Abstract Previous research has suggested reduced parasympathetic cardiac regulation during cognitive activity in major depressive disorder (MDD). However, little is known about possible abnormalities in sympathetic control and cardiovascular reactivity. This study aimed to provide a comprehensive analysis of autonomic cardiovascular control in the context of executive functions in MDD. Thirty six MDD patients and 39 healthy controls participated. Parameters of sympathetic (pre‐ejection period, PEP)...
Sat Jul 04, 2020 22:54
Abstract Resilience refers to the capacity to function well despite adversity and facilitates adaptation to various stressors, including pain. Previous studies have operationalized resilience via questionnaires or task performance behaviors that do not always correlate with one another and tested extreme (lower vs. higher) resilience subgroup differences that do not permit the assessment of nonlinear associations between resilience and brain matter volume. To address these limitations, we identified...
Sat Jul 04, 2020 22:48
Abstract Millions of people of all ages suffer from chronic respiratory diseases (CRDs), including asthma, respiratory allergies and chronic obstructive pulmonary disease. To date, although significant advances have been made in terms of treatment, end‐stage CRDs still remains one of the most frequent causes of death worldwide with a death rate that has been increasing over the past few years. Lung transplantation is the only therapeutic option when other treatments fail. However, it is often unavailable...
Sat Jul 04, 2020 20:03
Abstract High fractional exhaled nitric oxide (FeNO) levels, reflecting uncontrolled airway inflammation, are regarded as a risk factor for an upcoming asthma exacerbation. A previous study found that persistently high FeNO (> 40 ppb) was associated with a rapid decline in FEV1, even in controlled asthma patients, in a 3‐year prospective study. However, little is known about the effect of high FeNO levels on short‐term course of lung function. Oscillometry, also known as the forced oscillation...
Sat Jul 04, 2020 19:19
Abstract Background Investigation of preschool asthma is important since not all children outgrow their illness during this age. Data are scarce on the role of rhinovirus (RV) infections in this patient group. Objectives To investigate the role of RV infections in preschool asthma: (1) susceptibility factors, (2) clinical course, and (3) medium‐term outcome. Methods 130 asthmatic children aged 4 to 6 years from the multinational PreDicta cohort were prospectively followed for a 12‐month...
Fri Jul 03, 2020 17:43
Abstract Background Allergen‐specific immunotherapy via the skin targets an area rich in antigen presenting cells, but can be associated with local and systemic side effect. Allergen‐polysaccharide neoglycogonjugates increase immunization efficacy by targeting and activating dendritic cells via C‐type lectin receptors and reduce side effects. Objective We investigated the immunogenicity, allergenicity and therapeutic efficacy of laminarin‐ovalbumin neoglycoconjugates (LamOVA). Methods...
Fri Jul 03, 2020 16:29
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Thu Jul 02, 2020 21:08
Active surveillance is a commonly utilized management option for stage 1 testicular germ cell tumours, but has a loss‐to‐follow‐up rate of almost 20% that may limit its effectiveness. The recurrence rate was comparable to published literature. Abstract Background This study aimed to evaluate the compliance and loss‐to‐follow‐up (LTFU) rate in patients with stage 1 testicular germ cell tumours (GCTs) on active surveillance protocol at a metropolitan health service in Melbourne, Australia....
Thu Jul 02, 2020 17:10
Although surgical lung biopsy is essential for the diagnosis of interstitial lung disease, it could be accompanied by severe complications. Prepared surgical lung biopsy could be performed with reasonable complications rates. Clinicians should be aware of the risks and benefits of surgical diagnosis for interstitial lung diseases. Abstract Background The aim of this study was to evaluate mortality and morbidity after surgical lung biopsy in patients with interstitial lung diseases and...
Thu Jul 02, 2020 17:09
Abstract Introduction IFN‐lambda (type III‐IFN‐λ1) is a molecule primarily produced by epithelial cells that provides an important first‐line defense against viral respiratory infections and has been linked to the pathogenesis of viral induced wheezing in early life. The goal of this study was to better understand the regulation of innate IFN‐lambda responses in vitro in primary human infant airway epithelial cells (AECs) and in vivo using nasal aspirates during viral respiratory infections....
Sun Jul 05, 2020 11:26
Abstract Background Integrin β4 (ITGB4) is a hemi‐desmosome protein which is downregulated in the airway epithelial cells of asthma patients. The proximal promoters and exons of ITGB4 contain CpG islands or multiple CpG sites both in human and mice, which indicated the possible methylation regulation of ITGB4 in airway epithelia cells. Objective We sought to unveil that DNA methylation regulates the decreased ITGB4 during the pathogenesis of asthma. Methods Mice were exposed to house...
Fri Jul 03, 2020 13:25
Abstract Objective To compare machine learning (ML) of texture analysis (TA) features for classification of solid renal masses on non-contrast-enhanced CT (NCCT), corticomedullary (CM) and nephrographic (NG) phase contrast-enhanced (CE) CT. Materials and methods With IRB approval, we retrospectively identified 177 consecutive solid renal masses (116 renal...
Sun Jul 05, 2020 03:00
Abstract Emperipolesis is a physiologic or pathologic phenomenon characterized by the presence of intact viable cells within the cytoplasm of another cell. It has been described in normal tissues and in a variety of inflammatory and neoplastic lesions such as Rosai‐Dorfman disease, tumors, hematopoietic disorders and rarely lymphomas. Emperipolesis by mesothelial cells is rare. Few cases of mesothelial emperipolesis of neoplastic lymphocytes in pleural effusions involved by lymphomas have been reported...
