alberto Corsini Marat Ezhov Tiziana Sampietro Massimiliano Ruscica It is well-known that elevated lipoprotein(a)—Lp(a)—levels are associated with a higher risk of cardiovascular (CV) mortality and all-cause mortality, although a standard...
Fri Jul 03, 2020 03:00
JCM, Vol. 9, Pages 2101: Levonorgestrel-Releasing Intrauterine System as a Contraceptive Method in Nulliparous Women: A Systematic Review Journal of Clinical Medicine doi: 10.3390/jcm9072101 Authors: Magdalena Zgliczynska Karol Kocaj Iwona Szymusik Magdalena Maria Dutsch-Wicherek Michal Ciebiera Katarzyna Kosinska-Kaczynska The aim of this review was to summarize the available evidence about the use of levonorgestrel-releasing intrauterine system (LNG-IUS) as a contraceptive...
Fri Jul 03, 2020 03:00
JCM, Vol. 9, Pages 2099: Both Low and High PAPP-A Concentrations in the First Trimester of Pregnancy Are Associated with Increased Risk of Delivery before 32 Weeks in Twin Gestation Journal of Clinical Medicine doi: 10.3390/jcm9072099 Authors: Aleksandra Saletra-Bielińska Katarzyna Kosińska-Kaczyńska Iwona Szymusik Bartosz Kaczyński Robert Brawura-Biskupski-Samaha Szymon Kozłowski Patrycja Jarmużek Izabela Walasik Mirosław Wielgoś In twin gestation, the relationship...
Fri Jul 03, 2020 03:00
JCM, Vol. 9, Pages 2095: Atherosclerosis as Pathogenetic Substrate for Sars-Cov2 Cytokine Storm Journal of Clinical Medicine doi: 10.3390/jcm9072095 Authors: Mattia Vinciguerra Silvia Romiti Khalil Fattouch Antonio De Bellis Ernesto Greco The severe acute respiratory syndrome coronavirus 2 (Sars-CoV-2) outbreak is a public health emergency affecting different regions around the world. The lungs are often damaged due to the presence of Sars-CoV-2 binding receptor ACE2 on epithelial...
Fri Jul 03, 2020 03:00
JCM, Vol. 9, Pages 2093: PD-(L)1 Inhibitors in Combination with Chemotherapy as First-Line Treatment for Non-Small-Cell Lung Cancer: A Pairwise Meta-Analysis Journal of Clinical Medicine doi: 10.3390/jcm9072093 Authors: Jorge García-González Juan Ruiz-Bañobre Francisco J. Afonso-Afonso Margarita Amenedo-Gancedo María del Carmen Areses-Manrique Begoña Campos-Balea Joaquín Casal-Rubio Natalia Fernández-Núñez José Luis Fírvida Pérez Martín Lázaro-Quintela Diego Pérez...
Fri Jul 03, 2020 03:00
JCM, Vol. 9, Pages 2098: The Conceptual Framework of Dual Disorders and Its Flaws Journal of Clinical Medicine doi: 10.3390/jcm9072098 Authors: Matteo Pacini Angelo G.I. Maremmani Icro Maremmani When psychiatric illness and substance use disorder coexist, the clinical approach to the patient is, unsurprisingly, awkward. This fact is due to a cultural context and, more directly, to the patient’s psychiatric condition and addiction behaviors—a situation that does...
Fri Jul 03, 2020 03:00
JCM, Vol. 9, Pages 2097: Child–Adult Transition in Sarcoidosis: A Series of 52 Patients Journal of Clinical Medicine doi: 10.3390/jcm9072097 Authors: Chauveau Jeny Montagne Taam Houdouin Meinzer Delacourt Epaud Aubart Chapelon-Abric Israël-Biet Juvin Dossier Bodaghi Prévot Naccache Mattioni Deschildre Brouard Tazi Meckenstock Didier Haroche Clement Bernaudin Nunes Valeyre Nathan ...
Fri Jul 03, 2020 03:00
JCM, Vol. 9, Pages 2100: Reference Values of the QOLIBRI from General Population Samples in the United Kingdom and The Netherlands Journal of Clinical Medicine doi: 10.3390/jcm9072100 Authors: Anastasia Gorbunova Marina Zeldovich Daphne C. Voormolen Ugne Krenz Suzanne Polinder Juanita A. Haagsma York Hagmayer Amra Covic Ruben G. L. Real Thomas Asendorf Nicole von Steinbüchel The Quality of Life after Traumatic Brain Injury (QOLIBRI) instrument is an internationally...
Fri Jul 03, 2020 03:00
JCM, Vol. 9, Pages 2096: ACE2 as a Therapeutic Target for COVID-19; its Role in Infectious Processes and Regulation by Modulators of the RAAS System Journal of Clinical Medicine doi: 10.3390/jcm9072096 Authors: Veronique Michaud Malavika Deodhar Meghan Arwood Sweilem B Al Al Rihani Pamela Dow Jacques Turgeon Angiotensin converting enzyme 2 (ACE2) is the recognized host cell receptor responsiblefor mediating infection by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)....