Sat Jul 04, 2020 17:35
Abstract BACKGROUND Multinucleated giant cell (MGC) present in a variety of non‐neoplastic and neoplastic lesions of the thyroid on cytology samples. We aimed to investigate whether certain MGC features that can help us in routine cytopathology practice. METHOD One hundred and thirty seven cases thyroid fine‐needle aspiration material, which was diagnosed as indeterminate or malignant according to the Bethesda categorization, were reviewed. All cytomorphological features of the MGCs were...
Sat Jul 04, 2020 17:35
Abstract Purpose This study aimed to explore the effect of patient-controlled intravenous analgesia (PCIA) using tramadol combined with butorphanol on uterine cramping pain in women undergoing repeat caesarean section. Methods A total of 126 patients, who were scheduled to undergo repeat caesarean section under spinal anesthesia, were included. PCIA...
Sun Jul 05, 2020 03:00
The U.S. health care industry has often been referred to as "recession-proof." Historically, this characterization has held true. During the Great Recession, the numbers of health care jobs and national expenditures rose consistently, despite substantial cuts in other sectors. But the current…
Wed Jul 01, 2020 03:00
It’s a sunny Sunday in San Francisco as I tackle overdue clinic notes and Covid-19 sweeps the planet. I am scheduled to speak in 10 other states over the coming weeks, and as a healthy, middle-aged physician from a region with growing numbers of infections, I’m as likely to be a vector as a victim.…
Thu Jul 02, 2020 03:00
The dramatic saga of the acquired immunodeficiency syndrome (AIDS) features an early sense of helplessness and frustration in the face of a mysterious new disease, courage on the part of the afflicted, and the gradual accrual of groundbreaking scientific advances that have brought hope to a…
Thu Jul 02, 2020 03:00
Here is an important spotter case for MD/DNB Radiology examination on an important chest wall deformity. Famous Radiology Blog http://www.sumerdoc.blogspot.com TeleRad Providers at www.teleradproviders.com Mail us at sales@teleradproviders.com
Sun Jul 05, 2020 10:05
Abstract To characterize oral sites affected by radiation-induced oral mucositis (OM) and related clinical outcomes in oral cancer patients subjected to prophylactic photobiomodulation therapy (PBMT). This study included advanced oral squamous cell carcinoma (OSCC) patients treated with prophylactic PBMT for OM. The site distribution of OM, OM grading (CTCAE NCI, Version 4.0, 2010), OM-related pain (VAS), analgesic protocol (WHO Analgesic Ladder), and use of enteral nutrition...
Sun Jul 05, 2020 03:00
Abstract This study aims to evaluate the photodynamic efficacy of purpurin 18 (pu-18) on triple negative breast cancer both in vitro and in vivo. Two states of 4T1 cells, 2D culture and 3D spheroids, were used to evaluate the photodynamic action of pu-18 in vitro. The in vitro study results indicated that for the 4T1 2D cell culture, the photodynamic therapy (PDT) treatment showed significant photocytotoxicity at low pu-18 concentrations following light irradiation. Pu-18 was...
Sun Jul 05, 2020 03:00
Abstract Photobiomodulation (PBM) has been shown to improve cell proliferation and cell migration. Many cell types have been investigated, with most studies using deep penetrating red light irradiation. Considering the interest of surface biostimulation of oral mesenchymal cells after surgical wound, the present study aimed to assess green light irradiation effects on Dental Pulp Stem Cells’ (DPSC) proliferation and migration. To understand the mechanisms underlying these effects,...
Sat Jul 04, 2020 03:00
Abstract This study aims to investigate the effect of antimicrobial photodynamic therapy (a-PDT) using a novel combination of sinoporphyrin sodium (DVDMS) and light-emitting diode (LED) with a wavelength of 390–400 nm on Porphyromonas gingivalis in vitro. Absorption spectrum of DVDMS was determined by spectrometer for selecting suitable wavelength light source. The uptake of DVDMS by P. gingivalis was evaluated according to fluorescence intensity detected by a spectrometer. Then...
Fri Jul 03, 2020 03:00
Abstract The purpose of this study was to investigate in vivo the biomechanical and morphological changes in soft palates of Wistar rats from non-ablative irradiation with a 9.3-μm CO2 laser. A blinded, randomized, controlled study was designed with 45 Wistar rats categorized into treated and control sets. The treated set was exposed to 9.3-μm CO2 laser irradiation at an average power of 1.0 W and a single pulse fluence of 0.16 J/cm2 scanned using an automated system at a repetition...
Fri Jul 03, 2020 03:00
Prediction of long-term neurodevelopmental outcomes remains an elusive goal for neonatology. Clinical and socioeconomic markers have not proven to be adequately reliable. The limitation in prognostication incl...
Sat Jul 04, 2020 03:00
Introduction. Some studies have reported the occurrence of microorganisms isolated from water. Considering these microorganisms, fungi are known to occur ubiquitously in the environment, including water, and some are pathogenic and may cause health problems, especially in immunocompromised individuals. The aim of this study was to identify fungi in hospital water samples and to correlate their presence with the concentration of free residual chlorine. Methods. Water samples (100 mL) were collected...
Sat Jul 04, 2020 21:20
Girish Kumar Parida, Amitabh Upadhyay, Sujata Mitra, Akchata Suman, Gopal Sonai MuthuIndian Journal of Nuclear Medicine 2020 35(3):248-250 We report an extremely rare case of acute inflammatory myopathy during combination chemotherapy with docetaxel and transtuzumab for metastatic breast carcinoma in a 44-year-old female patient. Despite the significant response in the follow-up fluorodeoxyglucose (FDG) positron emission tomography/computed tomography, of the underlying malignancy to the chemotherapeutic...
Wed Jul 01, 2020 00:00
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