Fri Jul 03, 2020 03:00
JCM, Vol. 9, Pages 2092: New Insights into Immunological Involvement in Congenital Disorders of Glycosylation (CDG) from a People-Centric Approach Journal of Clinical Medicine doi: 10.3390/jcm9072092 Authors: Rita Francisco Carlota Pascoal Dorinda Marques-da-Silva Sandra Brasil Fernando M. Pimentel-Santos Ruqaiah Altassan Jaak Jaeken Ana Rita Grosso Vanessa dos Reis dos Reis Ferreira Paula A. Videira Congenital disorders of glycosylation (CDG) are rare diseases...
Fri Jul 03, 2020 03:00
JCM, Vol. 9, Pages 2094: Epidemiological Trends in the Timing of In-Hospital Death in Acute Myocardial Infarction-Cardiogenic Shock in the United States Journal of Clinical Medicine doi: 10.3390/jcm9072094 Authors: Saraschandra Vallabhajosyula Shannon M. Dunlay Malcolm R. Bell P. Elliott Miller Wisit Cheungpasitporn Pranathi R. Sundaragiri Kianoush Kashani Bernard J. Gersh Allan S. Jaffe David R. Holmes Gregory W. Barsness Background: There are limited data...
Fri Jul 03, 2020 03:00
JCM, Vol. 9, Pages 2090: Endothelial Dysfunction: A Contributor to Adverse Cardiovascular Remodeling and Heart Failure Development in Type 2 Diabetes beyond Accelerated Atherogenesis Journal of Clinical Medicine doi: 10.3390/jcm9072090 Authors: Aleksandra Gamrat Michał A. Surdacki Bernadeta Chyrchel Andrzej Surdacki Endothelial dysfunction, associated with depressed nitric oxide (NO) bioavailability, is awell-recognized contributor to both accelerated atherogenesis and microvascular...
Fri Jul 03, 2020 03:00
JCM, Vol. 9, Pages 2089: Estimated Population Prevalence of Heart Failure with Reduced Ejection Fraction in Spain, According to DAPA-HF Study Criteria Journal of Clinical Medicine doi: 10.3390/jcm9072089 Authors: Anna Camps-Vilaró Juan F. Delgado-Jiménez Núria Farré Helena Tizón-Marcos Jesús Álvarez-García Juan Cinca Irene R. Dégano Jaume Marrugat Heart failure (HF) is one of the main causes of morbidity, mortality, and high healthcare costs. Dapagliflozin, a sodium-glucose...
Fri Jul 03, 2020 03:00
JCM, Vol. 9, Pages 2088: Pain and Oral-Health-Related Quality of Life in Orthodontic Patients During Initial Therapy with Conventional, Low-Friction, and Lingual Brackets and Aligners (Invisalign): A Prospective Clinical Study Journal of Clinical Medicine doi: 10.3390/jcm9072088 Authors: Laura Antonio-Zancajo Javier Montero Alberto Albaladejo Maria Dolores Oteo-Calatayud Alfonso Alvarado-Lorenzo The aim of this study was to compare pain and its relationship with the oral...
Fri Jul 03, 2020 03:00
JCM, Vol. 9, Pages 2091: Hepatitis C Virus Influences HIV-1 Viral Splicing in Coinfected Patients Journal of Clinical Medicine doi: 10.3390/jcm9072091 Authors: Paula Martínez-Román María Rosa López-Huertas Celia Crespo-Bermejo Sonia Arca-Lafuente Isabel Cortegano Daniel Valle-Millares María Luisa Gaspar Luz Martín-Carbonero Lourdes Domínguez-Domínguez Pablo Ryan Ignacio de los Santos Sara de la Fuente-Moral Amanda Fernández-Rodríguez Mayte Coiras Verónica...
Fri Jul 03, 2020 03:00
JCM, Vol. 9, Pages 2086: Rapid Chairside Microbial Detection Predicts Endodontic Treatment Outcome Journal of Clinical Medicine doi: 10.3390/jcm9072086 Authors: Alan Knight Ian Blewitt Nassr Al-Nuaimi Tim Watson Dylan Herzog Frederic Festy Shanon Patel Federico Foschi Garrit Koller Francesco Mannocci Background. The aim of this longitudinal, one-year cohort study was to explore the hypothesis that fluorescence sampling of the root canal space prior to obturation...
Fri Jul 03, 2020 03:00
JCM, Vol. 9, Pages 2087: Assessment of Cardiac Remodeling—A Chance for Novel Cardiac Biomarkers? Journal of Clinical Medicine doi: 10.3390/jcm9072087 Authors: Peter Jirak Moritz Mirna Bernhard Wernly Vera Paar Uta C. Hoppe Michael Lichtenauer Biomarkers are defined as “cellular, biochemical or molecular alterations that are measurable in biological media such as human tissues, cells, or fluids”, providing “biological characteristics that can...
Fri Jul 03, 2020 03:00
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